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TDMS Study 05195-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: TSI Mason Research                                      SODIUM SELENATE                                   DATE: 10/19/04       
EXPERIMENT: 05195 TEST: 03                                                                                     TIME: 06:59:52       
TEST TYPE:  SUBCHRON 90-DAY                                                                                    PAGE:       1        
CONT: N01ES75146                                ROUTE: DOSED WATER                                             NTP C#: C62113       
PATHOLOGIST: F. VOELKER                      S. EUSTIS                       M.                                CAS: 13410-01-0      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0       PPM                                                                   
                                       INCLUDE 002    0       PPM                                                                   
                                       INCLUDE 003    3.75    PPM                                                                   
                                       INCLUDE 004    3.75    PPM                                                                   
                                       INCLUDE 005    7.5     PPM                                                                   
                                       INCLUDE 006    7.5     PPM                                                                   
                                       INCLUDE 007    15      PPM                                                                   
                                       INCLUDE 008    15      PPM                                                                   
                                       INCLUDE 009    30      PPM                                                                   
                                       INCLUDE 010    30      PPM                                                                   
                                       INCLUDE 011    60      PPM                                                                   
                                       INCLUDE 012    60      PPM                                                                   
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: TSI Mason Research                                      SODIUM SELENATE                                   DATE: 10/19/04       
EXPERIMENT: 05195 TEST: 03                                                                                     TIME: 06:59:52       
TEST TYPE:  SUBCHRON 90-DAY                                                                                                         
CONT: N01ES75146                                ROUTE: DOSED WATER                                             NTP C#: C62113       
PATHOLOGIST: F. VOELKER                      S. EUSTIS                       M.                                CAS: 13410-01-0      
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     SODIUM SELENATE                                                                              
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Bone Marrow: Femoral                   Depletion Cellular                                                                           
                                       Pigmentation Hemosiderin                                                                     
Bone: Distal, Femur, Metaphysis        Atrophy                                                                                      
Epididymis: Lumen                      Degeneration                                                                                 
Heart                                  Cardiomyopathy                                                                               
Kidney                                 Mineralization Focal                                                                         
Kidney: Papilla                        Degeneration                                                                                 
Kidney: Renal Tubule                   Dilatation Focal                                                                             
Liver                                  Hematopoietic Cell Proliferation Focal                                                       
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Necrosis Focal                                                                               
Lymph Node, Mandibular: Lymphocyte     Depletion Cellular                                                                           
Lymph Node, Mesenteric: Lymphocyte     Depletion Cellular                                                                           
Pancreas                               Atrophy                                                                                      
Preputial Gland                        Atrophy                                                                                      
Salivary Glands                        Atrophy                                                                                      
Seminal Vesicle                        Atrophy                                                                                      
Spleen: Lymphocyte                     Depletion Cellular                                                                           
Stomach, Forestomach: Mucosa           Erosion Focal                                                                                
Stomach, Glandular: Mucosa             Hemorrhage Focal                                                                             
Testes: Germinal Epithelium            Degeneration                                                                                 
Thymus                                 Depletion Lymphoid                                                                           
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow: Femoral                   Depletion Cellular                                                                           
                                       Pigmentation Hemosiderin                                                                     
Bone: Distal, Femur, Metaphysis        Atrophy                                                                                      
Clitoral Gland                         Atrophy                                                                                      
Kidney                                 Mineralization Focal                                                                         
Kidney: Papilla                        Degeneration                                                                                 
Liver                                  Hematopoietic Cell Proliferation Focal                                                       
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Inflammation Focal                                                                           
                                       Necrosis Focal                                                                               
Lymph Node, Mandibular: Lymphocyte     Depletion Cellular                                                                           
Lymph Node, Mesenteric                 Hyperplasia Lymphoid                                                                         
Lymph Node, Mesenteric: Lymphocyte     Depletion Cellular                                                                           
Mammary Gland                          Atrophy                                                                                      
Ovary                                  Cyst                                                                                         
Ovary: Interstitium                    Atrophy                                                                                      
Pancreas                               Atrophy                                                                                      
Salivary Glands                        Atrophy                                                                                      
Spleen: Lymphocyte                     Depletion Cellular                                                                           
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: TSI Mason Research                                      SODIUM SELENATE                                   DATE: 10/19/04       
EXPERIMENT: 05195 TEST: 03                                                                                     TIME: 06:59:52       
TEST TYPE:  SUBCHRON 90-DAY                                                                                                         
CONT: N01ES75146                                ROUTE: DOSED WATER                                             NTP C#: C62113       
PATHOLOGIST: F. VOELKER                      S. EUSTIS                       M.                                CAS: 13410-01-0      
Stomach, Glandular: Mucosa             Hemorrhage Focal                                                                             
Thymus                                 Depletion Lymphoid                                                                           
Uterus: Endometrium                    Atrophy                                                                                      
===============================================================                                                                     
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                      SODIUM SELENATE                  
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          2/3.14          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             63.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.136         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.059         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.091         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.046 *       | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         8/10 (80%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        10/10.00         0/0.00           0/0.00           0/0.00           8/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        100.0%           0.0%             0.0%             0.0%             80.0%            0.0%            | 
|TERMINAL (d)       |        10/10 (100%)     0/0 (0%)         0/0 (0%)         0/0 (0%)         8/10 (80%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.234N         (e)              (e)              (e)              P=0.234N         P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.227N         P=0.017N*       | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.227N         P<0.001N**      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.227N         P=0.782N        | 
|LOGISTIC REGRESSION|        P=0.234N         (e)              (e)              (e)              P=0.234N         (e)             | 
|COCH-ARM / FISHERS |        P<0.001N**       (e)              (e)              (e)              P=0.237N         P<0.001N**      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Femoral                                                                                                             | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        9/10 (90%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/10.00          9/10.00          9/9.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             90.0%            98.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        9/10 (90%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.494         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Femoral                                                                                                             | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/10 (0%)        3/10 (30%)       10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/10.00          3/10.00          10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             30.0%            100.0%           100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/10 (0%)        3/10 (30%)       10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              P=0.111          P<0.001 **       P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              P=0.095          P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              P=0.095          P<0.001 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              P=0.095          P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.111          P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              P=0.105          P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Femoral                                                                                                             | 
|     Pigmentation Hemosiderin                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)        5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/10.00          0/10.00          5/5.95          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             84.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.006 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.992          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Femoral                                                                                                             | 
|     Pigmentation Hemosiderin                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/10.00          0/10.00          0/10.00          3/3.32          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             90.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              35              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.014 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.004 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.010 *       | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|LOGISTIC REGRESSION|        P=0.622          (e)              (e)              (e)              (e)              P=0.976         | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Distal, Femur, Metaphysis                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/10.00          3/10.00          9/9.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             30.0%            98.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/10 (0%)        3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.111          P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.095          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.031 *        (e)              (e)              (e)              P=0.111          P=0.494         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.105          P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone: Distal, Femur, Metaphysis                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/10 (0%)        0/10 (0%)        9/10 (90%)       10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/10.00          0/10.00          9/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             90.0%            100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/10 (0%)        0/10 (0%)        9/10 (90%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/1 (0%)         0/10 (0%)        10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/1.00           0/1.00           0/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/1 (0%)         0/1 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Lumen                                                                                                                | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          9/9.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.265          (e)              (e)              (e)              (e)              P=0.494         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis: Lumen                                                                                                                | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        5/10.00          0/0.00           0/0.00           0/0.00           3/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        50.0%            0.0%             0.0%             0.0%             30.0%            0.0%            | 
|TERMINAL (d)       |        5/10 (50%)       0/0 (0%)         0/0 (0%)         0/0 (0%)         3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.328N         P=1.000          P=1.000N         P=1.000N         P=0.328N         P=1.000N        | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.329N         P=0.483N        | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.329N         P=0.237N        | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.329N         P=0.612N        | 
|LOGISTIC REGRESSION|        P=0.328N         (e)              (e)              (e)              P=0.328N         (e)             | 
|COCH-ARM / FISHERS |        P=0.011N*        P=1.000          P=1.000          P=1.000          P=0.325N         P=0.016N*       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/3 (0%)         0/6 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/3.00           0/6.00           0/10.00          1/2.17          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             46.2%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/3 (0%)         0/6 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              35              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.033 *        (e)              (e)              (e)              (e)              P=0.318         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.280         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.335         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.254         | 
|LOGISTIC REGRESSION|        P=0.995          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.199          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        9/10 (90%)       0/1 (0%)         0/5 (0%)         0/8 (0%)         4/10 (40%)       4/10 (40%)      | 
|POLY-3 RATE (b)    |        9/10.00          0/1.00           0/5.00           0/8.00           4/10.00          4/4.27          | 
|POLY-3 PERCENT (g) |        90.0%            0.0%             0.0%             0.0%             40.0%            93.6%           | 
|TERMINAL (d)       |        9/10 (90%)       0/1 (0%)         0/5 (0%)         0/8 (0%)         4/10 (40%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           24              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.010 *        P=0.205N         P=0.003N**       P<0.001N**       P=0.034N*        P<0.001 **      | 
|POLY 3             |        P=0.444N         P=0.146N         P<0.001N**       P<0.001N**       P=0.018N*        P=0.761         | 
|POLY 1.5           |        P=0.454N         P=0.146N         P<0.001N**       P<0.001N**       P=0.018N*        P=0.516N        | 
|POLY 6             |        P=0.433N         P=0.146N         P<0.001N**       P<0.001N**       P=0.018N*        P=0.658         | 
|LOGISTIC REGRESSION|        P=0.149N         (e)              (e)              (e)              P=0.034N*        P=0.999         | 
|COCH-ARM / FISHERS |        P=0.312N         P=0.182N         P=0.002N**       P<0.001N**       P=0.029N*        P=0.029N*       | 
|ORDER RESTRICTED   |        P=0.009N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         3/3 (100%)       6/6 (100%)       6/10 (60%)       7/10 (70%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           3/3.00           6/6.00           6/10.00          7/7.13          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             100.0%           100.0%           60.0%            98.2%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         3/3 (100%)       6/6 (100%)       6/10 (60%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              92 (T)           92 (T)           92 (T)           26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              P=0.003 **       P<0.001 **       P=0.009 **       P<0.001 **      | 
|POLY 3             |        (e)              (e)              P=0.003 **       P<0.001N**       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              P=0.003 **       P<0.001N**       P<0.001 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              P=0.003 **       P<0.001N**       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.008 **       (e)              P=0.003 **       P<0.001 **       P=0.009 **       P=0.073         | 
|COCH-ARM / FISHERS |        P=0.037 *        (e)              P=0.003 **       P<0.001 **       P=0.005 **       P=0.002 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       1/1 (100%)       5/5 (100%)       8/8 (100%)       7/10 (70%)       6/10 (60%)      | 
|POLY-3 RATE (b)    |        1/10.00          1/1.00           5/5.00           8/8.00           7/10.00          6/6.17          | 
|POLY-3 PERCENT (g) |        10.0%            100.0%           100.0%           100.0%           70.0%            97.2%           | 
|TERMINAL (d)       |        1/10 (10%)       1/1 (100%)       5/5 (100%)       8/8 (100%)       7/10 (70%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.205          P=0.003 **       P<0.001 **       P=0.013 *        P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.146          P<0.001 **       P<0.001 **       P=0.003 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.146          P<0.001 **       P<0.001 **       P=0.003 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.146          P<0.001 **       P<0.001 **       P=0.003 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.031 *        P=0.205          P=0.003 **       P<0.001 **       P=0.013 *        P=0.989         | 
|COCH-ARM / FISHERS |        P=0.281          P=0.182          P=0.002 **       P<0.001 **       P=0.010 *        P=0.029 *       | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/0 (0%)         0/3 (0%)         0/6 (0%)         1/10 (10%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        1/10.00          0/0.00           0/3.00           0/6.00           1/10.00          2/2.63          | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             0.0%             0.0%             10.0%            76.2%           | 
|TERMINAL (d)       |        1/10 (10%)       0/0 (0%)         0/3 (0%)         0/6 (0%)         1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              ---              ---              92 (T)           35              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=1.000          P=0.739N         P=0.602N         P=0.766          P=0.010 *       | 
|POLY 3             |        (e)              (e)              P=0.732N         P=0.600N         P=0.760          P=0.147         | 
|POLY 1.5           |        (e)              (e)              P=0.732N         P=0.600N         P=0.760          P=0.222         | 
|POLY 6             |        (e)              (e)              P=0.732N         P=0.600N         P=0.760          P=0.123         | 
|LOGISTIC REGRESSION|        P=0.274          (e)              (e)              (e)              P=0.766          P=0.437         | 
|COCH-ARM / FISHERS |        P=0.235          P=1.000          P=0.769N         P=0.625N         P=0.763N         P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/5 (0%)         0/8 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/5.00           0/8.00           0/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/5 (0%)         0/8 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation Focal                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        4/10 (40%)       2/6 (33%)        4/8 (50%)        2/10 (20%)       4/10 (40%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        4/10.00          2/6.00           4/8.00           2/10.00          4/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        40.0%            33.3%            50.0%            20.0%            40.0%            0.0%            | 
|TERMINAL (d)       |        4/10 (40%)       2/6 (33%)        4/8 (50%)        2/10 (20%)       4/10 (40%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.598N         P=0.602N         P=0.521          P=0.317N         P=0.672          P=1.000N        | 
|POLY 3             |        P=0.486N         P=0.599N         P=0.520          P=0.318N         P=0.667          P=0.525N        | 
|POLY 1.5           |        P=0.352N         P=0.599N         P=0.520          P=0.318N         P=0.667          P=0.317N        | 
|POLY 6             |        P=0.514N         P=0.599N         P=0.520          P=0.318N         P=0.667          P=0.626N        | 
|LOGISTIC REGRESSION|        P=0.598N         P=0.602N         P=0.521          P=0.317N         P=0.672          (e)             | 
|COCH-ARM / FISHERS |        P=0.030N*        P=0.608N         P=0.520          P=0.314N         P=0.675N         P=0.043N*       | 
|ORDER RESTRICTED   |        P=0.634N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation Focal                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        7/10 (70%)       5/8 (63%)        3/7 (43%)        2/10 (20%)       3/10 (30%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        7/10.00          5/8.00           3/7.00           2/10.00          3/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        70.0%            62.5%            42.9%            20.0%            30.0%            0.0%            | 
|TERMINAL (d)       |        7/10 (70%)       5/8 (63%)        3/7 (43%)        2/10 (20%)       3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.052N         P=0.565N         P=0.274N         P=0.040N*        P=0.095N         P=1.000N        | 
|POLY 3             |        P=0.018N*        P=0.563N         P=0.273N         P=0.024N*        P=0.082N         P=0.561N        | 
|POLY 1.5           |        P=0.014N*        P=0.563N         P=0.273N         P=0.024N*        P=0.082N         P=0.201N        | 
|POLY 6             |        P=0.018N*        P=0.563N         P=0.273N         P=0.024N*        P=0.082N         P=0.672N        | 
|LOGISTIC REGRESSION|        P=0.052N         P=0.565N         P=0.274N         P=0.040N*        P=0.095N         (e)             | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.563N         P=0.268N         P=0.035N*        P=0.089N         P=0.002N**      | 
|ORDER RESTRICTED   |        P=0.693N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       3/6 (50%)        3/8 (38%)        0/10 (0%)        1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        2/10.00          3/6.00           3/8.00           0/10.00          1/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        20.0%            50.0%            37.5%            0.0%             10.0%            0.0%            | 
|TERMINAL (d)       |        2/10 (20%)       3/6 (50%)        3/8 (38%)        0/10 (0%)        1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.156N         P=0.250          P=0.387          P=0.234N         P=0.500N         P=1.000N        | 
|POLY 3             |        P=0.069N         P=0.246          P=0.389          P=0.227N         P=0.500N         P=0.630N        | 
|POLY 1.5           |        P=0.061N         P=0.246          P=0.389          P=0.227N         P=0.500N         P=0.515N        | 
|POLY 6             |        P=0.070N         P=0.246          P=0.389          P=0.227N         P=0.500N         P=0.681N        | 
|LOGISTIC REGRESSION|        P=0.156N         P=0.250          P=0.387          (e)              P=0.500N         (e)             | 
|COCH-ARM / FISHERS |        P=0.028N*        P=0.242          P=0.382          P=0.237N         P=0.500N         P=0.237N        | 
|ORDER RESTRICTED   |        P=0.631N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        3/8 (38%)        5/7 (71%)        1/10 (10%)       1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          3/8.00           5/7.00           1/10.00          1/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             37.5%            71.4%            10.0%            10.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        3/8 (38%)        5/7 (71%)        1/10 (10%)       1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.379N         P=0.074          P=0.005 **       P=0.500          P=0.500          (e)             | 
|POLY 3             |        P=0.234N         P=0.053          P<0.001 **       P=0.500          P=0.500          (e)             | 
|POLY 1.5           |        P=0.198N         P=0.053          P<0.001 **       P=0.500          P=0.500          (e)             | 
|POLY 6             |        P=0.237N         P=0.053          P<0.001 **       P=0.500          P=0.500          (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.074          P=0.005 **       P=0.500          P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.054N         P=0.069          P=0.003 **       P=0.500          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.755N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        1/6 (17%)        1/8 (13%)        0/10 (0%)        1/10 (10%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          1/6.00           1/8.00           0/10.00          1/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        0.0%             16.7%            12.5%            0.0%             10.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        1/6 (17%)        1/8 (13%)        0/10 (0%)        1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.705          P=0.398          P=0.455          (e)              P=0.500          (e)             | 
|POLY 3             |        P=0.569          P=0.396          P=0.455          (e)              P=0.500          (e)             | 
|POLY 1.5           |        P=0.609          P=0.396          P=0.455          (e)              P=0.500          (e)             | 
|POLY 6             |        P=0.560          P=0.396          P=0.455          (e)              P=0.500          (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.398          P=0.455          (e)              P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.426N         P=0.375          P=0.444          (e)              P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.759          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        2/8 (25%)        0/7 (0%)         1/10 (10%)       4/10 (40%)       0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          2/8.00           0/7.00           1/10.00          4/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             25.0%            0.0%             10.0%            40.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        2/8 (25%)        0/7 (0%)         1/10 (10%)       4/10 (40%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           ---              92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.049 *        P=0.185          (e)              P=0.500          P=0.051          (e)             | 
|POLY 3             |        P=0.013 *        P=0.172          (e)              P=0.500          P=0.033 *        (e)             | 
|POLY 1.5           |        P=0.028 *        P=0.172          (e)              P=0.500          P=0.033 *        (e)             | 
|POLY 6             |        P=0.012 *        P=0.172          (e)              P=0.500          P=0.033 *        (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.185          (e)              P=0.500          P=0.051          (e)             | 
|COCH-ARM / FISHERS |        P=0.601N         P=0.183          (e)              P=0.500          P=0.043 *        (e)             | 
|ORDER RESTRICTED   |        P=0.729          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/6 (0%)         0/8 (0%)         0/10 (0%)        3/10 (30%)       2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/6.00           0/8.00           0/10.00          3/10.00          2/3.18          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             30.0%            63.0%           | 
|TERMINAL (d)       |        0/10 (0%)        0/6 (0%)         0/8 (0%)         0/10 (0%)        3/10 (30%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.111          P=0.214         | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.095          P=0.060         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.095          P=0.093         | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.095          P=0.046 *       | 
|LOGISTIC REGRESSION|        P=0.187          (e)              (e)              (e)              P=0.111          (e)             | 
|COCH-ARM / FISHERS |        P=0.022 *        (e)              (e)              (e)              P=0.105          P=0.237         | 
|ORDER RESTRICTED   |        P=0.011 *        (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/8 (0%)         0/7 (0%)         0/10 (0%)        2/10 (20%)       9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/8.00           0/7.00           0/10.00          2/10.00          9/9.06          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             20.0%            99.4%           | 
|TERMINAL (d)       |        0/10 (0%)        0/8 (0%)         0/7 (0%)         0/10 (0%)        2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.234          P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              P=0.227          P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.083          (e)              (e)              (e)              P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.237          P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       1/10 (10%)       2/10 (20%)       2/10 (20%)       0/9 (0%)         0/9 (0%)        | 
|POLY-3 RATE (b)    |        3/10.00          1/10.00          2/10.00          2/10.00          0/9.00           0/1.12          | 
|POLY-3 PERCENT (g) |        30.0%            10.0%            20.0%            20.0%            0.0%             0.0%            | 
|TERMINAL (d)       |        3/10 (30%)       1/10 (10%)       2/10 (20%)       2/10 (20%)       0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.196N         P=0.293N         P=0.500N         P=0.500N         P=0.129N         P=1.000N        | 
|POLY 3             |        P=0.109N         P=0.292N         P=0.500N         P=0.500N         P=0.114N         P=0.582N        | 
|POLY 1.5           |        P=0.102N         P=0.292N         P=0.500N         P=0.500N         P=0.114N         P=0.431N        | 
|POLY 6             |        P=0.110N         P=0.292N         P=0.500N         P=0.500N         P=0.114N         P=0.651N        | 
|LOGISTIC REGRESSION|        P=0.196N         P=0.293N         P=0.500N         P=0.500N         (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.056N         P=0.291N         P=0.500N         P=0.500N         P=0.124N         P=0.124N        | 
|ORDER RESTRICTED   |        P=0.672N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        1/10 (10%)       1/10 (10%)       0/10 (0%)        0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          1/10.00          1/10.00          0/10.00          0/10.00          0/0.46          | 
|POLY-3 PERCENT (g) |        0.0%             10.0%            10.0%            0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        1/10 (10%)       1/10 (10%)       0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              92 (T)           92 (T)           ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.600N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|POLY 3             |        P=0.392N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.380N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|POLY 6             |        P=0.393N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              P=0.500          P=0.500          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.345N         P=0.500          P=0.500          (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.809N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        1/10 (10%)       0/10 (0%)        1/10 (10%)       0/10 (0%)        1/9 (11%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        1/10.00          0/10.00          1/10.00          0/10.00          1/9.00           0/1.12          | 
|POLY-3 PERCENT (g) |        10.0%            0.0%             10.0%            0.0%             11.1%            0.0%            | 
|TERMINAL (d)       |        1/10 (10%)       0/10 (0%)        1/10 (10%)       0/10 (0%)        1/9 (11%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           ---              92 (T)           ---              92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.717          P=0.500N         P=0.766          P=0.500N         P=0.743          P=1.000N        | 
|POLY 3             |        P=0.570          P=0.500N         P=0.760          P=0.500N         P=0.737          P=0.738N        | 
|POLY 1.5           |        P=0.604          P=0.500N         P=0.760          P=0.500N         P=0.737          P=0.692N        | 
|POLY 6             |        P=0.563          P=0.500N         P=0.760          P=0.500N         P=0.737          P=0.757N        | 
|LOGISTIC REGRESSION|        P=0.717          (e)              P=0.766          (e)              P=0.743          (e)             | 
|COCH-ARM / FISHERS |        P=0.465N         P=0.500N         P=0.763N         P=0.500N         P=0.737          P=0.526N        | 
|ORDER RESTRICTED   |        P=0.757N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       1/10 (10%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          2/10.00          1/10.00          0/0.46          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             20.0%            10.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       1/10 (10%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.266          (e)              (e)              P=0.234          P=0.500          (e)             | 
|POLY 3             |        P=0.127          (e)              (e)              P=0.227          P=0.500          (e)             | 
|POLY 1.5           |        P=0.161          (e)              (e)              P=0.227          P=0.500          (e)             | 
|POLY 6             |        P=0.125          (e)              (e)              P=0.227          P=0.500          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.234          P=0.500          (e)             | 
|COCH-ARM / FISHERS |        P=0.628          (e)              (e)              P=0.237          P=0.500          (e)             | 
|ORDER RESTRICTED   |        P=0.787          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular: Lymphocyte                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         7/9 (78%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/9.00           7/7.64          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             91.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.971          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular: Lymphocyte                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        8/9 (89%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          8/8.02          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.8%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              24              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.717          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        1/10 (10%)       0/10 (0%)        0/10 (0%)        0/6 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          1/10.00          0/10.00          0/10.00          0/1.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             10.0%            0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        1/10 (10%)       0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              92 (T)           ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.856N         (e)              P=0.500          (e)              (e)              (e)             | 
|POLY 3             |        P=0.635N         (e)              P=0.500          (e)              (e)              (e)             | 
|POLY 1.5           |        P=0.602N         (e)              P=0.500          (e)              (e)              (e)             | 
|POLY 6             |        P=0.644N         (e)              P=0.500          (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.500          (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.632N         (e)              P=0.500          (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        P=0.795N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       2/10 (20%)       0/9 (0%)        | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          2/10.00          2/10.00          0/0.50          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             20.0%            20.0%            0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       2/10 (20%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.072          (e)              (e)              P=0.234          P=0.234          (e)             | 
|POLY 3             |        P=0.022 *        (e)              (e)              P=0.227          P=0.227          (e)             | 
|POLY 1.5           |        P=0.039 *        (e)              (e)              P=0.227          P=0.227          (e)             | 
|POLY 6             |        P=0.021 *        (e)              (e)              P=0.227          P=0.227          (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              P=0.234          P=0.234          (e)             | 
|COCH-ARM / FISHERS |        P=0.497          (e)              (e)              P=0.237          P=0.237          (e)             | 
|ORDER RESTRICTED   |        P=0.772          (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric: Lymphocyte                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        5/6 (83%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          5/5.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.0%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.112          (e)              (e)              (e)              (e)              P=0.438         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric: Lymphocyte                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        9/9 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          0/10.00          0/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              24              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        6/6 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          6/6.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        2/10 (20%)       1/1 (100%)       0/0 (0%)         2/10 (20%)       0/10 (0%)        0/9 (0%)        | 
|POLY-3 RATE (b)    |        2/10.00          1/1.00           0/0.00           2/10.00          0/10.00          0/0.50          | 
|POLY-3 PERCENT (g) |        20.0%            100.0%           0.0%             20.0%            0.0%             0.0%            | 
|TERMINAL (d)       |        2/10 (20%)       1/1 (100%)       0/0 (0%)         2/10 (20%)       0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           ---              92 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.168N         P=0.305          P=1.000N         P=0.707          P=0.234N         P=1.000N        | 
|POLY 3             |        (e)              P=0.286          (e)              P=0.702          P=0.227N         P=0.678N        | 
|POLY 1.5           |        (e)              P=0.286          (e)              P=0.702          P=0.227N         P=0.580N        | 
|POLY 6             |        (e)              P=0.286          (e)              P=0.702          P=0.227N         P=0.705N        | 
|LOGISTIC REGRESSION|        P=0.168N         P=0.305          (e)              P=0.707          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.049N*        P=0.273          P=1.000          P=0.709N         P=0.237N         P=0.263N        | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Interstitium                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Interstitium                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/10 (0%)        5/10 (50%)       9/9 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/0.00           0/10.00          5/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             50.0%            100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/10 (0%)        5/10 (50%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P=0.022 *        P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P=0.008 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              P=0.022 *        (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P=0.016 *        P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        6/9 (67%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          6/6.75          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             88.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.984          (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.003 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        8/10 (80%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          8/8.07          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             99.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              24              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.720          (e)              (e)              (e)              (e)              P=0.996         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        9/10 (90%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/0.00           0/0.00           0/10.00          9/9.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.9%           | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.256          (e)              (e)              (e)              (e)              P=0.494         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         8/9 (89%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/9.00           8/8.10          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.7%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/9 (0%)         0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.260          (e)              (e)              (e)              (e)              P=0.491         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        9/9 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001N**      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphocyte                                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        7/10 (70%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          7/7.18          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             97.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.092          (e)              (e)              (e)              (e)              P=0.149         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.002 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphocyte                                                                                                               | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        10/10 (100%)    | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          10/10.00        | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Mucosa                                                                                                     | 
|     Erosion Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         2/3 (67%)        1/1 (100%)       0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           2/3.00           1/1.00           0/10.00          0/1.22          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             66.7%            100.0%           0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         2/3 (67%)        1/1 (100%)       0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              92 (T)           92 (T)           ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.549N         (e)              P=0.034 *        P=0.077          (e)              (e)             | 
|POLY 3             |        (e)              (e)              P=0.003 **       P=0.091N         (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              P=0.003 **       P=0.091N         (e)              (e)             | 
|POLY 6             |        (e)              (e)              P=0.003 **       P=0.091N         (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              P=0.034 *        P=0.077          (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.171N         (e)              P=0.038 *        P=0.091          (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Mucosa                                                                                                     | 
|     Erosion Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/1 (0%)         0/0 (0%)         0/10 (0%)        0/10 (0%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/1.00           0/1.00           0/0.00           0/10.00          0/0.51          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             0.0%            | 
|TERMINAL (d)       |        0/10 (0%)        0/1 (0%)         0/1 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              ---             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Mucosa                                                                                                       | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          2/3.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             66.7%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              32              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.046 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.057         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.086         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.045 *       | 
|LOGISTIC REGRESSION|        P=0.641          (e)              (e)              (e)              (e)              P=0.924         | 
|COCH-ARM / FISHERS |        P=0.089          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Mucosa                                                                                                       | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        7/10 (70%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          7/7.14          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             98.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.766          (e)              (e)              (e)              (e)              P=0.995         | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.002 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        4/10 (40%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          4/4.59          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             87.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.010 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.002 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P=0.508          (e)              (e)              (e)              (e)              P=0.809         | 
|COCH-ARM / FISHERS |        P=0.011 *        (e)              (e)              (e)              (e)              P=0.043 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Depletion Lymphoid                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        8/8 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          8/8.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              26              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Depletion Lymphoid                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        9/9 (100%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/10.00          9/9.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             100.0%          | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              24              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/19/04                           EXPERIMENT: 05195 TEST: 03                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                      SODIUM SELENATE                   
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                                                                                                             | 
|POLY-3 RATE (b)    |                                                                                                             | 
|POLY-3 PERCENT (g) |                                                                                                             | 
|TERMINAL (d)       |                                                                                                             | 
|FIRST INCIDENCE    |                                                                                                             | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                                             | 
|POLY 3             |                                                                                                             | 
|POLY 1.5           |                                                                                                             | 
|POLY 6             |                                                                                                             | 
|LOGISTIC REGRESSION|                                                                                                             | 
|COCH-ARM / FISHERS |                                                                                                             | 
|ORDER RESTRICTED   |                                                                                                             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0                3.75             7.5              15               30               60              | 
|                   |        PPM              PPM              PPM              PPM              PPM              PPM             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/2 (0%)         0/0 (0%)         0/9 (0%)         10/10 (100%)     6/10 (60%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/2.00           0/0.00           0/9.00           10/10.00         6/6.25          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             100.0%           96.0%           | 
|TERMINAL (d)       |        0/10 (0%)        0/2 (0%)         0/0 (0%)         0/9 (0%)         10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              92 (T)           23              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.003 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              P<0.001 **       (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              P<0.001 **       P=0.005 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).