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TDMS Study 93020-05 Pathology Tables

NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97
Route: SKIN APPLICATION                                                                                           Time: 14:05:56

                                                       150 DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  693-13-0

       Lock Date:  03/26/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 7| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  A  +  M  +  +  M  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +                                             |   9        |
      Carcinoma                            |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +     +     +                                                   |   3        |
      Odontoma                             |          X     X     X                                                   |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  M  M  M  M  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  +  M  +  +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  M  +  +  M  +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 7| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  +  +  +  +                                             |   9        |
      Leukemia Erythrocytic                |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma, Multiple    |    X                                                                     |          1 |
      Skin, Site of Application, Squamous  |                                                                          |            |
          Cell Papilloma, Multiple         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Respiratory Epithelium, Adenoma      |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4|                                            |            |
                                           | 1| 1| 1| 3| 1| 1| 1| 1| 8| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    4.38                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +  +        +  +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +  +  +           +                                                |   4        |
      Odontoma                             |       X  X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +        +           +  +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M              M                                                |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +              +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4|                                            |            |
                                           | 1| 1| 1| 3| 1| 1| 1| 1| 8| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    4.38                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +           +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +           +  +                                                |   3        |
      Squamous Cell Papilloma              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +              +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +              +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +              +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +        +  +  +                                             |   8        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 3| 9| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    8.75                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +                                                   |   7        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +                 +                                             |   3        |
      Squamous Cell Papilloma              |       X                    X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +  +  M        +     +                                                |   4        |
      Odontoma                             |    X  X           X     X                                                |          4 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M  M                                                               |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +                                                               |   2        |
      Yolk Sac Carcinoma                   |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 0| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 3| 9| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    8.75                                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +     +                                                         |   3        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +     +           +                                             |   4        |
      Squamous Cell Papilloma, Multiple    |                X                                                         |          1 |
      Dermis, Skin, Site of Application,   |                                                                          |            |
           Fibrosarcoma                    |                X                                                         |          1 |
      Skin, Site of Application, Squamous  |                                                                          |            |
          Cell Papilloma, Multiple         |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  M                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +                                                               |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0|                                            |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    17.5                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  A  +  +  +  +  +                                             |   7        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +              +                                             |   3        |
      Squamous Cell Papilloma              |    X                       X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +        +  +     +     +                                             |   6        |
      Odontoma                             | X  X        X  X     X     X                                             |          6 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |             +     +        +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +              M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             I              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |             M              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +              +                                             |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0|                                            |            |
                                           | 1| 1| 1| 1| 2| 1| 1| 1| 1| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    17.5                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +              M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             A              +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  A              +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M              M                                             |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +              +                                             |   4        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
      Skin, Site of Application, Squamous  |                                                                          |            |
          Cell Papilloma, Multiple         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +              +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Nose                                    |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +              +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +              +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +              +                                             |   2        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +  +  +  +  +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 0| 1| 0| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5|                                            |            |
                                           | 1| 1| 8| 5| 1| 6| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    35                                     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +     M           +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +     +     +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +     +           +                                             |   4        |
      Duct, Squamous Cell Carcinoma        |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  A     +           A                                             |   2        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +        +     +                                                      |   3        |
      Odontoma                             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +     +  +        +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       M  M     M           M                                             |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  M     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +     +           +                                             |   4        |
      Teratoma Benign                      |       X                    X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 0| 0| 1| 0| 1| 1| 1| 0|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5|                                            |            |
                                           | 1| 1| 8| 5| 1| 6| 1| 1| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    35                                     | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +     +        +  A                                             |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  A     +     +  +  +                                             |   6        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +     +           A                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  +     +           M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +     +           +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +           +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +     +           +                                             |   4        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +                                             |   9        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    70                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |       X     X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +  +  +  +  +     +                                             |   7        |
      Odontoma                             |          X  X  X  X  X     X                                             |          6 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  M  M  +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  M  +  +  +  +  M  M                                             |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  M                                             |   8        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 93020-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 150-DAY                                      DIISOPROPYLCARBODIIMIDE                                  Date: 08/19/97  
Route: SKIN APPLICATION                                                                                           Time: 14:05:56  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TG.AC HETEROZYGOUS TRANSGENIC  FEMALE   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    70                                     | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Skin, Site of Application, Squamous  |                                                                          |            |
          Cell Papilloma                   |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
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                                  ----------              END OF REPORT             ----------                                      
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