National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11635

TDMS Study 97013-94 Pathology Tables

NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03
Route: DOSED WATER                                                                                                Time: 14:42:00

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3            4            4            7                                     
    Natural Death                                                   1            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            5            4            2                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
   Salivary Glands                                    (1)          (1)          (2)          (2)                                    
      Carcinoma                                        1 (100%)                  2 (100%)     2 (100%)                              
      Carcinoma, Metastatic, Zymbal's Gland                         1 (100%)                                                        
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Squamous Cell Papilloma                                       2 (20%)      3 (30%)                                            
      Squamous Cell Papilloma, Multiple                1 (10%)      2 (20%)                   1 (10%)                               
   Tooth                                              (3)          (5)          (2)          (5)                                    
      Odontogenic Tumor                                2 (67%)      4 (80%)      1 (50%)      5 (100%)                              
      Odontogenic Tumor, Multiple                      1 (33%)      1 (20%)      1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
   Pituitary Gland                                    (10)         (10)         (9)          (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (9)          (10)         (10)                                   
      Luteoma                                          1 (10%)                   1 (10%)                                            
   Uterus                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)          (2)                                                              
   Lymph Node, Mandibular                             (9)          (10)         (10)         (9)                                    
      Carcinoma, Metastatic, Uncertain Primary Site    1 (11%)                                                                      
      Carcinoma, Metastatic, Zymbal's Gland                         1 (10%)                                                         
   Lymph Node, Mesenteric                             (9)          (9)          (10)         (10)                                   
   Spleen                                             (10)         (10)         (10)         (10)                                   
   Thymus                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                                   (1)                                                              
      Adenocarcinoma                                                1 (100%)                                                        
   Skin                                               (6)          (8)          (8)          (4)                                    
      Squamous Cell Papilloma                          2 (33%)      3 (38%)      3 (38%)                                            
      Squamous Cell Papilloma, Multiple                3 (50%)      5 (63%)      4 (50%)      1 (25%)                               
      Subcutaneous Tissue, Fibrosarcoma                             1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar/Bronchiolar Adenoma                     1 (10%)      1 (10%)      1 (10%)                                            
      Carcinoma, Metastatic, Zymbal's Gland                         1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)          (1)                                                 
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Leukemia Erythrocytic                                         2 (20%)      2 (20%)      1 (10%)                               
      Lymphoma Malignant                                                         1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             8           9           9           8                                       
     Total Primary Neoplasms                           12          23          19          10                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  6           8           8           2                                       
     Total Benign Neoplasms                             8          13          12           2                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           5           5           3                                       
     Total Malignant Neoplasms                          1           5           5           3                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                                               
     Total Metastatic Neoplasm                          1           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  3           5           2           5                                       
     Total Uncertain Neoplasms                          3           5           2           5                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            2            4            3                                     
    Natural Death                                      2            1                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            7            6            4                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
   Salivary Glands                                                 (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Squamous Cell Papilloma                          2 (20%)      3 (30%)      1 (10%)      1 (10%)                               
      Squamous Cell Papilloma, Multiple                2 (20%)      1 (10%)                                                         
   Tooth                                              (3)          (2)          (4)          (2)                                    
      Odontogenic Tumor                                3 (100%)     2 (100%)     3 (75%)      2 (100%)                              
      Odontogenic Tumor, Multiple                                                1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                (1)                                    
   Lymph Node, Mandibular                             (9)          (10)         (10)         (7)                                    
   Spleen                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (9)          (9)          (9)          (8)                                    
      Squamous Cell Papilloma                                       2 (22%)      1 (11%)      3 (38%)                               
      Squamous Cell Papilloma, Multiple                5 (56%)      6 (67%)      5 (56%)      4 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar/Bronchiolar Adenoma                     1 (10%)      3 (30%)      1 (10%)                                            
   Trachea                                                                                   (1)                                    
      Adenoma                                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(10)        *(10)        *(10)        *(10)                                   
      Leukemia Erythrocytic                            2 (20%)                   2 (20%)      2 (20%)                               
      Lymphoma Malignant                                            1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03  
Route: DOSED WATER                                                                                                Time: 14:42:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/L       80 MG/L      400 MG/L     800 MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            10           9          10           9                                       
     Total Primary Neoplasms                           15          19          14          13                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  7           8           7           8                                       
     Total Benign Neoplasms                            10          15           8           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2           2           2           2                                       
     Total Malignant Neoplasms                          2           2           2           2                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  3           2           4           2                                       
     Total Uncertain Neoplasms                          3           2           4           2                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.