National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11639

TDMS Study 97013-94 Pathology Tables

NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03
Route: DOSED WATER                                                                                                Time: 14:43:35

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7789-38-0

       Lock Date:  07/30/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 0| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 5| 4| 9| 9| 9|                                            |            |
                                           | 5| 5| 3| 5| 5| 7| 6| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |       1  1        1                                                      |      3  1.0|
      Inflammation, Chronic Active         | 1  1  1  1  1  2  1  1  1  1                                             |     10  1.1|
      Mineralization                       |                2                                                         |      1  2.0|
      Hepatocyte, Necrosis                 |                      1                                                   |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic| 2  1     1  1        2  2  1                                             |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +        +                                                               |   2        |
      Fat, Fibrosis                        |          2                                                               |      1  2.0|
      Fat, Necrosis                        | 4        4                                                               |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |       2                                                                  |      1  2.0|
      Epithelium, Hyperplasia              |       2  1     2     2  2                                                |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +  +                 +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 0| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 5| 4| 9| 9| 9|                                            |            |
                                           | 5| 5| 3| 5| 5| 7| 6| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                      1                                                   |      1  1.0|
      Subcapsular, Hyperplasia             |       2  1  1     1        1                                             |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |    1              1  1                                                   |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Depletion Secretory        |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |          2                                                               |      1  2.0|
      Cyst                                 |          3                                                               |      1  3.0|
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     | 1  3     4  3     2  2  1  1                                             |      8  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
      Hyperplasia, Lymphoid                |    2  3                                                                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 0| 2| 2| 0| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 5| 4| 9| 9| 9|                                            |            |
                                           | 5| 5| 3| 5| 5| 7| 6| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          3        2        2                                             |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |       2        2                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +     +           +  +  +                                             |   6        |
      Inflammation, Chronic Active         | 1                                                                        |      1  1.0|
      Epidermis, Hyperplasia, Focal        | 2  2                 3  3  2                                             |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 1  1           1  1     1  1                                             |      6  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 9| 9| 9| 8| 8| 4| 9| 5|                                            |            |
                                           | 2| 5| 5| 5| 5| 7| 7| 4| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          1     1        1  2                                             |      4  1.3|
      Inflammation, Chronic Active         |       1  1  1  1        1  1                                             |      6  1.0|
      Hepatocyte, Necrosis                 |                1                                                         |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1     1  1        1                                                |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |                            +                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |    1           1                                                         |      2  1.0|
      Epithelium, Hyperplasia              |    2  2     2  2     2  2                                                |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +     +     +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 9| 9| 9| 8| 8| 4| 9| 5|                                            |            |
                                           | 2| 5| 5| 5| 5| 7| 7| 4| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Mineralization                       |    1              1                                                      |      2  1.0|
      Subcapsular, Hyperplasia             |    1  1  1     1  1     1                                                |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |          1              1                                                |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Infiltration Cellular, Lymphocyte    |          1        1                                                      |      2  1.0|
      Follicle, Degeneration               |    2                                                                     |      1  2.0|
      Follicle, Depletion Secretory        |    2  1  1  1     2  1  1  1                                             |      8  1.3|
      Follicular Cell, Hypertrophy         |    1  1  1  1  1  1     1  1                                             |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Cyst                                 |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |       3  4                 4                                             |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            |       2  2                 4                                             |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |    2  2  3     1  2     3  2                                             |      7  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 9| 9| 9| 8| 8| 4| 9| 5|                                            |            |
                                           | 2| 5| 5| 5| 5| 7| 7| 4| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +     +                                             |   2        |
      Mediastinal, Hyperplasia, Lymphoid   |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |    4  4  3                 3                                             |      4  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          2     3           3                                             |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    2           2  2  3     4                                             |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +     +  +                                             |   8        |
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Epidermis, Hyperplasia, Focal        |    3        3           3                                                |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 9| 9| 9| 8| 8| 4| 9| 5|                                            |            |
                                           | 2| 5| 5| 5| 5| 7| 7| 4| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |       1  1  1  1  1        1                                             |      6  1.0|
      Cortex, Cyst                         |    1              1                                                      |      2  1.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 1| 2| 2| 1| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 4| 9| 9| 8| 9| 7| 1| 9| 9|                                            |            |
                                           | 7| 4| 5| 7| 7| 5| 3| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |       1  1  1  1     1     1                                             |      6  1.0|
      Inflammation, Chronic Active         |       1  1  1  1     1  1  1                                             |      7  1.0|
      Hepatocyte, Fatty Change             | 2                                                                        |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1        1     1  2                                                |      4  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |          +           +                                                   |   2        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |             1                                                            |      1  1.0|
      Epithelium, Hyperplasia              |       2  2  2           2                                                |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcapsular, Hyperplasia             |                1                                                         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 1| 2| 2| 1| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 4| 9| 9| 8| 9| 7| 1| 9| 9|                                            |            |
                                           | 7| 4| 5| 7| 7| 5| 3| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +                                             |   9        |
      Pars Distalis, Hypertrophy           |       1  1                                                               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |    1  1  2  1  1        1  1                                             |      7  1.1|
      Follicle, Depletion Secretory        | 2  2  4  4  3  3     2  3  4                                             |      9  3.0|
      Follicular Cell, Hypertrophy         | 1  1  4  4  3  3  3  1  3  3                                             |     10  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Inflammation, Chronic Active         |                            4                                             |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     |    1  2     1           2  3                                             |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |          2  2                                                            |      2  2.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |       2  2  2  2     1     2                                             |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3  3        3  2  2  2                                                   |      6  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 1| 2| 2| 1| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 4| 9| 9| 8| 9| 7| 1| 9| 9|                                            |            |
                                           | 7| 4| 5| 7| 7| 5| 3| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Cyst                                 |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +        +                                             |   8        |
      Epidermis, Hyperplasia, Focal        |       3        3                                                         |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar Epithelium, Hyperplasia     |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                      1                                                   |      1  1.0|
      Nephropathy                          | 2  1  1  1  1  1        1  2                                             |      8  1.3|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            | 2  4                                                                     |      2  3.0|
      Renal Tubule, Hypertrophy            |       1  1                                                               |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 2| 0| 1| 2| 2| 1| 1| 2|                                            |            |
                             DAY ON TEST   | 0| 8| 9| 9| 9| 9| 7| 1| 9| 7|                                            |            |
                                           | 8| 8| 5| 3| 9| 5| 7| 5| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          1                                                               |      1  1.0|
      Inflammation, Chronic Active         |       1  1  1  1        1                                                |      5  1.0|
      Hepatocyte, Necrosis                 |                         1                                                |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       2        1        1                                                |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |                         +  +                                             |   2        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           | 1  2     1  1     1     1  2                                             |      7  1.3|
      Epithelium, Hyperplasia              | 2  2  2  2  2     2     2  2                                             |      8  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +     +     +     +  +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |             2                                                            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 2| 0| 1| 2| 2| 1| 1| 2|                                            |            |
                             DAY ON TEST   | 0| 8| 9| 9| 9| 9| 7| 1| 9| 7|                                            |            |
                                           | 8| 8| 5| 3| 9| 5| 7| 5| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                                        |   1        |
      Necrosis                             | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hypertrophy           |    2  2        3  2     2  2                                             |      6  2.2|
      Pars Distalis, Mineralization        |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |    1  2  1  1  2  1     2  1                                             |      8  1.4|
      Follicle, Depletion Secretory        | 1  4  4  3  4  4  4  1  4  4                                             |     10  3.3|
      Follicular Cell, Hypertrophy         | 2  4  4  2  3  4  4  2  4  4                                             |     10  3.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |             2  2                                                         |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     |             1  2                                                         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Hyperplasia, Lymphoid                |          4           2                                                   |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                            3                                             |      1  3.0|
      Hematopoietic Cell Proliferation     |       2  2           2  2                                                |      4  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 2| 0| 1| 2| 2| 1| 1| 2|                                            |            |
                             DAY ON TEST   | 0| 8| 9| 9| 9| 9| 7| 1| 9| 7|                                            |            |
                                           | 8| 8| 5| 3| 9| 5| 7| 5| 7| 3|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3  3  2  3  4  3  2  3     3                                             |      9  2.9|
      Cyst                                 |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |       +     +  +  +                                                      |   4        |
      Epidermis, Hyperplasia, Focal        |       1     2     2                                                      |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Nose                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       | 1                          1                                             |      2  1.0|
      Nephropathy                          | 1  1  2     1  2  1     1  1                                             |      8  1.3|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                   1                                                      |      1  1.0|
      Renal Tubule, Degeneration           | 1  3  2        3  3     2  2                                             |      7  2.3|
      Renal Tubule, Hypertrophy            |    2  1     1  2        2                                                |      5  1.6|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 1| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 2| 9| 9| 9| 8| 3| 9| 9|                                            |            |
                                           | 5| 3| 4| 5| 5| 5| 5| 9| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +           +                                             |   3        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |       1  1     1        1  1                                             |      5  1.0|
      Hepatocyte, Fatty Change             |             1           2                                                |      2  1.5|
      Hepatocyte, Necrosis                 |                1                                                         |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1           1  1        2  1                                             |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |       2              2                                                   |      2  2.0|
      Epithelium, Hyperplasia              | 2  2  2              2                                                   |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +  +           +                                                   |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 3        1  2  2           3                                             |      5  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 1| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 2| 9| 9| 9| 8| 3| 9| 9|                                            |            |
                                           | 5| 3| 4| 5| 5| 5| 5| 9| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Depletion Secretory        |       1  1                 1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                      X                                                   |      1     |
      Degeneration                         |                      4                                                   |      1  4.0|
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Germinal Epithelium, Degeneration    |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
      Hyperplasia, Lymphoid                |          2              3                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    3  3  2        4  4                                                   |      5  3.2|
      Cyst                                 | 2           1              1                                             |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 1| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 2| 9| 9| 9| 8| 3| 9| 9|                                            |            |
                                           | 5| 3| 4| 5| 5| 5| 5| 9| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
      Inflammation, Chronic Active         |          3                                                               |      1  3.0|
      Epidermis, Hyperplasia, Focal        | 2           1  3                                                         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Thrombosis                           |       3                                                                  |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                3                                                         |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 1  1     1  1  1        1  1                                             |      7  1.0|
      Cortex, Cyst                         |                         2                                                |      1  2.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |    4              3                                                      |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 0| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|                                            |            |
                                           | 5| 3| 5| 5| 5| 5| 9| 2| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |       1  1  1  2     1                                                   |      5  1.2|
      Hepatocyte, Vacuolization Cytoplasmic| 1     1  1  1  1           1                                             |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |    2                 2                                                   |      2  2.0|
      Epithelium, Hyperplasia, Focal       | 2                                                                        |      1  2.0|
      Epithelium, Hyperplasia              |    2                 2                                                   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +           +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 2     2  1  2  2        2  3                                             |      7  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 0| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|                                            |            |
                                           | 5| 3| 5| 5| 5| 5| 9| 2| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Cyst                       |             2                                                            |      1  2.0|
      Follicle, Depletion Secretory        | 1        1           1     1                                             |      4  1.0|
      Follicular Cell, Hypertrophy         | 1     1  1  1     1     1                                                |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration                         |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +              +                                                         |   2        |
      Atrophy                              | 3                                                                        |      1  3.0|
      Duct, Ectasia                        | 3              2                                                         |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |             1                                                            |      1  1.0|
      Germinal Epithelium, Degeneration    |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 0| 2| 2| 2| 2| 0| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 8| 9| 9| 9|                                            |            |
                                           | 5| 3| 5| 5| 5| 5| 9| 2| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    80 MG/L                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    3                                                                     |      1  3.0|
      Cyst                                 |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
      Epidermis, Hyperplasia, Focal        |       3  3           2     2                                             |      4  2.5|
      Hair Follicle, Sebaceous Gland,      |                                                                          |            |
          Atrophy                          |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 1  2  1  2  1           1                                                |      6  1.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 4| 7| 9| 9| 9| 8| 9| 9|                                            |            |
                                           | 6| 5| 4| 7| 5| 5| 5| 8| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +                                                            |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2              1                                                         |      2  1.5|
      Inflammation, Chronic Active         | 2  1           1  1  2  1  1                                             |      7  1.3|
      Hepatocyte, Fatty Change             |                         1                                                |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|    1        1  1  1     1  1                                             |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |    2                 2  2                                                |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +        +     +     +                                                   |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |    1        2  2  1     1  1                                             |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 4| 7| 9| 9| 9| 8| 9| 9|                                            |            |
                                           | 6| 5| 4| 7| 5| 5| 5| 8| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Depletion Secretory        | 2        1  2              1                                             |      4  1.5|
      Follicular Cell, Hypertrophy         | 2  2     2  2  2  2     2  2                                             |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Granuloma Sperm                      |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   | +                                                                        |   1        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +                       +  +                                             |   3        |
      Atrophy                              | 2                                                                        |      1  2.0|
      Duct, Ectasia                        |                         2  2                                             |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Degeneration                     |             2     2  2                                                   |      3  2.0|
      Germinal Epithelium, Degeneration    |          2     1                                                         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 3     4  4           2                                                   |      4  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 1| 2| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 4| 9| 4| 7| 9| 9| 9| 8| 9| 9|                                            |            |
                                           | 6| 5| 4| 7| 5| 5| 5| 8| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    400 MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 3                    2                                                   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +                                             |   9        |
      Atrophy                              | 3     3              3                                                   |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +                                             |   9        |
      Epidermis, Hyperplasia, Focal        |    3        2              2                                             |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 2                                                                        |      1  2.0|
      Nephropathy                          |       2     1  1  1  2  1  1                                             |      7  1.3|
      Renal Tubule, Degeneration           |                      3                                                   |      1  3.0|
      Renal Tubule, Hypertrophy            |                            1                                             |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 9| 8| 1| 2| 4| 7| 9| 9| 9|                                            |            |
                                           | 3| 5| 4| 8| 7| 6| 7| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |       1                                                                  |      1  1.0|
      Inflammation, Chronic Active         |          1        1  1  1                                                |      4  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      1  1  1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           | 2        2                                                               |      2  2.0|
      Epithelium, Hyperplasia              | 2  2     2              2  2                                             |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +        +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 9| 8| 1| 2| 4| 7| 9| 9| 9|                                            |            |
                                           | 3| 5| 4| 8| 7| 6| 7| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hypertrophy           | 1     2                                                                  |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +                                             |   9        |
      Infiltration Cellular, Lymphocyte    | 2     2           1     2                                                |      4  1.8|
      Follicle, Depletion Secretory        | 4  4  4           4  3  4  3                                             |      7  3.7|
      Follicular Cell, Hypertrophy         | 4  4  4        2  4  3  4  3                                             |      8  3.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration                         | 4  4  4        2  3  2  4                                                |      7  3.3|
                                           |__________________________________________________________________________|____________|
   Penis                                   | +                          +                                             |   2        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   1        |
      Duct, Ectasia                        |                         3                                                |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Degeneration                     | 4  3  4        2  3  2  4  1                                             |      8  2.9|
      Interstitial Cell, Hyperplasia       | 1     1                 2                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +  M  +  +  +  +  +                                             |   7        |
      Hyperplasia, Lymphoid                |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 9| 8| 1| 2| 4| 7| 9| 9| 9|                                            |            |
                                           | 3| 5| 4| 8| 7| 6| 7| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M                                             |   9        |
      Atrophy                              | 4     3  4  3  3  4                                                      |      6  3.5|
      Cyst                                 |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +     +                                             |   8        |
      Epidermis, Hyperplasia, Focal        |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar Epithelium, Hyperplasia     |       4                                                                  |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +                                                                        |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-94                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: DOSED WATER                                                                                                Time: 14:43:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 1| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 9| 8| 1| 2| 4| 7| 9| 9| 9|                                            |            |
                                           | 3| 5| 4| 8| 7| 6| 7| 5| 5| 5|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    800 MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Hydronephrosis                       | 2     2                                                                  |      2  2.0|
      Mineralization                       |       2                                                                  |      1  2.0|
      Nephropathy                          | 2  2  2  1  2  1  2  2  2  2                                             |     10  1.8|
      Cortex, Cyst                         |       3                                                                  |      1  3.0|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |             2  2                                                         |      2  2.0|
      Renal Tubule, Degeneration           | 3  3  3        3  3  3  3  3                                             |      8  3.0|
      Renal Tubule, Hypertrophy            | 1  1              1  2  1  2                                             |      6  1.3|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.