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TDMS Study 96022-02 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                    TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                              DATE: 04/27/04  
EXPERIMENT: 96022 TEST: 02                                                                                        TIME: 11:10:34    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C96022      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                DATE: 04/27/04    
EXPERIMENT: 96022 TEST: 02                                                                                        TIME: 11:22:25    
SPECIES: RATS, SPRAGUE-DAWLEY                                                                                                       
TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  C96022      
CONT: NO1-ES-75411                                                                                                CAS: TEFPCBMIX    
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                             
                       TWO YEAR ORAL GAVAGE STUDY OF TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                                   
==========================================================================================================================          
WEEK     0 NG /  0 UG           80 NG  /10 UG            240 NG /30 UG            800 NG /100 UG           2400 NG/300 UG           
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B       182.7       98       185.0    101.3    86     183.8    100.6    98     186.0    101.8    86     185.2    101.4    98      
  1       182.7       98       185.0    101.3    86     183.8    100.6    98     186.0    101.8    86     185.2    101.4    98      
  2       202.7       98       205.7    101.5    86     203.6    100.4    98     205.9    101.6    86     202.0     99.7    98      
  3       221.8       98       224.7    101.3    86     224.2    101.1    98     224.5    101.2    86     220.4     99.4    98      
  4       232.5       98       237.7    102.2    86     233.4    100.4    98     234.3    100.8    86     228.6     98.3    98      
  5       237.6       98       242.3    102.0    86     242.4    102.0    98     242.9    102.2    86     236.1     99.4    98      
  6       251.6       98       254.7    101.2    86     252.4    100.3    98     249.9     99.3    86     239.6     95.2    98      
  7       255.0       98       259.4    101.7    86     255.4    100.2    98     250.1     98.1    85     242.2     95.0    98      
  8       262.7       98       265.5    101.1    86     262.5     99.9    98     255.0     97.1    85     245.4     93.4    98      
  9       266.1       98       267.4    100.5    86     264.3     99.3    98     258.8     97.3    85     246.1     92.5    98      
 10       267.8       98       271.2    101.3    86     266.8     99.6    97     259.7     97.0    85     249.0     93.0    98      
 11       268.8       98       269.1    100.1    85     265.8     98.9    97     258.2     96.1    85     248.2     92.3    98      
 12       277.5       98       277.5    100.0    84     272.2     98.1    97     265.4     95.6    85     254.5     91.7    98      
 13       281.7       98       283.9    100.8    84     275.9     97.9    97     268.8     95.4    84     256.0     90.9    98      
 17       289.9       82 (I)   294.4    101.6    74 (I) 286.6     98.9    81 (I) 277.2     95.6    74 (I) 261.5     90.2    82 (I)  
 21       297.6       82       302.2    101.5    74     294.3     98.9    81     281.6     94.6    74     262.9     88.3    82      
 25       302.6       82       309.2    102.2    74     297.9     98.4    81     287.8     95.1    74     263.1     86.9    81      
 29       311.0       82       317.3    102.0    74     302.6     97.3    81     290.8     93.5    74     265.0     85.2    81      
 33       310.9       66 (I)   321.4    103.4    64 (I) 307.3     98.8    65 (I) 294.1     94.6    64 (I) 264.2     85.0    65 (I)  
 37       321.4       66       328.6    102.2    64     315.7     98.2    65     298.0     92.7    64     269.6     83.9    65      
 41       322.0       65       330.4    102.6    63     316.6     98.3    65     292.7     90.9    63     269.6     83.7    64      
 45       329.9       65       339.4    102.9    63     321.3     97.4    65     299.7     90.8    63     273.6     82.9    64      
 49       335.9       64       346.5    103.2    62     327.0     97.4    65     298.4     88.8    63     272.7     81.2    63      
 53       345.2       55 (I)   351.8    101.9    53 (I) 334.2     96.8    57 (I) 300.5     87.1    55 (I) 276.2     80.0    53 (I)  
 57       353.0       50       361.4    102.4    47     344.6     97.6    52     304.1     86.1    48     278.7     79.0    46      
 61       357.9       50       368.8    103.0    46     348.8     97.5    50     306.5     85.6    48     283.9     79.3    45      
 65       362.7       50       366.1    100.9    44     345.8     95.3    47     304.5     84.0    48     282.8     78.0    43      
 69       365.4       50       376.6    103.1    44     343.5     94.0    44     303.4     83.0    48     284.5     77.9    39      
 73       374.5       49       378.2    101.0    41     348.9     93.2    43     308.0     82.2    47     276.1     73.7    35      
 77       382.3       49       387.1    101.3    39     353.6     92.5    42     310.0     81.1    47     278.2     72.8    29      
 81       380.3       45       390.3    102.6    33     357.3     94.0    40     306.5     80.6    40     264.2     69.5    24      
 85       381.0       41       390.6    102.5    32     361.2     94.8    34     304.4     79.9    37     275.3     72.3    17      
 89       382.9       41       394.2    103.0    29     359.8     94.0    32     308.9     80.7    34     273.5     71.4    15      
 93       386.5       36       384.2     99.4    25     362.4     93.8    30     300.9     77.9    31     247.1     63.9     9      
 97       383.9       32       381.6     99.4    22     359.7     93.7    27     297.6     77.5    23     259.9     67.7     6      
101       378.8       29       376.2     99.3    19     359.3     94.9    26     294.3     77.7    19     243.0     64.1     2      
TERM. SAC.            27                         17                       24                       15                        0      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
    MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                                            
TWO YEAR ORAL GAVAGE STUDY OF TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                                                          
========================================================                                                                            
     4000 NG/500 UG             4000 NG/500UG ST                                                                                    
WEEK ----------------           ----------------                                                                                    
      AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                                                                                 
     (GRAMS)  OF CNTL  (A)     (GRAMS)  OF CNTL  (A)                                                                                
=======================================================                                                                             
  B   183.7    100.5    86     184.1    100.8    50                                                                                 
  1   183.7    100.5    86     184.1    100.8    50                                                                                 
  2   202.2     99.8    86     201.9     99.6    50                                                                                 
  3   217.4     98.0    86     217.1     97.9    50                                                                                 
  4   223.2     96.0    86     223.7     96.2    50                                                                                 
  5   226.7     95.4    86     230.2     96.9    50                                                                                 
  6   232.6     92.4    86     232.3     92.3    50                                                                                 
  7   230.0     90.2    86     234.0     91.8    50                                                                                 
  8   231.2     88.0    86     230.9     87.9    50                                                                                 
  9   238.3     89.6    85     237.9     89.4    50                                                                                 
 10   238.6     89.1    85     239.7     89.5    50                                                                                 
 11   240.0     89.3    85     242.8     90.3    50                                                                                 
 12   243.1     87.6    80*    245.2     88.4    50                                                                                 
 13   244.1     86.7    85     245.9     87.3    50                                                                                 
 17   245.8     84.8    74 (I) 246.2     84.9    50                                                                                 
 21   247.4     83.1    74     246.1     82.7    50                                                                                 
 25   247.8     81.9    74     250.1     82.7    50                                                                                 
 29   247.1     79.5    73     247.3     79.5    50                                                                                 
 33   247.8     79.7    59 (I) 248.6     80.0    48                                                                                 
 37   251.0     78.1    52     263.1     81.9    40                                                                                 
 41   255.6     79.4    43     269.8     83.8    32                                                                                 
 45   255.8     77.5    36     280.0     84.9    30                                                                                 
 49   264.8     78.8    30     282.5     84.1    30                                                                                 
 53   267.7     77.5    23     287.4     83.3    30                                                                                 
 57   270.1     76.5    21     295.9     83.8    29                                                                                 
 61   265.5     74.2    18     302.7     84.6    28                                                                                 
 65   259.3     71.5    15     306.9     84.6    28                                                                                 
 69   266.3     72.9    11     316.9     86.7    26                                                                                 
 73   276.7     73.9     5     321.9     86.0    24                                                                                 
 77   259.8     68.0     3     315.2     82.4    23                                                                                 
 81   262.0     68.9     2     322.9     84.9    21                                                                                 
 85   247.1     64.9     2     324.5     85.2    21                                                                                 
 89   252.4     65.9     1     324.0     84.6    16                                                                                 
 93                            320.0     82.8    14                                                                                 
 97                            334.9     87.2    12                                                                                 
101                            333.8     88.1    11                                                                                 
TERM. SAC.             0                         10                                                                                 
========================================================                                                                            
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.