National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14663

TDMS Study 96020-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL #1                                                              
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 002    10 NG / 10 UG                                                                 
                                       INCLUDE 003    100 NG /100 UG                                                                
                                       INCLUDE 005    300 NG /300 UG                                                                
                                       INCLUDE 007    1000 NG/1000 UG                                                               
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF    TEF EVALUATION (BINARY MIXTURE; PCB 126                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
Adrenal Medulla                        Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Esophagus                              Perforation                                                                                  
Eye: Anterior Chamber, Ciliary Body, Cornea                                                                                         
                                       Inflammation                                                                                 
Heart: Coronary Artery                 Inflammation Chronic                                                                         
Kidney                                 Calculus Micro Observation Only                                                              
                                       Nephropathy                                                                                  
                                       Pigmentation                                                                                 
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hyperplasia                                                                                  
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Cyst                                                                                         
                                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Inflammation                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lymph Node, Mandibular                 Ectasia                                                                                      
                                       Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric                 Hyperplasia                                                                                  
Lymph Node: Lumbar                     Ectasia                                                                                      
                                       Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:01:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
Mammary Gland                          Hyperplasia                                                                                  
                                       Inflammation Granulomatous                                                                   
Mesentery: Artery                      Inflammation Chronic                                                                         
Nose                                   Inflammation                                                                                 
Nose: Glands                           Hyperplasia                                                                                  
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
Oviduct                                Cyst                                                                                         
                                       Inflammation Chronic                                                                         
Pancreas                               Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Vacuolization Cytoplasmic                                                                    
Pituitary Gland                        Angiectasis                                                                                  
Pituitary Gland: Pars Intermedia       Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Spleen: Red Pulp                       Atrophy                                                                                      
Stomach, Forestomach                   Hyperplasia                                                                                  
Stomach, Glandular                     Erosion                                                                                      
                                       Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
                                       Hyperplasia Lymphoid                                                                         
Thyroid Gland: Follicle                Cyst                                                                                         
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Urinary Bladder                        Inflammation                                                                                 
Uterus                                 Inflammation                                                                                 
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/53 (32%)      26/53 (49%)      33/52 (63%)      23/52 (44%)      5/51 (10%)                       | 
|POLY-3 RATE (b)    |        17/41.18         26/40.40         33/44.42         23/42.61         5/36.82                          | 
|POLY-3 PERCENT (g) |        41.3%            64.4%            74.3%            54.0%            13.6%                            | 
|TERMINAL (d)       |        11/22 (50%)      17/21 (81%)      19/22 (86%)      11/24 (46%)      4/24 (17%)                       | 
|FIRST INCIDENCE    |        418              469              254              499              558                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.041 *        P=0.004 **       P=0.229          P=0.003N**                       | 
|POLY 3             |        P<0.001N**       P=0.023 *        P<0.001 **       P=0.164          P=0.005N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.028 *        P<0.001 **       P=0.141          P=0.005N**                       | 
|POLY 6             |        P<0.001N**       P=0.022 *        P<0.001 **       P=0.220          P=0.004N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.037 *        P<0.001 **       P=0.132          P=0.006N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.057          P<0.001 **       P=0.140          P=0.005N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        3/52 (6%)        35/51 (69%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          3/37.99          35/41.50                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             7.9%             84.4%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        2/24 (8%)        21/24 (88%)                      | 
|FIRST INCIDENCE    |        ---              ---              ---              539              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.133          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.117          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.115          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.119          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.117          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.118          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/53 (25%)      12/53 (23%)      13/52 (25%)      14/52 (27%)      16/51 (31%)                      | 
|POLY-3 RATE (b)    |        13/40.95         12/37.55         13/40.77         14/39.87         16/39.37                         | 
|POLY-3 PERCENT (g) |        31.7%            32.0%            31.9%            35.1%            40.6%                            | 
|TERMINAL (d)       |        6/22 (27%)       11/21 (52%)      6/22 (27%)       7/24 (29%)       10/24 (42%)                      | 
|FIRST INCIDENCE    |        556              689              581              505              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.261          P=0.548N         P=0.580N         P=0.521          P=0.354                          | 
|POLY 3             |        P=0.188          P=0.589          P=0.590          P=0.465          P=0.271                          | 
|POLY 1.5           |        P=0.173          P=0.566N         P=0.583          P=0.466          P=0.264                          | 
|POLY 6             |        P=0.207          P=0.541          P=0.593          P=0.469          P=0.277                          | 
|LOGISTIC REGRESSION|        P=0.157          P=0.520N         P=0.581N         P=0.473          P=0.267                          | 
|COCH-ARM / FISHERS |        P=0.179          P=0.500N         P=0.567          P=0.477          P=0.288                          | 
|ORDER RESTRICTED   |        P=0.338          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/53 (21%)      18/53 (34%)      23/52 (44%)      25/52 (48%)      18/51 (35%)                      | 
|POLY-3 RATE (b)    |        11/39.56         18/39.96         23/43.38         25/42.59         18/39.46                         | 
|POLY-3 PERCENT (g) |        27.8%            45.1%            53.0%            58.7%            45.6%                            | 
|TERMINAL (d)       |        7/22 (32%)       10/21 (48%)      10/22 (46%)      14/24 (58%)      11/24 (46%)                      | 
|FIRST INCIDENCE    |        499              469              458              254              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.470          P=0.089          P=0.023 *        P=0.010 *        P=0.129                          | 
|POLY 3             |        P=0.330          P=0.079          P=0.013 *        P=0.003 **       P=0.072                          | 
|POLY 1.5           |        P=0.304          P=0.078          P=0.010 *        P=0.002 **       P=0.065                          | 
|POLY 6             |        P=0.367          P=0.086          P=0.021 *        P=0.004 **       P=0.088                          | 
|LOGISTIC REGRESSION|        P=0.294          P=0.077          P=0.010 *        P=0.002 **       P=0.063                          | 
|COCH-ARM / FISHERS |        P=0.326          P=0.095          P=0.009 **       P=0.003 **       P=0.076                          | 
|ORDER RESTRICTED   |        P=0.015 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        47/53 (89%)      38/53 (72%)      44/52 (85%)      41/52 (79%)      32/51 (63%)                      | 
|POLY-3 RATE (b)    |        47/49.32         38/45.04         44/47.46         41/44.30         32/42.27                         | 
|POLY-3 PERCENT (g) |        95.3%            84.4%            92.7%            92.6%            75.7%                            | 
|TERMINAL (d)       |        21/22 (96%)      19/21 (91%)      20/22 (91%)      24/24 (100%)     17/24 (71%)                      | 
|FIRST INCIDENCE    |        418              296              461              479              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.016N*        P=0.165N         P=0.358N         P=0.163N         P=0.016N*                        | 
|POLY 3             |        P=0.003N**       P=0.055N         P=0.453N         P=0.441N         P=0.003N**                       | 
|POLY 1.5           |        P=0.003N**       P=0.033N*        P=0.409N         P=0.258N         P=0.002N**                       | 
|POLY 6             |        P=0.005N**       P=0.087N         P=0.502N         P=0.667N         P=0.008N**                       | 
|LOGISTIC REGRESSION|        P=0.002N**       P=0.027N*        P=0.270N         P=0.103N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P=0.005N**       P=0.025N*        P=0.373N         P=0.135N         P=0.002N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        11/53 (21%)      12/53 (23%)      14/52 (27%)      10/52 (19%)      13/51 (25%)                      | 
|POLY-3 RATE (b)    |        11/40.49         12/41.50         14/41.16         10/40.66         13/37.17                         | 
|POLY-3 PERCENT (g) |        27.2%            28.9%            34.0%            24.6%            35.0%                            | 
|TERMINAL (d)       |        6/22 (27%)       4/21 (19%)       6/22 (27%)       3/24 (13%)       9/24 (38%)                       | 
|FIRST INCIDENCE    |        451              367              458              330              606                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.500          P=0.472          P=0.359          P=0.469N         P=0.458                          | 
|POLY 3             |        P=0.329          P=0.528          P=0.331          P=0.495N         P=0.306                          | 
|POLY 1.5           |        P=0.350          P=0.508          P=0.320          P=0.509N         P=0.316                          | 
|POLY 6             |        P=0.310          P=0.559          P=0.346          P=0.472N         P=0.302                          | 
|LOGISTIC REGRESSION|        P=0.397          P=0.494          P=0.325          P=0.521N         P=0.350                          | 
|COCH-ARM / FISHERS |        P=0.415          P=0.500          P=0.304          P=0.520N         P=0.367                          | 
|ORDER RESTRICTED   |        P=0.396          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/52 (29%)      13/53 (25%)      14/52 (27%)      13/52 (25%)      3/51 (6%)                        | 
|POLY-3 RATE (b)    |        15/38.71         13/39.25         14/41.19         13/39.45         3/37.96                          | 
|POLY-3 PERCENT (g) |        38.8%            33.1%            34.0%            33.0%            7.9%                             | 
|TERMINAL (d)       |        9/21 (43%)       8/21 (38%)       8/22 (36%)       9/24 (38%)       0/24 (0%)                        | 
|FIRST INCIDENCE    |        556              534              458              479              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.428N         P=0.456N         P=0.321N         P=0.002N**                       | 
|POLY 3             |        P<0.001N**       P=0.386N         P=0.415N         P=0.380N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.399N         P=0.448N         P=0.397N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.363N         P=0.387N         P=0.360N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.393N         P=0.443N         P=0.399N         P=0.002N**                       | 
|COCH-ARM / FISHERS |        P=0.002N**       P=0.390N         P=0.500N         P=0.413N         P=0.002N**                       | 
|ORDER RESTRICTED   |        P=0.002N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/53 (74%)      38/53 (72%)      42/53 (79%)      48/53 (91%)      49/53 (92%)                      | 
|POLY-3 RATE (b)    |        39/51.35         38/51.35         42/53.00         48/53.00         49/50.85                         | 
|POLY-3 PERCENT (g) |        76.0%            74.0%            79.3%            90.6%            96.4%                            | 
|TERMINAL (d)       |        12/22 (55%)      10/21 (48%)      11/22 (50%)      19/24 (79%)      23/24 (96%)                      | 
|FIRST INCIDENCE    |        85               167              125              96               71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.087          P=0.548          P=0.439          P=0.186          P=0.131                          | 
|POLY 3             |        P<0.001 **       P=0.500N         P=0.433          P=0.037 *        P=0.002 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.502N         P=0.391          P=0.029 *        P=0.003 **                       | 
|POLY 6             |        P<0.001 **       P=0.497N         P=0.479          P=0.048 *        P=0.002 **                       | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.476N         P=0.282          P=0.019 *        P=0.012 *                        | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.500N         P=0.324          P=0.020 *        P=0.009 **                       | 
|ORDER RESTRICTED   |        P=0.003 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        45/53 (85%)      49/53 (92%)      46/53 (87%)      40/53 (75%)      23/50 (46%)                      | 
|POLY-3 RATE (b)    |        45/50.91         49/50.52         46/51.41         40/48.52         23/41.02                         | 
|POLY-3 PERCENT (g) |        88.4%            97.0%            89.5%            82.4%            56.1%                            | 
|TERMINAL (d)       |        18/22 (82%)      21/21 (100%)     20/22 (91%)      17/24 (71%)      12/24 (50%)                      | 
|FIRST INCIDENCE    |        345              178              125              254              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.282          P=0.534          P=0.253N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.085          P=0.558          P=0.282N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.110          P=0.575          P=0.244N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.065          P=0.526          P=0.313N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.153          P=0.501          P=0.180N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.179          P=0.500          P=0.165N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/53 (72%)      40/53 (75%)      48/53 (91%)      43/53 (81%)      43/50 (86%)                      | 
|POLY-3 RATE (b)    |        38/50.38         40/47.56         48/50.11         43/48.31         43/46.44                         | 
|POLY-3 PERCENT (g) |        75.4%            84.1%            95.8%            89.0%            92.6%                            | 
|TERMINAL (d)       |        13/22 (59%)      18/21 (86%)      21/22 (96%)      21/24 (88%)      21/24 (88%)                      | 
|FIRST INCIDENCE    |        345              178              254              254              206                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.472          P=0.379          P=0.141          P=0.346          P=0.310                          | 
|POLY 3             |        P=0.058          P=0.198          P=0.002 **       P=0.057          P=0.018 *                        | 
|POLY 1.5           |        P=0.052          P=0.267          P=0.004 **       P=0.084          P=0.019 *                        | 
|POLY 6             |        P=0.078          P=0.141          P=0.002 **       P=0.038 *        P=0.020 *                        | 
|LOGISTIC REGRESSION|        P=0.095          P=0.403          P=0.013 *        P=0.168          P=0.054                          | 
|COCH-ARM / FISHERS |        P=0.124          P=0.413          P=0.012 *        P=0.180          P=0.062                          | 
|ORDER RESTRICTED   |        P=0.005 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus                                                                                                                        | 
|     Perforation                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        0/53 (0%)        2/52 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/39.82          0/37.40          2/38.26                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.5%             0.0%             5.2%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              125              ---              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.079          (e)              P=0.504          (e)              P=0.238                          | 
|POLY 3             |        P=0.081          (e)              P=0.508          (e)              P=0.237                          | 
|POLY 1.5           |        P=0.080          (e)              P=0.505          (e)              P=0.234                          | 
|POLY 6             |        P=0.083          (e)              P=0.511          (e)              P=0.241                          | 
|LOGISTIC REGRESSION|        P=0.463          (e)              P=0.425          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.079          (e)              P=0.495          (e)              P=0.243                          | 
|ORDER RESTRICTED   |        P=0.047 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        1/53 (2%)        1/52 (2%)        3/53 (6%)        3/52 (6%)                        | 
|POLY-3 RATE (b)    |        3/39.27          1/37.65          1/38.82          3/39.07          3/37.26                          | 
|POLY-3 PERCENT (g) |        7.6%             2.7%             2.6%             7.7%             8.1%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        85               661              729 (T)          499              76                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.331          P=0.320N         P=0.301N         P=0.649N         P=0.642N                         | 
|POLY 3             |        P=0.307          P=0.319N         P=0.308N         P=0.661          P=0.639                          | 
|POLY 1.5           |        P=0.306          P=0.320N         P=0.312N         P=0.653          P=0.636                          | 
|POLY 6             |        P=0.309          P=0.316N         P=0.306N         P=0.653N         P=0.645                          | 
|LOGISTIC REGRESSION|        P=0.358          P=0.286N         P=0.324N         P=0.630N         P=0.608N                         | 
|COCH-ARM / FISHERS |        P=0.316          P=0.309N         P=0.316N         P=0.661N         P=0.652                          | 
|ORDER RESTRICTED   |        P=0.422          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Anterior Chamber, Ciliary Body, Cornea                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        1/52 (2%)        3/52 (6%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          1/37.28          3/37.17                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             8.1%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              580              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              P=0.500          P=0.121                          | 
|POLY 3             |        P=0.006 **       (e)              (e)              P=0.495          P=0.113                          | 
|POLY 1.5           |        P=0.006 **       (e)              (e)              P=0.493          P=0.110                          | 
|POLY 6             |        P=0.006 **       (e)              (e)              P=0.500          P=0.118                          | 
|LOGISTIC REGRESSION|        P=0.007 **       (e)              (e)              P=0.502          P=0.114                          | 
|COCH-ARM / FISHERS |        P=0.007 **       (e)              (e)              P=0.495          P=0.118                          | 
|ORDER RESTRICTED   |        P=0.010 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/53 (6%)        4/53 (8%)        2/52 (4%)        5/52 (10%)                       | 
|POLY-3 RATE (b)    |        1/38.18          3/37.65          4/39.09          2/36.79          5/36.27                          | 
|POLY-3 PERCENT (g) |        2.6%             8.0%             10.2%            5.4%             13.8%                            | 
|TERMINAL (d)       |        1/22 (5%)        2/21 (10%)       3/22 (14%)       2/24 (8%)        5/24 (21%)                       | 
|FIRST INCIDENCE    |        729 (T)          661              715              729 (T)          729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.183          P=0.293          P=0.188          P=0.531          P=0.118                          | 
|POLY 3             |        P=0.130          P=0.299          P=0.184          P=0.487          P=0.087                          | 
|POLY 1.5           |        P=0.130          P=0.298          P=0.182          P=0.485          P=0.087                          | 
|POLY 6             |        P=0.131          P=0.303          P=0.185          P=0.492          P=0.088                          | 
|LOGISTIC REGRESSION|        P=0.147          P=0.299          P=0.191          P=0.531          P=0.118                          | 
|COCH-ARM / FISHERS |        P=0.144          P=0.309          P=0.181          P=0.493          P=0.098                          | 
|ORDER RESTRICTED   |        P=0.056          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/53 (38%)      14/53 (26%)      16/53 (30%)      14/52 (27%)      16/52 (31%)                      | 
|POLY-3 RATE (b)    |        20/41.85         14/39.14         16/42.74         14/39.15         16/39.43                         | 
|POLY-3 PERCENT (g) |        47.8%            35.8%            37.4%            35.8%            40.6%                            | 
|TERMINAL (d)       |        10/22 (46%)      7/21 (33%)       7/22 (32%)       10/24 (42%)      9/24 (38%)                       | 
|FIRST INCIDENCE    |        418              580              254              330              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.414N         P=0.200N         P=0.275N         P=0.131N         P=0.265N                         | 
|POLY 3             |        P=0.527N         P=0.185N         P=0.223N         P=0.185N         P=0.329N                         | 
|POLY 1.5           |        P=0.535N         P=0.175N         P=0.235N         P=0.181N         P=0.335N                         | 
|POLY 6             |        P=0.524N         P=0.190N         P=0.214N         P=0.194N         P=0.327N                         | 
|LOGISTIC REGRESSION|        P=0.543N         P=0.155N         P=0.253N         P=0.176N         P=0.331N                         | 
|COCH-ARM / FISHERS |        P=0.493N         P=0.149N         P=0.269N         P=0.165N         P=0.293N                         | 
|ORDER RESTRICTED   |        P=0.279N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      19/52 (37%)      22/52 (42%)      26/53 (49%)      15/52 (29%)                      | 
|POLY-3 RATE (b)    |        22/41.41         19/38.93         22/41.36         26/41.49         15/39.21                         | 
|POLY-3 PERCENT (g) |        53.1%            48.8%            53.2%            62.7%            38.3%                            | 
|TERMINAL (d)       |        14/22 (64%)      10/21 (48%)      13/22 (59%)      17/24 (71%)      8/24 (33%)                       | 
|FIRST INCIDENCE    |        449              589              458              96               314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.074N         P=0.391N         P=0.551N         P=0.374          P=0.096N                         | 
|POLY 3             |        P=0.094N         P=0.433N         P=0.589          P=0.243          P=0.123N                         | 
|POLY 1.5           |        P=0.110N         P=0.427N         P=0.574          P=0.249          P=0.135N                         | 
|POLY 6             |        P=0.085N         P=0.408N         P=0.596N         P=0.248          P=0.110N                         | 
|LOGISTIC REGRESSION|        P=0.127N         P=0.394N         P=0.554N         P=0.233          P=0.143N                         | 
|COCH-ARM / FISHERS |        P=0.107N         P=0.374N         P=0.546          P=0.279          P=0.124N                         | 
|ORDER RESTRICTED   |        P=0.097N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Coronary Artery                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/52 (0%)        1/52 (2%)        0/53 (0%)        6/52 (12%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/36.71          1/38.82          0/37.40          6/36.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             0.0%             16.5%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        6/24 (25%)                       | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          ---              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          (e)              P=0.020 *                        | 
|POLY 3             |        P<0.001 **       (e)              P=0.503          (e)              P=0.012 *                        | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.501          (e)              P=0.012 *                        | 
|POLY 6             |        P<0.001 **       (e)              P=0.506          (e)              P=0.012 *                        | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.500          (e)              P=0.020 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.495          (e)              P=0.013 *                        | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        0/53 (0%)        0/52 (0%)        0/49 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          2/38.33          0/39.03          0/37.39          0/35.41                          | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              499              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.370N         P=0.240          (e)              (e)              (e)                              | 
|POLY 3             |        P=0.371N         P=0.237          (e)              (e)              (e)                              | 
|POLY 1.5           |        P=0.373N         P=0.235          (e)              (e)              (e)                              | 
|POLY 6             |        P=0.365N         P=0.242          (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.365N         P=0.243          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.370N         P=0.248          (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.234N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        0/53 (0%)        1/53 (2%)        3/50 (6%)                        | 
|POLY-3 RATE (b)    |        2/38.76          0/37.40          0/39.03          1/37.45          3/35.82                          | 
|POLY-3 PERCENT (g) |        5.2%             0.0%             0.0%             2.7%             8.4%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        3/24 (13%)                       | 
|FIRST INCIDENCE    |        636              ---              ---              715              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.086          P=0.250N         P=0.250N         P=0.514N         P=0.496                          | 
|POLY 3             |        P=0.069          P=0.244N         P=0.235N         P=0.512N         P=0.464                          | 
|POLY 1.5           |        P=0.069          P=0.243N         P=0.235N         P=0.510N         P=0.462                          | 
|POLY 6             |        P=0.070          P=0.246N         P=0.236N         P=0.513N         P=0.466                          | 
|LOGISTIC REGRESSION|        P=0.072          P=0.240N         P=0.236N         P=0.506N         P=0.476                          | 
|COCH-ARM / FISHERS |        P=0.072          P=0.248N         P=0.248N         P=0.500N         P=0.472                          | 
|ORDER RESTRICTED   |        P=0.079          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/52 (4%)        1/49 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/39.07          2/38.30          1/35.41                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.2%             2.8%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        1/24 (4%)                        | 
|FIRST INCIDENCE    |        ---              ---              664              330              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.386          (e)              P=0.487          P=0.243          P=0.517                          | 
|POLY 3             |        P=0.362          (e)              P=0.505          P=0.237          P=0.485                          | 
|POLY 1.5           |        P=0.355          (e)              P=0.501          P=0.235          P=0.482                          | 
|POLY 6             |        P=0.371          (e)              P=0.508          P=0.240          P=0.490                          | 
|LOGISTIC REGRESSION|        P=0.361          (e)              P=0.500          P=0.237          P=0.517                          | 
|COCH-ARM / FISHERS |        P=0.359          (e)              P=0.495          P=0.243          P=0.480                          | 
|ORDER RESTRICTED   |        P=0.194          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        1/52 (2%)        1/52 (2%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        2/39.63          0/37.40          1/39.26          1/38.39          1/37.24                          | 
|POLY-3 PERCENT (g) |        5.1%             0.0%             2.6%             2.6%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        449              ---              603              142              206                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.653          P=0.247N         P=0.492N         P=0.497N         P=0.514N                         | 
|POLY 3             |        P=0.663          P=0.250N         P=0.503N         P=0.511N         P=0.522N                         | 
|POLY 1.5           |        P=0.660          P=0.247N         P=0.504N         P=0.509N         P=0.521N                         | 
|POLY 6             |        P=0.664N         P=0.252N         P=0.502N         P=0.512N         P=0.522N                         | 
|LOGISTIC REGRESSION|        P=0.557N         P=0.212N         P=0.526N         P=0.480N         P=0.406N                         | 
|COCH-ARM / FISHERS |        P=0.658          P=0.248N         P=0.507N         P=0.507N         P=0.515N                         | 
|ORDER RESTRICTED   |        P=0.346N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/53 (13%)       4/53 (8%)        1/52 (2%)        4/52 (8%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        7/38.73          4/37.96          1/39.26          4/39.34          1/36.26                          | 
|POLY-3 PERCENT (g) |        18.1%            10.5%            2.6%             10.2%            2.8%                             | 
|TERMINAL (d)       |        5/22 (23%)       1/21 (5%)        0/22 (0%)        0/24 (0%)        1/24 (4%)                        | 
|FIRST INCIDENCE    |        647              603              603              499              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.079N         P=0.291N         P=0.035N*        P=0.253N         P=0.029N*                        | 
|POLY 3             |        P=0.089N         P=0.268N         P=0.027N*        P=0.248N         P=0.035N*                        | 
|POLY 1.5           |        P=0.090N         P=0.271N         P=0.029N*        P=0.261N         P=0.037N*                        | 
|POLY 6             |        P=0.089N         P=0.261N         P=0.025N*        P=0.229N         P=0.034N*                        | 
|LOGISTIC REGRESSION|        P=0.089N         P=0.266N         P=0.029N*        P=0.274N         P=0.033N*                        | 
|COCH-ARM / FISHERS |        P=0.087N         P=0.263N         P=0.032N*        P=0.274N         P=0.034N*                        | 
|ORDER RESTRICTED   |        P=0.014N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Casts Protein                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        1/53 (2%)        0/52 (0%)        0/52 (0%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        2/39.30          1/37.40          0/38.82          0/37.39          0/36.26                          | 
|POLY-3 PERCENT (g) |        5.1%             2.7%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        345              729 (T)          ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.227N         P=0.511N         P=0.242N         P=0.249N         P=0.255N                         | 
|POLY 3             |        P=0.232N         P=0.517N         P=0.239N         P=0.248N         P=0.255N                         | 
|POLY 1.5           |        P=0.232N         P=0.514N         P=0.240N         P=0.246N         P=0.255N                         | 
|POLY 6             |        P=0.231N         P=0.519N         P=0.239N         P=0.248N         P=0.254N                         | 
|LOGISTIC REGRESSION|        P=0.226N         P=0.491N         P=0.252N         P=0.234N         P=0.218N                         | 
|COCH-ARM / FISHERS |        P=0.231N         P=0.500N         P=0.252N         P=0.252N         P=0.257N                         | 
|ORDER RESTRICTED   |        P=0.057N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        3/53 (6%)        1/52 (2%)        5/52 (10%)       1/51 (2%)                        | 
|POLY-3 RATE (b)    |        5/38.24          3/37.40          1/39.26          5/37.96          1/36.26                          | 
|POLY-3 PERCENT (g) |        13.1%            8.0%             2.6%             13.2%            2.8%                             | 
|TERMINAL (d)       |        4/22 (18%)       3/21 (14%)       0/22 (0%)        4/24 (17%)       1/24 (4%)                        | 
|FIRST INCIDENCE    |        714              729 (T)          603              552              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.156N         P=0.379N         P=0.099N         P=0.584N         P=0.083N                         | 
|POLY 3             |        P=0.207N         P=0.367N         P=0.093N         P=0.628          P=0.111N                         | 
|POLY 1.5           |        P=0.209N         P=0.368N         P=0.098N         P=0.621          P=0.114N                         | 
|POLY 6             |        P=0.205N         P=0.362N         P=0.088N         P=0.628N         P=0.107N                         | 
|LOGISTIC REGRESSION|        P=0.197N         P=0.359N         P=0.095N         P=0.630          P=0.087N                         | 
|COCH-ARM / FISHERS |        P=0.200N         P=0.358N         P=0.107N         P=0.617          P=0.112N                         | 
|ORDER RESTRICTED   |        P=0.075N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/53 (79%)      38/53 (72%)      39/52 (75%)      42/52 (81%)      35/51 (69%)                      | 
|POLY-3 RATE (b)    |        42/50.36         38/47.49         39/49.00         42/48.93         35/45.19                         | 
|POLY-3 PERCENT (g) |        83.4%            80.0%            79.6%            85.8%            77.5%                            | 
|TERMINAL (d)       |        15/22 (68%)      16/21 (76%)      19/22 (86%)      19/24 (79%)      17/24 (71%)                      | 
|FIRST INCIDENCE    |        85               178              125              254              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.192N         P=0.404N         P=0.372N         P=0.498N         P=0.191N                         | 
|POLY 3             |        P=0.348N         P=0.429N         P=0.404N         P=0.476          P=0.309N                         | 
|POLY 1.5           |        P=0.317N         P=0.381N         P=0.385N         P=0.466          P=0.266N                         | 
|POLY 6             |        P=0.373N         P=0.479N         P=0.466N         P=0.481          P=0.361N                         | 
|LOGISTIC REGRESSION|        P=0.222N         P=0.257N         P=0.400N         P=0.519          P=0.163N                         | 
|COCH-ARM / FISHERS |        P=0.211N         P=0.249N         P=0.388N         P=0.520          P=0.156N                         | 
|ORDER RESTRICTED   |        P=0.379N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        29/53 (55%)      22/53 (42%)      29/52 (56%)      34/52 (65%)      43/51 (84%)                      | 
|POLY-3 RATE (b)    |        29/44.67         22/40.11         29/41.95         34/43.59         43/44.94                         | 
|POLY-3 PERCENT (g) |        64.9%            54.9%            69.1%            78.0%            95.7%                            | 
|TERMINAL (d)       |        17/22 (77%)      14/21 (67%)      18/22 (82%)      23/24 (96%)      24/24 (100%)                     | 
|FIRST INCIDENCE    |        345              337              469              142              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.175N         P=0.539N         P=0.320          P=0.023 *                        | 
|POLY 3             |        P<0.001 **       P=0.222N         P=0.420          P=0.108          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.186N         P=0.465          P=0.137          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.246N         P=0.368          P=0.084          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.132N         P=0.567N         P=0.165          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.122N         P=0.535          P=0.180          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        3/52 (6%)        7/52 (13%)       35/51 (69%)                      | 
|POLY-3 RATE (b)    |        0/38.18          1/37.40          3/39.12          7/38.16          35/40.29                         | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             7.7%             18.3%            86.9%                            | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        1/22 (5%)        6/24 (25%)       23/24 (96%)                      | 
|FIRST INCIDENCE    |        ---              729 (T)          664              451              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.491          P=0.130          P=0.011 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.496          P=0.122          P=0.007 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.496          P=0.119          P=0.007 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.497          P=0.125          P=0.007 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.491          P=0.124          P=0.008 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          P=0.118          P=0.006 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        0/52 (0%)        2/52 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        1/38.18          0/37.40          0/38.82          2/37.83          1/36.94                          | 
|POLY-3 PERCENT (g) |        2.6%             0.0%             0.0%             5.3%             2.7%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          ---              ---              618              499                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.434          P=0.509N         P=0.500N         P=0.506          P=0.753N                         | 
|POLY 3             |        P=0.425          P=0.504N         P=0.497N         P=0.497          P=0.754                          | 
|POLY 1.5           |        P=0.420          P=0.504N         P=0.499N         P=0.493          P=0.750                          | 
|POLY 6             |        P=0.432          P=0.503N         P=0.494N         P=0.504          P=0.760                          | 
|LOGISTIC REGRESSION|        P=0.422          (e)              (e)              P=0.494          P=0.755                          | 
|COCH-ARM / FISHERS |        P=0.424          P=0.500N         P=0.505N         P=0.493          P=0.743                          | 
|ORDER RESTRICTED   |        P=0.297          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/53 (0%)        4/52 (8%)        3/52 (6%)        5/51 (10%)                       | 
|POLY-3 RATE (b)    |        3/39.42          0/37.40          4/39.96          3/38.07          5/37.95                          | 
|POLY-3 PERCENT (g) |        7.6%             0.0%             10.0%            7.9%             13.2%                            | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        1/22 (5%)        2/24 (8%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        499              ---              531              499              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.119          P=0.128N         P=0.500          P=0.637N         P=0.364                          | 
|POLY 3             |        P=0.105          P=0.127N         P=0.507          P=0.648          P=0.334                          | 
|POLY 1.5           |        P=0.100          P=0.125N         P=0.500          P=0.648          P=0.327                          | 
|POLY 6             |        P=0.111          P=0.129N         P=0.516          P=0.649          P=0.343                          | 
|LOGISTIC REGRESSION|        P=0.100          P=0.117N         P=0.486          P=0.654          P=0.340                          | 
|COCH-ARM / FISHERS |        P=0.100          P=0.121N         P=0.489          P=0.652          P=0.336                          | 
|ORDER RESTRICTED   |        P=0.097          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/52 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.82          2/37.67          1/36.26                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.3%             2.8%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        1/24 (4%)        1/24 (4%)                        | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          654              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.397          (e)              P=0.500          P=0.239          P=0.517                          | 
|POLY 3             |        P=0.368          (e)              P=0.503          P=0.233          P=0.490                          | 
|POLY 1.5           |        P=0.365          (e)              P=0.501          P=0.232          P=0.488                          | 
|POLY 6             |        P=0.372          (e)              P=0.506          P=0.237          P=0.492                          | 
|LOGISTIC REGRESSION|        P=0.371          (e)              P=0.500          P=0.233          P=0.517                          | 
|COCH-ARM / FISHERS |        P=0.372          (e)              P=0.495          P=0.243          P=0.490                          | 
|ORDER RESTRICTED   |        P=0.190          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        2/53 (4%)        4/52 (8%)        11/52 (21%)      6/51 (12%)                       | 
|POLY-3 RATE (b)    |        2/38.18          2/38.38          4/39.07          11/39.29         6/38.65                          | 
|POLY-3 PERCENT (g) |        5.2%             5.2%             10.2%            28.0%            15.5%                            | 
|TERMINAL (d)       |        2/22 (9%)        1/21 (5%)        3/22 (14%)       7/24 (29%)       2/24 (8%)                        | 
|FIRST INCIDENCE    |        729 (T)          178              664              539              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.118          P=0.682          P=0.330          P=0.012 *        P=0.148                          | 
|POLY 3             |        P=0.093          P=0.693N         P=0.346          P=0.007 **       P=0.133                          | 
|POLY 1.5           |        P=0.081          P=0.694          P=0.339          P=0.006 **       P=0.124                          | 
|POLY 6             |        P=0.110          P=0.690N         P=0.354          P=0.008 **       P=0.147                          | 
|LOGISTIC REGRESSION|        P=0.080          P=0.688N         P=0.352          P=0.007 **       P=0.121                          | 
|COCH-ARM / FISHERS |        P=0.084          P=0.691N         P=0.330          P=0.007 **       P=0.123                          | 
|ORDER RESTRICTED   |        P=0.018 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        1/53 (2%)        1/52 (2%)        2/52 (4%)        5/51 (10%)                       | 
|POLY-3 RATE (b)    |        3/38.74          1/37.40          1/38.82          2/37.66          5/36.26                          | 
|POLY-3 PERCENT (g) |        7.7%             2.7%             2.6%             5.3%             13.8%                            | 
|TERMINAL (d)       |        2/22 (9%)        1/21 (5%)        1/22 (5%)        1/24 (4%)        5/24 (21%)                       | 
|FIRST INCIDENCE    |        556              729 (T)          729 (T)          659              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.073          P=0.320N         P=0.303N         P=0.487N         P=0.395                          | 
|POLY 3             |        P=0.048 *        P=0.317N         P=0.303N         P=0.513N         P=0.318                          | 
|POLY 1.5           |        P=0.049 *        P=0.315N         P=0.306N         P=0.513N         P=0.319                          | 
|POLY 6             |        P=0.048 *        P=0.317N         P=0.302N         P=0.510N         P=0.318                          | 
|LOGISTIC REGRESSION|        P=0.050          P=0.311N         P=0.299N         P=0.509N         P=0.334                          | 
|COCH-ARM / FISHERS |        P=0.053          P=0.309N         P=0.316N         P=0.509N         P=0.336                          | 
|ORDER RESTRICTED   |        P=0.070          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      22/53 (42%)      14/52 (27%)      3/52 (6%)        6/51 (12%)                       | 
|POLY-3 RATE (b)    |        22/43.23         22/40.41         14/41.62         3/37.45          6/36.96                          | 
|POLY-3 PERCENT (g) |        50.9%            54.5%            33.6%            8.0%             16.2%                            | 
|TERMINAL (d)       |        9/22 (41%)       14/21 (67%)      7/22 (32%)       2/24 (8%)        5/24 (21%)                       | 
|FIRST INCIDENCE    |        377              296              254              715              491                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.530          P=0.092N         P<0.001N**       P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.456          P=0.075N         P<0.001N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.496          P=0.075N         P<0.001N**       P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.418          P=0.081N         P<0.001N**       P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.547          P=0.077N         P<0.001N**       P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.578N         P=0.085N         P<0.001N**       P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        1/53 (2%)        0/52 (0%)        7/52 (13%)       39/51 (76%)                      | 
|POLY-3 RATE (b)    |        0/38.18          1/38.22          0/38.82          7/37.86          39/41.56                         | 
|POLY-3 PERCENT (g) |        0.0%             2.6%             0.0%             18.5%            93.8%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        5/24 (21%)       24/24 (100%)                     | 
|FIRST INCIDENCE    |        ---              407              ---              612              540                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.483          (e)              P=0.012 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.500          (e)              P=0.007 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.498          (e)              P=0.007 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.503          (e)              P=0.007 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.527          (e)              P=0.008 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500          (e)              P=0.006 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/53 (17%)       3/53 (6%)        3/52 (6%)        3/52 (6%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        9/38.43          3/37.40          3/38.82          3/37.39          1/37.26                          | 
|POLY-3 PERCENT (g) |        23.4%            8.0%             7.7%             8.0%             2.7%                             | 
|TERMINAL (d)       |        8/22 (36%)       3/21 (14%)       3/22 (14%)       3/24 (13%)       0/24 (0%)                        | 
|FIRST INCIDENCE    |        664              729 (T)          729 (T)          729 (T)          71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.025N*        P=0.062N         P=0.053N         P=0.039N*        P=0.007N**                       | 
|POLY 3             |        P=0.036N*        P=0.060N         P=0.052N         P=0.060N         P=0.008N**                       | 
|POLY 1.5           |        P=0.038N*        P=0.062N         P=0.057N         P=0.063N         P=0.009N**                       | 
|POLY 6             |        P=0.034N*        P=0.057N         P=0.049N*        P=0.056N         P=0.007N**                       | 
|LOGISTIC REGRESSION|        P=0.042N*        P=0.054N         P=0.043N*        P=0.045N*        P=0.012N*                        | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.061N         P=0.066N         P=0.066N         P=0.009N**                       | 
|ORDER RESTRICTED   |        P=0.002N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/53 (26%)      16/53 (30%)      30/52 (58%)      40/52 (77%)      18/51 (35%)                      | 
|POLY-3 RATE (b)    |        14/42.00         16/40.12         30/45.64         40/47.53         18/42.64                         | 
|POLY-3 PERCENT (g) |        33.3%            39.9%            65.7%            84.2%            42.2%                            | 
|TERMINAL (d)       |        4/22 (18%)       10/21 (48%)      11/22 (50%)      18/24 (75%)      5/24 (21%)                       | 
|FIRST INCIDENCE    |        451              296              254              330              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.494N         P=0.378          P=0.010 *        P<0.001 **       P=0.297                          | 
|POLY 3             |        P=0.450N         P=0.347          P<0.001 **       P<0.001 **       P=0.265                          | 
|POLY 1.5           |        P=0.544N         P=0.373          P<0.001 **       P<0.001 **       P=0.236                          | 
|POLY 6             |        P=0.344N         P=0.312          P=0.002 **       P<0.001 **       P=0.303                          | 
|LOGISTIC REGRESSION|        P=0.465          P=0.396          P<0.001 **       P<0.001 **       P=0.222                          | 
|COCH-ARM / FISHERS |        P=0.485          P=0.415          P<0.001 **       P<0.001 **       P=0.221                          | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        1/53 (2%)        9/52 (17%)       31/52 (60%)      38/51 (75%)                      | 
|POLY-3 RATE (b)    |        3/39.19          1/37.87          9/40.34          31/45.69         38/47.97                         | 
|POLY-3 PERCENT (g) |        7.7%             2.6%             22.3%            67.8%            79.2%                            | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        6/22 (27%)       15/24 (63%)      16/24 (67%)                      | 
|FIRST INCIDENCE    |        449              589              125              254              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.322N         P=0.068          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.317N         P=0.062          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.315N         P=0.061          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.315N         P=0.062          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.302N         P=0.059          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.309N         P=0.057          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        4/53 (8%)        7/52 (13%)       1/52 (2%)        12/51 (24%)                      | 
|POLY-3 RATE (b)    |        3/38.27          4/37.52          7/39.16          1/37.83          12/37.11                         | 
|POLY-3 PERCENT (g) |        7.8%             10.7%            17.9%            2.6%             32.3%                            | 
|TERMINAL (d)       |        2/22 (9%)        3/21 (14%)       5/22 (23%)       0/24 (0%)        9/24 (38%)                       | 
|FIRST INCIDENCE    |        708              698              654              603              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       P=0.472          P=0.169          P=0.288N         P=0.018 *                        | 
|POLY 3             |        P<0.001 **       P=0.489          P=0.162          P=0.308N         P=0.007 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.489          P=0.158          P=0.312N         P=0.007 **                       | 
|POLY 6             |        P<0.001 **       P=0.494          P=0.167          P=0.301N         P=0.007 **                       | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.493          P=0.167          P=0.310N         P=0.008 **                       | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.500          P=0.152          P=0.316N         P=0.009 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/53 (51%)      29/53 (55%)      30/52 (58%)      19/52 (37%)      11/51 (22%)                      | 
|POLY-3 RATE (b)    |        27/49.38         29/45.61         30/48.78         19/44.94         11/40.88                         | 
|POLY-3 PERCENT (g) |        54.7%            63.6%            61.5%            42.3%            26.9%                            | 
|TERMINAL (d)       |        5/22 (23%)       11/21 (52%)      8/22 (36%)       6/24 (25%)       5/24 (21%)                       | 
|FIRST INCIDENCE    |        85               167              254              142              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.406          P=0.422          P=0.143N         P=0.007N**                       | 
|POLY 3             |        P<0.001N**       P=0.247          P=0.314          P=0.156N         P=0.005N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.298          P=0.308          P=0.130N         P=0.003N**                       | 
|POLY 6             |        P<0.001N**       P=0.205          P=0.310          P=0.189N         P=0.012N*                        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.445          P=0.256          P=0.083N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.423          P=0.309          P=0.098N         P=0.002N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        0/52 (0%)        0/52 (0%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          2/38.54          0/38.82          0/37.39          0/36.26                          | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              178              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.360N         P=0.252          (e)              (e)              (e)                              | 
|POLY 3             |        P=0.364N         P=0.238          (e)              (e)              (e)                              | 
|POLY 1.5           |        P=0.365N         P=0.237          (e)              (e)              (e)                              | 
|POLY 6             |        P=0.361N         P=0.242          (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.321N         P=0.261          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.363N         P=0.248          (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.229N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/52 (4%)        24/52 (46%)      42/51 (82%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/39.12          24/39.96         42/43.59                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.1%             60.1%            96.4%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        16/24 (67%)      24/24 (100%)                     | 
|FIRST INCIDENCE    |        ---              ---              664              552              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.250          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.242          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.238          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.246          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.241          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.243          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        44/53 (83%)      41/53 (77%)      46/52 (88%)      48/52 (92%)      46/51 (90%)                      | 
|POLY-3 RATE (b)    |        44/50.14         41/48.11         46/50.19         48/50.71         46/49.13                         | 
|POLY-3 PERCENT (g) |        87.8%            85.2%            91.7%            94.7%            93.6%                            | 
|TERMINAL (d)       |        19/22 (86%)      18/21 (86%)      20/22 (91%)      23/24 (96%)      23/24 (96%)                      | 
|FIRST INCIDENCE    |        85               178              125              254              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.415          P=0.456N         P=0.481          P=0.407          P=0.479                          | 
|POLY 3             |        P=0.140          P=0.469N         P=0.369          P=0.175          P=0.240                          | 
|POLY 1.5           |        P=0.103          P=0.441N         P=0.326          P=0.129          P=0.195                          | 
|POLY 6             |        P=0.183          P=0.467N         P=0.417          P=0.238          P=0.302                          | 
|LOGISTIC REGRESSION|        P=0.082          P=0.333N         P=0.309          P=0.123          P=0.203                          | 
|COCH-ARM / FISHERS |        P=0.096          P=0.313N         P=0.303          P=0.125          P=0.217                          | 
|ORDER RESTRICTED   |        P=0.133          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        26/53 (49%)      22/53 (42%)      30/52 (58%)      26/52 (50%)      3/51 (6%)                        | 
|POLY-3 RATE (b)    |        26/43.18         22/40.56         30/44.57         26/38.98         3/36.26                          | 
|POLY-3 PERCENT (g) |        60.2%            54.2%            67.3%            66.7%            8.3%                             | 
|TERMINAL (d)       |        16/22 (73%)      16/21 (76%)      17/22 (77%)      23/24 (96%)      3/24 (13%)                       | 
|FIRST INCIDENCE    |        377              330              254              499              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.343N         P=0.315          P=0.456N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.363N         P=0.309          P=0.341          P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.335N         P=0.285          P=0.424          P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.401N         P=0.338          P=0.238          P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.303N         P=0.272          P=0.536          P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.279N         P=0.245          P=0.539          P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        8/53 (15%)       5/52 (10%)       4/52 (8%)        20/51 (39%)                      | 
|POLY-3 RATE (b)    |        4/39.53          8/40.10          5/40.50          4/38.13          20/44.06                         | 
|POLY-3 PERCENT (g) |        10.1%            20.0%            12.4%            10.5%            45.4%                            | 
|TERMINAL (d)       |        0/22 (0%)        1/21 (5%)        0/22 (0%)        2/24 (8%)        8/24 (33%)                       | 
|FIRST INCIDENCE    |        533              499              469              552              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.186          P=0.514          P=0.636          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.179          P=0.515          P=0.625          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.173          P=0.506          P=0.626          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.191          P=0.521          P=0.624          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.178          P=0.485          P=0.632          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.179          P=0.488          P=0.631          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        5/53 (9%)        38/52 (73%)      50/52 (96%)      50/51 (98%)                      | 
|POLY-3 RATE (b)    |        2/38.18          5/39.17          38/45.72         50/50.05         50/50.00                         | 
|POLY-3 PERCENT (g) |        5.2%             12.8%            83.1%            99.9%            100.0%                           | 
|TERMINAL (d)       |        2/22 (9%)        1/21 (5%)        20/22 (91%)      24/24 (100%)     24/24 (100%)                     | 
|FIRST INCIDENCE    |        729 (T)          407              458              310              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.219          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.224          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.217          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.237          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.213          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.219          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        34/52 (65%)      48/52 (92%)      49/51 (96%)                      | 
|POLY-3 RATE (b)    |        0/38.18          2/38.48          34/45.02         48/48.25         49/49.02                         | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             75.5%            99.5%            100.0%                           | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        17/22 (77%)      24/24 (100%)     24/24 (100%)                     | 
|FIRST INCIDENCE    |        ---              407              461              330              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.231          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.238          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.236          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.242          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.249          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.248          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        3/53 (6%)        1/52 (2%)        5/52 (10%)       23/51 (45%)                      | 
|POLY-3 RATE (b)    |        4/38.46          3/38.22          1/38.82          5/37.44          23/36.69                         | 
|POLY-3 PERCENT (g) |        10.4%            7.9%             2.6%             13.4%            62.7%                            | 
|TERMINAL (d)       |        3/22 (14%)       2/21 (10%)       1/22 (5%)        4/24 (17%)       20/24 (83%)                      | 
|FIRST INCIDENCE    |        654              407              729 (T)          719              654                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.529N         P=0.179N         P=0.542          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.503N         P=0.174N         P=0.483          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.506N         P=0.178N         P=0.483          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.499N         P=0.171N         P=0.485          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.510N         P=0.166N         P=0.510          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.187N         P=0.488          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/53 (6%)        3/52 (6%)        4/52 (8%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        1/38.41          3/38.00          3/39.97          4/38.64          0/36.26                          | 
|POLY-3 PERCENT (g) |        2.6%             7.9%             7.5%             10.4%            0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        2/21 (10%)       1/22 (5%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        670              534              499              506              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.159N         P=0.304          P=0.315          P=0.188          P=0.507N                         | 
|POLY 3             |        P=0.174N         P=0.300          P=0.319          P=0.178          P=0.511N                         | 
|POLY 1.5           |        P=0.175N         P=0.299          P=0.311          P=0.175          P=0.512N                         | 
|POLY 6             |        P=0.173N         P=0.303          P=0.326          P=0.186          P=0.510N                         | 
|LOGISTIC REGRESSION|        P=0.168N         P=0.299          P=0.296          P=0.173          P=0.511N                         | 
|COCH-ARM / FISHERS |        P=0.167N         P=0.309          P=0.302          P=0.176          P=0.510N                         | 
|ORDER RESTRICTED   |        P=0.156N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       2/53 (4%)        9/52 (17%)       29/52 (56%)      46/51 (90%)                      | 
|POLY-3 RATE (b)    |        8/39.10          2/37.94          9/40.07          29/42.15         46/46.37                         | 
|POLY-3 PERCENT (g) |        20.5%            5.3%             22.5%            68.8%            99.2%                            | 
|TERMINAL (d)       |        5/22 (23%)       1/21 (5%)        4/22 (18%)       17/24 (71%)      24/24 (100%)                     | 
|FIRST INCIDENCE    |        533              563              588              505              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.055N         P=0.519          P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.047N*        P=0.523          P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.048N*        P=0.507          P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.045N*        P=0.542          P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.050N         P=0.517          P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.046N*        P=0.483          P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        7/53 (13%)       2/52 (4%)        4/52 (8%)        3/51 (6%)                        | 
|POLY-3 RATE (b)    |        5/39.53          7/40.74          2/39.46          4/38.67          3/38.89                          | 
|POLY-3 PERCENT (g) |        12.7%            17.2%            5.1%             10.3%            7.7%                             | 
|TERMINAL (d)       |        1/22 (5%)        1/21 (5%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        449              407              531              552              181                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.271N         P=0.380          P=0.217N         P=0.501N         P=0.370N                         | 
|POLY 3             |        P=0.262N         P=0.399          P=0.214N         P=0.514N         P=0.364N                         | 
|POLY 1.5           |        P=0.267N         P=0.384          P=0.218N         P=0.516N         P=0.372N                         | 
|POLY 6             |        P=0.260N         P=0.420          P=0.214N         P=0.507N         P=0.359N                         | 
|LOGISTIC REGRESSION|        P=0.246N         P=0.388          P=0.223N         P=0.513N         P=0.325N                         | 
|COCH-ARM / FISHERS |        P=0.271N         P=0.380          P=0.226N         P=0.512N         P=0.380N                         | 
|ORDER RESTRICTED   |        P=0.253N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        7/53 (13%)       17/52 (33%)      33/52 (63%)      50/51 (98%)                      | 
|POLY-3 RATE (b)    |        1/38.74          7/39.50          17/44.38         33/47.28         50/50.00                         | 
|POLY-3 PERCENT (g) |        2.6%             17.7%            38.3%            69.8%            100.0%                           | 
|TERMINAL (d)       |        0/22 (0%)        2/21 (10%)       6/22 (27%)       14/24 (58%)      24/24 (100%)                     | 
|FIRST INCIDENCE    |        556              378              125              254              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.035 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.030 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.029 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.033 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.033 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.030 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        14/52 (27%)      46/52 (88%)      48/51 (94%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          14/40.64         46/47.78         48/50.00                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             34.5%            96.3%            96.0%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        9/22 (41%)       23/24 (96%)      22/24 (92%)                      | 
|FIRST INCIDENCE    |        ---              ---              531              310              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        2/53 (4%)        15/52 (29%)      39/52 (75%)      46/51 (90%)                      | 
|POLY-3 RATE (b)    |        2/38.18          2/37.40          15/40.18         39/43.48         46/46.37                         | 
|POLY-3 PERCENT (g) |        5.2%             5.4%             37.3%            89.7%            99.2%                            | 
|TERMINAL (d)       |        2/22 (9%)        2/21 (10%)       8/22 (36%)       22/24 (92%)      24/24 (100%)                     | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          603              499              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.681          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.688          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.687          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.691          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.681          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.691N         P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        7/52 (13%)       34/51 (67%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          7/37.83          34/41.62                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             18.5%            81.7%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        6/24 (25%)       19/24 (79%)                      | 
|FIRST INCIDENCE    |        ---              ---              ---              603              540                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.011 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.006 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        47/53 (89%)      41/53 (77%)      47/52 (90%)      46/53 (87%)      45/52 (87%)                      | 
|POLY-3 RATE (b)    |        47/48.79         41/47.13         47/48.37         46/46.97         45/46.54                         | 
|POLY-3 PERCENT (g) |        96.3%            87.0%            97.2%            97.9%            96.7%                            | 
|TERMINAL (d)       |        22/22 (100%)     17/21 (81%)      22/22 (100%)     24/24 (100%)     24/24 (100%)                     | 
|FIRST INCIDENCE    |        345              167              461              254              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.466N         P=0.306N         P=0.524N         P=0.413N         P=0.392N                         | 
|POLY 3             |        P=0.201          P=0.068N         P=0.669          P=0.583          P=0.714                          | 
|POLY 1.5           |        P=0.156          P=0.071N         P=0.561          P=0.593          P=0.585                          | 
|POLY 6             |        P=0.290          P=0.069N         P=0.821          P=0.697          P=0.726N                         | 
|LOGISTIC REGRESSION|        P=0.177          P=0.120N         P=0.629          P=0.584          P=0.478                          | 
|COCH-ARM / FISHERS |        P=0.445          P=0.098N         P=0.514          P=0.500N         P=0.485N                         | 
|ORDER RESTRICTED   |        P=0.103          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/53 (15%)       5/53 (9%)        2/52 (4%)        4/53 (8%)        1/52 (2%)                        | 
|POLY-3 RATE (b)    |        8/40.26          5/38.99          2/39.57          4/38.58          1/36.33                          | 
|POLY-3 PERCENT (g) |        19.9%            12.8%            5.1%             10.4%            2.8%                             | 
|TERMINAL (d)       |        4/22 (18%)       3/21 (14%)       1/22 (5%)        2/24 (8%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        85               178              461              330              714                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.038N*        P=0.304N         P=0.052N         P=0.181N         P=0.020N*                        | 
|POLY 3             |        P=0.047N*        P=0.292N         P=0.045N*        P=0.193N         P=0.022N*                        | 
|POLY 1.5           |        P=0.047N*        P=0.292N         P=0.047N*        P=0.194N         P=0.022N*                        | 
|POLY 6             |        P=0.046N*        P=0.293N         P=0.045N*        P=0.191N         P=0.022N*                        | 
|LOGISTIC REGRESSION|        P=0.038N*        P=0.267N         P=0.054N         P=0.175N         P=0.020N*                        | 
|COCH-ARM / FISHERS |        P=0.041N*        P=0.278N         P=0.049N*        P=0.179N         P=0.017N*                        | 
|ORDER RESTRICTED   |        P=0.010N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/53 (4%)        11/52 (21%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.82          2/37.40          11/38.97                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.4%             28.2%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        2/24 (8%)        5/24 (21%)                       | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          729 (T)          477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.500          P=0.257          P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              P=0.503          P=0.232          P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.501          P=0.232          P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              P=0.506          P=0.233          P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              P=0.500          P=0.257          P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              P=0.495          P=0.248          P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/53 (43%)      20/53 (38%)      17/52 (33%)      5/53 (9%)        5/52 (10%)                       | 
|POLY-3 RATE (b)    |        23/41.69         20/39.33         17/41.13         5/38.38          5/36.54                          | 
|POLY-3 PERCENT (g) |        55.2%            50.9%            41.3%            13.0%            13.7%                            | 
|TERMINAL (d)       |        15/22 (68%)      13/21 (62%)      10/22 (46%)      2/24 (8%)        4/24 (17%)                       | 
|FIRST INCIDENCE    |        345              534              461              505              654                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.399N         P=0.156N         P<0.001N**       P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.431N         P=0.139N         P<0.001N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.412N         P=0.153N         P<0.001N**       P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.439N         P=0.127N         P<0.001N**       P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.365N         P=0.135N         P<0.001N**       P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.346N         P=0.177N         P<0.001N**       P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        6/53 (11%)       23/52 (44%)      34/53 (64%)      32/52 (62%)                      | 
|POLY-3 RATE (b)    |        0/38.18          6/37.53          23/43.10         34/41.55         32/41.06                         | 
|POLY-3 PERCENT (g) |        0.0%             16.0%            53.4%            81.8%            77.9%                            | 
|TERMINAL (d)       |        0/22 (0%)        4/21 (19%)       11/22 (50%)      23/24 (96%)      21/24 (88%)                      | 
|FIRST INCIDENCE    |        ---              698              491              505              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.016 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.013 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.014 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.013 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.015 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.013 *        P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        3/51 (6%)        6/52 (12%)       3/50 (6%)        6/51 (12%)                       | 
|POLY-3 RATE (b)    |        0/38.18          3/37.12          6/39.91          3/35.88          6/36.73                          | 
|POLY-3 PERCENT (g) |        0.0%             8.1%             15.0%            8.4%             16.3%                            | 
|TERMINAL (d)       |        0/22 (0%)        2/21 (10%)       2/22 (9%)        2/24 (8%)        4/23 (17%)                       | 
|FIRST INCIDENCE    |        ---              589              469              603              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.091          P=0.118          P=0.023 *        P=0.131          P=0.020 *                        | 
|POLY 3             |        P=0.072          P=0.112          P=0.017 *        P=0.106          P=0.012 *                        | 
|POLY 1.5           |        P=0.070          P=0.111          P=0.016 *        P=0.105          P=0.012 *                        | 
|POLY 6             |        P=0.075          P=0.115          P=0.018 *        P=0.111          P=0.013 *                        | 
|LOGISTIC REGRESSION|        P=0.068          P=0.113          P=0.018 *        P=0.108          P=0.015 *                        | 
|COCH-ARM / FISHERS |        P=0.079          P=0.114          P=0.013 *        P=0.111          P=0.012 *                        | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        37/53 (70%)      37/51 (73%)      40/52 (77%)      36/50 (72%)      31/51 (61%)                      | 
|POLY-3 RATE (b)    |        37/46.61         37/44.00         40/48.42         36/42.27         31/41.45                         | 
|POLY-3 PERCENT (g) |        79.4%            84.1%            82.6%            85.2%            74.8%                            | 
|TERMINAL (d)       |        18/22 (82%)      19/21 (91%)      19/22 (86%)      23/24 (96%)      18/23 (78%)                      | 
|FIRST INCIDENCE    |        418              337              125              363              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.092N         P=0.493          P=0.416          P=0.399N         P=0.210N                         | 
|POLY 3             |        P=0.194N         P=0.369          P=0.441          P=0.317          P=0.391N                         | 
|POLY 1.5           |        P=0.154N         P=0.386          P=0.381          P=0.346          P=0.348N                         | 
|POLY 6             |        P=0.245N         P=0.385          P=0.519          P=0.312          P=0.428N                         | 
|LOGISTIC REGRESSION|        P=0.123N         P=0.425          P=0.295          P=0.403          P=0.300N                         | 
|COCH-ARM / FISHERS |        P=0.073N         P=0.464          P=0.273          P=0.489          P=0.223N                         | 
|ORDER RESTRICTED   |        P=0.260N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        2/51 (4%)        3/52 (6%)        2/50 (4%)        5/51 (10%)                       | 
|POLY-3 RATE (b)    |        1/38.18          2/37.38          3/40.46          2/36.99          5/36.79                          | 
|POLY-3 PERCENT (g) |        2.6%             5.4%             7.4%             5.4%             13.6%                            | 
|TERMINAL (d)       |        1/22 (5%)        1/21 (5%)        1/22 (5%)        0/24 (0%)        3/23 (13%)                       | 
|FIRST INCIDENCE    |        729 (T)          469              254              363              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.080          P=0.492          P=0.310          P=0.508          P=0.112                          | 
|POLY 3             |        P=0.064          P=0.493          P=0.325          P=0.489          P=0.090                          | 
|POLY 1.5           |        P=0.064          P=0.488          P=0.316          P=0.481          P=0.088                          | 
|POLY 6             |        P=0.065          P=0.500          P=0.334          P=0.502          P=0.094                          | 
|LOGISTIC REGRESSION|        P=0.092          P=0.485          P=0.282          P=0.508          P=0.096                          | 
|COCH-ARM / FISHERS |        P=0.070          P=0.485          P=0.302          P=0.478          P=0.094                          | 
|ORDER RESTRICTED   |        P=0.044 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        1/52 (2%)        2/49 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          1/38.06          2/35.41                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.6%             5.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              506              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        (e)              (e)              P=0.500          P=0.257                          | 
|POLY 3             |        P=0.036 *        (e)              (e)              P=0.499          P=0.220                          | 
|POLY 1.5           |        P=0.035 *        (e)              (e)              P=0.497          P=0.216                          | 
|POLY 6             |        P=0.037 *        (e)              (e)              P=0.503          P=0.224                          | 
|LOGISTIC REGRESSION|        P=0.036 *        (e)              (e)              P=0.501          P=0.257                          | 
|COCH-ARM / FISHERS |        P=0.037 *        (e)              (e)              P=0.495          P=0.228                          | 
|ORDER RESTRICTED   |        P=0.040 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/4 (100%)       4/7 (57%)        0/2 (0%)         1/7 (14%)        0/14 (0%)                        | 
|POLY-3 RATE (b)    |        4/4.00           4/4.24           0/0.91           1/4.32           0/10.53                          | 
|POLY-3 PERCENT (g) |        100.0%           94.4%            0.0%             23.2%            0.0%                             | 
|TERMINAL (d)       |        1/1 (100%)       3/3 (100%)       0/0 (0%)         0/2 (0%)         0/9 (0%)                         | 
|FIRST INCIDENCE    |        449              469              ---              552              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002N**       P=0.322N         P=0.118N         P=0.150N         P=0.022N*                        | 
|POLY 3             |        P<0.001N**       P=1.000N         P=0.047N*        P=0.009N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.719N         P<0.001N**       P=0.002N**       P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=1.000N         P=0.638N         P=0.043N*        P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       (e)              P=0.064N         P=0.017N*        P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.212N         P=0.067N         P=0.015N*        P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         2/7 (29%)        0/2 (0%)         0/7 (0%)         0/14 (0%)                        | 
|POLY-3 RATE (b)    |        0/2.13           2/4.24           0/0.91           0/3.75           0/10.53                          | 
|POLY-3 PERCENT (g) |        0.0%             47.2%            0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/1 (0%)         1/3 (33%)        0/0 (0%)         0/2 (0%)         0/9 (0%)                         | 
|FIRST INCIDENCE    |        ---              469              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.169N         P=0.353          (e)              (e)              (e)                              | 
|POLY 3             |        P=0.083N         P=0.381          (e)              (e)              (e)                              | 
|POLY 1.5           |        P=0.129N         P=0.341          (e)              (e)              (e)                              | 
|POLY 6             |        P=0.040N*        P=0.461          (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.147N         P=0.332          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.166N         P=0.382          (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.212N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Lumbar                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/4 (100%)       2/7 (29%)        0/2 (0%)         0/7 (0%)         0/14 (0%)                        | 
|POLY-3 RATE (b)    |        4/4.00           2/3.51           0/0.91           0/3.75           0/10.53                          | 
|POLY-3 PERCENT (g) |        100.0%           57.1%            0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/1 (100%)       2/3 (67%)        0/0 (0%)         0/2 (0%)         0/9 (0%)                         | 
|FIRST INCIDENCE    |        449              729 (T)          ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.007N**       P=0.105N         P=0.118N         P=0.048N*        P=0.022N*                        | 
|POLY 3             |        P<0.001N**       P=0.259N         P=0.047N*        P<0.001N**       P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.102N         P<0.001N**       P<0.001N**       P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.404N         P=0.638N         P<0.001N**       P<0.001N**                       | 
|LOGISTIC REGRESSION|        P=0.002N**       P=0.054N         P=0.064N         P=0.004N**       P<0.001N**                       | 
|COCH-ARM / FISHERS |        P=0.006N**       P=0.045N*        P=0.067N         P=0.003N**       P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/7 (0%)         0/2 (0%)         0/7 (0%)         3/14 (21%)                       | 
|POLY-3 RATE (b)    |        0/2.13           0/3.51           0/0.91           0/3.75           3/12.45                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             24.1%                            | 
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         0/2 (0%)         0/9 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       (e)              (e)              (e)              P=0.129                          | 
|POLY 3             |        P=0.139          (e)              (e)              (e)              P=0.536                          | 
|POLY 1.5           |        P=0.093          (e)              (e)              (e)              P=0.477                          | 
|POLY 6             |        P=0.193          (e)              (e)              (e)              P=0.593                          | 
|LOGISTIC REGRESSION|        P=0.035 *        (e)              (e)              (e)              P=0.377                          | 
|COCH-ARM / FISHERS |        P=0.051          (e)              (e)              (e)              P=0.446                          | 
|ORDER RESTRICTED   |        P=0.417          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/7 (0%)         0/2 (0%)         1/7 (14%)        2/14 (14%)                       | 
|POLY-3 RATE (b)    |        0/2.13           0/3.51           0/0.91           1/4.66           2/11.80                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             21.5%            16.9%                            | 
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         0/2 (0%)         0/9 (0%)                         | 
|FIRST INCIDENCE    |        ---              ---              ---              330              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.041 *        (e)              (e)              P=0.488          P=0.232                          | 
|POLY 3             |        P=0.459          (e)              (e)              P=0.653          P=0.631                          | 
|POLY 1.5           |        P=0.369          (e)              (e)              P=0.635          P=0.588                          | 
|POLY 6             |        P=0.539          (e)              (e)              P=0.673          P=0.673                          | 
|LOGISTIC REGRESSION|        P=0.192          (e)              (e)              (e)              P=0.526                          | 
|COCH-ARM / FISHERS |        P=0.247          (e)              (e)              P=0.636          P=0.595                          | 
|ORDER RESTRICTED   |        P=0.522          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         1/7 (14%)        0/2 (0%)         1/7 (14%)        5/14 (36%)                       | 
|POLY-3 RATE (b)    |        0/2.13           1/4.41           0/0.91           1/4.42           5/12.36                          | 
|POLY-3 PERCENT (g) |        0.0%             22.7%            0.0%             22.6%            40.5%                            | 
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         0/2 (0%)         2/9 (22%)                        | 
|FIRST INCIDENCE    |        ---              337              ---              506              76                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.014 *        P=0.492          (e)              P=0.500          P=0.105                          | 
|POLY 3             |        P=0.195          P=0.643          (e)              P=0.645          P=0.380                          | 
|POLY 1.5           |        P=0.129          P=0.617          (e)              P=0.627          P=0.305                          | 
|POLY 6             |        P=0.281          P=0.681          (e)              P=0.669          P=0.465                          | 
|LOGISTIC REGRESSION|        P=0.039 *        P=0.805          (e)              P=0.625          P=0.197                          | 
|COCH-ARM / FISHERS |        P=0.065          P=0.636          (e)              P=0.636          P=0.234                          | 
|ORDER RESTRICTED   |        P=0.340          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         0/7 (0%)         0/2 (0%)         1/7 (14%)        3/14 (21%)                       | 
|POLY-3 RATE (b)    |        0/2.13           0/3.51           0/0.91           1/3.75           3/10.53                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             26.6%            28.5%                            | 
|TERMINAL (d)       |        0/1 (0%)         0/3 (0%)         0/0 (0%)         1/2 (50%)        3/9 (33%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.315          (e)              (e)              P=0.638          P=0.669                          | 
|POLY 3             |        P=0.225          (e)              (e)              P=0.619          P=0.497                          | 
|POLY 1.5           |        P=0.171          (e)              (e)              P=0.613          P=0.445                          | 
|POLY 6             |        P=0.278          (e)              (e)              P=0.626          P=0.555                          | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.638          P=0.669                          | 
|COCH-ARM / FISHERS |        P=0.111          (e)              (e)              P=0.636          P=0.446                          | 
|ORDER RESTRICTED   |        P=0.399          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/4 (0%)         1/7 (14%)        0/2 (0%)         2/7 (29%)        2/14 (14%)                       | 
|POLY-3 RATE (b)    |        0/2.13           1/3.51           0/0.91           2/4.81           2/10.53                          | 
|POLY-3 PERCENT (g) |        0.0%             28.5%            0.0%             41.6%            19.0%                            | 
|TERMINAL (d)       |        0/1 (0%)         1/3 (33%)        0/0 (0%)         0/2 (0%)         2/9 (22%)                        | 
|FIRST INCIDENCE    |        ---              729 (T)          ---              506              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.591          P=0.718          (e)              P=0.227          P=0.773                          | 
|POLY 3             |        P=0.562N         P=0.605          (e)              P=0.422          P=0.613                          | 
|POLY 1.5           |        P=0.643N         P=0.590          (e)              P=0.386          P=0.575                          | 
|POLY 6             |        P=0.474N         P=0.643          (e)              P=0.478          P=0.655                          | 
|LOGISTIC REGRESSION|        P=0.595N         P=0.718          (e)              P=0.356          P=0.773                          | 
|COCH-ARM / FISHERS |        P=0.564          P=0.636          (e)              P=0.382          P=0.595                          | 
|ORDER RESTRICTED   |        P=0.466          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        2/53 (4%)        2/52 (4%)        3/53 (6%)        1/52 (2%)                        | 
|POLY-3 RATE (b)    |        3/39.88          2/38.20          2/39.26          3/38.06          1/36.59                          | 
|POLY-3 PERCENT (g) |        7.5%             5.2%             5.1%             7.9%             2.7%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        1/22 (5%)        2/24 (8%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        345              589              603              506              640                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.310N         P=0.522N         P=0.499N         P=0.650N         P=0.329N                         | 
|POLY 3             |        P=0.331N         P=0.520N         P=0.507N         P=0.642          P=0.336N                         | 
|POLY 1.5           |        P=0.330N         P=0.518N         P=0.509N         P=0.644          P=0.335N                         | 
|POLY 6             |        P=0.329N         P=0.515N         P=0.505N         P=0.646          P=0.332N                         | 
|LOGISTIC REGRESSION|        P=0.300N         P=0.477N         P=0.525N         P=0.649N         P=0.272N                         | 
|COCH-ARM / FISHERS |        P=0.308N         P=0.500N         P=0.509N         P=0.661N         P=0.316N                         | 
|ORDER RESTRICTED   |        P=0.322N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        29/53 (55%)      29/53 (55%)      25/52 (48%)      22/53 (42%)      3/52 (6%)                        | 
|POLY-3 RATE (b)    |        29/44.60         29/41.84         25/41.84         22/41.66         3/36.97                          | 
|POLY-3 PERCENT (g) |        65.0%            69.3%            59.8%            52.8%            8.1%                             | 
|TERMINAL (d)       |        16/22 (73%)      16/21 (76%)      15/22 (68%)      11/24 (46%)      1/24 (4%)                        | 
|FIRST INCIDENCE    |        418              469              469              499              606                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.504          P=0.272N         P=0.117N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.418          P=0.382N         P=0.164N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.458          P=0.348N         P=0.157N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.418          P=0.428N         P=0.154N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.532          P=0.259N         P=0.134N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.577N         P=0.314N         P=0.122N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/53 (9%)        0/53 (0%)        4/52 (8%)        3/53 (6%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        5/39.94          0/37.40          4/39.50          3/37.73          0/36.27                          | 
|POLY-3 PERCENT (g) |        12.5%            0.0%             10.1%            8.0%             0.0%                             | 
|TERMINAL (d)       |        2/22 (9%)        0/21 (0%)        2/22 (9%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        345              ---              603              650              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.085N         P=0.042N*        P=0.496N         P=0.345N         P=0.034N*                        | 
|POLY 3             |        P=0.090N         P=0.035N*        P=0.507N         P=0.387N         P=0.038N*                        | 
|POLY 1.5           |        P=0.092N         P=0.035N*        P=0.510N         P=0.382N         P=0.038N*                        | 
|POLY 6             |        P=0.088N         P=0.035N*        P=0.501N         P=0.384N         P=0.038N*                        | 
|LOGISTIC REGRESSION|        P=0.091N         P=0.031N*        P=0.513N         P=0.359N         P=0.032N*                        | 
|COCH-ARM / FISHERS |        P=0.088N         P=0.028N*        P=0.512N         P=0.358N         P=0.030N*                        | 
|ORDER RESTRICTED   |        P=0.016N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/47 (2%)        1/47 (2%)        1/46 (2%)        2/47 (4%)        4/42 (10%)                       | 
|POLY-3 RATE (b)    |        1/34.51          1/32.95          1/34.30          2/33.24          4/32.89                          | 
|POLY-3 PERCENT (g) |        2.9%             3.0%             2.9%             6.0%             12.2%                            | 
|TERMINAL (d)       |        0/19 (0%)        1/18 (6%)        0/20 (0%)        2/21 (10%)       2/22 (9%)                        | 
|FIRST INCIDENCE    |        688              729 (T)          531              729 (T)          563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.062          P=0.758N         P=0.749N         P=0.528          P=0.197                          | 
|POLY 3             |        P=0.040 *        P=0.751          P=0.760          P=0.487          P=0.161                          | 
|POLY 1.5           |        P=0.037 *        P=0.751          P=0.756          P=0.487          P=0.150                          | 
|POLY 6             |        P=0.045 *        P=0.754          P=0.759N         P=0.491          P=0.176                          | 
|LOGISTIC REGRESSION|        P=0.039 *        P=0.758          P=0.763          P=0.503          P=0.150                          | 
|COCH-ARM / FISHERS |        P=0.034 *        P=0.753N         P=0.747          P=0.500          P=0.147                          | 
|ORDER RESTRICTED   |        P=0.067          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/47 (0%)        2/47 (4%)        2/46 (4%)        1/47 (2%)        0/42 (0%)                        | 
|POLY-3 RATE (b)    |        0/34.35          2/33.28          2/33.74          1/33.92          0/32.03                          | 
|POLY-3 PERCENT (g) |        0.0%             6.0%             5.9%             3.0%             0.0%                             | 
|TERMINAL (d)       |        0/19 (0%)        1/18 (6%)        1/20 (5%)        0/21 (0%)        0/22 (0%)                        | 
|FIRST INCIDENCE    |        ---              636              715              499              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.252N         P=0.231          P=0.259          P=0.509          (e)                              | 
|POLY 3             |        P=0.269N         P=0.229          P=0.232          P=0.497          (e)                              | 
|POLY 1.5           |        P=0.278N         P=0.228          P=0.230          P=0.495          (e)                              | 
|POLY 6             |        P=0.258N         P=0.233          P=0.235          P=0.503          (e)                              | 
|LOGISTIC REGRESSION|        P=0.275N         P=0.229          P=0.241          P=0.564          (e)                              | 
|COCH-ARM / FISHERS |        P=0.282N         P=0.247          P=0.242          P=0.500          (e)                              | 
|ORDER RESTRICTED   |        P=0.299N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/53 (42%)      13/53 (25%)      13/53 (25%)      13/53 (25%)      31/53 (58%)                      | 
|POLY-3 RATE (b)    |        22/43.64         13/40.23         13/42.58         13/40.22         31/43.98                         | 
|POLY-3 PERCENT (g) |        50.4%            32.3%            30.5%            32.3%            70.5%                            | 
|TERMINAL (d)       |        10/22 (46%)      7/21 (33%)       4/22 (18%)       5/24 (21%)       17/24 (71%)                      | 
|FIRST INCIDENCE    |        418              178              407              539              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.085N         P=0.069N         P=0.067N         P=0.106                          | 
|POLY 3             |        P<0.001 **       P=0.066N         P=0.043N*        P=0.067N         P=0.036 *                        | 
|POLY 1.5           |        P<0.001 **       P=0.057N         P=0.043N*        P=0.062N         P=0.034 *                        | 
|POLY 6             |        P<0.001 **       P=0.076N         P=0.043N*        P=0.069N         P=0.044 *                        | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.052N         P=0.047N*        P=0.053N         P=0.041 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.049N*        P=0.049N*        P=0.049N*        P=0.060                          | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        8/53 (15%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          0/37.40          8/37.65                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             21.3%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        5/24 (21%)                       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              595                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.006 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.003 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.003 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P=0.004 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.003 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        0/53 (0%)        0/53 (0%)        2/53 (4%)                        | 
|POLY-3 RATE (b)    |        1/38.18          0/37.40          0/39.03          0/37.40          2/37.98                          | 
|POLY-3 PERCENT (g) |        2.6%             0.0%             0.0%             0.0%             5.3%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          ---              ---              ---              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.110          P=0.509N         P=0.500N         P=0.483N         P=0.507                          | 
|POLY 3             |        P=0.105          P=0.504N         P=0.496N         P=0.504N         P=0.498                          | 
|POLY 1.5           |        P=0.105          P=0.504N         P=0.497N         P=0.505N         P=0.494                          | 
|POLY 6             |        P=0.106          P=0.503N         P=0.494N         P=0.502N         P=0.506                          | 
|LOGISTIC REGRESSION|        P=0.152          (e)              (e)              (e)              P=0.587                          | 
|COCH-ARM / FISHERS |        P=0.106          P=0.500N         P=0.500N         P=0.500N         P=0.500                          | 
|ORDER RESTRICTED   |        P=0.081          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        3/53 (6%)        5/53 (9%)        6/53 (11%)       15/53 (28%)                      | 
|POLY-3 RATE (b)    |        4/38.51          3/37.55          5/39.70          6/38.67          15/37.97                         | 
|POLY-3 PERCENT (g) |        10.4%            8.0%             12.6%            15.5%            39.5%                            | 
|TERMINAL (d)       |        2/22 (9%)        2/21 (10%)       2/22 (9%)        1/24 (4%)        11/24 (46%)                      | 
|FIRST INCIDENCE    |        664              689              636              603              595                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.517N         P=0.510          P=0.388          P=0.007 **                       | 
|POLY 3             |        P<0.001 **       P=0.514N         P=0.519          P=0.370          P=0.002 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.513N         P=0.511          P=0.361          P=0.002 **                       | 
|POLY 6             |        P<0.001 **       P=0.513N         P=0.529          P=0.389          P=0.003 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.507N         P=0.517          P=0.357          P=0.003 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.500N         P=0.500          P=0.371          P=0.005 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/53 (19%)      5/53 (9%)        7/53 (13%)       11/53 (21%)      20/53 (38%)                      | 
|POLY-3 RATE (b)    |        10/39.82         5/37.87          7/40.47          11/40.12         20/41.12                         | 
|POLY-3 PERCENT (g) |        25.1%            13.2%            17.3%            27.4%            48.6%                            | 
|TERMINAL (d)       |        6/22 (27%)       4/21 (19%)       2/22 (9%)        3/24 (13%)       11/24 (46%)                      | 
|FIRST INCIDENCE    |        418              589              581              539              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.154N         P=0.293N         P=0.529          P=0.039 *                        | 
|POLY 3             |        P<0.001 **       P=0.146N         P=0.278N         P=0.508          P=0.020 *                        | 
|POLY 1.5           |        P<0.001 **       P=0.144N         P=0.287N         P=0.489          P=0.017 *                        | 
|POLY 6             |        P<0.001 **       P=0.146N         P=0.264N         P=0.549          P=0.029 *                        | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.137N         P=0.284N         P=0.481          P=0.018 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.132N         P=0.299N         P=0.500          P=0.026 *                        | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/12 (67%)       8/11 (73%)       18/25 (72%)      22/30 (73%)      24/36 (67%)                      | 
|POLY-3 RATE (b)    |        8/11.04          8/10.69          18/23.89         22/27.81         24/32.83                         | 
|POLY-3 PERCENT (g) |        72.5%            74.9%            75.3%            79.1%            73.1%                            | 
|TERMINAL (d)       |        2/3 (67%)        2/4 (50%)        8/11 (73%)       12/15 (80%)      14/17 (82%)                      | 
|FIRST INCIDENCE    |        451              499              469              451              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.110          P=0.552N         P=0.232          P=0.188          P=0.172                          | 
|POLY 3             |        P=0.489N         P=0.642          P=0.595          P=0.491          P=0.646                          | 
|POLY 1.5           |        P=0.436N         P=0.602          P=0.558          P=0.480          P=0.642                          | 
|POLY 6             |        P=0.582N         P=0.697          P=0.654          P=0.525          P=0.648                          | 
|LOGISTIC REGRESSION|        P=0.389N         P=0.535          P=0.510          P=0.491          P=0.635N                         | 
|COCH-ARM / FISHERS |        P=0.386N         P=0.556          P=0.513          P=0.469          P=0.631                          | 
|ORDER RESTRICTED   |        P=0.706          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        45/53 (85%)      44/53 (83%)      45/52 (87%)      43/52 (83%)      16/49 (33%)                      | 
|POLY-3 RATE (b)    |        45/49.16         44/48.17         45/50.01         43/48.11         16/37.95                         | 
|POLY-3 PERCENT (g) |        91.5%            91.4%            90.0%            89.4%            42.2%                            | 
|TERMINAL (d)       |        21/22 (96%)      19/21 (91%)      20/22 (91%)      22/24 (92%)      9/24 (38%)                       | 
|FIRST INCIDENCE    |        345              330              254              254              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.539          P=0.526N         P=0.363N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.644N         P=0.535N         P=0.493N         P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.637N         P=0.611N         P=0.480N         P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.583N         P=0.438N         P=0.514N         P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.583N         P=0.547          P=0.499N         P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500N         P=0.516          P=0.483N         P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/53 (26%)      7/53 (13%)       17/52 (33%)      14/52 (27%)      13/49 (27%)                      | 
|POLY-3 RATE (b)    |        14/40.50         7/38.46          17/42.41         14/39.03         13/37.89                         | 
|POLY-3 PERCENT (g) |        34.6%            18.2%            40.1%            35.9%            34.3%                            | 
|TERMINAL (d)       |        8/22 (36%)       3/21 (14%)       6/22 (27%)       11/24 (46%)      7/24 (29%)                       | 
|FIRST INCIDENCE    |        451              580              469              330              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.516          P=0.091N         P=0.366          P=0.519N         P=0.467N                         | 
|POLY 3             |        P=0.379          P=0.077N         P=0.383          P=0.546          P=0.586N                         | 
|POLY 1.5           |        P=0.352          P=0.077N         P=0.352          P=0.554          P=0.577                          | 
|POLY 6             |        P=0.417          P=0.075N         P=0.419          P=0.532          P=0.551N                         | 
|LOGISTIC REGRESSION|        P=0.344          P=0.074N         P=0.335          P=0.563          P=0.579                          | 
|COCH-ARM / FISHERS |        P=0.353          P=0.071N         P=0.312          P=0.564          P=0.583                          | 
|ORDER RESTRICTED   |        P=0.278          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/1 (100%)       0/0 (0%)         1/1 (100%)       2/2 (100%)       0/3 (0%)                         | 
|POLY-3 RATE (b)    |        1/1.00           0/0.00           1/1.00           2/2.00           0/1.60                           | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             100.0%           100.0%           0.0%                             | 
|TERMINAL (d)       |        1/1 (100%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/1 (0%)                         | 
|FIRST INCIDENCE    |        729 (T)          ---              603              539              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.367N         (e)              (e)              (e)              P=0.500N                         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.207N                         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.008N**                       | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.429N                         | 
|LOGISTIC REGRESSION|        P=0.030N*        (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.026N*        (e)              (e)              (e)              P=0.250N                         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/1 (0%)         0/0 (0%)         1/1 (100%)       0/2 (0%)         3/3 (100%)                       | 
|POLY-3 RATE (b)    |        0/1.00           0/0.00           1/1.00           0/1.14           3/3.00                           | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             100.0%           0.0%             100.0%                           | 
|TERMINAL (d)       |        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/1 (100%)                       | 
|FIRST INCIDENCE    |        ---              ---              603              ---              485                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.041 *        (e)              P=0.500          (e)              P=0.127                          | 
|POLY 3             |        (e)              (e)              P=1.000N         (e)              P=0.250                          | 
|POLY 1.5           |        (e)              (e)              P=1.000N         (e)              P=0.250                          | 
|POLY 6             |        (e)              (e)              P=1.000N         (e)              P=0.250                          | 
|LOGISTIC REGRESSION|        P=0.173          (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.124          (e)              P=0.500          (e)              P=0.250                          | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        3/53 (6%)        3/52 (6%)        1/52 (2%)        4/50 (8%)                        | 
|POLY-3 RATE (b)    |        0/38.18          3/37.40          3/39.29          1/37.39          4/36.68                          | 
|POLY-3 PERCENT (g) |        0.0%             8.0%             7.6%             2.7%             10.9%                            | 
|TERMINAL (d)       |        0/22 (0%)        3/21 (14%)       2/22 (9%)        1/24 (4%)        2/24 (8%)                        | 
|FIRST INCIDENCE    |        ---              729 (T)          589              729 (T)          563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.187          P=0.110          P=0.125          P=0.517          P=0.067                          | 
|POLY 3             |        P=0.148          P=0.114          P=0.123          P=0.496          P=0.054                          | 
|POLY 1.5           |        P=0.143          P=0.114          P=0.120          P=0.495          P=0.052                          | 
|POLY 6             |        P=0.156          P=0.114          P=0.126          P=0.498          P=0.058                          | 
|LOGISTIC REGRESSION|        P=0.144          P=0.110          P=0.122          P=0.517          P=0.054                          | 
|COCH-ARM / FISHERS |        P=0.147          P=0.121          P=0.118          P=0.495          P=0.052                          | 
|ORDER RESTRICTED   |        P=0.030 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        2/53 (4%)        1/52 (2%)        1/52 (2%)        8/50 (16%)                       | 
|POLY-3 RATE (b)    |        0/38.18          2/37.40          1/39.29          1/37.39          8/38.53                          | 
|POLY-3 PERCENT (g) |        0.0%             5.4%             2.5%             2.7%             20.8%                            | 
|TERMINAL (d)       |        0/22 (0%)        2/21 (10%)       0/22 (0%)        1/24 (4%)        3/24 (13%)                       | 
|FIRST INCIDENCE    |        ---              729 (T)          589              729 (T)          491                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.227          P=0.511          P=0.517          P=0.007 **                       | 
|POLY 3             |        P<0.001 **       P=0.232          P=0.506          P=0.496          P=0.003 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.232          P=0.502          P=0.495          P=0.003 **                       | 
|POLY 6             |        P<0.001 **       P=0.233          P=0.510          P=0.498          P=0.004 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.227          P=0.491          P=0.517          P=0.004 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.248          P=0.495          P=0.495          P=0.002 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        0/52 (0%)        1/52 (2%)        0/50 (0%)                        | 
|POLY-3 RATE (b)    |        2/38.18          0/37.40          0/38.82          1/37.39          0/35.82                          | 
|POLY-3 PERCENT (g) |        5.2%             0.0%             0.0%             2.7%             0.0%                             | 
|TERMINAL (d)       |        2/22 (9%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          ---              ---              729 (T)          ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.355N         P=0.247N         P=0.237N         P=0.469N         P=0.218N                         | 
|POLY 3             |        P=0.394N         P=0.241N         P=0.233N         P=0.507N         P=0.251N                         | 
|POLY 1.5           |        P=0.395N         P=0.242N         P=0.236N         P=0.509N         P=0.254N                         | 
|POLY 6             |        P=0.393N         P=0.239N         P=0.230N         P=0.504N         P=0.246N                         | 
|LOGISTIC REGRESSION|        P=0.355N         (e)              (e)              P=0.469N         (e)                              | 
|COCH-ARM / FISHERS |        P=0.393N         P=0.248N         P=0.252N         P=0.507N         P=0.262N                         | 
|ORDER RESTRICTED   |        P=0.054N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        7/52 (13%)       40/50 (80%)                      | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          7/38.39          40/42.41                         | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             18.2%            94.3%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        5/24 (21%)       24/24 (100%)                     | 
|FIRST INCIDENCE    |        ---              ---              ---              552              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.012 *        P<0.001 **                       | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.007 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              P=0.008 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.006 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/52 (4%)        2/50 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.86          2/38.06          2/36.36                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.3%             5.5%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        1/24 (4%)                        | 
|FIRST INCIDENCE    |        ---              ---              720              506              563                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.140          (e)              P=0.517          P=0.249          P=0.252                          | 
|POLY 3             |        P=0.119          (e)              P=0.504          P=0.236          P=0.225                          | 
|POLY 1.5           |        P=0.115          (e)              P=0.501          P=0.234          P=0.222                          | 
|POLY 6             |        P=0.124          (e)              P=0.506          P=0.240          P=0.231                          | 
|LOGISTIC REGRESSION|        P=0.114          (e)              P=0.508          P=0.234          P=0.223                          | 
|COCH-ARM / FISHERS |        P=0.116          (e)              P=0.495          P=0.243          P=0.233                          | 
|ORDER RESTRICTED   |        P=0.112          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/53 (32%)      20/53 (38%)      15/53 (28%)      17/52 (33%)      1/52 (2%)                        | 
|POLY-3 RATE (b)    |        17/40.84         20/40.36         15/40.14         17/39.38         1/36.27                          | 
|POLY-3 PERCENT (g) |        41.6%            49.6%            37.4%            43.2%            2.8%                             | 
|TERMINAL (d)       |        11/22 (50%)      9/21 (43%)       10/22 (46%)      9/24 (38%)       1/24 (4%)                        | 
|FIRST INCIDENCE    |        418              563              588              506              729 (T)                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.318          P=0.400N         P=0.519N         P<0.001N**                       | 
|POLY 3             |        P<0.001N**       P=0.305          P=0.433N         P=0.535          P<0.001N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.298          P=0.426N         P=0.521          P<0.001N**                       | 
|POLY 6             |        P<0.001N**       P=0.352          P=0.439N         P=0.581          P<0.001N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.307          P=0.380N         P=0.531          P<0.001N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.342          P=0.416N         P=0.556          P<0.001N**                       | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        3/53 (6%)        0/53 (0%)        0/52 (0%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        1/38.18          3/39.59          0/39.03          0/36.79          0/36.27                          | 
|POLY-3 PERCENT (g) |        2.6%             7.6%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        729 (T)          178              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.159N         P=0.309          P=0.500N         P=0.483N         P=0.483N                         | 
|POLY 3             |        P=0.159N         P=0.317          P=0.496N         P=0.507N         P=0.510N                         | 
|POLY 1.5           |        P=0.161N         P=0.311          P=0.497N         P=0.508N         P=0.512N                         | 
|POLY 6             |        P=0.156N         P=0.327          P=0.494N         P=0.504N         P=0.508N                         | 
|LOGISTIC REGRESSION|        P=0.130N         P=0.335          (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.160N         P=0.309          P=0.500N         P=0.505N         P=0.505N                         | 
|ORDER RESTRICTED   |        P=0.095N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        3/53 (6%)        0/52 (0%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          3/39.90          0/36.79          0/36.27                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             7.5%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              589              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.402N         (e)              P=0.135          (e)              (e)                              | 
|POLY 3             |        P=0.379N         (e)              P=0.126          (e)              (e)                              | 
|POLY 1.5           |        P=0.384N         (e)              P=0.123          (e)              (e)                              | 
|POLY 6             |        P=0.372N         (e)              P=0.130          (e)              (e)                              | 
|LOGISTIC REGRESSION|        P=0.390N         (e)              P=0.122          (e)              (e)                              | 
|COCH-ARM / FISHERS |        P=0.385N         (e)              P=0.121          (e)              (e)                              | 
|ORDER RESTRICTED   |        P=0.307          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        13/53 (25%)      13/53 (25%)      19/53 (36%)      20/52 (38%)      13/52 (25%)                      | 
|POLY-3 RATE (b)    |        13/41.27         13/39.68         19/43.31         20/40.07         13/37.42                         | 
|POLY-3 PERCENT (g) |        31.5%            32.8%            43.9%            49.9%            34.7%                            | 
|TERMINAL (d)       |        6/22 (27%)       7/21 (33%)       10/22 (46%)      11/24 (46%)      9/24 (38%)                       | 
|FIRST INCIDENCE    |        451              534              469              505              606                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.368N         P=0.549          P=0.174          P=0.147          P=0.566N                         | 
|POLY 3             |        P=0.533          P=0.547          P=0.166          P=0.065          P=0.474                          | 
|POLY 1.5           |        P=0.550N         P=0.554          P=0.156          P=0.066          P=0.489                          | 
|POLY 6             |        P=0.509          P=0.547          P=0.176          P=0.072          P=0.460                          | 
|LOGISTIC REGRESSION|        P=0.491N         P=0.570          P=0.150          P=0.077          P=0.531                          | 
|COCH-ARM / FISHERS |        P=0.443N         P=0.589N         P=0.145          P=0.092          P=0.567                          | 
|ORDER RESTRICTED   |        P=0.243          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/53 (0%)        0/52 (0%)        2/52 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/39.03          0/36.79          2/37.68                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             5.3%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.017 *        (e)              (e)              (e)              P=0.225                          | 
|POLY 3             |        P=0.018 *        (e)              (e)              (e)              P=0.233                          | 
|POLY 1.5           |        P=0.018 *        (e)              (e)              (e)              P=0.229                          | 
|POLY 6             |        P=0.019 *        (e)              (e)              (e)              P=0.239                          | 
|LOGISTIC REGRESSION|        P=0.032 *        (e)              (e)              (e)              P=0.284                          | 
|COCH-ARM / FISHERS |        P=0.019 *        (e)              (e)              (e)              P=0.243                          | 
|ORDER RESTRICTED   |        P=0.015 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/53 (4%)        0/53 (0%)        1/53 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/39.13          0/37.40          1/36.53                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.1%             0.0%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              705              ---              714                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.520          (e)              P=0.252          (e)              P=0.516                          | 
|POLY 3             |        P=0.490          (e)              P=0.242          (e)              P=0.491                          | 
|POLY 1.5           |        P=0.488          (e)              P=0.240          (e)              P=0.491                          | 
|POLY 6             |        P=0.493          (e)              P=0.244          (e)              P=0.493                          | 
|LOGISTIC REGRESSION|        P=0.491          (e)              P=0.245          (e)              P=0.495                          | 
|COCH-ARM / FISHERS |        P=0.498          (e)              P=0.248          (e)              P=0.500                          | 
|ORDER RESTRICTED   |        P=0.297          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        51/53 (96%)      51/53 (96%)      49/52 (94%)      47/52 (90%)      44/50 (88%)                      | 
|POLY-3 RATE (b)    |        51/51.98         51/52.01         49/50.88         47/50.21         44/46.03                         | 
|POLY-3 PERCENT (g) |        98.1%            98.1%            96.3%            93.6%            95.6%                            | 
|TERMINAL (d)       |        22/22 (100%)     21/21 (100%)     22/22 (100%)     24/24 (100%)     24/24 (100%)                     | 
|FIRST INCIDENCE    |        85               167              125              142              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.105N         P=0.474          P=0.409N         P=0.267N         P=0.161N                         | 
|POLY 3             |        P=0.313N         P=0.791N         P=0.518N         P=0.228N         P=0.427N                         | 
|POLY 1.5           |        P=0.189N         P=0.754          P=0.493N         P=0.215N         P=0.282N                         | 
|POLY 6             |        P=0.541N         P=0.808N         P=0.591N         P=0.263N         P=0.737N                         | 
|LOGISTIC REGRESSION|        P=0.061N         P=0.677          P=0.480N         P=0.212N         P=0.153N                         | 
|COCH-ARM / FISHERS |        P=0.047N*        P=0.691N         P=0.491N         P=0.211N         P=0.117N                         | 
|ORDER RESTRICTED   |        P=0.227N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        47/53 (89%)      46/53 (87%)      43/52 (83%)      51/52 (98%)      46/50 (92%)                      | 
|POLY-3 RATE (b)    |        47/50.25         46/50.00         43/48.90         51/51.01         46/47.94                         | 
|POLY-3 PERCENT (g) |        93.5%            92.0%            87.9%            100.0%           96.0%                            | 
|TERMINAL (d)       |        21/22 (96%)      20/21 (95%)      21/22 (96%)      24/24 (100%)     23/24 (96%)                      | 
|FIRST INCIDENCE    |        85               178              125              254              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.483N         P=0.537          P=0.306N         P=0.417          P=0.460N                         | 
|POLY 3             |        P=0.153          P=0.541N         P=0.240N         P=0.055          P=0.461                          | 
|POLY 1.5           |        P=0.101          P=0.563N         P=0.255N         P=0.033 *        P=0.341                          | 
|POLY 6             |        P=0.300          P=0.510N         P=0.236N         P=0.156          P=0.670                          | 
|LOGISTIC REGRESSION|        P=0.133          P=0.528N         P=0.262N         P=0.053          P=0.351                          | 
|COCH-ARM / FISHERS |        P=0.163          P=0.500N         P=0.276N         P=0.059          P=0.408                          | 
|ORDER RESTRICTED   |        P=0.082          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        2/52 (4%)        4/52 (8%)        5/50 (10%)                       | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          2/39.85          4/38.83          5/37.92                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%             10.3%            13.2%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              491              310              574                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              P=0.242          P=0.068          P=0.028 *                        | 
|POLY 3             |        P=0.006 **       (e)              P=0.246          P=0.061          P=0.029 *                        | 
|POLY 1.5           |        P=0.005 **       (e)              P=0.241          P=0.060          P=0.026 *                        | 
|POLY 6             |        P=0.008 **       (e)              P=0.252          P=0.064          P=0.034 *                        | 
|LOGISTIC REGRESSION|        P=0.006 **       (e)              P=0.225          P=0.061          P=0.029 *                        | 
|COCH-ARM / FISHERS |        P=0.006 **       (e)              P=0.243          P=0.057          P=0.024 *                        | 
|ORDER RESTRICTED   |        P=0.009 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Red Pulp                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/53 (0%)        1/52 (2%)        0/52 (0%)        5/50 (10%)                       | 
|POLY-3 RATE (b)    |        1/38.41          0/37.40          1/39.52          0/37.39          5/38.10                          | 
|POLY-3 PERCENT (g) |        2.6%             0.0%             2.5%             0.0%             13.1%                            | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        670              ---              491              ---              491                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.493N         P=0.755N         P=0.500N         P=0.091                          | 
|POLY 3             |        P=0.002 **       P=0.505N         P=0.755N         P=0.505N         P=0.097                          | 
|POLY 1.5           |        P<0.001 **       P=0.505N         P=0.759N         P=0.505N         P=0.090                          | 
|POLY 6             |        P=0.002 **       P=0.505N         P=0.752N         P=0.505N         P=0.109                          | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.503N         P=0.752          P=0.504N         P=0.093                          | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.500N         P=0.748          P=0.505N         P=0.090                          | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/52 (4%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.86          2/37.84          0/36.26                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.3%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              720              612              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.628N         (e)              P=0.517          P=0.239          (e)                              | 
|POLY 3             |        P=0.636N         (e)              P=0.504          P=0.234          (e)                              | 
|POLY 1.5           |        P=0.639N         (e)              P=0.501          P=0.233          (e)                              | 
|POLY 6             |        P=0.633N         (e)              P=0.506          P=0.239          (e)                              | 
|LOGISTIC REGRESSION|        P=0.637N         (e)              P=0.508          P=0.233          (e)                              | 
|COCH-ARM / FISHERS |        P=0.633N         (e)              P=0.495          P=0.243          (e)                              | 
|ORDER RESTRICTED   |        P=0.306          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        1/53 (2%)        2/52 (4%)        7/52 (13%)       8/51 (16%)                       | 
|POLY-3 RATE (b)    |        1/38.18          1/37.89          2/39.13          7/39.86          8/37.61                          | 
|POLY-3 PERCENT (g) |        2.6%             2.6%             5.1%             17.6%            21.3%                            | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        6/24 (25%)                       | 
|FIRST INCIDENCE    |        729 (T)          580              654              479              314                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.758          P=0.505          P=0.041 *        P=0.021 *                        | 
|POLY 3             |        P<0.001 **       P=0.760          P=0.509          P=0.033 *        P=0.013 *                        | 
|POLY 1.5           |        P<0.001 **       P=0.758          P=0.503          P=0.030 *        P=0.013 *                        | 
|POLY 6             |        P<0.001 **       P=0.760N         P=0.515          P=0.038 *        P=0.014 *                        | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.759          P=0.509          P=0.031 *        P=0.014 *                        | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.752N         P=0.493          P=0.028 *        P=0.013 *                        | 
|ORDER RESTRICTED   |        P=0.004 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        1/52 (2%)        2/52 (4%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          1/38.82          2/37.86          1/36.65                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             2.6%             5.3%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              729 (T)          618              619                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.377          (e)              P=0.500          P=0.240          P=0.471                          | 
|POLY 3             |        P=0.373          (e)              P=0.503          P=0.234          P=0.492                          | 
|POLY 1.5           |        P=0.367          (e)              P=0.501          P=0.233          P=0.489                          | 
|POLY 6             |        P=0.381          (e)              P=0.506          P=0.239          P=0.496                          | 
|LOGISTIC REGRESSION|        P=0.367          (e)              P=0.500          P=0.233          P=0.493                          | 
|COCH-ARM / FISHERS |        P=0.372          (e)              P=0.495          P=0.243          P=0.490                          | 
|ORDER RESTRICTED   |        P=0.191          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/53 (0%)        0/53 (0%)        0/52 (0%)        1/52 (2%)        2/51 (4%)                        | 
|POLY-3 RATE (b)    |        0/38.18          0/37.40          0/38.82          1/37.39          2/37.97                          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             2.7%             5.3%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/21 (0%)        0/22 (0%)        1/24 (4%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        ---              ---              ---              729 (T)          71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.047 *        (e)              (e)              P=0.517          P=0.240                          | 
|POLY 3             |        P=0.042 *        (e)              (e)              P=0.496          P=0.235                          | 
|POLY 1.5           |        P=0.041 *        (e)              (e)              P=0.495          P=0.231                          | 
|POLY 6             |        P=0.044 *        (e)              (e)              P=0.498          P=0.240                          | 
|LOGISTIC REGRESSION|        P=0.064          (e)              (e)              P=0.517          P=0.324                          | 
|COCH-ARM / FISHERS |        P=0.040 *        (e)              (e)              P=0.495          P=0.238                          | 
|ORDER RESTRICTED   |        P=0.047 *        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/53 (8%)        3/53 (6%)        3/52 (6%)        1/52 (2%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        4/38.98          3/39.05          3/39.36          1/37.99          0/36.26                          | 
|POLY-3 PERCENT (g) |        10.3%            7.7%             7.6%             2.6%             0.0%                             | 
|TERMINAL (d)       |        2/22 (9%)        0/21 (0%)        1/22 (5%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        556              534              654              539              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.045N*        P=0.510N         P=0.505N         P=0.183N         P=0.065N                         | 
|POLY 3             |        P=0.046N*        P=0.499N         P=0.495N         P=0.184N         P=0.069N                         | 
|POLY 1.5           |        P=0.045N*        P=0.505N         P=0.500N         P=0.186N         P=0.069N                         | 
|POLY 6             |        P=0.046N*        P=0.489N         P=0.490N         P=0.182N         P=0.068N                         | 
|LOGISTIC REGRESSION|        P=0.044N*        P=0.499N         P=0.496N         P=0.186N         P=0.069N                         | 
|COCH-ARM / FISHERS |        P=0.043N*        P=0.500N         P=0.511N         P=0.187N         P=0.064N                         | 
|ORDER RESTRICTED   |        P=0.041N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        33/53 (62%)      33/50 (66%)      43/48 (90%)      42/50 (84%)      49/51 (96%)                      | 
|POLY-3 RATE (b)    |        33/43.47         33/41.83         43/45.48         42/43.09         49/49.02                         | 
|POLY-3 PERCENT (g) |        75.9%            78.9%            94.6%            97.5%            100.0%                           | 
|TERMINAL (d)       |        18/22 (82%)      14/19 (74%)      18/19 (95%)      24/24 (100%)     24/24 (100%)                     | 
|FIRST INCIDENCE    |        449              167              125              479              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.026 *        P=0.409          P=0.047 *        P=0.142          P=0.017 *                        | 
|POLY 3             |        P<0.001 **       P=0.470          P=0.006 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.439          P=0.002 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.519          P=0.020 *        P=0.002 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.322          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.425          P<0.001 **       P=0.011 *        P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/53 (2%)        0/50 (0%)        0/48 (0%)        3/50 (6%)        1/51 (2%)                        | 
|POLY-3 RATE (b)    |        1/39.00          0/34.71          0/34.86          3/38.30          1/36.76                          | 
|POLY-3 PERCENT (g) |        2.6%             0.0%             0.0%             7.8%             2.7%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/19 (0%)        0/19 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        418              ---              ---              96               76                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.420          P=0.521N         P=0.500N         P=0.296          P=0.751                          | 
|POLY 3             |        P=0.439          P=0.523N         P=0.522N         P=0.298          P=0.748                          | 
|POLY 1.5           |        P=0.432          P=0.521N         P=0.521N         P=0.292          P=0.746                          | 
|POLY 6             |        P=0.451          P=0.524N         P=0.525N         P=0.307          P=0.752                          | 
|LOGISTIC REGRESSION|        P=0.610N         P=0.479N         P=0.527N         P=0.429          P=0.613N                         | 
|COCH-ARM / FISHERS |        P=0.436          P=0.515N         P=0.525N         P=0.287          P=0.743                          | 
|ORDER RESTRICTED   |        P=0.191          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/50 (0%)        0/48 (0%)        0/50 (0%)        0/51 (0%)                        | 
|POLY-3 RATE (b)    |        2/39.43          0/34.71          0/34.86          0/35.50          0/35.76                          | 
|POLY-3 PERCENT (g) |        5.1%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        0/22 (0%)        0/19 (0%)        0/19 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        85               ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.355N         P=0.247N         P=0.247N         P=0.251N         P=0.259N                         | 
|POLY 3             |        P=0.331N         P=0.266N         P=0.264N         P=0.260N         P=0.259N                         | 
|POLY 1.5           |        P=0.334N         P=0.263N         P=0.263N         P=0.261N         P=0.260N                         | 
|POLY 6             |        P=0.327N         P=0.267N         P=0.267N         P=0.258N         P=0.256N                         | 
|LOGISTIC REGRESSION|        P=0.262N         P=0.195N         P=0.254N         P=0.180N         P=0.146N                         | 
|COCH-ARM / FISHERS |        P=0.342N         P=0.262N         P=0.273N         P=0.262N         P=0.257N                         | 
|ORDER RESTRICTED   |        P=0.022N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/53 (28%)      19/53 (36%)      22/51 (43%)      12/52 (23%)      15/52 (29%)                      | 
|POLY-3 RATE (b)    |        15/41.78         19/39.63         22/42.21         12/38.36         15/39.51                         | 
|POLY-3 PERCENT (g) |        35.9%            48.0%            52.1%            31.3%            38.0%                            | 
|TERMINAL (d)       |        7/22 (32%)       13/21 (62%)      13/22 (59%)      7/24 (29%)       7/24 (29%)                       | 
|FIRST INCIDENCE    |        377              407              407              552              479                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.199N         P=0.235          P=0.140          P=0.307N         P=0.565N                         | 
|POLY 3             |        P=0.264N         P=0.183          P=0.093          P=0.419N         P=0.515                          | 
|POLY 1.5           |        P=0.282N         P=0.205          P=0.091          P=0.405N         P=0.504                          | 
|POLY 6             |        P=0.236N         P=0.164          P=0.095          P=0.422N         P=0.537                          | 
|LOGISTIC REGRESSION|        P=0.289N         P=0.238          P=0.103          P=0.367N         P=0.526                          | 
|COCH-ARM / FISHERS |        P=0.245N         P=0.266          P=0.084          P=0.349N         P=0.561                          | 
|ORDER RESTRICTED   |        P=0.268N         (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/53 (4%)        0/53 (0%)        0/51 (0%)        0/52 (0%)        0/52 (0%)                        | 
|POLY-3 RATE (b)    |        2/38.43          0/37.40          0/38.82          0/36.79          0/36.27                          | 
|POLY-3 PERCENT (g) |        5.2%             0.0%             0.0%             0.0%             0.0%                             | 
|TERMINAL (d)       |        1/22 (5%)        0/21 (0%)        0/22 (0%)        0/24 (0%)        0/24 (0%)                        | 
|FIRST INCIDENCE    |        664              ---              ---              ---              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.342N         P=0.252N         P=0.247N         P=0.241N         P=0.245N                         | 
|POLY 3             |        P=0.346N         P=0.242N         P=0.234N         P=0.246N         P=0.249N                         | 
|POLY 1.5           |        P=0.346N         P=0.242N         P=0.237N         P=0.247N         P=0.251N                         | 
|POLY 6             |        P=0.346N         P=0.242N         P=0.233N         P=0.244N         P=0.247N                         | 
|LOGISTIC REGRESSION|        P=0.350N         P=0.241N         P=0.232N         P=0.243N         P=0.247N                         | 
|COCH-ARM / FISHERS |        P=0.345N         P=0.248N         P=0.257N         P=0.252N         P=0.252N                         | 
|ORDER RESTRICTED   |        P=0.019N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/53 (26%)      17/53 (32%)      34/51 (67%)      35/52 (67%)      42/52 (81%)                      | 
|POLY-3 RATE (b)    |        14/43.47         17/41.12         34/46.24         35/45.78         42/45.75                         | 
|POLY-3 PERCENT (g) |        32.2%            41.3%            73.5%            76.5%            91.8%                            | 
|TERMINAL (d)       |        5/22 (23%)       8/21 (38%)       17/22 (77%)      20/24 (83%)      23/24 (96%)                      | 
|FIRST INCIDENCE    |        418              330              254              142              71                               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.325          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 3             |        P<0.001 **       P=0.256          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 1.5           |        P<0.001 **       P=0.277          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|POLY 6             |        P<0.001 **       P=0.242          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.330          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.335          P<0.001 **       P<0.001 **       P<0.001 **                       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        23/23 (100%)     14/14 (100%)     33/33 (100%)     35/35 (100%)     31/31 (100%)                     | 
|POLY-3 RATE (b)    |        23/23.00         14/14.00         33/33.00         35/35.00         31/31.00                         | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%           100.0%           100.0%                           | 
|TERMINAL (d)       |        10/10 (100%)     8/8 (100%)       16/16 (100%)     17/17 (100%)     17/17 (100%)                     | 
|FIRST INCIDENCE    |        451              499              407              254              169                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)                              | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)                              | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)                              | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)                              | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/53 (13%)       8/53 (15%)       5/53 (9%)        7/52 (13%)       0/50 (0%)                        | 
|POLY-3 RATE (b)    |        7/40.77          8/40.04          5/41.06          7/39.03          0/35.82                          | 
|POLY-3 PERCENT (g) |        17.2%            20.0%            12.2%            17.9%            0.0%                             | 
|TERMINAL (d)       |        3/22 (14%)       1/21 (5%)        2/22 (9%)        4/24 (17%)       0/24 (0%)                        | 
|FIRST INCIDENCE    |        345              469              254              499              ---                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008N**       P=0.488          P=0.388N         P=0.589N         P=0.011N*                        | 
|POLY 3             |        P=0.010N*        P=0.485          P=0.372N         P=0.581          P=0.012N*                        | 
|POLY 1.5           |        P=0.010N*        P=0.479          P=0.373N         P=0.582          P=0.012N*                        | 
|POLY 6             |        P=0.010N*        P=0.507          P=0.373N         P=0.589          P=0.012N*                        | 
|LOGISTIC REGRESSION|        P=0.008N**       P=0.506          P=0.391N         P=0.599          P=0.011N*                        | 
|COCH-ARM / FISHERS |        P=0.008N**       P=0.500          P=0.380N         P=0.598          P=0.008N**                       | 
|ORDER RESTRICTED   |        P=0.013N*        (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        5/53 (9%)        8/53 (15%)       10/52 (19%)      5/50 (10%)                       | 
|POLY-3 RATE (b)    |        3/39.57          5/38.45          8/39.64          10/39.56         5/36.31                          | 
|POLY-3 PERCENT (g) |        7.6%             13.0%            20.2%            25.3%            13.8%                            | 
|TERMINAL (d)       |        0/22 (0%)        3/21 (14%)       6/22 (27%)       6/24 (25%)       4/24 (17%)                       | 
|FIRST INCIDENCE    |        345              337              638              506              581                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.560N         P=0.341          P=0.101          P=0.046 *        P=0.352                          | 
|POLY 3             |        P=0.477          P=0.339          P=0.094          P=0.031 *        P=0.308                          | 
|POLY 1.5           |        P=0.470          P=0.342          P=0.096          P=0.031 *        P=0.306                          | 
|POLY 6             |        P=0.488          P=0.337          P=0.093          P=0.033 *        P=0.311                          | 
|LOGISTIC REGRESSION|        P=0.490          P=0.360          P=0.105          P=0.035 *        P=0.320                          | 
|COCH-ARM / FISHERS |        P=0.497          P=0.358          P=0.101          P=0.033 *        P=0.325                          | 
|ORDER RESTRICTED   |        P=0.113          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/53 (6%)        0/53 (0%)        1/53 (2%)        7/52 (13%)       2/50 (4%)                        | 
|POLY-3 RATE (b)    |        3/38.79          0/37.40          1/39.09          7/39.10          2/36.51                          | 
|POLY-3 PERCENT (g) |        7.7%             0.0%             2.6%             17.9%            5.5%                             | 
|TERMINAL (d)       |        2/22 (9%)        0/21 (0%)        0/22 (0%)        2/24 (8%)        1/24 (4%)                        | 
|FIRST INCIDENCE    |        533              ---              715              310              491                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.452          P=0.128N         P=0.293N         P=0.181          P=0.479N                         | 
|POLY 3             |        P=0.419          P=0.124N         P=0.301N         P=0.156          P=0.528N                         | 
|POLY 1.5           |        P=0.407          P=0.124N         P=0.303N         P=0.153          P=0.534N                         | 
|POLY 6             |        P=0.436          P=0.124N         P=0.301N         P=0.165          P=0.519N                         | 
|LOGISTIC REGRESSION|        P=0.407          P=0.123N         P=0.298N         P=0.151          P=0.530N                         | 
|COCH-ARM / FISHERS |        P=0.411          P=0.121N         P=0.309N         P=0.152          P=0.528N                         | 
|ORDER RESTRICTED   |        P=0.113          (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/03/04                           EXPERIMENT: 96020 TEST: 01                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/53 (51%)      30/53 (57%)      35/53 (66%)      36/52 (69%)      14/50 (28%)                      | 
|POLY-3 RATE (b)    |        27/44.63         30/45.71         35/49.50         36/44.30         14/38.69                         | 
|POLY-3 PERCENT (g) |        60.5%            65.6%            70.7%            81.3%            36.2%                            | 
|TERMINAL (d)       |        12/22 (55%)      13/21 (62%)      15/22 (68%)      21/24 (88%)      7/24 (29%)                       | 
|FIRST INCIDENCE    |        345              330              254              310              477                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.329          P=0.164          P=0.133          P=0.017N*                        | 
|POLY 3             |        P<0.001N**       P=0.382          P=0.196          P=0.018 *        P=0.018N*                        | 
|POLY 1.5           |        P<0.001N**       P=0.356          P=0.144          P=0.024 *        P=0.017N*                        | 
|POLY 6             |        P=0.002N**       P=0.411          P=0.251          P=0.012 *        P=0.021N*                        | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.329          P=0.085          P=0.036 *        P=0.016N*                        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.349          P=0.084          P=0.043 *        P=0.014N*                        | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0 NG /           10 NG /          100 NG /         300 NG /         1000 NG/                         | 
|                   |        0 UG             10 UG            100 UG           300 UG           1000 UG                          | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        28/53 (53%)      23/53 (43%)      34/53 (64%)      18/52 (35%)      12/50 (24%)                      | 
|POLY-3 RATE (b)    |        28/44.64         23/42.81         34/46.65         18/41.18         12/36.59                         | 
|POLY-3 PERCENT (g) |        62.7%            53.7%            72.9%            43.7%            32.8%                            | 
|TERMINAL (d)       |        13/22 (59%)      12/21 (57%)      19/22 (86%)      13/24 (54%)      10/24 (42%)                      | 
|FIRST INCIDENCE    |        345              296              254              142              581                              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.299N         P=0.223          P=0.040N*        P=0.002N**                       | 
|POLY 3             |        P<0.001N**       P=0.253N         P=0.193          P=0.051N         P=0.004N**                       | 
|POLY 1.5           |        P<0.001N**       P=0.248N         P=0.177          P=0.044N*        P=0.003N**                       | 
|POLY 6             |        P<0.001N**       P=0.253N         P=0.213          P=0.066N         P=0.006N**                       | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.234N         P=0.169          P=0.046N*        P=0.002N**                       | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.218N         P=0.162          P=0.046N*        P=0.002N**                       | 
|ORDER RESTRICTED   |        P=0.003N**       (e)              (e)              (e)              (e)                              | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.