Share This:
https://ntp.niehs.nih.gov/go/18210

TDMS Study 96020-01 Pathology Tables

                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                      TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   DATE: 05/24/04       
EXPERIMENT: 96020 TEST: 01                                                                                     TIME: 11:04:59       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96020       
PATHOLOGIST: SELLS, DONALD                                                                                     CAS: TEFBINARYMIX    
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF    TEF EVALUATION (BINARY MIXTURE; PCB 126                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Eye: Retina                            Atrophy                                                                                      
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Mineralization                                                                               
                                       Pigmentation                                                                                 
Kidney: Pelvis                         Dilatation                                                                                   
                                       Inflammation                                                                                 
Liver                                  Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Hypertrophy                                                                                  
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Infiltration Cellular Histiocyte                                                             
Lung: Alveolar Epithelium              Metaplasia Bronchiolar                                                                       
Mammary Gland                          Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Inflammation Chronic                                                                         
Oviduct                                Cyst                                                                                         
                                       Inflammation Chronic                                                                         
Pancreas: Acinus                       Vacuolization Cytoplasmic                                                                    
Pituitary Gland                        Angiectasis                                                                                  
Skin                                   Inflammation                                                                                 
Stomach, Forestomach                   Inflammation                                                                                 
Stomach, Glandular                     Erosion                                                                                      
Thymus                                 Atrophy                                                                                      
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus                                 Inflammation                                                                                 
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        28/49 (57%)      23/52 (44%)      7/51 (14%)                                                         | 
|POLY-3 RATE (b)    |        28/41.28         23/42.61         7/41.65                                                            | 
|POLY-3 PERCENT (g) |        67.8%            54.0%            16.8%                                                              | 
|TERMINAL (d)       |        22/28 (79%)      11/24 (46%)      4/27 (15%)                                                         | 
|FIRST INCIDENCE    |        491              499              463                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001N**       P=0.424N         P<0.001N**                                                         | 
|POLY 3             |        P<0.001N**       P=0.128N         P<0.001N**                                                         | 
|POLY 1.5           |        P<0.001N**       P=0.151N         P<0.001N**                                                         | 
|POLY 6             |        P<0.001N**       P=0.088N         P<0.001N**                                                         | 
|LOGISTIC REGRESSION|        P<0.001N**       P=0.239N         P<0.001N**                                                         | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.136N         P<0.001N**                                                         | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/49 (4%)        3/52 (6%)        5/51 (10%)                                                         | 
|POLY-3 RATE (b)    |        2/38.87          3/37.99          5/40.32                                                            | 
|POLY-3 PERCENT (g) |        5.2%             7.9%             12.4%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        2/24 (8%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        729 (T)          539              647                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.219          P=0.442          P=0.210                                                            | 
|POLY 3             |        P=0.214          P=0.489          P=0.229                                                            | 
|POLY 1.5           |        P=0.210          P=0.498          P=0.229                                                            | 
|POLY 6             |        P=0.218          P=0.485          P=0.231                                                            | 
|LOGISTIC REGRESSION|        P=0.221          P=0.484          P=0.224                                                            | 
|COCH-ARM / FISHERS |        P=0.205          P=0.528          P=0.235                                                            | 
|ORDER RESTRICTED   |        P=0.168          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/49 (29%)      14/52 (27%)      18/51 (35%)                                                        | 
|POLY-3 RATE (b)    |        14/42.18         14/39.87         18/43.61                                                           | 
|POLY-3 PERCENT (g) |        33.2%            35.1%            41.3%                                                              | 
|TERMINAL (d)       |        8/28 (29%)       7/24 (29%)       11/27 (41%)                                                        | 
|FIRST INCIDENCE    |        484              505              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.264          P=0.462          P=0.257                                                            | 
|POLY 3             |        P=0.261          P=0.520          P=0.288                                                            | 
|POLY 1.5           |        P=0.250          P=0.556          P=0.291                                                            | 
|POLY 6             |        P=0.266          P=0.501          P=0.285                                                            | 
|LOGISTIC REGRESSION|        P=0.234          P=0.572N         P=0.309                                                            | 
|COCH-ARM / FISHERS |        P=0.222          P=0.515N         P=0.307                                                            | 
|ORDER RESTRICTED   |        P=0.291          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/49 (35%)      25/52 (48%)      21/51 (41%)                                                        | 
|POLY-3 RATE (b)    |        17/40.68         25/42.59         21/42.72                                                           | 
|POLY-3 PERCENT (g) |        41.8%            58.7%            49.2%                                                              | 
|TERMINAL (d)       |        13/28 (46%)      14/24 (58%)      14/27 (52%)                                                        | 
|FIRST INCIDENCE    |        491              254              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.542N         P=0.037 *        P=0.245                                                            | 
|POLY 3             |        P=0.560N         P=0.083          P=0.320                                                            | 
|POLY 1.5           |        P=0.569N         P=0.088          P=0.314                                                            | 
|POLY 6             |        P=0.553N         P=0.087          P=0.330                                                            | 
|LOGISTIC REGRESSION|        P=0.540N         P=0.071          P=0.301                                                            | 
|COCH-ARM / FISHERS |        P=0.553          P=0.123          P=0.322                                                            | 
|ORDER RESTRICTED   |        P=0.172          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/49 (86%)      41/52 (79%)      40/51 (78%)                                                        | 
|POLY-3 RATE (b)    |        42/46.24         41/44.30         40/47.73                                                           | 
|POLY-3 PERCENT (g) |        90.8%            92.6%            83.8%                                                              | 
|TERMINAL (d)       |        26/28 (93%)      24/24 (100%)     24/27 (89%)                                                        | 
|FIRST INCIDENCE    |        441              479              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.340N         P=0.314          P=0.489N                                                           | 
|POLY 3             |        P=0.106N         P=0.540          P=0.221N                                                           | 
|POLY 1.5           |        P=0.173N         P=0.628N         P=0.244N                                                           | 
|POLY 6             |        P=0.064N         P=0.471          P=0.190N                                                           | 
|LOGISTIC REGRESSION|        P=0.240N         P=0.617N         P=0.272N                                                           | 
|COCH-ARM / FISHERS |        P=0.345N         P=0.261N         P=0.247N                                                           | 
|ORDER RESTRICTED   |        P=0.115N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/49 (6%)        0/52 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        3/39.68          0/37.39          2/41.77                                                            | 
|POLY-3 PERCENT (g) |        7.6%             0.0%             4.8%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        612              ---              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.604          P=0.151N         P=0.509N                                                           | 
|POLY 3             |        P=0.646          P=0.129N         P=0.477N                                                           | 
|POLY 1.5           |        P=0.634          P=0.123N         P=0.478N                                                           | 
|POLY 6             |        P=0.655          P=0.135N         P=0.479N                                                           | 
|LOGISTIC REGRESSION|        P=0.562          P=0.112N         P=0.367N                                                           | 
|COCH-ARM / FISHERS |        P=0.603          P=0.111N         P=0.481N                                                           | 
|ORDER RESTRICTED   |        P=0.172N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/49 (31%)      10/52 (19%)      13/51 (25%)                                                        | 
|POLY-3 RATE (b)    |        15/42.24         10/40.66         13/40.68                                                           | 
|POLY-3 PERCENT (g) |        35.5%            24.6%            32.0%                                                              | 
|TERMINAL (d)       |        7/28 (25%)       3/24 (13%)       10/27 (37%)                                                        | 
|FIRST INCIDENCE    |        478              330              636                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.558N         P=0.278N         P=0.442N                                                           | 
|POLY 3             |        P=0.537          P=0.196N         P=0.456N                                                           | 
|POLY 1.5           |        P=0.556          P=0.179N         P=0.421N                                                           | 
|POLY 6             |        P=0.506          P=0.213N         P=0.499N                                                           | 
|LOGISTIC REGRESSION|        P=0.565N         P=0.130N         P=0.375N                                                           | 
|COCH-ARM / FISHERS |        P=0.569          P=0.137N         P=0.364N                                                           | 
|ORDER RESTRICTED   |        P=0.321N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/49 (16%)       13/52 (25%)      6/49 (12%)                                                         | 
|POLY-3 RATE (b)    |        8/39.28          13/39.45         6/39.40                                                            | 
|POLY-3 PERCENT (g) |        20.4%            33.0%            15.2%                                                              | 
|TERMINAL (d)       |        7/28 (25%)       9/24 (38%)       5/26 (19%)                                                         | 
|FIRST INCIDENCE    |        612              479              596                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.145N         P=0.090          P=0.438N                                                           | 
|POLY 3             |        P=0.136N         P=0.153          P=0.381N                                                           | 
|POLY 1.5           |        P=0.142N         P=0.162          P=0.384N                                                           | 
|POLY 6             |        P=0.134N         P=0.150          P=0.381N                                                           | 
|LOGISTIC REGRESSION|        P=0.131N         P=0.135          P=0.385N                                                           | 
|COCH-ARM / FISHERS |        P=0.162N         P=0.204          P=0.387N                                                           | 
|ORDER RESTRICTED   |        P=0.150N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/50 (76%)      48/53 (91%)      39/51 (76%)                                                        | 
|POLY-3 RATE (b)    |        38/48.54         48/53.00         39/48.89                                                           | 
|POLY-3 PERCENT (g) |        78.3%            90.6%            79.8%                                                              | 
|TERMINAL (d)       |        19/28 (68%)      19/24 (79%)      19/27 (70%)                                                        | 
|FIRST INCIDENCE    |        441              96               233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.264N         P=0.043 *        P=0.470                                                            | 
|POLY 3             |        P=0.327N         P=0.070          P=0.528                                                            | 
|POLY 1.5           |        P=0.288N         P=0.056          P=0.544                                                            | 
|POLY 6             |        P=0.371N         P=0.092          P=0.514                                                            | 
|LOGISTIC REGRESSION|        P=0.269N         P=0.069          P=0.581                                                            | 
|COCH-ARM / FISHERS |        P=0.236N         P=0.042 *        P=0.570                                                            | 
|ORDER RESTRICTED   |        P=0.237          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        38/49 (78%)      40/53 (75%)      40/50 (80%)                                                        | 
|POLY-3 RATE (b)    |        38/45.36         40/48.52         40/45.91                                                           | 
|POLY-3 PERCENT (g) |        83.8%            82.4%            87.1%                                                              | 
|TERMINAL (d)       |        25/28 (89%)      17/24 (71%)      24/27 (89%)                                                        | 
|FIRST INCIDENCE    |        441              254              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.540N         P=0.220          P=0.382                                                            | 
|POLY 3             |        P=0.346          P=0.543N         P=0.431                                                            | 
|POLY 1.5           |        P=0.373          P=0.590N         P=0.428                                                            | 
|POLY 6             |        P=0.321          P=0.433N         P=0.471                                                            | 
|LOGISTIC REGRESSION|        P=0.450          P=0.558          P=0.428                                                            | 
|COCH-ARM / FISHERS |        P=0.392          P=0.495N         P=0.479                                                            | 
|ORDER RESTRICTED   |        P=0.390          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        41/49 (84%)      43/53 (81%)      41/50 (82%)                                                        | 
|POLY-3 RATE (b)    |        41/46.10         43/48.31         41/47.73                                                           | 
|POLY-3 PERCENT (g) |        88.9%            89.0%            85.9%                                                              | 
|TERMINAL (d)       |        25/28 (89%)      21/24 (88%)      22/27 (82%)                                                        | 
|FIRST INCIDENCE    |        462              254              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.399N         P=0.201          P=0.520                                                            | 
|POLY 3             |        P=0.385N         P=0.638          P=0.443N                                                           | 
|POLY 1.5           |        P=0.428N         P=0.624N         P=0.473N                                                           | 
|POLY 6             |        P=0.342N         P=0.641          P=0.414N                                                           | 
|LOGISTIC REGRESSION|        P=0.500N         P=0.524          P=0.546N                                                           | 
|COCH-ARM / FISHERS |        P=0.557N         P=0.471N         P=0.518N                                                           | 
|ORDER RESTRICTED   |        P=0.424N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        3/53 (6%)        0/50 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          3/39.07          0/39.67                                                            | 
|POLY-3 PERCENT (g) |        0.0%             7.7%             0.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              499              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.304N         P=0.116          (e)                                                                | 
|POLY 3             |        P=0.312N         P=0.115          (e)                                                                | 
|POLY 1.5           |        P=0.314N         P=0.117          (e)                                                                | 
|POLY 6             |        P=0.309N         P=0.117          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.341N         P=0.171          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.313N         P=0.132          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.189N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Anterior Chamber, Ciliary Body, Cornea                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        1/52 (2%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/40.02          1/37.28          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        5.0%             2.7%             0.0%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        603              580              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.243N         P=0.536N         P=0.252N                                                           | 
|POLY 3             |        P=0.230N         P=0.525N         P=0.237N                                                           | 
|POLY 1.5           |        P=0.233N         P=0.517N         P=0.236N                                                           | 
|POLY 6             |        P=0.229N         P=0.528N         P=0.237N                                                           | 
|LOGISTIC REGRESSION|        P=0.248N         P=0.485N         P=0.234N                                                           | 
|COCH-ARM / FISHERS |        P=0.246N         P=0.485N         P=0.243N                                                           | 
|ORDER RESTRICTED   |        P=0.103N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/52 (4%)        5/51 (10%)                                                         | 
|POLY-3 RATE (b)    |        0/39.59          2/36.79          5/40.52                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.4%             12.3%                                                              | 
|TERMINAL (d)       |        0/28 (0%)        2/24 (8%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        ---              729 (T)          588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.040 *        P=0.204          P=0.036 *                                                          | 
|POLY 3             |        P=0.032 *        P=0.221          P=0.032 *                                                          | 
|POLY 1.5           |        P=0.032 *        P=0.226          P=0.031 *                                                          | 
|POLY 6             |        P=0.033 *        P=0.218          P=0.032 *                                                          | 
|LOGISTIC REGRESSION|        P=0.037 *        P=0.204          P=0.034 *                                                          | 
|COCH-ARM / FISHERS |        P=0.032 *        P=0.257          P=0.030 *                                                          | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        15/49 (31%)      14/52 (27%)      17/51 (33%)                                                        | 
|POLY-3 RATE (b)    |        15/39.74         14/39.15         17/40.73                                                           | 
|POLY-3 PERCENT (g) |        37.8%            35.8%            41.7%                                                              | 
|TERMINAL (d)       |        13/28 (46%)      10/24 (42%)      14/27 (52%)                                                        | 
|FIRST INCIDENCE    |        491              330              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.378          P=0.511          P=0.373                                                            | 
|POLY 3             |        P=0.369          P=0.521N         P=0.444                                                            | 
|POLY 1.5           |        P=0.369          P=0.509N         P=0.447                                                            | 
|POLY 6             |        P=0.368          P=0.518N         P=0.447                                                            | 
|LOGISTIC REGRESSION|        P=0.410          P=0.567N         P=0.445                                                            | 
|COCH-ARM / FISHERS |        P=0.352          P=0.425N         P=0.469                                                            | 
|ORDER RESTRICTED   |        P=0.433          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/50 (36%)      26/53 (49%)      25/50 (50%)                                                        | 
|POLY-3 RATE (b)    |        18/40.91         26/41.49         25/41.97                                                           | 
|POLY-3 PERCENT (g) |        44.0%            62.7%            59.6%                                                              | 
|TERMINAL (d)       |        13/28 (46%)      17/24 (71%)      17/27 (63%)                                                        | 
|FIRST INCIDENCE    |        625              96               463                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.338          P=0.030 *        P=0.106                                                            | 
|POLY 3             |        P=0.263          P=0.059          P=0.105                                                            | 
|POLY 1.5           |        P=0.245          P=0.071          P=0.103                                                            | 
|POLY 6             |        P=0.284          P=0.053          P=0.110                                                            | 
|LOGISTIC REGRESSION|        P=0.303          P=0.046 *        P=0.101                                                            | 
|COCH-ARM / FISHERS |        P=0.223          P=0.127          P=0.113                                                            | 
|ORDER RESTRICTED   |        P=0.065          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        1/53 (2%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        1/39.59          1/37.45          2/40.67                                                            | 
|POLY-3 PERCENT (g) |        2.5%             2.7%             4.9%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          715              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.430          P=0.735          P=0.489                                                            | 
|POLY 3             |        P=0.437          P=0.749          P=0.509                                                            | 
|POLY 1.5           |        P=0.431          P=0.754          P=0.507                                                            | 
|POLY 6             |        P=0.443          P=0.746          P=0.514                                                            | 
|LOGISTIC REGRESSION|        P=0.427          P=0.745          P=0.510                                                            | 
|COCH-ARM / FISHERS |        P=0.419          P=0.738N         P=0.508                                                            | 
|ORDER RESTRICTED   |        P=0.379          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/53 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        1/39.59          0/37.40          2/40.01                                                            | 
|POLY-3 PERCENT (g) |        2.5%             0.0%             5.0%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          ---              720                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.291          P=0.531N         P=0.492                                                            | 
|POLY 3             |        P=0.289          P=0.511N         P=0.504                                                            | 
|POLY 1.5           |        P=0.285          P=0.506N         P=0.503                                                            | 
|POLY 6             |        P=0.292          P=0.515N         P=0.506                                                            | 
|LOGISTIC REGRESSION|        P=0.291          (e)              P=0.505                                                            | 
|COCH-ARM / FISHERS |        P=0.274          P=0.485N         P=0.508                                                            | 
|ORDER RESTRICTED   |        P=0.201          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/52 (4%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          2/38.30          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.2%             0.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        1/24 (4%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              330              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.428N         P=0.221          (e)                                                                | 
|POLY 3             |        P=0.436N         P=0.229          (e)                                                                | 
|POLY 1.5           |        P=0.436N         P=0.233          (e)                                                                | 
|POLY 6             |        P=0.435N         P=0.227          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.455N         P=0.323          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.432N         P=0.257          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.255N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        1/52 (2%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          1/38.39          2/40.75                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.6%             4.9%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              142              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.264          P=0.508          P=0.251                                                            | 
|POLY 3             |        P=0.257          P=0.501          P=0.251                                                            | 
|POLY 1.5           |        P=0.255          P=0.505          P=0.250                                                            | 
|POLY 6             |        P=0.260          P=0.497          P=0.253                                                            | 
|LOGISTIC REGRESSION|        P=0.193          (e)              P=0.260                                                            | 
|COCH-ARM / FISHERS |        P=0.254          P=0.520          P=0.263                                                            | 
|ORDER RESTRICTED   |        P=0.113          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/48 (13%)       4/52 (8%)        6/51 (12%)                                                         | 
|POLY-3 RATE (b)    |        6/39.79          4/39.34          6/41.82                                                            | 
|POLY-3 PERCENT (g) |        15.1%            10.2%            14.4%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        0/24 (0%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        491              499              462                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.498          P=0.420N         P=0.599                                                            | 
|POLY 3             |        P=0.524          P=0.375N         P=0.587N                                                           | 
|POLY 1.5           |        P=0.516          P=0.362N         P=0.584N                                                           | 
|POLY 6             |        P=0.524          P=0.387N         P=0.594N                                                           | 
|LOGISTIC REGRESSION|        P=0.477          P=0.277N         P=0.563N                                                           | 
|COCH-ARM / FISHERS |        P=0.494          P=0.320N         P=0.576N                                                           | 
|ORDER RESTRICTED   |        P=0.483N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        0/52 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          0/37.39          2/40.51                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.9%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              ---              647                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.111          (e)              P=0.250                                                            | 
|POLY 3             |        P=0.105          (e)              P=0.250                                                            | 
|POLY 1.5           |        P=0.104          (e)              P=0.249                                                            | 
|POLY 6             |        P=0.107          (e)              P=0.251                                                            | 
|LOGISTIC REGRESSION|        P=0.104          (e)              P=0.251                                                            | 
|COCH-ARM / FISHERS |        P=0.103          (e)              P=0.263                                                            | 
|ORDER RESTRICTED   |        P=0.059          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        0/52 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          0/37.39          2/40.21                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              ---              668                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.112          (e)              P=0.243                                                            | 
|POLY 3             |        P=0.104          (e)              P=0.248                                                            | 
|POLY 1.5           |        P=0.103          (e)              P=0.248                                                            | 
|POLY 6             |        P=0.105          (e)              P=0.248                                                            | 
|LOGISTIC REGRESSION|        P=0.108          (e)              P=0.247                                                            | 
|COCH-ARM / FISHERS |        P=0.103          (e)              P=0.263                                                            | 
|ORDER RESTRICTED   |        P=0.058          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/48 (13%)       5/52 (10%)       3/51 (6%)                                                          | 
|POLY-3 RATE (b)    |        6/38.87          5/37.96          3/39.98                                                            | 
|POLY-3 PERCENT (g) |        15.4%            13.2%            7.5%                                                               | 
|TERMINAL (d)       |        4/28 (14%)       4/24 (17%)       3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        633              552              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.217N         P=0.590N         P=0.257N                                                           | 
|POLY 3             |        P=0.205N         P=0.517N         P=0.225N                                                           | 
|POLY 1.5           |        P=0.209N         P=0.497N         P=0.221N                                                           | 
|POLY 6             |        P=0.206N         P=0.538N         P=0.232N                                                           | 
|LOGISTIC REGRESSION|        P=0.201N         P=0.519N         P=0.219N                                                           | 
|COCH-ARM / FISHERS |        P=0.221N         P=0.443N         P=0.214N                                                           | 
|ORDER RESTRICTED   |        P=0.190N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/48 (81%)      42/52 (81%)      33/51 (65%)                                                        | 
|POLY-3 RATE (b)    |        39/47.30         42/48.93         33/46.82                                                           | 
|POLY-3 PERCENT (g) |        82.5%            85.8%            70.5%                                                              | 
|TERMINAL (d)       |        22/28 (79%)      19/24 (79%)      19/27 (70%)                                                        | 
|FIRST INCIDENCE    |        441              254              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.094N         P=0.187          P=0.253N                                                           | 
|POLY 3             |        P=0.041N*        P=0.428          P=0.119N                                                           | 
|POLY 1.5           |        P=0.027N*        P=0.473          P=0.085N                                                           | 
|POLY 6             |        P=0.070N         P=0.400          P=0.174N                                                           | 
|LOGISTIC REGRESSION|        P=0.023N*        P=0.564N         P=0.049N*                                                          | 
|COCH-ARM / FISHERS |        P=0.022N*        P=0.577N         P=0.052N                                                           | 
|ORDER RESTRICTED   |        P=0.056N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        30/48 (63%)      34/52 (65%)      34/51 (67%)                                                        | 
|POLY-3 RATE (b)    |        30/41.51         34/43.59         34/43.74                                                           | 
|POLY-3 PERCENT (g) |        72.3%            78.0%            77.7%                                                              | 
|TERMINAL (d)       |        23/28 (82%)      23/24 (96%)      24/27 (89%)                                                        | 
|FIRST INCIDENCE    |        478              142              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.454          P=0.074          P=0.213                                                            | 
|POLY 3             |        P=0.432          P=0.344          P=0.356                                                            | 
|POLY 1.5           |        P=0.427          P=0.378          P=0.368                                                            | 
|POLY 6             |        P=0.444          P=0.319          P=0.353                                                            | 
|LOGISTIC REGRESSION|        P=0.514          P=0.265          P=0.367                                                            | 
|COCH-ARM / FISHERS |        P=0.433          P=0.463          P=0.412                                                            | 
|ORDER RESTRICTED   |        P=0.344          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/48 (4%)        7/52 (13%)       17/51 (33%)                                                        | 
|POLY-3 RATE (b)    |        2/38.62          7/38.16          17/42.67                                                           | 
|POLY-3 PERCENT (g) |        5.2%             18.3%            39.8%                                                              | 
|TERMINAL (d)       |        1/28 (4%)        6/24 (25%)       10/27 (37%)                                                        | 
|FIRST INCIDENCE    |        612              451              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.052          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.072          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.080          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.066          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.077          P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.100          P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/48 (8%)        2/52 (4%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        4/39.17          2/37.83          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        10.2%            5.3%             0.0%                                                               | 
|TERMINAL (d)       |        2/28 (7%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        478              618              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.080N         P=0.390N         P=0.069N                                                           | 
|POLY 3             |        P=0.067N         P=0.352N         P=0.057N                                                           | 
|POLY 1.5           |        P=0.069N         P=0.338N         P=0.056N                                                           | 
|POLY 6             |        P=0.066N         P=0.365N         P=0.058N                                                           | 
|LOGISTIC REGRESSION|        P=0.076N         P=0.312N         P=0.054N                                                           | 
|COCH-ARM / FISHERS |        P=0.077N         P=0.301N         P=0.052N                                                           | 
|ORDER RESTRICTED   |        P=0.024N*        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/48 (2%)        3/52 (6%)        8/51 (16%)                                                         | 
|POLY-3 RATE (b)    |        1/38.73          3/38.07          8/40.77                                                            | 
|POLY-3 PERCENT (g) |        2.6%             7.9%             19.6%                                                              | 
|TERMINAL (d)       |        0/28 (0%)        2/24 (8%)        6/27 (22%)                                                         | 
|FIRST INCIDENCE    |        569              499              556                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.278          P=0.019 *                                                          | 
|POLY 3             |        P=0.011 *        P=0.298          P=0.018 *                                                          | 
|POLY 1.5           |        P=0.011 *        P=0.308          P=0.019 *                                                          | 
|POLY 6             |        P=0.011 *        P=0.289          P=0.017 *                                                          | 
|LOGISTIC REGRESSION|        P=0.014 *        P=0.344          P=0.021 *                                                          | 
|COCH-ARM / FISHERS |        P=0.012 *        P=0.340          P=0.019 *                                                          | 
|ORDER RESTRICTED   |        P=0.006 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        2/52 (4%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          2/37.67          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.3%             0.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        1/24 (4%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              654              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.425N         P=0.223          (e)                                                                | 
|POLY 3             |        P=0.432N         P=0.233          (e)                                                                | 
|POLY 1.5           |        P=0.431N         P=0.239          (e)                                                                | 
|POLY 6             |        P=0.434N         P=0.229          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.419N         P=0.233          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.426N         P=0.268          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.253N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/48 (13%)       11/52 (21%)      9/51 (18%)                                                         | 
|POLY-3 RATE (b)    |        6/39.39          11/39.29         9/40.65                                                            | 
|POLY-3 PERCENT (g) |        15.2%            28.0%            22.1%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       7/24 (29%)       7/27 (26%)                                                         | 
|FIRST INCIDENCE    |        569              539              601                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.537          P=0.101          P=0.279                                                            | 
|POLY 3             |        P=0.516          P=0.132          P=0.306                                                            | 
|POLY 1.5           |        P=0.520          P=0.145          P=0.315                                                            | 
|POLY 6             |        P=0.505          P=0.122          P=0.294                                                            | 
|LOGISTIC REGRESSION|        P=0.548          P=0.146          P=0.320                                                            | 
|COCH-ARM / FISHERS |        P=0.520          P=0.189          P=0.334                                                            | 
|ORDER RESTRICTED   |        P=0.195          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/52 (4%)        3/51 (6%)                                                          | 
|POLY-3 RATE (b)    |        1/39.59          2/37.66          3/40.43                                                            | 
|POLY-3 PERCENT (g) |        2.5%             5.3%             7.4%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        1/24 (4%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          659              596                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.330          P=0.461          P=0.296                                                            | 
|POLY 3             |        P=0.324          P=0.482          P=0.312                                                            | 
|POLY 1.5           |        P=0.319          P=0.490          P=0.310                                                            | 
|POLY 6             |        P=0.329          P=0.479          P=0.316                                                            | 
|LOGISTIC REGRESSION|        P=0.329          P=0.475          P=0.308                                                            | 
|COCH-ARM / FISHERS |        P=0.313          P=0.515          P=0.316                                                            | 
|ORDER RESTRICTED   |        P=0.219          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       3/52 (6%)        18/51 (35%)                                                        | 
|POLY-3 RATE (b)    |        5/39.94          3/37.45          18/42.98                                                           | 
|POLY-3 PERCENT (g) |        12.5%            8.0%             41.9%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       2/24 (8%)        9/27 (33%)                                                         | 
|FIRST INCIDENCE    |        664              715              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.427N         P=0.004 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.391N         P=0.002 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.376N         P=0.002 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.404N         P=0.003 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.398N         P=0.002 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.336N         P=0.002 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       7/52 (13%)       13/51 (25%)                                                        | 
|POLY-3 RATE (b)    |        5/39.94          7/37.86          13/41.27                                                           | 
|POLY-3 PERCENT (g) |        12.5%            18.5%            31.5%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       5/24 (21%)       10/27 (37%)                                                        | 
|FIRST INCIDENCE    |        664              612              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.032 *        P=0.293          P=0.033 *                                                          | 
|POLY 3             |        P=0.026 *        P=0.339          P=0.033 *                                                          | 
|POLY 1.5           |        P=0.025 *        P=0.356          P=0.033 *                                                          | 
|POLY 6             |        P=0.027 *        P=0.327          P=0.033 *                                                          | 
|LOGISTIC REGRESSION|        P=0.029 *        P=0.324          P=0.034 *                                                          | 
|COCH-ARM / FISHERS |        P=0.025 *        P=0.408          P=0.037 *                                                          | 
|ORDER RESTRICTED   |        P=0.019 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       3/52 (6%)        11/51 (22%)                                                        | 
|POLY-3 RATE (b)    |        5/39.59          3/37.39          11/41.02                                                           | 
|POLY-3 PERCENT (g) |        12.6%            8.0%             26.8%                                                              | 
|TERMINAL (d)       |        5/28 (18%)       3/24 (13%)       9/27 (33%)                                                         | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          463                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.017 *        P=0.442N         P=0.070                                                            | 
|POLY 3             |        P=0.019 *        P=0.387N         P=0.090                                                            | 
|POLY 1.5           |        P=0.018 *        P=0.374N         P=0.089                                                            | 
|POLY 6             |        P=0.021 *        P=0.395N         P=0.094                                                            | 
|LOGISTIC REGRESSION|        P=0.019 *        P=0.442N         P=0.086                                                            | 
|COCH-ARM / FISHERS |        P=0.017 *        P=0.336N         P=0.093                                                            | 
|ORDER RESTRICTED   |        P=0.025 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      40/52 (77%)      45/51 (88%)                                                        | 
|POLY-3 RATE (b)    |        27/46.61         40/47.53         45/47.97                                                           | 
|POLY-3 PERCENT (g) |        57.9%            84.2%            93.8%                                                              | 
|TERMINAL (d)       |        11/28 (39%)      18/24 (75%)      26/27 (96%)                                                        | 
|FIRST INCIDENCE    |        441              330              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        P=0.016 *        P=0.005 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.003 **       P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.003 **       P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.003 **       P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P=0.002 **       P=0.011 *        P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.013 *        P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        28/50 (56%)      31/52 (60%)      47/51 (92%)                                                        | 
|POLY-3 RATE (b)    |        28/45.86         31/45.69         47/49.08                                                           | 
|POLY-3 PERCENT (g) |        61.1%            67.8%            95.8%                                                              | 
|TERMINAL (d)       |        15/28 (54%)      15/24 (63%)      27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              254              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.219          P=0.002 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.317          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.339          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.307          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.427          P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.433          P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        1/52 (2%)        11/51 (22%)                                                        | 
|POLY-3 RATE (b)    |        4/40.12          1/37.83          11/41.62                                                           | 
|POLY-3 PERCENT (g) |        10.0%            2.6%             26.4%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       0/24 (0%)        7/27 (26%)                                                         | 
|FIRST INCIDENCE    |        567              603              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       P=0.225N         P=0.045 *                                                          | 
|POLY 3             |        P=0.002 **       P=0.195N         P=0.048 *                                                          | 
|POLY 1.5           |        P=0.002 **       P=0.189N         P=0.047 *                                                          | 
|POLY 6             |        P=0.003 **       P=0.199N         P=0.050                                                            | 
|LOGISTIC REGRESSION|        P=0.003 **       P=0.185N         P=0.048 *                                                          | 
|COCH-ARM / FISHERS |        P=0.002 **       P=0.169N         P=0.050                                                            | 
|ORDER RESTRICTED   |        P=0.003 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        18/50 (36%)      19/52 (37%)      29/51 (57%)                                                        | 
|POLY-3 RATE (b)    |        18/44.86         19/44.94         29/46.24                                                           | 
|POLY-3 PERCENT (g) |        40.1%            42.3%            62.7%                                                              | 
|TERMINAL (d)       |        9/28 (32%)       6/24 (25%)       16/27 (59%)                                                        | 
|FIRST INCIDENCE    |        441              142              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.040 *        P=0.396          P=0.042 *                                                          | 
|POLY 3             |        P=0.011 *        P=0.503          P=0.021 *                                                          | 
|POLY 1.5           |        P=0.010 *        P=0.513          P=0.021 *                                                          | 
|POLY 6             |        P=0.012 *        P=0.513          P=0.023 *                                                          | 
|LOGISTIC REGRESSION|        P=0.009 **       P=0.453N         P=0.030 *                                                          | 
|COCH-ARM / FISHERS |        P=0.012 *        P=0.559          P=0.028 *                                                          | 
|ORDER RESTRICTED   |        P=0.017 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/50 (40%)      24/52 (46%)      21/51 (41%)                                                        | 
|POLY-3 RATE (b)    |        20/40.25         24/39.96         21/41.77                                                           | 
|POLY-3 PERCENT (g) |        49.7%            60.1%            50.3%                                                              | 
|TERMINAL (d)       |        18/28 (64%)      16/24 (67%)      15/27 (56%)                                                        | 
|FIRST INCIDENCE    |        633              552              602                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.426N         P=0.103          P=0.451                                                            | 
|POLY 3             |        P=0.404N         P=0.227          P=0.569                                                            | 
|POLY 1.5           |        P=0.440N         P=0.241          P=0.541                                                            | 
|POLY 6             |        P=0.357N         P=0.247          P=0.569N                                                           | 
|LOGISTIC REGRESSION|        P=0.392N         P=0.144          P=0.528                                                            | 
|COCH-ARM / FISHERS |        P=0.490N         P=0.335          P=0.533                                                            | 
|ORDER RESTRICTED   |        P=0.413          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        47/50 (94%)      48/52 (92%)      46/51 (90%)                                                        | 
|POLY-3 RATE (b)    |        47/48.90         48/50.71         46/49.21                                                           | 
|POLY-3 PERCENT (g) |        96.1%            94.7%            93.5%                                                              | 
|TERMINAL (d)       |        27/28 (96%)      23/24 (96%)      26/27 (96%)                                                        | 
|FIRST INCIDENCE    |        441              254              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.353N         P=0.230          P=0.554N                                                           | 
|POLY 3             |        P=0.444N         P=0.557N         P=0.443N                                                           | 
|POLY 1.5           |        P=0.415N         P=0.591N         P=0.435N                                                           | 
|POLY 6             |        P=0.480N         P=0.513N         P=0.452N                                                           | 
|LOGISTIC REGRESSION|        P=0.328N         P=0.623N         P=0.410N                                                           | 
|COCH-ARM / FISHERS |        P=0.363N         P=0.522N         P=0.369N                                                           | 
|ORDER RESTRICTED   |        P=0.367N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      26/52 (50%)      27/51 (53%)                                                        | 
|POLY-3 RATE (b)    |        27/41.19         26/38.98         27/43.00                                                           | 
|POLY-3 PERCENT (g) |        65.6%            66.7%            62.8%                                                              | 
|TERMINAL (d)       |        24/28 (86%)      23/24 (96%)      21/27 (78%)                                                        | 
|FIRST INCIDENCE    |        462              499              463                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.539N         P=0.302          P=0.525                                                            | 
|POLY 3             |        P=0.425N         P=0.556          P=0.484N                                                           | 
|POLY 1.5           |        P=0.504N         P=0.580N         P=0.524N                                                           | 
|POLY 6             |        P=0.311N         P=0.523          P=0.409N                                                           | 
|LOGISTIC REGRESSION|        P=0.498N         P=0.503          P=0.559N                                                           | 
|COCH-ARM / FISHERS |        P=0.530          P=0.418N         P=0.537N                                                           | 
|ORDER RESTRICTED   |        P=0.491N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/50 (12%)       4/52 (8%)        7/51 (14%)                                                         | 
|POLY-3 RATE (b)    |        6/41.80          4/38.13          7/42.46                                                            | 
|POLY-3 PERCENT (g) |        14.4%            10.5%            16.5%                                                              | 
|TERMINAL (d)       |        1/28 (4%)        2/24 (8%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        484              552              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.368          P=0.433N         P=0.494                                                            | 
|POLY 3             |        P=0.382          P=0.428N         P=0.512                                                            | 
|POLY 1.5           |        P=0.367          P=0.403N         P=0.511                                                            | 
|POLY 6             |        P=0.395          P=0.452N         P=0.513                                                            | 
|LOGISTIC REGRESSION|        P=0.324          P=0.336N         P=0.551                                                            | 
|COCH-ARM / FISHERS |        P=0.337          P=0.346N         P=0.515                                                            | 
|ORDER RESTRICTED   |        P=0.404          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        50/50 (100%)     50/52 (96%)      44/51 (86%)                                                        | 
|POLY-3 RATE (b)    |        50/50.00         50/50.05         44/48.31                                                           | 
|POLY-3 PERCENT (g) |        100.0%           99.9%            91.1%                                                              | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              310              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.119N         P=0.264          P=0.259N                                                           | 
|POLY 3             |        P<0.001N**       P=1.000N         P=0.024N*                                                          | 
|POLY 1.5           |        P<0.001N**       P=0.999N         P=0.016N*                                                          | 
|POLY 6             |        P=0.004N**       P=1.000N         P=0.048N*                                                          | 
|LOGISTIC REGRESSION|        P<0.001N**       (e)              P=0.012N*                                                          | 
|COCH-ARM / FISHERS |        P=0.005N**       P=0.257N         P=0.007N**                                                         | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        44/50 (88%)      48/52 (92%)      48/51 (94%)                                                        | 
|POLY-3 RATE (b)    |        44/46.21         48/48.25         48/49.68                                                           | 
|POLY-3 PERCENT (g) |        95.2%            99.5%            96.6%                                                              | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        462              330              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.506          P=0.097          P=0.262                                                            | 
|POLY 3             |        P=0.660N         P=0.146          P=0.586                                                            | 
|POLY 1.5           |        P=0.564          P=0.132          P=0.352                                                            | 
|POLY 6             |        P=0.442N         P=0.573          P=0.706N                                                           | 
|LOGISTIC REGRESSION|        P=0.353          P=0.013 *        P=0.132                                                            | 
|COCH-ARM / FISHERS |        P=0.284          P=0.346          P=0.234                                                            | 
|ORDER RESTRICTED   |        P=0.193          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        5/52 (10%)       6/51 (12%)                                                         | 
|POLY-3 RATE (b)    |        4/39.59          5/37.44          6/40.36                                                            | 
|POLY-3 PERCENT (g) |        10.1%            13.4%            14.9%                                                              | 
|TERMINAL (d)       |        4/28 (14%)       4/24 (17%)       5/27 (19%)                                                         | 
|FIRST INCIDENCE    |        729 (T)          719              622                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.398          P=0.405          P=0.346                                                            | 
|POLY 3             |        P=0.400          P=0.464          P=0.380                                                            | 
|POLY 1.5           |        P=0.391          P=0.479          P=0.377                                                            | 
|POLY 6             |        P=0.412          P=0.455          P=0.386                                                            | 
|LOGISTIC REGRESSION|        P=0.411          P=0.435          P=0.376                                                            | 
|COCH-ARM / FISHERS |        P=0.376          P=0.525          P=0.383                                                            | 
|ORDER RESTRICTED   |        P=0.356          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        4/52 (8%)        5/51 (10%)                                                         | 
|POLY-3 RATE (b)    |        0/39.59          4/38.64          5/41.42                                                            | 
|POLY-3 PERCENT (g) |        0.0%             10.4%            12.1%                                                              | 
|TERMINAL (d)       |        0/28 (0%)        1/24 (4%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              506              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.139          P=0.055          P=0.038 *                                                          | 
|POLY 3             |        P=0.119          P=0.056          P=0.034 *                                                          | 
|POLY 1.5           |        P=0.114          P=0.058          P=0.033 *                                                          | 
|POLY 6             |        P=0.127          P=0.056          P=0.036 *                                                          | 
|LOGISTIC REGRESSION|        P=0.111          P=0.069          P=0.036 *                                                          | 
|COCH-ARM / FISHERS |        P=0.114          P=0.064          P=0.030 *                                                          | 
|ORDER RESTRICTED   |        P=0.024 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        20/50 (40%)      29/52 (56%)      40/51 (78%)                                                        | 
|POLY-3 RATE (b)    |        20/41.49         29/42.15         40/45.51                                                           | 
|POLY-3 PERCENT (g) |        48.2%            68.8%            87.9%                                                              | 
|TERMINAL (d)       |        14/28 (50%)      17/24 (71%)      26/27 (96%)                                                        | 
|FIRST INCIDENCE    |        484              505              462                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.002 **       P=0.025 *        P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.036 *        P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.040 *        P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.041 *        P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.024 *        P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.081          P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/50 (12%)       4/52 (8%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        6/41.72          4/38.67          2/41.55                                                            | 
|POLY-3 PERCENT (g) |        14.4%            10.3%            4.8%                                                               | 
|TERMINAL (d)       |        2/28 (7%)        1/24 (4%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        478              552              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.159N         P=0.427N         P=0.150N                                                           | 
|POLY 3             |        P=0.135N         P=0.417N         P=0.132N                                                           | 
|POLY 1.5           |        P=0.140N         P=0.398N         P=0.131N                                                           | 
|POLY 6             |        P=0.135N         P=0.430N         P=0.135N                                                           | 
|LOGISTIC REGRESSION|        P=0.168N         P=0.307N         P=0.086N                                                           | 
|COCH-ARM / FISHERS |        P=0.155N         P=0.346N         P=0.128N                                                           | 
|ORDER RESTRICTED   |        P=0.092N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        22/50 (44%)      33/52 (63%)      47/51 (92%)                                                        | 
|POLY-3 RATE (b)    |        22/45.91         33/47.28         47/48.94                                                           | 
|POLY-3 PERCENT (g) |        47.9%            69.8%            96.0%                                                              | 
|TERMINAL (d)       |        8/28 (29%)       14/24 (58%)      27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              254              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.032 *        P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.022 *        P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.024 *        P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.021 *        P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.056          P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.038 *        P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        42/50 (84%)      46/52 (88%)      44/51 (86%)                                                        | 
|POLY-3 RATE (b)    |        42/46.55         46/47.78         44/47.16                                                           | 
|POLY-3 PERCENT (g) |        90.2%            96.3%            93.3%                                                              | 
|TERMINAL (d)       |        27/28 (96%)      23/24 (96%)      27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              310              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.466N         P=0.105          P=0.368                                                            | 
|POLY 3             |        P=0.625          P=0.182          P=0.422                                                            | 
|POLY 1.5           |        P=0.611          P=0.173          P=0.414                                                            | 
|POLY 6             |        P=0.639          P=0.306          P=0.487                                                            | 
|LOGISTIC REGRESSION|        P=0.520N         P=0.090          P=0.405                                                            | 
|COCH-ARM / FISHERS |        P=0.579          P=0.357          P=0.483                                                            | 
|ORDER RESTRICTED   |        P=0.201          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        33/50 (66%)      39/52 (75%)      43/51 (84%)                                                        | 
|POLY-3 RATE (b)    |        33/43.22         39/43.48         43/46.51                                                           | 
|POLY-3 PERCENT (g) |        76.4%            89.7%            92.5%                                                              | 
|TERMINAL (d)       |        23/28 (82%)      22/24 (92%)      27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        484              499              462                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.147          P=0.053          P=0.040 *                                                          | 
|POLY 3             |        P=0.050          P=0.056          P=0.016 *                                                          | 
|POLY 1.5           |        P=0.040 *        P=0.077          P=0.015 *                                                          | 
|POLY 6             |        P=0.078          P=0.072          P=0.026 *                                                          | 
|LOGISTIC REGRESSION|        P=0.041 *        P=0.029 *        P=0.010 *                                                          | 
|COCH-ARM / FISHERS |        P=0.042 *        P=0.218          P=0.028 *                                                          | 
|ORDER RESTRICTED   |        P=0.005 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        7/52 (13%)       10/51 (20%)                                                        | 
|POLY-3 RATE (b)    |        3/39.90          7/37.83          10/41.29                                                           | 
|POLY-3 PERCENT (g) |        7.5%             18.5%            24.2%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        6/24 (25%)       7/27 (26%)                                                         | 
|FIRST INCIDENCE    |        643              603              490                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.075          P=0.108          P=0.037 *                                                          | 
|POLY 3             |        P=0.070          P=0.132          P=0.037 *                                                          | 
|POLY 1.5           |        P=0.067          P=0.143          P=0.037 *                                                          | 
|POLY 6             |        P=0.073          P=0.125          P=0.038 *                                                          | 
|LOGISTIC REGRESSION|        P=0.074          P=0.127          P=0.038 *                                                          | 
|COCH-ARM / FISHERS |        P=0.065          P=0.176          P=0.039 *                                                          | 
|ORDER RESTRICTED   |        P=0.025 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        49/50 (98%)      46/53 (87%)      40/50 (80%)                                                        | 
|POLY-3 RATE (b)    |        49/49.59         46/46.97         40/45.90                                                           | 
|POLY-3 PERCENT (g) |        98.8%            97.9%            87.1%                                                              | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     25/27 (93%)                                                        | 
|FIRST INCIDENCE    |        441              254              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065N         P=0.427          P=0.126N                                                           | 
|POLY 3             |        P<0.001N**       P=0.764N         P=0.015N*                                                          | 
|POLY 1.5           |        P=0.002N**       P=0.348N         P=0.009N**                                                         | 
|POLY 6             |        P=0.002N**       P=0.990          P=0.030N*                                                          | 
|LOGISTIC REGRESSION|        P=0.002N**       P=0.361N         P=0.005N**                                                         | 
|COCH-ARM / FISHERS |        P=0.020N*        P=0.036N*        P=0.004N**                                                         | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 28      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        4/53 (8%)        2/50 (4%)                                                          | 
|POLY-3 RATE (b)    |        2/39.59          4/38.58          2/40.50                                                            | 
|POLY-3 PERCENT (g) |        5.1%             10.4%            4.9%                                                               | 
|TERMINAL (d)       |        2/28 (7%)        2/24 (8%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          330              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.444N         P=0.291          P=0.692                                                            | 
|POLY 3             |        P=0.452N         P=0.324          P=0.687N                                                           | 
|POLY 1.5           |        P=0.463N         P=0.331          P=0.692N                                                           | 
|POLY 6             |        P=0.438N         P=0.322          P=0.678N                                                           | 
|LOGISTIC REGRESSION|        P=0.483N         P=0.349          P=0.695                                                            | 
|COCH-ARM / FISHERS |        P=0.480N         P=0.367          P=0.691N                                                           | 
|ORDER RESTRICTED   |        P=0.425N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        2/53 (4%)        6/50 (12%)                                                         | 
|POLY-3 RATE (b)    |        3/40.28          2/37.40          6/40.41                                                            | 
|POLY-3 PERCENT (g) |        7.5%             5.4%             14.9%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        2/24 (8%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        491              729 (T)          632                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.131          P=0.558N         P=0.242                                                            | 
|POLY 3             |        P=0.122          P=0.534N         P=0.241                                                            | 
|POLY 1.5           |        P=0.116          P=0.519N         P=0.238                                                            | 
|POLY 6             |        P=0.130          P=0.545N         P=0.248                                                            | 
|LOGISTIC REGRESSION|        P=0.122          P=0.517N         P=0.241                                                            | 
|COCH-ARM / FISHERS |        P=0.105          P=0.472N         P=0.243                                                            | 
|ORDER RESTRICTED   |        P=0.128          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 29      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       5/53 (9%)        8/50 (16%)                                                         | 
|POLY-3 RATE (b)    |        5/39.59          5/38.38          8/41.69                                                            | 
|POLY-3 PERCENT (g) |        12.6%            13.0%            19.2%                                                              | 
|TERMINAL (d)       |        5/28 (18%)       2/24 (8%)        4/27 (15%)                                                         | 
|FIRST INCIDENCE    |        729 (T)          505              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.238          P=0.555          P=0.265                                                            | 
|POLY 3             |        P=0.246          P=0.612          P=0.307                                                            | 
|POLY 1.5           |        P=0.227          P=0.620          P=0.291                                                            | 
|POLY 6             |        P=0.267          P=0.615          P=0.328                                                            | 
|LOGISTIC REGRESSION|        P=0.213          P=0.592          P=0.274                                                            | 
|COCH-ARM / FISHERS |        P=0.193          P=0.592N         P=0.277                                                            | 
|ORDER RESTRICTED   |        P=0.277          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        39/50 (78%)      34/53 (64%)      30/50 (60%)                                                        | 
|POLY-3 RATE (b)    |        39/45.77         34/41.55         30/42.62                                                           | 
|POLY-3 PERCENT (g) |        85.2%            81.8%            70.4%                                                              | 
|TERMINAL (d)       |        25/28 (89%)      23/24 (96%)      22/27 (82%)                                                        | 
|FIRST INCIDENCE    |        478              505              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.060N         P=0.540N         P=0.090N                                                           | 
|POLY 3             |        P=0.038N*        P=0.437N         P=0.057N                                                           | 
|POLY 1.5           |        P=0.049N*        P=0.295N         P=0.050N                                                           | 
|POLY 6             |        P=0.034N*        P=0.595N         P=0.070N                                                           | 
|LOGISTIC REGRESSION|        P=0.024N*        P=0.295N         P=0.030N*                                                          | 
|COCH-ARM / FISHERS |        P=0.104N         P=0.092N         P=0.041N*                                                          | 
|ORDER RESTRICTED   |        P=0.033N*        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 30      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/49 (0%)        3/50 (6%)        2/49 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.12          3/35.88          2/38.99                                                            | 
|POLY-3 PERCENT (g) |        0.0%             8.4%             5.1%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        2/24 (8%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        ---              603              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.523          P=0.099          P=0.230                                                            | 
|POLY 3             |        P=0.507          P=0.103          P=0.236                                                            | 
|POLY 1.5           |        P=0.506          P=0.106          P=0.235                                                            | 
|POLY 6             |        P=0.511          P=0.102          P=0.237                                                            | 
|LOGISTIC REGRESSION|        P=0.535          P=0.105          P=0.230                                                            | 
|COCH-ARM / FISHERS |        P=0.512          P=0.125          P=0.247                                                            | 
|ORDER RESTRICTED   |        P=0.096          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        33/49 (67%)      36/50 (72%)      32/49 (65%)                                                        | 
|POLY-3 RATE (b)    |        33/44.17         36/42.27         32/44.54                                                           | 
|POLY-3 PERCENT (g) |        74.7%            85.2%            71.9%                                                              | 
|TERMINAL (d)       |        22/28 (79%)      23/24 (96%)      20/27 (74%)                                                        | 
|FIRST INCIDENCE    |        441              363              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.292N         P=0.133          P=0.546N                                                           | 
|POLY 3             |        P=0.214N         P=0.151          P=0.473N                                                           | 
|POLY 1.5           |        P=0.250N         P=0.178          P=0.489N                                                           | 
|POLY 6             |        P=0.185N         P=0.153          P=0.445N                                                           | 
|LOGISTIC REGRESSION|        P=0.279N         P=0.145          P=0.517N                                                           | 
|COCH-ARM / FISHERS |        P=0.372N         P=0.388          P=0.500N                                                           | 
|ORDER RESTRICTED   |        P=0.227N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 31      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/49 (0%)        2/50 (4%)        2/49 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.12          2/36.99          2/39.96                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.4%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              363              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.400          P=0.238          P=0.238                                                            | 
|POLY 3             |        P=0.396          P=0.224          P=0.241                                                            | 
|POLY 1.5           |        P=0.393          P=0.226          P=0.240                                                            | 
|POLY 6             |        P=0.400          P=0.225          P=0.243                                                            | 
|LOGISTIC REGRESSION|        P=0.281          P=0.415          P=0.320                                                            | 
|COCH-ARM / FISHERS |        P=0.388          P=0.253          P=0.247                                                            | 
|ORDER RESTRICTED   |        P=0.138          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/49 (2%)        1/52 (2%)        2/49 (4%)                                                          | 
|POLY-3 RATE (b)    |        1/38.87          1/38.06          2/38.45                                                            | 
|POLY-3 PERCENT (g) |        2.6%             2.6%             5.2%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        0/24 (0%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          506              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.434          P=0.741          P=0.487                                                            | 
|POLY 3             |        P=0.418          P=0.757          P=0.496                                                            | 
|POLY 1.5           |        P=0.416          P=0.760          P=0.496                                                            | 
|POLY 6             |        P=0.420          P=0.755          P=0.498                                                            | 
|LOGISTIC REGRESSION|        P=0.418          P=0.738N         P=0.487                                                            | 
|COCH-ARM / FISHERS |        P=0.411          P=0.737N         P=0.500                                                            | 
|ORDER RESTRICTED   |        P=0.363          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 32      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/2 (0%)         0/7 (0%)         2/5 (40%)                                                          | 
|POLY-3 RATE (b)    |        0/1.26           0/3.75           2/4.56                                                             | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             43.9%                                                              | 
|TERMINAL (d)       |        0/1 (0%)         0/2 (0%)         2/4 (50%)                                                          | 
|FIRST INCIDENCE    |        ---              ---              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.282          (e)              P=0.581                                                            | 
|POLY 3             |        P=0.175          (e)              P=0.547                                                            | 
|POLY 1.5           |        P=0.135          (e)              P=0.513                                                            | 
|POLY 6             |        P=0.224          (e)              P=0.572                                                            | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.581                                                            | 
|COCH-ARM / FISHERS |        P=0.103          (e)              P=0.476                                                            | 
|ORDER RESTRICTED   |        P=0.308          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/2 (0%)         1/7 (14%)        2/5 (40%)                                                          | 
|POLY-3 RATE (b)    |        0/1.26           1/4.66           2/4.56                                                             | 
|POLY-3 PERCENT (g) |        0.0%             21.5%            43.9%                                                              | 
|TERMINAL (d)       |        0/1 (0%)         0/2 (0%)         2/4 (50%)                                                          | 
|FIRST INCIDENCE    |        ---              330              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.466          P=0.492          P=0.581                                                            | 
|POLY 3             |        P=0.392          P=0.757          P=0.547                                                            | 
|POLY 1.5           |        P=0.342          P=0.751          P=0.513                                                            | 
|POLY 6             |        P=0.446          P=0.755          P=0.572                                                            | 
|LOGISTIC REGRESSION|        P=0.177          (e)              P=0.581                                                            | 
|COCH-ARM / FISHERS |        P=0.269          P=0.778          P=0.476                                                            | 
|ORDER RESTRICTED   |        P=0.371          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 33      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/2 (0%)         2/7 (29%)        0/5 (0%)                                                           | 
|POLY-3 RATE (b)    |        0/1.26           2/4.81           0/4.56                                                             | 
|POLY-3 PERCENT (g) |        0.0%             41.6%            0.0%                                                               | 
|TERMINAL (d)       |        0/1 (0%)         0/2 (0%)         0/4 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              506              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.424N         P=0.225          (e)                                                                | 
|POLY 3             |        P=0.282N         P=0.568          (e)                                                                | 
|POLY 1.5           |        P=0.318N         P=0.553          (e)                                                                | 
|POLY 6             |        P=0.256N         P=0.581          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.509N         P=0.547          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.381N         P=0.583          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.394N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        3/53 (6%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        2/40.31          3/38.06          2/40.45                                                            | 
|POLY-3 PERCENT (g) |        5.0%             7.9%             4.9%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        2/24 (8%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        478              506              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.541N         P=0.452          P=0.689                                                            | 
|POLY 3             |        P=0.549N         P=0.474          P=0.693N                                                           | 
|POLY 1.5           |        P=0.553N         P=0.485          P=0.693N                                                           | 
|POLY 6             |        P=0.545N         P=0.467          P=0.692N                                                           | 
|LOGISTIC REGRESSION|        P=0.565N         P=0.533          P=0.679N                                                           | 
|COCH-ARM / FISHERS |        P=0.564N         P=0.528          P=0.684N                                                           | 
|ORDER RESTRICTED   |        P=0.528N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 34      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/50 (28%)      22/53 (42%)      15/51 (29%)                                                        | 
|POLY-3 RATE (b)    |        14/42.77         22/41.66         15/42.12                                                           | 
|POLY-3 PERCENT (g) |        32.7%            52.8%            35.6%                                                              | 
|TERMINAL (d)       |        7/28 (25%)       11/24 (46%)      10/27 (37%)                                                        | 
|FIRST INCIDENCE    |        462              499              463                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.298N         P=0.053          P=0.480                                                            | 
|POLY 3             |        P=0.334N         P=0.044 *        P=0.479                                                            | 
|POLY 1.5           |        P=0.327N         P=0.053          P=0.493                                                            | 
|POLY 6             |        P=0.353N         P=0.042 *        P=0.463                                                            | 
|LOGISTIC REGRESSION|        P=0.300N         P=0.066          P=0.517                                                            | 
|COCH-ARM / FISHERS |        P=0.337N         P=0.109          P=0.525                                                            | 
|ORDER RESTRICTED   |        P=0.185          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        3/53 (6%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        2/40.28          3/37.73          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        5.0%             8.0%             0.0%                                                               | 
|TERMINAL (d)       |        1/28 (4%)        1/24 (4%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        491              650              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.135N         P=0.460          P=0.246N                                                           | 
|POLY 3             |        P=0.130N         P=0.470          P=0.238N                                                           | 
|POLY 1.5           |        P=0.131N         P=0.483          P=0.237N                                                           | 
|POLY 6             |        P=0.129N         P=0.463          P=0.239N                                                           | 
|LOGISTIC REGRESSION|        P=0.132N         P=0.499          P=0.218N                                                           | 
|COCH-ARM / FISHERS |        P=0.135N         P=0.528          P=0.243N                                                           | 
|ORDER RESTRICTED   |        P=0.100N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 35      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/31 (3%)        2/47 (4%)        1/47 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/23.96          2/33.24          1/36.01                                                            | 
|POLY-3 PERCENT (g) |        4.2%             6.0%             2.8%                                                               | 
|TERMINAL (d)       |        1/17 (6%)        2/21 (10%)       0/23 (0%)                                                          | 
|FIRST INCIDENCE    |        729 (T)          729 (T)          720                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.513N         P=0.575          P=0.727N                                                           | 
|POLY 3             |        P=0.483N         P=0.615          P=0.668N                                                           | 
|POLY 1.5           |        P=0.487N         P=0.621          P=0.668N                                                           | 
|POLY 6             |        P=0.482N         P=0.612          P=0.669N                                                           | 
|LOGISTIC REGRESSION|        P=0.490N         P=0.575          P=0.678N                                                           | 
|COCH-ARM / FISHERS |        P=0.498N         P=0.654          P=0.640N                                                           | 
|ORDER RESTRICTED   |        P=0.453N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/50 (34%)      13/53 (25%)      15/51 (29%)                                                        | 
|POLY-3 RATE (b)    |        17/43.73         13/40.22         15/41.65                                                           | 
|POLY-3 PERCENT (g) |        38.9%            32.3%            36.0%                                                              | 
|TERMINAL (d)       |        9/28 (32%)       5/24 (21%)       10/27 (37%)                                                        | 
|FIRST INCIDENCE    |        441              539              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.505N         P=0.389N         P=0.451N                                                           | 
|POLY 3             |        P=0.561N         P=0.344N         P=0.480N                                                           | 
|POLY 1.5           |        P=0.548N         P=0.309N         P=0.450N                                                           | 
|POLY 6             |        P=0.567          P=0.357N         P=0.509N                                                           | 
|LOGISTIC REGRESSION|        P=0.528N         P=0.239N         P=0.396N                                                           | 
|COCH-ARM / FISHERS |        P=0.561N         P=0.200N         P=0.389N                                                           | 
|ORDER RESTRICTED   |        P=0.438N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 36      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/50 (10%)       6/53 (11%)       5/51 (10%)                                                         | 
|POLY-3 RATE (b)    |        5/41.00          6/38.67          5/41.38                                                            | 
|POLY-3 PERCENT (g) |        12.2%            15.5%            12.1%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       1/24 (4%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        478              603              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.520N         P=0.444          P=0.613                                                            | 
|POLY 3             |        P=0.517N         P=0.458          P=0.626N                                                           | 
|POLY 1.5           |        P=0.525N         P=0.474          P=0.626N                                                           | 
|POLY 6             |        P=0.509N         P=0.457          P=0.621N                                                           | 
|LOGISTIC REGRESSION|        P=0.543N         P=0.515          P=0.605N                                                           | 
|COCH-ARM / FISHERS |        P=0.546N         P=0.541          P=0.617N                                                           | 
|ORDER RESTRICTED   |        P=0.549N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/50 (28%)      11/53 (21%)      12/51 (24%)                                                        | 
|POLY-3 RATE (b)    |        14/43.24         11/40.12         12/41.65                                                           | 
|POLY-3 PERCENT (g) |        32.4%            27.4%            28.8%                                                              | 
|TERMINAL (d)       |        7/28 (25%)       3/24 (13%)       7/27 (26%)                                                         | 
|FIRST INCIDENCE    |        441              539              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.470N         P=0.441N         P=0.442N                                                           | 
|POLY 3             |        P=0.504N         P=0.399N         P=0.452N                                                           | 
|POLY 1.5           |        P=0.497N         P=0.369N         P=0.431N                                                           | 
|POLY 6             |        P=0.521N         P=0.412N         P=0.473N                                                           | 
|LOGISTIC REGRESSION|        P=0.495N         P=0.290N         P=0.390N                                                           | 
|COCH-ARM / FISHERS |        P=0.515N         P=0.265N         P=0.387N                                                           | 
|ORDER RESTRICTED   |        P=0.452N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 37      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        21/28 (75%)      22/30 (73%)      29/41 (71%)                                                        | 
|POLY-3 RATE (b)    |        21/26.86         22/27.81         29/38.96                                                           | 
|POLY-3 PERCENT (g) |        78.2%            79.1%            74.4%                                                              | 
|TERMINAL (d)       |        10/15 (67%)      12/15 (80%)      17/24 (71%)                                                        | 
|FIRST INCIDENCE    |        491              451              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.515          P=0.445          P=0.453                                                            | 
|POLY 3             |        P=0.404N         P=0.600          P=0.477N                                                           | 
|POLY 1.5           |        P=0.413N         P=0.620N         P=0.463N                                                           | 
|POLY 6             |        P=0.409N         P=0.549          P=0.509N                                                           | 
|LOGISTIC REGRESSION|        P=0.436N         P=0.565N         P=0.456N                                                           | 
|COCH-ARM / FISHERS |        P=0.436N         P=0.562N         P=0.457N                                                           | 
|ORDER RESTRICTED   |        P=0.464N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        46/48 (96%)      43/52 (83%)      36/50 (72%)                                                        | 
|POLY-3 RATE (b)    |        46/47.26         43/48.11         36/46.64                                                           | 
|POLY-3 PERCENT (g) |        97.4%            89.4%            77.2%                                                              | 
|TERMINAL (d)       |        27/28 (96%)      22/24 (92%)      21/27 (78%)                                                        | 
|FIRST INCIDENCE    |        441              254              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.051N         P=0.448          P=0.098N                                                           | 
|POLY 3             |        P=0.002N**       P=0.095N         P=0.002N**                                                         | 
|POLY 1.5           |        P=0.002N**       P=0.064N         P<0.001N**                                                         | 
|POLY 6             |        P=0.003N**       P=0.181N         P=0.004N**                                                         | 
|LOGISTIC REGRESSION|        P=0.005N**       P=0.069N         P=0.002N**                                                         | 
|COCH-ARM / FISHERS |        P=0.006N**       P=0.035N*        P<0.001N**                                                         | 
|ORDER RESTRICTED   |        P<0.001N**       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 38      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/48 (33%)      14/52 (27%)      19/50 (38%)                                                        | 
|POLY-3 RATE (b)    |        16/41.13         14/39.03         19/42.91                                                           | 
|POLY-3 PERCENT (g) |        38.9%            35.9%            44.3%                                                              | 
|TERMINAL (d)       |        10/28 (36%)      11/24 (46%)      12/27 (44%)                                                        | 
|FIRST INCIDENCE    |        484              330              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.266          P=0.574N         P=0.321                                                            | 
|POLY 3             |        P=0.292          P=0.480N         P=0.389                                                            | 
|POLY 1.5           |        P=0.264          P=0.422N         P=0.385                                                            | 
|POLY 6             |        P=0.325          P=0.551N         P=0.392                                                            | 
|LOGISTIC REGRESSION|        P=0.240          P=0.405N         P=0.385                                                            | 
|COCH-ARM / FISHERS |        P=0.223          P=0.315N         P=0.393                                                            | 
|ORDER RESTRICTED   |        P=0.350          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        0/52 (0%)        4/50 (8%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          0/37.39          4/39.49                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             10.1%                                                              | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        ---              ---              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.012 *        (e)              P=0.063                                                            | 
|POLY 3             |        P=0.009 **       (e)              P=0.063                                                            | 
|POLY 1.5           |        P=0.009 **       (e)              P=0.064                                                            | 
|POLY 6             |        P=0.009 **       (e)              P=0.063                                                            | 
|LOGISTIC REGRESSION|        P=0.010 *        (e)              P=0.065                                                            | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              P=0.064                                                            | 
|ORDER RESTRICTED   |        P=0.008 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 39      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/1 (0%)         2/2 (100%)       0/3 (0%)                                                           | 
|POLY-3 RATE (b)    |        0/1.00           2/2.00           0/2.94                                                             | 
|POLY-3 PERCENT (g) |        0.0%             100.0%           0.0%                                                               | 
|TERMINAL (d)       |        0/1 (0%)         0/0 (0%)         0/2 (0%)                                                           | 
|FIRST INCIDENCE    |        ---              539              ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.422N         P=0.236          (e)                                                                | 
|POLY 3             |        P<0.001N**       P=0.333          (e)                                                                | 
|POLY 1.5           |        P<0.001N**       P=0.333          (e)                                                                | 
|POLY 6             |        P<0.001N**       P=0.333          (e)                                                                | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.211N         P=0.333          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.095N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oviduct                                                                                                                          | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/1 (0%)         0/2 (0%)         3/3 (100%)                                                         | 
|POLY-3 RATE (b)    |        0/1.00           0/1.14           3/3.00                                                             | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             100.0%                                                             | 
|TERMINAL (d)       |        0/1 (0%)         0/0 (0%)         2/2 (100%)                                                         | 
|FIRST INCIDENCE    |        ---              ---              714                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.104          (e)              P=0.166                                                            | 
|POLY 3             |        P<0.001 **       (e)              P=0.250                                                            | 
|POLY 1.5           |        P<0.001 **       (e)              P=0.250                                                            | 
|POLY 6             |        P<0.001 **       (e)              P=0.250                                                            | 
|LOGISTIC REGRESSION|        P=0.165          (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.049 *        (e)              P=0.250                                                            | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 40      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/49 (10%)       1/52 (2%)        5/49 (10%)                                                         | 
|POLY-3 RATE (b)    |        5/40.27          1/37.39          5/38.46                                                            | 
|POLY-3 PERCENT (g) |        12.4%            2.7%             13.0%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        1/24 (4%)        4/27 (15%)                                                         | 
|FIRST INCIDENCE    |        491              729 (T)          668                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.340          P=0.136N         P=0.613                                                            | 
|POLY 3             |        P=0.324          P=0.118N         P=0.602                                                            | 
|POLY 1.5           |        P=0.319          P=0.108N         P=0.611                                                            | 
|POLY 6             |        P=0.329          P=0.128N         P=0.593                                                            | 
|LOGISTIC REGRESSION|        P=0.316          P=0.096N         P=0.623                                                            | 
|COCH-ARM / FISHERS |        P=0.303          P=0.089N         P=0.630N                                                           | 
|ORDER RESTRICTED   |        P=0.287          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/49 (8%)        1/52 (2%)        5/49 (10%)                                                         | 
|POLY-3 RATE (b)    |        4/40.03          1/37.39          5/38.23                                                            | 
|POLY-3 PERCENT (g) |        10.0%            2.7%             13.1%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        1/24 (4%)        5/27 (19%)                                                         | 
|FIRST INCIDENCE    |        491              729 (T)          729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.240          P=0.222N         P=0.477                                                            | 
|POLY 3             |        P=0.226          P=0.199N         P=0.471                                                            | 
|POLY 1.5           |        P=0.223          P=0.187N         P=0.480                                                            | 
|POLY 6             |        P=0.226          P=0.210N         P=0.460                                                            | 
|LOGISTIC REGRESSION|        P=0.226          P=0.170N         P=0.490                                                            | 
|COCH-ARM / FISHERS |        P=0.214          P=0.163N         P=0.500                                                            | 
|ORDER RESTRICTED   |        P=0.201          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 41      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/49 (6%)        7/52 (13%)       44/49 (90%)                                                        | 
|POLY-3 RATE (b)    |        3/39.04          7/38.39          44/45.45                                                           | 
|POLY-3 PERCENT (g) |        7.7%             18.2%            96.8%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        5/24 (21%)       27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        701              552              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.114          P<0.001 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.146          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.154          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.142          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.139          P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.185          P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/49 (8%)        2/52 (4%)        3/49 (6%)                                                          | 
|POLY-3 RATE (b)    |        4/39.04          2/38.06          3/38.67                                                            | 
|POLY-3 PERCENT (g) |        10.3%            5.3%             7.8%                                                               | 
|TERMINAL (d)       |        3/28 (11%)       1/24 (4%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        701              506              601                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.597N         P=0.394N         P=0.513N                                                           | 
|POLY 3             |        P=0.609N         P=0.348N         P=0.505N                                                           | 
|POLY 1.5           |        P=0.616N         P=0.339N         P=0.506N                                                           | 
|POLY 6             |        P=0.601N         P=0.353N         P=0.502N                                                           | 
|LOGISTIC REGRESSION|        P=0.620N         P=0.350N         P=0.510N                                                           | 
|COCH-ARM / FISHERS |        P=0.633N         P=0.311N         P=0.500N                                                           | 
|ORDER RESTRICTED   |        P=0.370N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 42      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        14/50 (28%)      17/52 (33%)      7/51 (14%)                                                         | 
|POLY-3 RATE (b)    |        14/41.76         17/39.38         7/40.52                                                            | 
|POLY-3 PERCENT (g) |        33.5%            43.2%            17.3%                                                              | 
|TERMINAL (d)       |        8/28 (29%)       9/24 (38%)       5/27 (19%)                                                         | 
|FIRST INCIDENCE    |        491              506              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.023N*        P=0.224          P=0.085N                                                           | 
|POLY 3             |        P=0.017N*        P=0.249          P=0.071N                                                           | 
|POLY 1.5           |        P=0.017N*        P=0.272          P=0.068N                                                           | 
|POLY 6             |        P=0.018N*        P=0.244          P=0.077N                                                           | 
|LOGISTIC REGRESSION|        P=0.015N*        P=0.258          P=0.064N                                                           | 
|COCH-ARM / FISHERS |        P=0.022N*        P=0.383          P=0.063N                                                           | 
|ORDER RESTRICTED   |        P=0.022N*        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        0/52 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        1/40.20          0/36.79          2/39.98                                                            | 
|POLY-3 PERCENT (g) |        2.5%             0.0%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        2/27 (7%)                                                          | 
|FIRST INCIDENCE    |        534              ---              729 (T)                                                            | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.288          P=0.510N         P=0.494                                                            | 
|POLY 3             |        P=0.289          P=0.518N         P=0.498                                                            | 
|POLY 1.5           |        P=0.286          P=0.512N         P=0.500                                                            | 
|POLY 6             |        P=0.290          P=0.522N         P=0.496                                                            | 
|LOGISTIC REGRESSION|        P=0.282          P=0.417N         P=0.506                                                            | 
|COCH-ARM / FISHERS |        P=0.276          P=0.490N         P=0.508                                                            | 
|ORDER RESTRICTED   |        P=0.199          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 43      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/52 (2%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          1/36.79          2/40.04                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        1/24 (4%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              729 (T)          714                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.262          P=0.469          P=0.240                                                            | 
|POLY 3             |        P=0.247          P=0.485          P=0.239                                                            | 
|POLY 1.5           |        P=0.247          P=0.490          P=0.239                                                            | 
|POLY 6             |        P=0.249          P=0.483          P=0.240                                                            | 
|LOGISTIC REGRESSION|        P=0.262          P=0.469          P=0.240                                                            | 
|COCH-ARM / FISHERS |        P=0.248          P=0.510          P=0.252                                                            | 
|ORDER RESTRICTED   |        P=0.105          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        17/50 (34%)      20/52 (38%)      21/51 (41%)                                                        | 
|POLY-3 RATE (b)    |        17/42.72         20/40.07         21/42.87                                                           | 
|POLY-3 PERCENT (g) |        39.8%            49.9%            49.0%                                                              | 
|TERMINAL (d)       |        11/28 (39%)      11/24 (46%)      15/27 (56%)                                                        | 
|FIRST INCIDENCE    |        484              505              458                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.376          P=0.215          P=0.245                                                            | 
|POLY 3             |        P=0.354          P=0.236          P=0.256                                                            | 
|POLY 1.5           |        P=0.355          P=0.263          P=0.268                                                            | 
|POLY 6             |        P=0.337          P=0.235          P=0.242                                                            | 
|LOGISTIC REGRESSION|        P=0.376          P=0.271          P=0.282                                                            | 
|COCH-ARM / FISHERS |        P=0.328          P=0.397          P=0.295                                                            | 
|ORDER RESTRICTED   |        P=0.243          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 44      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/53 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          0/37.40          2/41.69                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             4.8%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              ---              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.102          (e)              P=0.240                                                            | 
|POLY 3             |        P=0.105          (e)              P=0.248                                                            | 
|POLY 1.5           |        P=0.103          (e)              P=0.246                                                            | 
|POLY 6             |        P=0.107          (e)              P=0.251                                                            | 
|LOGISTIC REGRESSION|        P=0.028 *        (e)              P=0.564                                                            | 
|COCH-ARM / FISHERS |        P=0.098          (e)              P=0.252                                                            | 
|ORDER RESTRICTED   |        P=0.059          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        41/49 (84%)      47/52 (90%)      45/49 (92%)                                                        | 
|POLY-3 RATE (b)    |        41/45.57         47/50.21         45/46.44                                                           | 
|POLY-3 PERCENT (g) |        90.0%            93.6%            96.9%                                                              | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              142              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.547N         P=0.053          P=0.246                                                            | 
|POLY 3             |        P=0.158          P=0.371          P=0.117                                                            | 
|POLY 1.5           |        P=0.174          P=0.284          P=0.120                                                            | 
|POLY 6             |        P=0.171          P=0.596          P=0.160                                                            | 
|LOGISTIC REGRESSION|        P=0.282          P=0.166          P=0.109                                                            | 
|COCH-ARM / FISHERS |        P=0.257          P=0.239          P=0.178                                                            | 
|ORDER RESTRICTED   |        P=0.071          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 45      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        48/49 (98%)      51/52 (98%)      49/49 (100%)                                                       | 
|POLY-3 RATE (b)    |        48/48.68         51/51.01         49/49.00                                                           | 
|POLY-3 PERCENT (g) |        98.6%            100.0%           100.0%                                                             | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              254              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.421N         P=0.144          P=0.445                                                            | 
|POLY 3             |        P=0.765          P=0.679          P=0.682                                                            | 
|POLY 1.5           |        P=0.654          P=0.615          P=0.585                                                            | 
|POLY 6             |        P=0.927          P=0.876          P=0.879                                                            | 
|LOGISTIC REGRESSION|        P=0.441          P=0.494          P=0.496                                                            | 
|COCH-ARM / FISHERS |        P=0.397          P=0.737          P=0.500                                                            | 
|ORDER RESTRICTED   |        P=0.151          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/49 (10%)       4/52 (8%)        2/49 (4%)                                                          | 
|POLY-3 RATE (b)    |        5/40.77          4/38.83          2/39.64                                                            | 
|POLY-3 PERCENT (g) |        12.3%            10.3%            5.1%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        567              310              233                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.205N         P=0.546N         P=0.225N                                                           | 
|POLY 3             |        P=0.205N         P=0.531N         P=0.226N                                                           | 
|POLY 1.5           |        P=0.207N         P=0.509N         P=0.221N                                                           | 
|POLY 6             |        P=0.206N         P=0.555N         P=0.235N                                                           | 
|LOGISTIC REGRESSION|        P=0.238N         P=0.400N         P=0.153N                                                           | 
|COCH-ARM / FISHERS |        P=0.220N         P=0.462N         P=0.218N                                                           | 
|ORDER RESTRICTED   |        P=0.180N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 46      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        2/52 (4%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          2/37.84          2/40.33                                                            | 
|POLY-3 PERCENT (g) |        0.0%             5.3%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              612              632                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.406          P=0.213          P=0.236                                                            | 
|POLY 3             |        P=0.392          P=0.227          P=0.241                                                            | 
|POLY 1.5           |        P=0.390          P=0.231          P=0.240                                                            | 
|POLY 6             |        P=0.396          P=0.225          P=0.243                                                            | 
|LOGISTIC REGRESSION|        P=0.400          P=0.234          P=0.240                                                            | 
|COCH-ARM / FISHERS |        P=0.393          P=0.257          P=0.252                                                            | 
|ORDER RESTRICTED   |        P=0.139          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        6/50 (12%)       7/52 (13%)       9/51 (18%)                                                         | 
|POLY-3 RATE (b)    |        6/41.04          7/39.86          9/41.81                                                            | 
|POLY-3 PERCENT (g) |        14.6%            17.6%            21.5%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       1/24 (4%)        5/27 (19%)                                                         | 
|FIRST INCIDENCE    |        491              479              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.309          P=0.428          P=0.277                                                            | 
|POLY 3             |        P=0.294          P=0.477          P=0.297                                                            | 
|POLY 1.5           |        P=0.289          P=0.486          P=0.295                                                            | 
|POLY 6             |        P=0.301          P=0.478          P=0.303                                                            | 
|LOGISTIC REGRESSION|        P=0.277          P=0.549          P=0.301                                                            | 
|COCH-ARM / FISHERS |        P=0.277          P=0.531          P=0.303                                                            | 
|ORDER RESTRICTED   |        P=0.281          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 47      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        1/52 (2%)        6/51 (12%)                                                         | 
|POLY-3 RATE (b)    |        0/39.59          1/37.47          6/41.36                                                            | 
|POLY-3 PERCENT (g) |        0.0%             2.7%             14.5%                                                              | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        3/27 (11%)                                                         | 
|FIRST INCIDENCE    |        ---              710              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       P=0.493          P=0.018 *                                                          | 
|POLY 3             |        P=0.004 **       P=0.489          P=0.017 *                                                          | 
|POLY 1.5           |        P=0.004 **       P=0.494          P=0.016 *                                                          | 
|POLY 6             |        P=0.004 **       P=0.486          P=0.018 *                                                          | 
|LOGISTIC REGRESSION|        P=0.004 **       P=0.485          P=0.019 *                                                          | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.510          P=0.014 *                                                          | 
|ORDER RESTRICTED   |        P=0.003 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/50 (2%)        2/52 (4%)        1/51 (2%)                                                          | 
|POLY-3 RATE (b)    |        1/40.00          2/37.86          1/40.67                                                            | 
|POLY-3 PERCENT (g) |        2.5%             5.3%             2.5%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        612              618              491                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.565N         P=0.467          P=0.752                                                            | 
|POLY 3             |        P=0.566N         P=0.481          P=0.757N                                                           | 
|POLY 1.5           |        P=0.570N         P=0.489          P=0.758N                                                           | 
|POLY 6             |        P=0.564N         P=0.476          P=0.757N                                                           | 
|LOGISTIC REGRESSION|        P=0.590N         P=0.511          P=0.721N                                                           | 
|COCH-ARM / FISHERS |        P=0.578N         P=0.515          P=0.748N                                                           | 
|ORDER RESTRICTED   |        P=0.493N         (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 48      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Artery                                                                                                     | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/50 (0%)        0/52 (0%)        2/51 (4%)                                                          | 
|POLY-3 RATE (b)    |        0/39.59          0/37.39          2/40.01                                                            | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             5.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        1/27 (4%)                                                          | 
|FIRST INCIDENCE    |        ---              ---              720                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.110          (e)              P=0.236                                                            | 
|POLY 3             |        P=0.101          (e)              P=0.239                                                            | 
|POLY 1.5           |        P=0.100          (e)              P=0.239                                                            | 
|POLY 6             |        P=0.102          (e)              P=0.240                                                            | 
|LOGISTIC REGRESSION|        P=0.108          (e)              P=0.239                                                            | 
|COCH-ARM / FISHERS |        P=0.100          (e)              P=0.252                                                            | 
|ORDER RESTRICTED   |        P=0.053          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/50 (6%)        1/52 (2%)        0/51 (0%)                                                          | 
|POLY-3 RATE (b)    |        3/41.18          1/37.39          0/39.98                                                            | 
|POLY-3 PERCENT (g) |        7.3%             2.7%             0.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        1/24 (4%)        0/27 (0%)                                                          | 
|FIRST INCIDENCE    |        478              729 (T)          ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.160N         P=0.343N         P=0.125N                                                           | 
|POLY 3             |        P=0.144N         P=0.340N         P=0.123N                                                           | 
|POLY 1.5           |        P=0.148N         P=0.325N         P=0.121N                                                           | 
|POLY 6             |        P=0.141N         P=0.355N         P=0.126N                                                           | 
|LOGISTIC REGRESSION|        P=0.166N         P=0.244N         P=0.083N                                                           | 
|COCH-ARM / FISHERS |        P=0.160N         P=0.294N         P=0.118N                                                           | 
|ORDER RESTRICTED   |        P=0.042N*        (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 49      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        48/48 (100%)     42/50 (84%)      45/47 (96%)                                                        | 
|POLY-3 RATE (b)    |        48/48.00         42/43.09         45/45.28                                                           | 
|POLY-3 PERCENT (g) |        100.0%           97.5%            99.4%                                                              | 
|TERMINAL (d)       |        28/28 (100%)     24/24 (100%)     26/26 (100%)                                                       | 
|FIRST INCIDENCE    |        441              479              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.493N         P=0.512N         P=0.494N                                                           | 
|POLY 3             |        P=0.885          P=0.398N         P=0.998N                                                           | 
|POLY 1.5           |        P=0.675          P=0.064N         P=0.717N                                                           | 
|POLY 6             |        P=0.999          P=0.990N         P=1.000N                                                           | 
|LOGISTIC REGRESSION|        P=0.683          P=0.100N         P=0.526N                                                           | 
|COCH-ARM / FISHERS |        P=0.369          P=0.003N**       P=0.242N                                                           | 
|ORDER RESTRICTED   |        P=0.113N         (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/48 (0%)        3/50 (6%)        0/47 (0%)                                                          | 
|POLY-3 RATE (b)    |        0/38.21          3/38.30          0/37.46                                                            | 
|POLY-3 PERCENT (g) |        0.0%             7.8%             0.0%                                                               | 
|TERMINAL (d)       |        0/28 (0%)        0/24 (0%)        0/26 (0%)                                                          | 
|FIRST INCIDENCE    |        ---              96               ---                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.307N         P=0.125          (e)                                                                | 
|POLY 3             |        P=0.315N         P=0.118          (e)                                                                | 
|POLY 1.5           |        P=0.316N         P=0.119          (e)                                                                | 
|POLY 6             |        P=0.314N         P=0.118          (e)                                                                | 
|LOGISTIC REGRESSION|        P=0.481N         P=0.640          (e)                                                                | 
|COCH-ARM / FISHERS |        P=0.316N         P=0.129          (e)                                                                | 
|ORDER RESTRICTED   |        P=0.192          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 50      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        16/49 (33%)      12/52 (23%)      17/50 (34%)                                                        | 
|POLY-3 RATE (b)    |        16/42.03         12/38.36         17/42.66                                                           | 
|POLY-3 PERCENT (g) |        38.1%            31.3%            39.9%                                                              | 
|TERMINAL (d)       |        10/28 (36%)      7/24 (29%)       12/27 (44%)                                                        | 
|FIRST INCIDENCE    |        491              552              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.349          P=0.383N         P=0.467                                                            | 
|POLY 3             |        P=0.378          P=0.341N         P=0.522                                                            | 
|POLY 1.5           |        P=0.355          P=0.302N         P=0.520                                                            | 
|POLY 6             |        P=0.391          P=0.368N         P=0.523                                                            | 
|LOGISTIC REGRESSION|        P=0.334          P=0.286N         P=0.523                                                            | 
|COCH-ARM / FISHERS |        P=0.293          P=0.197N         P=0.528                                                            | 
|ORDER RESTRICTED   |        P=0.423          (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        28/49 (57%)      35/52 (67%)      44/50 (88%)                                                        | 
|POLY-3 RATE (b)    |        28/43.27         35/45.78         44/47.40                                                           | 
|POLY-3 PERCENT (g) |        64.7%            76.5%            92.8%                                                              | 
|TERMINAL (d)       |        20/28 (71%)      20/24 (83%)      27/27 (100%)                                                       | 
|FIRST INCIDENCE    |        441              142              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.015 *        P=0.045 *        P=0.003 **                                                         | 
|POLY 3             |        P<0.001 **       P=0.146          P<0.001 **                                                         | 
|POLY 1.5           |        P<0.001 **       P=0.148          P<0.001 **                                                         | 
|POLY 6             |        P<0.001 **       P=0.157          P<0.001 **                                                         | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.137          P<0.001 **                                                         | 
|COCH-ARM / FISHERS |        P<0.001 **       P=0.198          P<0.001 **                                                         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 51      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        25/25 (100%)     35/35 (100%)     42/42 (100%)                                                       | 
|POLY-3 RATE (b)    |        25/25.00         35/35.00         42/42.00                                                           | 
|POLY-3 PERCENT (g) |        100.0%           100.0%           100.0%                                                             | 
|TERMINAL (d)       |        17/17 (100%)     17/17 (100%)     25/25 (100%)                                                       | 
|FIRST INCIDENCE    |        491              254              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)                                                                | 
|POLY 3             |        (e)              (e)              (e)                                                                | 
|POLY 1.5           |        (e)              (e)              (e)                                                                | 
|POLY 6             |        (e)              (e)              (e)                                                                | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)                                                                | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)                                                                | 
|ORDER RESTRICTED   |        (e)              (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/49 (6%)        7/52 (13%)       8/50 (16%)                                                         | 
|POLY-3 RATE (b)    |        3/39.40          7/39.03          8/39.25                                                            | 
|POLY-3 PERCENT (g) |        7.6%             17.9%            20.4%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        4/24 (17%)       7/27 (26%)                                                         | 
|FIRST INCIDENCE    |        569              499              668                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.215          P=0.123          P=0.093                                                            | 
|POLY 3             |        P=0.174          P=0.149          P=0.093                                                            | 
|POLY 1.5           |        P=0.178          P=0.156          P=0.097                                                            | 
|POLY 6             |        P=0.169          P=0.147          P=0.089                                                            | 
|LOGISTIC REGRESSION|        P=0.198          P=0.165          P=0.097                                                            | 
|COCH-ARM / FISHERS |        P=0.184          P=0.185          P=0.106                                                            | 
|ORDER RESTRICTED   |        P=0.076          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 52      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/50 (4%)        10/52 (19%)      8/50 (16%)                                                         | 
|POLY-3 RATE (b)    |        2/39.59          10/39.56         8/39.90                                                            | 
|POLY-3 PERCENT (g) |        5.1%             25.3%            20.1%                                                              | 
|TERMINAL (d)       |        2/28 (7%)        6/24 (25%)       5/27 (19%)                                                         | 
|FIRST INCIDENCE    |        729 (T)          506              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.318          P=0.009 **       P=0.047 *                                                          | 
|POLY 3             |        P=0.270          P=0.012 *        P=0.044 *                                                          | 
|POLY 1.5           |        P=0.265          P=0.012 *        P=0.043 *                                                          | 
|POLY 6             |        P=0.281          P=0.012 *        P=0.045 *                                                          | 
|LOGISTIC REGRESSION|        P=0.284          P=0.013 *        P=0.044 *                                                          | 
|COCH-ARM / FISHERS |        P=0.268          P=0.017 *        P=0.046 *                                                          | 
|ORDER RESTRICTED   |        P=0.020 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/50 (8%)        7/52 (13%)       8/50 (16%)                                                         | 
|POLY-3 RATE (b)    |        4/40.12          7/39.10          8/39.83                                                            | 
|POLY-3 PERCENT (g) |        10.0%            17.9%            20.1%                                                              | 
|TERMINAL (d)       |        3/28 (11%)       2/24 (8%)        6/27 (22%)                                                         | 
|FIRST INCIDENCE    |        567              310              588                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.283          P=0.219          P=0.170                                                            | 
|POLY 3             |        P=0.242          P=0.242          P=0.168                                                            | 
|POLY 1.5           |        P=0.239          P=0.251          P=0.170                                                            | 
|POLY 6             |        P=0.245          P=0.241          P=0.170                                                            | 
|LOGISTIC REGRESSION|        P=0.250          P=0.264          P=0.169                                                            | 
|COCH-ARM / FISHERS |        P=0.238          P=0.286          P=0.178                                                            | 
|ORDER RESTRICTED   |        P=0.146          (e)              (e)                                                                | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/24/04                           EXPERIMENT: 96020 TEST: 01                                            Page 53      
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(SD)  -     TEF EVALUATION (BINARY MIXTURE; PCB 126
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        27/50 (54%)      36/52 (69%)      34/50 (68%)                                                        | 
|POLY-3 RATE (b)    |        27/43.83         36/44.30         34/45.44                                                           | 
|POLY-3 PERCENT (g) |        61.6%            81.3%            74.8%                                                              | 
|TERMINAL (d)       |        18/28 (64%)      21/24 (88%)      20/27 (74%)                                                        | 
|FIRST INCIDENCE    |        441              310              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.406          P=0.022 *        P=0.129                                                            | 
|POLY 3             |        P=0.351          P=0.024 *        P=0.120                                                            | 
|POLY 1.5           |        P=0.298          P=0.035 *        P=0.107                                                            | 
|POLY 6             |        P=0.422          P=0.017 *        P=0.141                                                            | 
|LOGISTIC REGRESSION|        P=0.279          P=0.032 *        P=0.094                                                            | 
|COCH-ARM / FISHERS |        P=0.249          P=0.084          P=0.109                                                            | 
|ORDER RESTRICTED   |        P=0.039 *        (e)              (e)                                                                | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        300 NG /         300 NG /         300 NG /                                                           | 
|                   |        100 UG           300 UG           3000 UG                                                            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        25/50 (50%)      18/52 (35%)      15/50 (30%)                                                        | 
|POLY-3 RATE (b)    |        25/44.81         18/41.18         15/41.92                                                           | 
|POLY-3 PERCENT (g) |        55.8%            43.7%            35.8%                                                              | 
|TERMINAL (d)       |        16/28 (57%)      13/24 (54%)      8/27 (30%)                                                         | 
|FIRST INCIDENCE    |        441              142              409                                                                | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.072N         P=0.249N         P=0.058N                                                           | 
|POLY 3             |        P=0.067N         P=0.174N         P=0.043N*                                                          | 
|POLY 1.5           |        P=0.074N         P=0.135N         P=0.040N*                                                          | 
|POLY 6             |        P=0.058N         P=0.226N         P=0.045N*                                                          | 
|LOGISTIC REGRESSION|        P=0.082N         P=0.091N         P=0.034N*                                                          | 
|COCH-ARM / FISHERS |        P=0.085N         P=0.085N         P=0.033N*                                                          | 
|ORDER RESTRICTED   |        P=0.033N*        (e)              (e)                                                                | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).