National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19240

TDMS Study 93020-08 Pathology Tables

NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04
Route: SKIN APPLICATION                                                                                           Time: 09:18:40

                                                         FINAL #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  693-13-0

       Lock Date:  03/14/03

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  I  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                      2                                                   |             
      Congestion                           |                                  2                                       |             
      Eosinophilic Focus                   |             X        X              X        X                           |             
      Infiltration Cellular, Mixed Cell    | 1                 1              1        2  1  2              1  2      |             
      Hepatocyte, Basophilic Focus         |                                                                          |             
      Hepatocyte, Clear Cell Focus         |             X                             X                              |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Mixed Cell Focus         |                                              X  X                        |             
      Hepatocyte, Necrosis, Focal          |                   1              2                                       |             
      Hepatocyte, Vacuolization Cytoplasmic|                   1           2  2                                       |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                +     +  +  +        +     +        +  +     +           +|             
      Infiltration Cellular, Lymphoid      |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation                         |                                           4                              |             
      Fat, Necrosis, Focal                 |                3     3  1  3        3              2  3                 2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Thrombosis                           |          3           3                                                   |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                2                                    |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |    2                    2                 2                              |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                            2                                             |             
      Pars Distalis, Degeneration, Cystic, |                                                                          |             
           Focal                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Degeneration, Cystic, Focal|                                        2        3              2        2|             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphoid                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | 3     3              3  3                 3        2           3  2  2   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                   4      |             
      Thrombosis                           |                      3                                                   |             
      Bilateral, Inflammation, Suppurative |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                   +      |             
      Inflammation, Suppurative            |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                   2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3     3  3     2  3  2  3  2  3  2  1  3  2  3  2  3  2  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3           3              4     2        3  3     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                            +              +     +           +     +     +|             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                         2|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                   3      |             
      Mediastinal, Ectasia                 |                                           3                              |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                3  3  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                                3         |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                   2  3  2     3  2              4  3  3        3  3     3|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |    3  2                                                  2               |             
      Capsule, Inflammation, Chronic, Focal|                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                         3|             
      Control Dermis, Inflammation, Focal  |                                                                         2|             
      Control Epidermis, Hyperplasia, Focal|                                                                          |             
      Epidermis, Hyperplasia, Focal        |                                                                         3|             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                                2         |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |                                                 2              2        3|             
      Site of Application, Ulcer           |                                                                3        3|             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                        3                                 |             
      Hemorrhage, Focal                    | 1                                                                        |             
      Infarct                              |                            X                                             |             
      Cerebellum, Hippocampus, Necrosis    |                            2                                             |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                                       |             
      Mineralization, Focal                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|             
                                           | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |                                                                4         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            3                                             |             
      Cyst                                 |                                              1                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |    2                                         1                           |             
      Inflammation                         |                                                                          |             
      Metaplasia, Focal, Osseous           |             1                                                           1|             
      Nephropathy                          | 1                 1  1        1     1  1              2                  |             
      Capsule, Congestion                  |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                    3                     |             
      Renal Tubule, Necrosis               |                            4                                             |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic, Focal               |                         2                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  I  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                              X                 X         |      6     |
      Infiltration Cellular, Mixed Cell    | 2     1     2              1  2        3  1                          2   |     16  1.6|
      Hepatocyte, Basophilic Focus         |                X                                                         |      1     |
      Hepatocyte, Clear Cell Focus         |                                        X                                 |      3     |
      Hepatocyte, Karyomegaly              |                                  1                                       |      1  1.0|
      Hepatocyte, Mixed Cell Focus         |                                                                          |      2     |
      Hepatocyte, Necrosis, Focal          | 1                                                                        |      3  1.3|
      Hepatocyte, Vacuolization Cytoplasmic|                                                 1        3               |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +           +  +  +  +  +  +        +        +           +        +  +|  23        |
      Infiltration Cellular, Lymphoid      |                3                                                         |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                         3                                            3   |      3  3.3|
      Fat, Necrosis, Focal                 | 3              2  3  3     3  3        2        2                       3|     17  2.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |                         2                                                |      1  2.0|
      Acinus, Atrophy, Focal               |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |    2  2                                                                  |      2  2.0|
      Inflammation, Focal                  |    2                                                                     |      1  2.0|
      Ulcer                                |                                                       2                  |      1  2.0|
      Epithelium, Hyperplasia              |    2  2                 1                    2                           |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Mixed Cell    |                                        2                                 |      1  2.0|
      Thrombosis                           |                                        3                       3         |      4  3.0|
      Artery, Inflammation, Chronic        |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      1        1                                          |      2  1.0|
      Cytoplasmic Alteration, Focal        |                            1                                             |      1  1.0|
      Degeneration, Cystic                 |                                                                      2   |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                        3                                 |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                          |      3  2.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                      1   |      2  1.5|
      Pars Distalis, Degeneration, Cystic, |                                                                          |            |
           Focal                           |                               2                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |             3                 2                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Degeneration, Cystic, Focal| 1           2                 2        2  1  3           2  1     1  1   |     14  1.8|
      Follicular Cell, Hyperplasia, Focal  |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |    +     M        +     +                                   +            |   5        |
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Lymphoid                        |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|  46        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                   4     3|      2  3.5|
      Cyst                                 | 3        2                             3  3        2                     |     14  2.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hemorrhage                           | 3        2                                                               |      2  2.5|
      Inflammation, Suppurative            |             3                                                            |      2  3.5|
      Thrombosis                           |                                                                   3      |      2  3.0|
      Bilateral, Inflammation, Suppurative |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |             +                                                        +   |   3        |
      Inflammation, Suppurative            |             3                                                        3   |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     3                                    |      1  3.0|
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
      Inflammation, Suppurative            |             3           3              3           2                     |      5  2.6|
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3     2  3  3  3  1  3  3  3  3  3  2  3  1  2  3  3     3  3|     46  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2           4     3     3              4        3                    3   |     14  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +     +        +  +  +                                                |  11        |
      Iliac, Hemorrhage                    |          3        3                                                      |      2  3.0|
      Iliac, Hyperplasia, Lymphoid         |                         3                                                |      2  2.5|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Ectasia                 |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                         2                                                |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                         3                                                |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                   3                                                      |      1  3.0|
      Hyperplasia, Lymphoid                |                               3              3                           |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  M  +  +  +|  47        |
      Ectasia                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |                         3                    3                           |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                              3                           |      1  3.0|
      Hematopoietic Cell Proliferation     | 2     3     3     3     3  3           3              2  4     2  2  3  2|     24  2.8|
      Hyperplasia, Histiocytic             |             3                                                            |      1  3.0|
      Hyperplasia, Lymphoid                |                3              3              3                           |      6  2.7|
      Capsule, Inflammation, Chronic, Focal|                                                 2                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                         3     3              3                          2|      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
      Control Dermis, Inflammation, Focal  |                                                                          |      1  2.0|
      Control Epidermis, Hyperplasia, Focal|       3                                                                  |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  3.0|
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |    1  1                                                                  |      3  1.3|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |    1  2                                                                  |      5  2.0|
      Site of Application, Ulcer           |                                                                          |      2  3.0|
      Subcutaneous Tissue, Edema           |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                        2                          2  3   |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                3                                                         |      2  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      1     |
      Cerebellum, Hippocampus, Necrosis    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                +         |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    3                                                                     |      2  3.0|
      Mineralization, Focal                | 2                                                                        |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3|            |
                                           | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                2        3                                                |      2  2.5|
      Infarct                              |                                                                         1|      3  1.3|
      Inflammation                         |                                        3                                 |      1  3.0|
      Metaplasia, Focal, Osseous           |       2                                2                                2|      5  1.6|
      Nephropathy                          | 1              1     1  1                                         1  1   |     13  1.1|
      Capsule, Congestion                  |                                                                         2|      1  2.0|
      Papilla, Necrosis                    |                                        3                                 |      1  3.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |    3              3                                                      |      3  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                3                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                   2                                                      |             
      Eosinophilic Focus                   |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                                        3           3                     |             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                3         |             
      Infiltration Cellular, Mixed Cell    |          3                 1     1                 2                     |             
      Mineralization, Focal                |                                                                          |             
      Hepatocyte, Clear Cell Focus         |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                         3                          2                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                              3                           |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +     +  +     +        +        +           +        +        +|             
      Inflammation                         |          4              3                                      3         |             
      Fat, Necrosis, Focal                 | 2  3           2  3     3        3        3           2                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Diffuse             | 4                             4                                          |             
      Acinus, Atrophy, Focal               |                                                                          |             
      Duct, Cyst, Focal, Multiple          | 3                             4                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |       2                                                                  |             
      Epithelium, Hyperplasia              |       2           2                 2                                    |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Focal           |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Malformation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1     1                                                   |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                2         |             
      Inflammation, Chronic, Focal         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            1                                             |             
      Angiectasis                          |    2                                                                     |             
      Cytoplasmic Alteration, Focal        |                                     1                       2            |             
      Inflammation, Suppurative            |                                                                3         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Inflammation, Suppurative            |                                                                2         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                              2                           |             
      Follicle, Degeneration, Cystic, Focal|       1           2     2        2        2        2           1        2|             
      Follicular Cell, Hyperplasia, Focal  | 1  2     2     2                    2              2                    1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |       +  +                 +                                             |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |          3                                                               |             
      Nasal, Hemorrhage                    |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 3                 3      |             
      Cyst                                 | 3        3                       2     3              2                 3|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Inflammation, Suppurative            |                                                    4           2         |             
      Thrombosis                           |                                                 4                        |             
      Interstitial Cell, Hyperplasia       |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |       +                                                                  |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2     3  3                                   3     4           4         |             
      Cervix, Hypertrophy                  |                                                                3         |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3     3  2        3  3  3  3  3  3  3  2  3  3     3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  3     4           4           3         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +                                +  +        +  +        +         |             
      Iliac, Ectasia                       |                                           3                              |             
      Iliac, Hyperplasia, Lymphoid         |                                                    3           4         |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                3         |             
      Mediastinal, Hyperplasia             |                                                    3                     |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Ectasia                       |                                           3                              |             
      Renal, Hyperplasia, Lymphoid         |                                                                4         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Ectasia                              |                                           3                              |             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3  3        2  3  3  2     3     3  2        4           4  3     3|             
      Hyperplasia, Lymphoid                | 3              2     2           2              3        2  3        3   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     3                       3        3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                                2        3|             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |       1                                                                 3|             
      Site of Application, Ulcer           |                                                                         2|             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |          2                                                               |             
      Subcutaneous Tissue, Edema           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                               +        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                               4                                          |             
      Hemorrhage, Focal                    |                            2                                             |             
      Inflammation, Focal                  |                                                                          |             
      Cerebrum, Atrophy, Focal             |                                                                          |             
      Hippocampus, Necrosis, Acute         |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                               +        +                                 |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                               +        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia, Histiocytic             |                   3                                                      |             
      Infiltration Cellular,               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
          Polymorphonuclear                |          3                                                     3         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    1                                                                     |             
      Mediastinum, Hyperplasia, Lymphoid   |                3                                                     3   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Cornea, Hyperplasia, Squamous        |                                                 2                        |             
      Cornea, Inflammation, Chronic        |                                                 2                        |             
      Iris, Synechia                       |                                                                          |             
      Lens, Cataract                       |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 3  2                     |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                        3   |             
      Infarct                              |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                2         |             
      Infiltration Cellular, Mixed Cell    |                                                    2                     |             
      Inflammation                         |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                          1               |             
      Nephropathy                          |       1                             1           1           1            |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic, Focal               |                                           1                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|             
                                           | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                       +                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Cyst                                 |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  45        |
      Inflammation, Focal                  |                                                 2                        |      1  2.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                  3                                       |      2  2.5|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hyperplasia, Focal, Lymphoid         |                                     2                                    |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |       1     2           2  2                                         1   |      9  1.7|
      Mineralization, Focal                |                                                             3            |      1  3.0|
      Hepatocyte, Clear Cell Focus         |                         X                 X                              |      2     |
      Hepatocyte, Necrosis, Focal          |                                                             4            |      3  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                           2                          2   |      3  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               |          +     +        +                 +              +  +  +        +|  20        |
      Inflammation                         |                                                          3              3|      5  3.2|
      Fat, Necrosis, Focal                 |          3                                3              3  3           2|     13  2.7|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Acinus, Atrophy, Diffuse             |                                                                          |      2  4.0|
      Acinus, Atrophy, Focal               |          4                                                           3   |      2  3.5|
      Duct, Cyst, Focal, Multiple          |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                           1                              |      4  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Glands, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                   +      |   1        |
      Malformation                         |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                             3            |      3  1.7|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Angiectasis                          |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                               2                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  I  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  I  +  +  +|  43        |
      Cyst                                 |                                                 2                    2   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                        2              2                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  2        2                              |      2  2.0|
      C-Cell, Hyperplasia                  |                                                 1                        |      2  1.5|
      Follicle, Degeneration, Cystic, Focal|    2                 1        2     2           2              3         |     14  1.9|
      Follicular Cell, Hyperplasia, Focal  |                      1  1                             1  2               |     11  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |          +  +  +        +                                      +         |   8        |
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Nasal, Hemorrhage                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   2      |      3  2.7|
      Cyst                                 |                   2  2  2     3     3  3     2     3           2        3|     16  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Thrombosis                           |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                    3        2            |      8  3.0|
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3     3  3  3  2|     44  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     3                                    |      5  3.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +     +        +                                   +  +  +     +|  13        |
      Iliac, Ectasia                       |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  3.5|
      Mediastinal, Hemorrhage              |                                                             3            |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                         3|      2  3.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Pancreatic, Hemorrhage               |                3                                                         |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                   3      |      1  3.0|
      Renal, Ectasia                       |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |             3              3        3                                   3|      4  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Ectasia                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |             3                          3                 4        3     3|      6  3.2|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |       3     3  3        2  3        3              2                 2   |     21  2.8|
      Hyperplasia, Lymphoid                |                                     3  3                             2  3|     12  2.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                         3|      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |                                                                          |      2  2.5|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |                                                 1                        |      3  1.7|
      Site of Application, Ulcer           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                3                                                         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                             +         |   4        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                              3                           |      2  3.5|
      Hemorrhage, Focal                    |                                                             2            |      2  2.0|
      Inflammation, Focal                  |                                                             1            |      1  1.0|
      Cerebrum, Atrophy, Focal             |                4                                                         |      1  4.0|
      Hippocampus, Necrosis, Acute         |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                +         |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |          1                                                               |      2  1.0|
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Cornea, Hyperplasia, Squamous        |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Iris, Synechia                       |                                                                      X   |      1     |
      Lens, Cataract                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3|            |
                                           | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      2  2.5|
      Epithelium, Hyperplasia, Focal       |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Infarct                              |    2                                                                 2   |      2  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation                         |                                                                         3|      1  3.0|
      Metaplasia, Focal, Osseous           |                   3                                                      |      2  2.0|
      Nephropathy                          |             1     1                 1                 1                  |      8  1.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                2         |      1  2.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  A  +  +  +  I  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                             3            |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                               X        X                 X               |             
      Hyperplasia, Focal, Lymphoid         |                               2                                          |             
      Infiltration Cellular, Mixed Cell    |                                                 1  1                    1|             
      Necrosis, Focal                      |                                                                   2      |             
      Hepatocyte, Basophilic Focus         |                                                       X                  |             
      Hepatocyte, Eosinophilic Focus       |       X                                               X  X               |             
      Hepatocyte, Mixed Cell Focus         |                                                                          |             
      Hepatocyte, Necrosis, Focal          |                                                    1                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +     +  +        +  +           +     +           +     +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Fat, Necrosis, Focal                 |       1                 1  2           3                 3     3     2  3|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Erosion                              |                                  2                                       |             
      Inflammation, Focal                  |                2                                                         |             
      Epithelium, Hyperplasia              |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              1                           |             
      Thrombosis                           | 3                          4                                             |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Accessory Adrenal Cortical Nodule    |                                                       1                  |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    3                                                                     |             
      Hemorrhage                           |    3                                                                     |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
          Alteration, Focal                |                                                    1     2               |             
      Pars Distalis, Hyperplasia, Focal    |          2                    2                             2            |             
      Pars Intermedia, Hyperplasia, Focal  |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                             3                                       |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Follicle, Degeneration, Cystic, Focal|                         2     2  1                          1  3  1     2|             
      Follicular Cell, Hyperplasia, Focal  |       2           1              2     1           2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |             +  +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             3                                                            |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     4                                    |             
      Cyst                                 |             2                                      2  3  2     3  3     3|             
      Thrombosis                           |                                     4                                    |             
      Bilateral, Cyst                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |             2                                                     3  3   |             
      Endometrium, Hyperplasia, Cystic     |    3  3  2  3  2  3  3  3  1  2  3  3  3  2  2  3  4  3  3  2  2  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2           3              3                 3  3     3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +  +                                +                 +  +   |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Iliac, Ectasia                       |                                                                      3   |             
      Iliac, Hyperplasia, Lymphoid         |                                                 3                        |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                 3                        |             
      Renal, Hyperplasia, Lymphoid         |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   3        3                       4                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Atrophy                              |                                           2                              |             
      Hematopoietic Cell Proliferation     | 3  2        3                       3                    2     3         |             
      Hyperplasia, Lymphoid                |                      3        3     3                 2              2  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  A  +  +  +  +  M  +  +  +  +  I  I  +  +  +  +  M  I  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 3                    3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Control Dermis, Inflammation, Focal  |                                                                         2|             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |    2     2              1                                   2            |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |    2                    2                                   2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Hyperplasia, Squamous        |                               1                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2                                                |             
      Hydronephrosis                       |                            3                                             |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Infarct                              |                                                                         2|             
      Nephropathy                          |    1              1  1           1     1                                 |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic, Focal               |                         2                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Perforation                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |    X           X                          X                              |      6     |
      Hyperplasia, Focal, Lymphoid         |                   2                                                      |      2  2.0|
      Infiltration Cellular, Mixed Cell    | 2     1     1  1        1                                      1     2   |     10  1.2|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Hepatocyte, Basophilic Focus         |                                                                          |      1     |
      Hepatocyte, Eosinophilic Focus       |                                                    X                     |      4     |
      Hepatocyte, Mixed Cell Focus         |                X                                                         |      1     |
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                           +        +                     |  14        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                    3                     |      9  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Acinus, Atrophy, Focal               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                   1      |      1  1.0|
      Erosion                              |                                                 1                        |      2  1.5|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                 2                        |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      2  3.5|
      Artery, Inflammation, Chronic        |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                             2            |      1  2.0|
      Degeneration, Cystic                 |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                              2                           |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                              2        1                  |      4  1.5|
      Pars Distalis, Hyperplasia, Focal    |    2           2                                2                    2   |      7  2.0|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                    2                     |      3  2.7|
      Inflammation, Chronic, Focal         |                                                                1         |      1  1.0|
      Follicle, Degeneration, Cystic, Focal| 2                 1        2              2  2  1     1     2     2  2  2|     18  1.7|
      Follicular Cell, Hyperplasia, Focal  |       1        1                                         1        1      |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 |                4     4                          3           2  3     3   |     13  2.8|
      Thrombosis                           |                                                                          |      1  4.0|
      Bilateral, Cyst                      |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Hyperplasia, Lymphoid                | 3                                                                        |      1  3.0|
      Inflammation, Suppurative            |                2                             3           3               |      6  2.7|
      Endometrium, Hyperplasia, Cystic     | 2  2  3     3  3  3  3  3  3  4  3     3  2  3  3  3  3  3  3  3  3  3  3|     47  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3                                                     3           3     3|     10  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                    +                    +  +        +                  |  10        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Bronchial, Hyperplasia, Lymphoid     |                                              3                           |      1  3.0|
      Iliac, Ectasia                       |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         | 3                                                                        |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                      2                                                   |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                   3      |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                   4                             2                        |      5  3.2|
      Hyperplasia, Lymphoid                |                                                 3              3         |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     | X                                                                        |      1     |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  3  2           2  3  2           4                 3  2        3  2  2|     18  2.6|
      Hyperplasia, Lymphoid                | 4           2                                2           2     3     2   |     12  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Lymphoid                |                3                             3                           |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Control Dermis, Inflammation, Focal  |                                                                          |      1  2.0|
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              | 1                    1                       1                           |      7  1.4|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     | 1           1        1                       1                           |      7  1.4|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                             2            |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |          3                                                               |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                             2            |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3|            |
                                           | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                         4                                               4|      2  4.0|
      Phthisis Bulbi                       |                                                                         X|      1     |
      Cornea, Hyperplasia, Squamous        |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                               2                       2           1      |      4  1.8|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  2.0|
      Nephropathy                          |                      1                 1  1     2  1                 1   |     11  1.1|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic, Focal               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Edema                                |                                           3                              |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                3                                                         |             
      Infiltration Cellular, Mixed Cell    | 1     1                          1  1        1  1           1        1  1|             
      Hepatocyte, Basophilic Focus         |                                                       X                  |             
      Hepatocyte, Clear Cell Focus         |                                                                          |             
      Hepatocyte, Mixed Cell Focus         |                      X     X                          X     X        X   |             
      Hepatocyte, Necrosis, Focal          |                                  1                                       |             
      Hepatocyte, Vacuolization Cytoplasmic|                                        1  4                              |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +           +        +        +     +              +     +         |             
      Inflammation                         |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Fat, Necrosis, Focal                 |       1           3        3        3     1                    3         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |       3                                      4                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Duct, Cyst, Focal, Multiple          |                                              4                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                1         |             
      Inflammation, Focal                  |                                           3                              |             
      Ulcer                                |                                           3                              |             
      Epithelium, Hyperplasia              |                                           3                              |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          1                                                               |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                    +     +               |             
      Malformation                         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                               2           1                 1            |             
      Degeneration, Cystic                 |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  I  I  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                              1                           |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 2                        |             
      Follicle, Degeneration, Cystic, Focal|                            2     1        2           2                  |             
      Follicular Cell, Hyperplasia, Focal  |                      1                                                   |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |       +     +           +                                                |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Lymphoid                        |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |       3           3                 3           4  2        2  2        4|             
      Inflammation, Suppurative            |       4                                                                  |             
      Bilateral, Inflammation, Suppurative |                3                                                         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             2  1                                                         |             
      Thrombosis                           |                            3                                             |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3     2  3  3  1  2  3  2  2  3  3  3  4  3  3  3  3  4  3  3  1  3|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3        3                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |       +        +                                      +  +  +     +  +  +|             
      Iliac, Ectasia                       |       3                                               3     2            |             
      Iliac, Hyperplasia, Lymphoid         |       3                                                              2   |             
      Mediastinal, Hyperplasia, Lymphoid   |       3        3                                                     3   |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                         3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    3        3        3   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3        3        4     2                    2     3               |             
      Hyperplasia, Lymphoid                |                                                       2              3   |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Control Dermis, Hyperplasia, Focal   |                                                                          |             
      Control Dermis, Inflammation, Focal  |                                                                          |             
      Control Epidermis, Hyperplasia, Focal|                                                                          |             
      Site of Application - Dermis,        |                                                                          |             
          Fibrosis                         |                                                                1         |             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                                          |             
      Site of Application - Epidermis,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
           Hyperplasia                     |                1                          1                    1         |             
      Subcutaneous Tissue, Edema           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                    3                    1|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression, Focal                   |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          2                                                               |             
      Foreign Body                         |          1                                                               |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
      Infarct                              |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                    1                     |             
      Nephropathy                          | 1     1        1  1  1              2           1  1                 2   |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                          3               |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Edema                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Epithelium, Hyperplasia, Focal       | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                         X                                                |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    | 1  1  1     1        2  1  1  1  2  2              1  1                 2|     22  1.2|
      Hepatocyte, Basophilic Focus         |                                                                          |      1     |
      Hepatocyte, Clear Cell Focus         |                                                                         X|      1     |
      Hepatocyte, Mixed Cell Focus         |                                                                         X|      6     |
      Hepatocyte, Necrosis, Focal          |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                           2              1              3|      5  2.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +     +     +        +  +  +        +              +     +           +|  18        |
      Inflammation                         |                2                                                         |      1  2.0|
      Artery, Inflammation                 |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis, Focal                 | 3  2           1        3  2           3              3     3           1|     15  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |    1                                                                     |      3  2.7|
      Duct, Cyst, Focal, Multiple          |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1  1.0|
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Ulcer                                |                                                             2            |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Malformation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      3  1.3|
      Degeneration, Cystic                 |                   2                                                      |      1  2.0|
      Necrosis, Focal                      |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                    2              1      |      3  1.7|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |                         2                 2                       2      |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  2.0|
      Follicle, Degeneration, Cystic, Focal|    2  2     2           2  2                 3           1        2      |     12  1.9|
      Follicular Cell, Hyperplasia, Focal  |          2  2                                                        1   |      4  1.5|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic, Focal               |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   4        |
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Lymphoid                        |             2                                                            |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                  3                                       |      1  3.0|
      Cyst                                 | 2  2  3     3           2                 2           3     2        2  2|     18  2.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Suppurative            |                                     3                                    |      2  3.5|
      Bilateral, Inflammation, Suppurative |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Thrombosis                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  3  2  3  3  3  3  3  2  3  3  3  4  3  2  3  3  3  3  3  3  3  3  3|     49  2.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                   +                           |  10        |
      Iliac, Ectasia                       |                                                                          |      3  2.7|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   3           3                                          |      2  3.0|
      Hemorrhage                           |                            3                                             |      1  3.0|
      Hyperplasia, Lymphoid                |       3           3                                                      |      5  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  2     3  2              4        3        3                           |     13  2.8|
      Hyperplasia, Lymphoid                |       2           2              2        3                              |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Control Dermis, Hyperplasia, Focal   |                   1                                                      |      1  1.0|
      Control Dermis, Inflammation, Focal  |                   1                                                      |      1  1.0|
      Control Epidermis, Hyperplasia, Focal|                            1                                             |      1  1.0|
      Site of Application - Dermis,        |                                                                          |            |
          Fibrosis                         |                                                                          |      1  1.0|
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |    1                       2                                             |      2  1.5|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |    1                       2           2                       1         |      7  1.3|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression, Focal                   |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                +         |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                           +                    +         |   2        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8|            |
                                           | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Hyperplasia, Histiocytic             |                         3                                                |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2  1                                                   |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                             3            |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Infarct                              |                                                 2                        |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                                          |      1  1.0|
      Nephropathy                          | 1              1     1     1  1                    2  1  2           1   |     18  1.2|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                             3            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                             +            |   1        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Cyst                                 |                            2                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                               3                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X                                                                        |             
      Eosinophilic Focus                   |                                                                   X      |             
      Fibrosis, Focal                      |                   2                                                      |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                   4                                                      |             
      Infiltration Cellular, Mixed Cell    |       3     1        1                    1  1  1              2         |             
      Bile Duct, Hyperplasia               |                   2                                                      |             
      Hepatocyte, Clear Cell Focus         | X  X  X  X  X           X     X        X     X              X        X   |             
      Hepatocyte, Eosinophilic Focus       |                      X        X                                          |             
      Hepatocyte, Mixed Cell Focus         |                                                                          |             
      Hepatocyte, Necrosis, Focal          |       3  2        2  1                                      1            |             
      Hepatocyte, Vacuolization Cytoplasmic|                      2  2  1  2  1     1              2     1        1   |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Fat, Necrosis, Focal                 |                   2                                                     2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                         1                                                |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +  +     +     +  +  +                 +           +     +  +   |             
      Malformation                         | 2        3  4     2     1  3  4                 3           2     3  2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             1                                         1                  |             
      Cytoplasmic Alteration, Focal        |          2                             1        2        2               |             
      Vacuolization Cytoplasmic, Focal     |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2           3   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    1                                                                     |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                         1                                                |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
          Alteration, Focal                |                      2                                                   |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                     2                                    |             
      Follicle, Degeneration, Cystic, Focal|                   3                             2                        |             
      Follicular Cell, Hyperplasia, Focal  |                      2        2  2        3                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Chronic                | 3                                               4              3  3     3|             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                             3                 3      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +              +                                            +  +      |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                3  3      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Hematopoietic Cell Proliferation     |                                              2  3        3     3  3      |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I|             
      Cyst                                 |                                  2                                       |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                   3      |             
      Epidermis, Hyperplasia, Focal        |                                                                          |             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                 2                        |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                       2                 2|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Hyperplasia, Histiocytic             |                            2                                             |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Inflammation, Chronic, Focal         |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       1                                                     2            |             
      Mediastinum, Hyperplasia, Lymphoid   |                                                             2            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    3                     |             
      Nasolacrimal Duct, Hyperplasia, Focal|                      2                                                   |             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Atrophy                              |                                                    4                     |             
      Inflammation                         |          2                                                               |             
      Cornea, Inflammation, Chronic        |                                              1                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2                                         2                              |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |                                                                          |             
      Metaplasia, Focal, Osseous           |                                     2                                    |             
      Nephropathy                          | 1  2  1  2  2  1  1  1  1  1  1  1  1  1  2  2  3  1  1  2  1  1  1  2  2|             
      Renal Tubule, Hyperplasia, Focal     | 1                                         1                              |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|             
                                           | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  45        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
      Necrosis                             |                4                                                         |      1  4.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A|  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                              3                           |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          2                                                               |      1  2.0|
      Basophilic Focus                     |                                           X                              |      1     |
      Clear Cell Focus                     |                                                          X               |      2     |
      Eosinophilic Focus                   |                                                                   X      |      2     |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                              1                           |      8  1.4|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
      Hepatocyte, Clear Cell Focus         | X     X           X        X           X                 X     X     X   |     19     |
      Hepatocyte, Eosinophilic Focus       |                                                                          |      2     |
      Hepatocyte, Mixed Cell Focus         |                                                                   X      |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hepatocyte, Necrosis, Focal          |                                                                          |      5  1.8|
      Hepatocyte, Vacuolization Cytoplasmic| 2           2           3  2                    3        3     2  1  3   |     18  1.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  49        |
      Fat, Necrosis, Focal                 |                3                       2                                 |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                           2           2                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |          1     2                                                        2|      4  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +           +     +  +  +                                +     +   |  18        |
      Malformation                         |       2           3     3  2  2                                2     2   |     18  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                      1   |      3  1.0|
      Cytoplasmic Alteration, Focal        |       1                 1                       1        1        1      |      9  1.3|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1  1.0|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicle, Degeneration, Cystic, Focal| 1              2                                                         |      4  2.0|
      Follicular Cell, Hyperplasia, Focal  |       1                             2           1                        |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |    3           3                 2                                       |      3  2.7|
      Inflammation, Chronic                | 3                                3  3              3              3  3   |     11  3.1|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |             2                                            2               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |                   2              3  3        3     3  3                  |      9  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                +                                   +                     |   6        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                      3           3                                       |      3  3.0|
      Hyperplasia, Lymphoid                |                                        3                 2               |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    3     3           3           3  3     2  2     4  3     2            |     15  2.8|
      Hyperplasia, Lymphoid                |                                                                   3      |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |             2                                                            |      2  2.0|
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  3.0|
      Epidermis, Hyperplasia, Focal        |                         1                                                |      1  1.0|
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |                                                    2                     |      2  2.0|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |                                                    2                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 1                                                     1                  |      4  1.3|
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                   2                                                      |      2  2.5|
      Nasolacrimal Duct, Hyperplasia, Focal|                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation      |                                              2                           |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9|            |
                                           | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    0 MG/KG                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Eye                                     | +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
      Atrophy                              |                                                                          |      1  4.0|
      Inflammation                         |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                3         |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                      4                                                   |      1  4.0|
      Epithelium, Hyperplasia, Focal       |       2                             2                 2                  |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Cyst                                 |                         1                                                |      3  1.7|
      Hydronephrosis                       |                      3                             2                     |      2  2.5|
      Infarct                              |                   1        2                                             |      2  1.5|
      Metaplasia, Focal, Osseous           |       2                                         1              2         |      4  1.8|
      Nephropathy                          | 1     2  1  2  1  2  3  1  1        1  1  1  2  1  2  2  1  1  1  2  1   |     46  1.4|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|             
                                           | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |                                                                          |             
      Epithelium, Degeneration, Hyaline    |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Focal                  |                                                 3                        |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |    3                                                                     |             
      Infiltration Cellular, Mixed Cell    |                         3        1                                       |             
      Pigmentation, Focal                  |    3                                                                     |             
      Hepatocyte, Clear Cell Focus         | X     X     X              X        X  X           X              X      |             
      Hepatocyte, Mixed Cell Focus         |                      X                                                   |             
      Hepatocyte, Necrosis, Focal          |                1                          3                              |             
      Hepatocyte, Vacuolization Cytoplasmic|       2     2  3           3        2  2                    2     2      |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Inflammation                         |                                                    3                     |             
      Artery, Inflammation                 |                               3                                          |             
      Fat, Necrosis, Focal                 |                                     3              3                     |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|             
                                           | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +              +           +        +  +           +        +  +  +      |             
      Malformation                         | 2              3           2        3  2           2        3  3  3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                       4                  |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        1                                 |             
      Cytoplasmic Alteration, Focal        |       1           1                                                      |             
      Hyperplasia, Focal, Histiocytic      |                               2                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          1                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|             
                                           | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Degeneration, Cystic, Focal|    2  3           2                                            2         |             
      Follicular Cell, Hyperplasia, Focal  |                2                       1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |             3                                                            |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                3         |             
      Hyperplasia, Lymphoid                |    4                                                                     |             
      Inflammation, Chronic                |    3     3                    4     3                                    |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          4               |             
      Epithelium, Hyperplasia, Focal       |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3                                                            |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3     3        3     3                 3     3  3              3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +              +                                          |             
      Bronchial, Hyperplasia, Lymphoid     |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                               3                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|             
                                           | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                3                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                         3                                                |             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Lymphoid                |                                                                         3|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3                    3     3                       3  3           3   |             
      Hyperplasia, Lymphoid                |          2     2           2           3        3                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  +  +  I  +  +|             
      Cyst                                 |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                          1           3   |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |                                                                      3   |             
      Site of Application, Ulcer           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|             
                                           | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    10 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                   1      |             
      Hyperplasia, Lymphoid                |                                                                   1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Hyperplasia, Focal| 2                                                                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cornea, Hyperplasia, Squamous        |                                                                          |             
      Cornea, Inflammation, Chronic        |                2                                                         |             
      Cornea, Necrosis, Focal              |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 2           2        2                 2                                 |             
      Hydronephrosis                       |                                                                          |             
      Infarct                              |       2                    2                                             |             
      Metaplasia, Focal, Osseous           |    2                                                                     |             
      Nephropathy                          | 2  1  1  2  2  2  2  1  3  1  2  1  2  1        2  2  4  2  1  1  1  2  2|             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          3               |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  I  +  +  +  A  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +|  42        |
      Cyst                                 |                               2                                          |      1  2.0|
      Epithelium, Degeneration, Hyaline    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +|  43        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +|  44        |
      Ectopic Tissue                       |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +|  43        |
      Inflammation, Focal                  |                                                                          |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |    X                                                                     |      1     |
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |          1     1                                                  1      |      5  1.4|
      Pigmentation, Focal                  |                                                                          |      1  3.0|
      Hepatocyte, Clear Cell Focus         |       X        X              X  X  X        X        X        X     X   |     17     |
      Hepatocyte, Mixed Cell Focus         |       X                                                                  |      2     |
      Hepatocyte, Necrosis, Focal          |                                                    3                     |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic| 2     1                 2        2     2     1        2        2     2   |     17  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         |                                                                          |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis, Focal                      |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                            2                                             |      1  2.0|
      Epithelium, Hyperplasia              |                            2                                             |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  47        |
      Erosion                              |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                              +                          +|  11        |
      Malformation                         |                                              2                          2|     11  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                        2                                 |      2  1.5|
      Cytoplasmic Alteration, Focal        |          1              1                                      2         |      5  1.2|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                          2               |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  I  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                          1               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       1                             2                 2                  |      3  1.7|
      Follicle, Degeneration, Cystic, Focal|                   2                                                  2   |      6  2.2|
      Follicular Cell, Hyperplasia, Focal  | 2  1                             1                       1  1            |      7  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spermatocele                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic                | 4                             3           3                             3|      8  3.3|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  4.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3                 3                       2              3  3            |     13  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                             +                       +                  |   5        |
      Bronchial, Hyperplasia, Lymphoid     |                                                       3                  |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      | 3                             3                                          |      3  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          3               |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |             2     2                       3     2        2  3           2|     13  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +|  44        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |                                                                          |      2  2.0|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |                   2                                      2               |      3  2.3|
      Site of Application, Ulcer           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |    2                                                                     |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +        +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Histiocytic             |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                         1                                2               |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Cyst              |                   2                                                      |      1  2.0|
      Nasolacrimal Duct, Hyperplasia, Focal|          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2|            |
                                           | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      A     |
    10 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Cornea, Hyperplasia, Squamous        |                               2                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                   3           2                                          |      3  2.3|
      Cornea, Necrosis, Focal              |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic, Focal          |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |       2     2                 2     2                       2        2   |     10  2.0|
      Hydronephrosis                       |                                                             3            |      1  3.0|
      Infarct                              |             2                                                            |      3  2.0|
      Metaplasia, Focal, Osseous           |    2                                                                     |      2  2.0|
      Nephropathy                          | 2  2  1  1  1  1  2     1     2  1  1     1  1  1  1  2  1     2  2  1  2|     44  1.6|
      Renal Tubule, Hyperplasia, Focal     |       1                                               2                 2|      3  1.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  A  +  A|             
      Cyst                                 |                                              1                           |             
      Epithelium, Degeneration, Hyaline    |                                                    3                     |             
      Epithelium, Hyperplasia              |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A|             
      Inflammation, Focal                  |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  A|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |          X                                                               |             
      Eosinophilic Focus                   |                                              X                           |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                   1                       3                          1   |             
      Thrombosis                           |                                                                         4|             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Clear Cell Focus         | X     X  X     X                                   X                     |             
      Hepatocyte, Necrosis, Focal          |                                           2                              |             
      Hepatocyte, Vacuolization Cytoplasmic|       2  2                                   2           2               |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                2                                                         |             
      Fat, Necrosis, Focal                 | 2                                                  1                 2   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                         2                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                 2                        |             
      Epithelium, Hyperplasia              |                                              1  2                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Erosion                              |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +        +              +           +              +        +            |             
      Malformation                         | 2        3              2           3              3        3            |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            |          +                                                               |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                         2|             
      Inflammation, Chronic, Focal         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          1                                                               |             
      Cytoplasmic Alteration, Focal        |                         1                             1              1   |             
      Hypertrophy                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                         2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2           3                              |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                1                                                         |             
      Pars Distalis, Cytoplasmic           |                                                                          |             
          Alteration, Focal                |                                  2  1                                    |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Degeneration, Cystic, Focal|          2              2              2  3                             2|             
      Follicular Cell, Hyperplasia, Focal  |    2           2  1                                   2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
      Abdominal, Cyst                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |             3                                                            |             
      Inflammation, Chronic                |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Chronic                |                3     3  3  1           3                                 |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Interstitial Cell, Hyperplasia, Focal|                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3              3                 2     3  3                              |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +                       +           +                     |             
      Inguinal, Hyperplasia, Lymphoid      |                2                       3                                 |             
      Mediastinal, Hyperplasia, Lymphoid   |                2                                                         |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                           3                              |             
      Hemorrhage                           |    3                                                                    3|             
      Hyperplasia, Lymphoid                |                                           3                          3   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                2         |             
      Hematopoietic Cell Proliferation     |    3           3           3              4              2  3           3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  I|             
      Cyst                                 |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Hyperplasia, Focal        |                                     1                                    |             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              | 1     1              2        2     1     3           1  1               |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     | 2     2              2        2           2           1  2  2            |             
      Site of Application, Ulcer           |                                           3                              |             
      Subcutaneous Tissue, Angiectasis,    |                                                                          |             
           Focal                           |                   3                                                      |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
           Chronic, Focal                  |                   3                                                      |             
      Subcutaneous Tissue, Thrombosis      |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasolacrimal Duct, Hyperplasia, Focal|                                              3                           |             
      Nasolacrimal Duct, Inflammation      |                                              3                           |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|             
                             DAY ON TEST   | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|             
                                           | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    20 MG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                           2                              |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Nephropathy                          | 1  2  2  1  2  2  2  1     2  1  1  2  2     2     1  1  2  2        1  3|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  A|  43        |
      Cyst                                 |                                  2                                       |      2  1.5|
      Epithelium, Degeneration, Hyaline    |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  44        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  44        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A|  44        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Infarct                              |                               3                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |    1                                                     1               |      5  1.4|
      Thrombosis                           |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               |                               3                                          |      1  3.0|
      Hepatocyte, Clear Cell Focus         |    X  X  X              X              X           X              X      |     12     |
      Hepatocyte, Necrosis, Focal          |                                  3                                       |      2  2.5|
      Hepatocyte, Vacuolization Cytoplasmic|       2     2           3           1  2  3  1     2  1     3  2  2  1   |     17  1.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Fat, Necrosis, Focal                 |                   3                                                      |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              | 2                                                                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Erosion                              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +        +     +     +              +           +  +  +        +      |  15        |
      Malformation                         |    3        2     1     2              3           3  3  3        2      |     15  2.5|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                          2               |      1  2.0|
      Pulp, Inflammation                   |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |             +                                                            |   2        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    | 2                                                                        |      2  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cytoplasmic Alteration, Focal        |                            1           2  1                          3   |      7  1.4|
      Hypertrophy                          |                                                                4         |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |       3                                                                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                2                                   2                     |      3  1.7|
      Pars Distalis, Cytoplasmic           |                                                                          |            |
          Alteration, Focal                |                                                          1     2     1   |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Degeneration, Cystic, Focal| 1                                         1              1               |      8  1.8|
      Follicular Cell, Hyperplasia, Focal  |          2           1     1                                             |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                  +|   3        |
      Abdominal, Cyst                      |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                         3|      1  3.0|
      Inflammation, Chronic                |             3  3              4     3                 3                  |     10  2.9|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia, Focal|                                           1                              |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 3        3           3        3     3                    3           3   |     12  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                               +     +                                    |   5        |
      Inguinal, Hyperplasia, Lymphoid      |                               3     3                                    |      4  2.8|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Ectasia                              |                                                                          |      1  3.0|
      Hemorrhage                           |                                        3                                 |      3  3.0|
      Hyperplasia, Lymphoid                |                3                                         3               |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                   3  2        3  2  3                                2  3|     14  2.8|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                           2                              |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Hyperplasia, Focal        |                                                                          |      1  1.0|
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |          1                                                               |      9  1.4|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |          2           1                                                   |     10  1.8|
      Site of Application, Ulcer           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Angiectasis,    |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic, Focal                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Thrombosis      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                          +               |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9|            |
                                           | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    20 MG/KG                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                         3|      1  3.0|
      Hyperplasia, Histiocytic             | 3        3           3                 3                                 |      4  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                1         |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |          2                                                               |      1  2.0|
      Nasolacrimal Duct, Hyperplasia, Focal|                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation      |                                                                         3|      2  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Cornea, Inflammation, Chronic        |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia, Focal       |                               1                 2                        |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      2              2                 2           2  2   |      5  2.0|
      Infarct                              |                               2                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                       1                  |      1  1.0|
      Nephropathy                          | 2  2  1  1  1  2     2  2  1     1  1     2  1  1  1  2  2  1  2  2  2   |     41  1.6|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Gallbladder                             | M  A  +  +  +  +  A  +  +  +  +  +  M  +  +  I  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  +  +  +  A  +  I  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                                                    X                     |             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                              2                           |             
      Infarct                              |                                                                         4|             
      Infiltration Cellular, Mixed Cell    | 3                                1        1                 1     1      |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Capsule, Inflammation, Chronic       |                                                                          |             
      Hepatocyte, Clear Cell Focus         |                                  X     X                                 |             
      Hepatocyte, Mixed Cell Focus         |                            X     X                                       |             
      Hepatocyte, Necrosis, Focal          |                   2              1        1        2  1                  |             
      Hepatocyte, Vacuolization Cytoplasmic|          2                 2  2  3     3        2  1  3                  |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |                                                                         3|             
      Fat, Necrosis, Focal                 | 2                                                  2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               | 3                                         3                              |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         | 2                                                                        |             
      Inflammation, Focal                  |                                                                          |             
      Epithelium, Cyst                     |       1                                                                  |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +     +        +                       +           +  +                 +|             
      Malformation                         | 2     3        2                       3           3  3                 3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                              2                           |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         3                                                |             
      Cytoplasmic Alteration, Focal        |                                                                         1|             
      Degeneration, Cystic                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Degeneration, Cystic, Focal|                   2                                                  2   |             
      Follicular Cell, Hyperplasia, Focal  |                      1     1                                      1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                   +                                                      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       3     3            |             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Chronic                |                                  3              4              3         |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                3                             3                           |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4                 3                 2                                2   |             
      Thrombosis                           |                                                                         1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                          4               |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2              3  3              3                    2              2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Thrombosis                           |                                                                   3      |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Site of Application - Dermis,        |                                                                          |             
          Inflammation, Focal              |                                                                          |             
      Site of Application - Epidermis,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Site of         |                                                                          |             
          Application, Infiltration        |                                                                          |             
          Cellular                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                              +                    +      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +                             +                    +      |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                              +                    +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    2                    2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      | 2                 1                                                  2   |             
                                           |__________________________________________________________________________|             
   Pleura                                  |                               +                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Hyperplasia, Squamous        |          1                                                               |             
      Cornea, Inflammation, Chronic        |                         3                                            3   |             
      Cornea, Necrosis, Focal              |                                                                      3   |             
      Retrobulbar, Inflammation            |                                                             2            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|             
                                           | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    40 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2     1                                      2   |             
      Infarct                              |                                        2                                 |             
      Inflammation                         |                3                                                         |             
      Nephropathy                          |       1  1  1     2  3  1  2     1     1  1     1  1  1  1  1  1  1  1  3|             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                3                             3                           |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  41        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|  42        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|  40        |
      Serosa, Inflammation, Chronic        |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|  40        |
      Cyst                                 |          3                                                               |      1  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|  40        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |                                              X                           |      2     |
      Eosinophilic Focus                   |                                  X           X                 X         |      4     |
      Hemorrhage, Focal                    |                                                                   3      |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                        1                                 |      6  1.3|
      Inflammation, Focal, Granulomatous   |                                                                   3      |      1  3.0|
      Capsule, Inflammation, Chronic       |                                                                      3   |      1  3.0|
      Hepatocyte, Clear Cell Focus         |                      X     X  X           X  X     X                     |      8     |
      Hepatocyte, Mixed Cell Focus         |                                                                          |      2     |
      Hepatocyte, Necrosis, Focal          |    3                                                        3            |      7  1.9|
      Hepatocyte, Vacuolization Cytoplasmic| 3                    3  3  2  2  1        2  2     3           1         |     18  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                      3   |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 | 2                                               2                        |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                        2                                 |      3  2.7|
      Serosa, Inflammation, Chronic        |                                                                      3   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                                                                          |      1  2.0|
      Inflammation, Focal                  |                                                       2                  |      1  2.0|
      Epithelium, Cyst                     |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |                2                                      2                  |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                      +     +     +        +                    +         |  12        |
      Malformation                         |                      3     2     2        2                    2         |     12  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                    1                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      2  2.0|
      Cytoplasmic Alteration, Focal        |                               2           1                       2      |      4  1.5|
      Degeneration, Cystic                 |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Cyst                                 |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                        1              2        3         |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicle, Degeneration, Cystic, Focal|                      1           2                                   1  2|      6  1.7|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                          +               |   2        |
      Hemorrhage                           |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                  2                                       |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2  3.0|
      Degeneration, Cystic                 |                3     3     3                                         3   |      4  3.0|
      Inflammation, Chronic                |                2                 3                                3      |      6  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        3                          3  3   |      7  2.9|
      Thrombosis                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                            +                 +   |   4        |
      Iliac, Hyperplasia, Lymphoid         |                                                                      3   |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                      3   |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                    3                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                         3|      2  3.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  47        |
      Fibrosis, Focal                      |                                                       3                  |      1  3.0|
      Hematopoietic Cell Proliferation     |       3  2                             2              3           3  3   |     13  2.6|
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Capsule, Inflammation, Chronic       |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  A  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Site of Application - Dermis,        |                                                                          |            |
          Inflammation, Focal              |                                        1                                 |      1  1.0|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |                                        1                                 |      1  1.0|
      Subcutaneous Tissue, Edema           |       2                                                              3   |      2  2.5|
      Subcutaneous Tissue, Site of         |                                                                          |            |
          Application, Infiltration        |                                                                          |            |
          Cellular                         |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |       +        +                                                     +   |   5        |
      Inflammation, Chronic                |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   3        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                    +                     |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                              1                           |      3  1.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 93020-08                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                      DIISOPROPYLCARBODIIMIDE                                  Date: 07/19/04    
Route: SKIN APPLICATION                                                                                           Time: 09:18:40    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2|            |
                                           | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    40 MG/KG                               | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation      |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Pleura                                  |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  44        |
      Cornea, Hyperplasia, Squamous        |                                                                          |      1  1.0|
      Cornea, Inflammation, Chronic        |                                                 2                        |      3  2.7|
      Cornea, Necrosis, Focal              |                                                                          |      1  3.0|
      Retrobulbar, Inflammation            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                    1                     |      1  1.0|
      Epithelium, Hyperplasia, Focal       |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      3  1.7|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation                         |                                        1                             3   |      3  2.3|
      Nephropathy                          | 2  1  2  1     1     1  1  1  1  1  1     1  2  1  2  2     1  1  2  3  1|     40  1.4|
      Pelvis, Dilatation                   |                                                                      3   |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |                               1                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.