National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10722

TDMS Study 61529-01 Pathology Tables

NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04
Route: GAVAGE                                                                                                     Time: 08:51:52




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  108-42-09

       Lock Date:  11/16/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 001    0 MG/KG
                               Include 004    10 MG/KG
                               Include 003    10 MG/KG
                               Include 006    20 MG/KG
                               Include 005    20 MG/KG
                               Include 008    40 MG/KG
                               Include 007    40 MG/KG
                               Include 010    80 MG/KG
                               Include 009    80 MG/KG
                               Include 012    160     MG/KG
                               Include 011    160     MG/KG

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                                                                                       1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10            9           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (9)                                                              (10)         
      Muscularis, Inflammation, Chronic, Focal                                                                          1 (10%)     
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                 2 (20%)                   1 (10%)     10 (100%)    10 (100%)    10 (100%)    
      Hepatodiaphragmatic Nodule                       1 (10%)                                                                      
      Inflammation, Chronic, Multifocal                1 (10%)                                                                      
      Pigmentation                                     3 (30%)                                                                      
      Bile Duct, Inflammation, Chronic, Focal                                                                           1 (10%)     
      Kupffer Cell, Pigmentation                                                             10 (100%)    10 (100%)    10 (100%)    
   Pancreas                                           (10)                                                             (10)         
      Acinus, Atrophy                                  1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                   4 (40%)                                                          5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)                      (1)                                    (10)         
      Cyst                                                                       1 (100%)                                           
      Ultimobranchial Cyst                             1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                                                             (10)         
      Inflammation, Chronic                            1 (10%)                                                                      
      Inflammation, Chronic, Focal                     1 (10%)                                                          1 (10%)     
      Inflammation, Chronic, Multifocal                3 (30%)                                                          6 (60%)     
      Inflammation, Chronic, Multifocal,                                                                                            
        Suppurative                                    1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Multifocal, Histiocyte                                                                     1 (10%)     
      Infiltration Cellular, Histiocyte                             1 (10%)      2 (20%)      3 (30%)                               
      Myelofibrosis                                    3 (30%)      1 (10%)                                1 (10%)      1 (10%)     
      Pigmentation, Hemosiderin                                                               3 (30%)     10 (100%)     9 (90%)     
      Erythroid Cell, Hyperplasia                                                             6 (60%)     10 (100%)    10 (100%)    
      Erythroid Cell, Myelofibrosis                                                           1 (10%)                               
   Lymph Node                                                                   (1)                                                 
      Lumbar, Pigmentation                                                       1 (100%)                                           
   Lymph Node, Mesenteric                             (10)                                                             (10)         
      Hyperplasia, Histiocytic                         1 (10%)                                                                      
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Congestion                                                                 8 (80%)      9 (90%)     10 (100%)    10 (100%)    
      Hematopoietic Cell Proliferation                              5 (50%)      8 (80%)     10 (100%)    10 (100%)     9 (90%)     
      Pigmentation, Hemosiderin                                    10 (100%)    10 (100%)     9 (90%)     10 (100%)    10 (100%)    
      Capsule, Fibrosis                                                                       6 (60%)     10 (100%)     8 (80%)     
      Capsule, Fibrosis, Multifocal                                                                                     1 (10%)     
      Capsule, Infiltration Cellular                   1 (10%)      1 (10%)                   9 (90%)     10 (100%)     8 (80%)     
      Lymphoid Follicle, Atrophy                                                                                        1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Congestion                                                                                                        1 (10%)     
      Inflammation, Chronic Active, Focal                                                                               1 (10%)     
      Inflammation, Chronic Active, Multifocal         1 (10%)                                                                      
      Arteriole, Inflammation, Granulomatous                                                                            1 (10%)     
      Artery, Mineralization                           3 (30%)                                                          5 (50%)     
      Vein, Mineralization                                                                                              1 (10%)     
   Nose                                               (10)                                                             (10)         
      Respiratory Epithelium, Inflammation, Chronic                                                                     1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Mineralization                                  10 (100%)    10 (100%)    10 (100%)    10 (100%)    10 (100%)     9 (90%)     
      Cortex, Inflammation, Chronic, Focal                          1 (10%)                                                         
      Cortex, Pigmentation, Hemosiderin                                          1 (10%)     10 (100%)    10 (100%)    10 (100%)    
      Renal Tubule, Regeneration, Focal                2 (20%)                   1 (10%)                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Hematopoietic Cell Proliferation                              1 (10%)                                9 (90%)      9 (90%)     
      Hemorrhage                                       1 (10%)                                                                      
      Inflammation, Acute                                           1 (10%)                                                         
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Necrosis, Focal                                               1 (10%)                                                         
      Necrosis, Multifocal                                          1 (10%)                                                         
      Vacuolization Cytoplasmic                                                               1 (10%)                               
      Kupffer Cell, Pigmentation                                                              9 (90%)     10 (100%)     9 (90%)     
      Kupffer Cell, Pigmentation, Hemosiderin                                                                           1 (10%)     
   Pancreas                                           (10)                                                             (10)         
      Acinus, Atrophy                                                                                                   1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Cardiomyopathy                                  10 (100%)                                                         5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)                                                             (10)         
      Ultimobranchial Cyst                             1 (10%)                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                             (10)         
      Inflammation, Chronic                            1 (10%)                                                          4 (40%)     
      Inflammation, Chronic, Focal                     1 (10%)                                                                      
      Inflammation, Chronic, Multifocal                4 (40%)                                                                      
      Inflammation, Chronic, Suppurative               1 (10%)                                                          1 (10%)     
      Inflammation, Granulomatous                                                                                       1 (10%)     
   Testes                                             (10)                                                             (10)         
      Atrophy                                                                                                           1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)         (10)         (10)         (10)         (10)         (10)         
      Pigmentation, Hemosiderin                                                                           10 (100%)    10 (100%)    
      Erythroid Cell, Hyperplasia                                                            10 (100%)    10 (100%)    10 (100%)    
   Spleen                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Congestion                                                    1 (10%)      9 (90%)     10 (100%)    10 (100%)    10 (100%)    
      Fibrosis                                                                   1 (10%)                                            
      Hematopoietic Cell Proliferation                              7 (70%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Pigmentation, Hemosiderin                                     6 (60%)     10 (100%)    10 (100%)    10 (100%)    10 (100%)    
      Capsule, Fibrosis                                             2 (20%)      2 (20%)      8 (80%)     10 (100%)    10 (100%)    
      Capsule, Infiltration Cellular                   1 (10%)      2 (20%)      2 (20%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 61529-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                  M-CHLOROANILINE                                      Date: 10/20/04    
Route: GAVAGE                                                                                                     Time: 08:51:52    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      10 MG/KG     20 MG/KG     40 MG/KG     80 MG/KG     160             
                                                                                                                    MG/KG           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage, Focal                                1 (10%)                                                          1 (10%)     
      Alveolar Epithelium, Hyperplasia                 1 (10%)                                                                      
      Artery, Mineralization                           6 (60%)                                                          5 (50%)     
      Interstitium, Inflammation, Chronic, Focal       1 (10%)                                                                      
      Interstitium, Inflammation, Chronic,                                                                                          
        Multifocal                                                                                                      1 (10%)     
      Vein, Mineralization                                                                                              1 (10%)     
   Nose                                               (10)                                                             (10)         
      Lateral Wall, Inflammation, Granulomatous        1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Inflammation, Chronic, Multifocal                             1 (10%)                                                         
      Mineralization                                  10 (100%)    10 (100%)     9 (90%)     10 (100%)    10 (100%)    10 (100%)    
      Cortex, Pigmentation, Hemosiderin                                                      10 (100%)    10 (100%)    10 (100%)    
      Renal Tubule, Regeneration, Focal                2 (20%)                                1 (10%)      2 (20%)                  
      Renal Tubule, Regeneration, Multifocal           7 (70%)      8 (80%)      7 (70%)      2 (20%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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