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TDMS Study 60855-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 02                                                                                     TIME: 14:17:54       
TEST TYPE:  18-33 DAYS                                                                                         PAGE:       1        
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 02                                                                                     TIME: 14:17:54       
TEST TYPE:  18-33 DAYS                                                                                                              
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF              BETA-BROMO-BETA-NITROSTYRENE                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Bone Marrow: Erythroid Cell            Depletion Cellular                                                                           
Gallbladder                            Degeneration                                                                                 
                                       Inflammation                                                                                 
Intestine Small, Jejunum               Inflammation                                                                                 
Kidney                                 Congestion                                                                                   
Liver                                  Depletion Glycogen                                                                           
                                       Necrosis                                                                                     
Lung                                   Congestion                                                                                   
Lymph Node, Mandibular                 Atrophy                                                                                      
Lymph Node, Mesenteric                 Atrophy                                                                                      
                                       Necrosis                                                                                     
Pancreas                               Inflammation                                                                                 
                                       Necrosis                                                                                     
Spleen                                 Atrophy                                                                                      
                                       Congestion                                                                                   
Stomach, Forestomach                   Inflammation                                                                                 
                                       Ulcer                                                                                        
Stomach, Forestomach: Epithelium       Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Testes                                 Degeneration                                                                                 
Thymus                                 Atrophy                                                                                      
                                       Necrosis                                                                                     
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow: Erythroid Cell            Depletion Cellular                                                                           
Gallbladder                            Inflammation                                                                                 
                                       Necrosis                                                                                     
Kidney                                 Congestion                                                                                   
Liver                                  Depletion Glycogen                                                                           
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
Lung                                   Hemorrhage                                                                                   
Lymph Node, Mesenteric                 Atrophy                                                                                      
Pancreas                               Inflammation                                                                                 
                                       Necrosis                                                                                     
Spleen                                 Atrophy                                                                                      
                                       Congestion                                                                                   
                                       Hematopoietic Cell Proliferation                                                             
                                       Inflammation                                                                                 
Stomach, Forestomach                   Inflammation                                                                                 
                                       Necrosis                                                                                     
Stomach, Forestomach: Epithelium       Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Stomach, Glandular                     Inflammation                                                                                 
Thymus                                 Atrophy                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: BIORELIANCE                                      BETA-BROMO-BETA-NITROSTYRENE                             DATE: 10/19/04       
EXPERIMENT: 60855 TEST: 02                                                                                     TIME: 14:17:54       
TEST TYPE:  18-33 DAYS                                                                                                              
CONT: NO1-ES-15319                              ROUTE: GAVAGE                                                  NTP C#: C60855       
PATHOLOGIST: MISSING                                                                                           CAS: 7166-19-0       
                                       Necrosis                                                                                     
===============================================================                                                                     
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                 
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Erythroid Cell                                                                                                      | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           5/5.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.022 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Erythroid Cell                                                                                                      | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           0/10.00          5/5.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.350          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        1/8 (13%)        4/5 (80%)       | 
|POLY-3 RATE (b)    |        0/9.00           0/10.00          0/10.00          0/10.00          1/7.01           4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             14.3%            100.0%          | 
|TERMINAL (d)       |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        1/7 (14%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.450          P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.450          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.452          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.450          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.111          (e)              (e)              (e)              P=0.450          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.471          P=0.005 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         0/7 (0%)         0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/8.00           0/10.00          0/10.00          0/8.00           0/7.00           0/0.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         0/7 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        3/8 (38%)        5/5 (100%)      | 
|POLY-3 RATE (b)    |        0/9.00           0/10.00          0/10.00          0/10.00          3/8.00           5/5.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             37.5%            100.0%          | 
|TERMINAL (d)       |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        2/7 (29%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.091          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.067          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.067          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.067          P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.082          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         2/7 (29%)        7/9 (78%)       | 
|POLY-3 RATE (b)    |        0/8.00           0/10.00          0/10.00          0/8.00           2/7.00           7/7.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             28.6%            100.0%          | 
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         2/7 (29%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.202          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.188          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.188          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.188          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.020 *        (e)              (e)              (e)              P=0.202          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.200          P=0.002 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        0/8 (0%)         0/5 (0%)        | 
|POLY-3 RATE (b)    |        0/9.00           0/10.00          0/10.00          0/10.00          0/7.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        0/7 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Gallbladder                                                                                                                      | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         1/7 (14%)        2/9 (22%)       | 
|POLY-3 RATE (b)    |        0/8.00           0/10.00          0/10.00          0/8.00           1/7.00           2/2.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             14.3%            99.5%           | 
|TERMINAL (d)       |        0/8 (0%)         0/10 (0%)        0/10 (0%)        0/8 (0%)         1/7 (14%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.473          P=0.097         | 
|POLY 3             |        P=0.018 *        (e)              (e)              (e)              P=0.473          P=0.042 *       | 
|POLY 1.5           |        P=0.015 *        (e)              (e)              (e)              P=0.473          P=0.046 *       | 
|POLY 6             |        P=0.018 *        (e)              (e)              (e)              P=0.473          P=0.042 *       | 
|LOGISTIC REGRESSION|        P=0.211          (e)              (e)              (e)              P=0.473          (e)             | 
|COCH-ARM / FISHERS |        P=0.013 *        (e)              (e)              (e)              P=0.467          P=0.265         | 
|ORDER RESTRICTED   |        P=0.002 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.00           4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.051         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.012 *        (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/0.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/10.00          5/5.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.022 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.501N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.006 **       (e)              (e)              (e)              P=0.500          P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           0/10.00          3/3.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.081         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        P=0.908          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.028 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Depletion Glycogen                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           1/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Depletion Glycogen                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         1/1 (100%)       0/10 (0%)        9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           1/1.00           0/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             100.0%           0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              6                ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.500          (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.091          (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.091          (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              P=0.091          (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.737N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.091          (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           0/10.00          2/2.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.4%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.005 **       (e)              (e)              (e)              (e)              P=0.166         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.044 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.831          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.083          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           2/2.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.234         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.042 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         1/10 (10%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           1/10.00          4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.005 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.207          (e)              (e)              (e)              P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.015 *        (e)              (e)              (e)              P=0.500          P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.111         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         1/1 (100%)       0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           1/1.00           0/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             100.0%           0.0%             98.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              6                ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.051          (e)              (e)              P=0.500          (e)              P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              P=0.091          (e)              P=0.243         | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.091          (e)              P=0.252         | 
|POLY 6             |        (e)              (e)              (e)              P=0.091          (e)              P=0.243         | 
|LOGISTIC REGRESSION|        P=0.102N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.488          (e)              (e)              P=0.091          (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        1/10.00          0/0.00           0/0.00           0/0.00           0/9.01           1/1.00          | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             0.0%             0.0%             0.0%             99.7%           | 
|TERMINAL (d)       |        1/10 (10%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        29 (T)           ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.327          P=1.000N         P=1.000N         P=1.000N         P=0.521N         P=0.500         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.521N         P=0.352         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.519N         P=0.362         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.521N         P=0.352         | 
|LOGISTIC REGRESSION|        P=0.570N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.673          P=1.000          P=1.000          P=1.000          P=0.500N         P=0.763N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         2/10 (20%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           2/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            98.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.014 *        (e)              (e)              (e)              P=0.234          P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.227          P=0.243         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.227          P=0.252         | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.227          P=0.243         | 
|LOGISTIC REGRESSION|        P=0.189          (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P=0.340          (e)              (e)              (e)              P=0.237          P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/7 (0%)         2/9 (22%)       | 
|POLY-3 RATE (b)    |        0/9.00           0/0.00           0/0.00           0/0.00           0/7.00           2/2.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/7 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.210         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.038 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.038 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.096          (e)              (e)              (e)              (e)              P=0.235         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           0/10.00          0/0.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.111         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        1/9 (11%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.046 *        (e)              (e)              (e)              (e)              P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.237         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.245         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.237         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.251          (e)              (e)              (e)              (e)              P=0.474         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           2/2.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.234         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.042 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        1/9 (11%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.095          (e)              (e)              (e)              (e)              P=0.479         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.237         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.246         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.237         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.251          (e)              (e)              (e)              (e)              P=0.474         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           6/6.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.009 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         1/10 (10%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           1/10.00          4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             10.0%            99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.500          P=0.005 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.500          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.207          (e)              (e)              (e)              P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.015 *        (e)              (e)              (e)              P=0.500          P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.111         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.01           0/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.045 *        (e)              (e)              (e)              (e)              P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.243         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.252         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.243         | 
|LOGISTIC REGRESSION|        P=0.869          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.258          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           6/6.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.009 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/1.01           0/10.00          1/1.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.045 *        (e)              (e)              (e)              (e)              P=0.362         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.243         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.252         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.243         | 
|LOGISTIC REGRESSION|        P=0.870          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.250          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.111         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/1.01           0/10.00          4/4.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.7%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.051         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.008 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/1.01           0/10.00          2/2.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.097         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.044 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.686          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.077          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/2 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/1.01           0/10.00          2/2.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.097         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.044 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.686          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.077          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           1/1.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.7%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.107          (e)              (e)              (e)              (e)              P=0.500         | 
|POLY 3             |        P=0.569          (e)              (e)              (e)              (e)              P=0.243         | 
|POLY 1.5           |        P=0.538          (e)              (e)              (e)              (e)              P=0.248         | 
|POLY 6             |        P=0.569          (e)              (e)              (e)              (e)              P=0.243         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.105          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        P=0.009 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/9.01           0/10.00          8/8.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.279          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/9.01           0/10.00          4/4.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.437          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          2/10.00          0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              6                ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.061          (e)              (e)              (e)              P=0.228          (e)             | 
|POLY 3             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 1.5           |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|LOGISTIC REGRESSION|        P=0.855N         (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.413          (e)              (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.830          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/9.01           0/10.00          0/0.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/10 (90%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          9/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             99.9%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/9 (100%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.078          (e)              (e)              (e)              P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.827          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/9.01           2/10.00          0/0.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065          (e)              (e)              (e)              P=0.234          (e)             | 
|POLY 3             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 1.5           |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|POLY 6             |        P=0.010 *        (e)              (e)              (e)              P=0.227          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P=0.413          (e)              (e)              (e)              P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.829          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/10 (90%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          9/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             99.9%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/9 (100%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.078          (e)              (e)              (e)              P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.827          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        10/10 (100%)     0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/9.01           10/10.00         0/0.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             100.0%           0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              29 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.062          (e)              (e)              (e)              P<0.001 **       (e)             | 
|ORDER RESTRICTED   |        P=0.745          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/10.00          0/9.01           0/0.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/9.01           0/10.00          2/2.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/9 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.097         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.044 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.040 *       | 
|LOGISTIC REGRESSION|        P=0.693          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.043 *        (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           6/6.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.009 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           3/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.111         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.031 *        (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        2/8 (25%)       | 
|POLY-3 RATE (b)    |        0/9.00           0/0.00           0/0.00           0/0.01           0/10.00          2/2.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.8%           | 
|TERMINAL (d)       |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.034 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.032 *       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.035 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.032 *       | 
|LOGISTIC REGRESSION|        P=0.632          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.066          (e)              (e)              (e)              (e)              P=0.206         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 60855 TEST: 02                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -               BETA-BROMO-BETA-NITROSTYRENE                  
                                         Terminal Sacrifice at 5 weeks                                                              
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.01           8/8.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        CONTROL          0.037            0.075            0.150            0.300            0.600           | 
|                   |                         G/KG             G/KG             G/KG             G/KG             G/KG            | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/1 (0%)         0/10 (0%)        6/8 (75%)       | 
|POLY-3 RATE (b)    |        0/9.00           0/0.00           0/0.00           0/0.01           0/10.00          6/6.01          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.9%           | 
|TERMINAL (d)       |        0/9 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              2               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.002 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).