National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14665

TDMS Study 96020-01 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:05:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                              FINAL #1                                                              
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 004    300 NG /100 UG                                                                
                                       INCLUDE 005    300 NG /300 UG                                                                
                                       INCLUDE 006    300 NG /3000 UG                                                               
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 03/03/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 10:05:10       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                                                                                                                   
                 TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 0 NG /  0 UG                                   |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 53     UNCENSORED DEATHS 30     CENSORED DEATHS 1    TERMINAL 22        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      345   377   418   426   449   451   451   451   484   499                 |                                                 
 |      533   556   556   556   581   636   640   647   654   654                 |                                                 
 |      664   664   664   664   670   684   688   708   714   719                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      85                                                                        |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 300 NG /100 UG                                 |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      441   462   478   484   491   491   494   534   567   569                 |                                                 
 |      603   612   615   625   633   636   640   643   653   664                 |                                                 
 |      689   701                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                          DOSE = 300 NG /300 UG                                 |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 53     UNCENSORED DEATHS 29     CENSORED DEATHS 0    TERMINAL 24        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      96    142   254   310   330   363   451   479   499   505                 |                                                 
 |      505   506   539   552   556   580   583   603   603   612                 |                                                 
 |      618   650   654   659   665   684   710   715   719                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                 TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = 300 NG /3000 UG                                |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 51     UNCENSORED DEATHS 23     CENSORED DEATHS 1    TERMINAL 27        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      409   458   462   463   490   491   556   588   588   588                 |                                                 
 |      596   601   602   622   632   636   643   647   668   673                 |                                                 
 |      712   714   720                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      233                                                                       |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                 TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                                                                   
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0          |   100.0 100.0 100.0  98.1  94.2  82.7  78.8  71.2  53.8  42.3      |                                                 
 |NG /  0 UG |                                                                    |                                                 
 |           |                                                                    |                                                 
 |300        |   100.0 100.0 100.0 100.0 100.0  92.0  84.0  78.0  60.0  56.0      |                                                 
 |NG /100 UG |                                                                    |                                                 
 |           |                                                                    |                                                 
 |300        |   100.0  96.2  94.3  88.7  88.7  84.9  75.5  64.2  52.8  45.3      |                                                 
 |NG /300 UG |                                                                    |                                                 
 |           |                                                                    |                                                 
 |300        |   100.0 100.0 100.0 100.0  98.0  92.0  88.0  74.0  64.0  54.0      |                                                 
 |NG /3000 UG|                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0            300          300          300      |                                                 
 |                                NG /  0 UG   NG /100 UG   NG /300 UG   NG /3000 |G                                                
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       42.3%        56.0%        45.3%        54.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.463N     P=0.280N     P=1.000N     P=0.301N |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       573.4        578.4        522.1        589.5    |                                                 
 |NATURAL DEATHS (C)      |       (20.5)       (17.1)       (30.7)       (18.6)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       628.8        662.7        615.8        656.4    |                                                 
 |(STANDARD ERROR)        |       (18.8)       (13.0)       (21.9)       (15.3)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                                          
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 NG /  0 UG     = 1                                                        
                                                        300 NG /100 UG   = 2                                                        
                                                        300 NG /300 UG   = 3                                                        
                                                        300 NG /3000 UG  = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1              3                                       1         4   2                                                      
      |                3       3                               1   1     4   2   2                                                  
      |                        3                 3        3        1      11     24 22                                              
      |                                                   3  3             1    1 4  22                                             
P  90 +                                                      3   3                   44                                             
E     |                                                          3              3   3 4         4                                   
R     |                                                                         1   3123     2  42  4                               
C     |                                                                              1 13        22                                 
E  80 +                                                                                1     1  1 2 4  42                           
N     |                                                                                 3    3          22                          
T     |                                                                                      3 3       4 242                        
      |                                                                                        31  1      422                       
S  70 +                                                                                            13       11                      
U     |                                                                                             3   3   211                     
R     |                                                                                                 33   211  4                 
V     |                                                                                                  33    1 144                
I  60 +                                                                                                   3   3  2 4 2  4           
V     |                                                                                                       33 3   2 2            
A     |                                                                                                          11    244  2       
L     |                                                                                                          31 1               
   50 +                                                                                                             11  33          
      |                                                                                                              1  1           
      |                                                                                                                 11  3       
      |                                                                                                                  1  1       
   40 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 35 obs hidden.                                                                                                                
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