Share This:
https://ntp.niehs.nih.gov/go/20517

TDMS Study 96022-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:11:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                   FINAL#1 RATS_CTRL VS STOP GRP.                                                   
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 007    4000 NG/500UG ST                                                              
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:11:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Inflammation                                                                                 
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel: Aorta, Adventitia        Hemorrhage                                                                                   
                                       Inflammation                                                                                 
Bone Marrow                            Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Esophagus: Muscularis                  Inflammation                                                                                 
Harderian Gland                        Inflammation                                                                                 
Heart                                  Cardiomyopathy                                                                               
Heart: Coronary Artery                 Inflammation Chronic                                                                         
Intestine Large, Colon                 Parasite Metazoan                                                                            
Intestine Large, Rectum                Parasite Metazoan                                                                            
Intestine Large, Rectum: Artery        Inflammation Chronic                                                                         
Kidney                                 Calculus Micro Observation Only                                                              
                                       Infarct                                                                                      
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Pelvis                         Inflammation                                                                                 
Kidney: Renal Tubule                   Hyperplasia                                                                                  
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
Liver: Bile Duct                       Cyst                                                                                         
                                       Fibrosis                                                                                     
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:11:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                       Hyperplasia                                                                                  
Liver: Centrilobular                   Degeneration                                                                                 
                                       Fibrosis                                                                                     
Liver: Hepatocyte                      Glandular Structures                                                                         
                                       Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
                                       Inflammation                                                                                 
                                       Inflammation Granulomatous                                                                   
                                       Keratin Cyst                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lung: Serosa                           Fibrosis                                                                                     
Lymph Node, Mandibular                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Renal                      Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
                                       Inflammation Granulomatous                                                                   
Mesentery: Artery                      Inflammation Chronic                                                                         
Nose                                   Inflammation                                                                                 
Nose: Olfactory Epithelium             Metaplasia                                                                                   
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Oral Mucosa: Gingival                  Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
Pancreas                               Edema                                                                                        
                                       Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Hyperplasia                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Pancreas: Artery                       Inflammation Chronic                                                                         
Pituitary Gland                        Angiectasis                                                                                  
                                       Cyst                                                                                         
                                       Cytoplasmic Alteration                                                                       
                                       Vacuolization Cytoplasmic                                                                    
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Ulcer                                                                                        
Stomach, Glandular                     Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
Thyroid Gland                          Infiltration Cellular Lymphoid                                                               
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 04/29/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:11:57       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Urinary Bladder                        Inflammation                                                                                 
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
Uterus                                 Inflammation                                                                                 
                                       Inflammation Chronic                                                                         
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P        
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              42/53 (79%)                                       21/50 (42%)                  | 
|POLY-3 RATE (b)    |                              42/48.03                                          21/28.18                     | 
|POLY-3 PERCENT (g) |                              87.4%                                             74.5%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       9/10 (90%)                   | 
|FIRST INCIDENCE    |                              482                                               232                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.190                      | 
|POLY 3             |                                                                                P=0.134N                     | 
|POLY 1.5           |                                                                                P=0.017N*                    | 
|POLY 6             |                                                                                P=0.364N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.169N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         12/50 (24%)                  | 
|POLY-3 RATE (b)    |                              2/42.18                                           12/30.21                     | 
|POLY-3 PERCENT (g) |                              4.7%                                              39.7%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              649                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.102                      | 
|COCH-ARM / FISHERS |                                                                                P=0.003 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/53 (23%)                                       9/50 (18%)                   | 
|POLY-3 RATE (b)    |                              12/43.80                                          9/22.95                      | 
|POLY-3 PERCENT (g) |                              27.4%                                             39.2%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        4/10 (40%)                   | 
|FIRST INCIDENCE    |                              482                                               504                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.098                      | 
|POLY 3             |                                                                                P=0.303                      | 
|POLY 1.5           |                                                                                P=0.438                      | 
|POLY 6             |                                                                                P=0.236                      | 
|LOGISTIC REGRESSION|                                                                                P=0.233                      | 
|COCH-ARM / FISHERS |                                                                                P=0.368N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              13/53 (25%)                                       10/50 (20%)                  | 
|POLY-3 RATE (b)    |                              13/44.54                                          10/25.67                     | 
|POLY-3 PERCENT (g) |                              29.2%                                             39.0%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        4/10 (40%)                   | 
|FIRST INCIDENCE    |                              362                                               258                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.109                      | 
|POLY 3             |                                                                                P=0.331                      | 
|POLY 1.5           |                                                                                P=0.454                      | 
|POLY 6             |                                                                                P=0.259                      | 
|LOGISTIC REGRESSION|                                                                                P=0.582                      | 
|COCH-ARM / FISHERS |                                                                                P=0.377N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/53 (85%)                                       29/50 (58%)                  | 
|POLY-3 RATE (b)    |                              45/48.89                                          29/31.75                     | 
|POLY-3 PERCENT (g) |                              92.1%                                             91.3%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               230                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.009 **                   | 
|POLY 3             |                                                                                P=0.700N                     | 
|POLY 1.5           |                                                                                P=0.243N                     | 
|POLY 6             |                                                                                P=0.725                      | 
|LOGISTIC REGRESSION|                                                                                P=0.452                      | 
|COCH-ARM / FISHERS |                                                                                P=0.002N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/22.11                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              9.1%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               279                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.110                      | 
|POLY 3             |                                                                                P=0.230                      | 
|POLY 1.5           |                                                                                P=0.216                      | 
|POLY 6             |                                                                                P=0.247                      | 
|LOGISTIC REGRESSION|                                                                                P=0.288                      | 
|COCH-ARM / FISHERS |                                                                                P=0.233                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              1/42.24                                           2/22.01                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              9.1%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              628                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.253                      | 
|POLY 3             |                                                                                P=0.417                      | 
|POLY 1.5           |                                                                                P=0.422                      | 
|POLY 6             |                                                                                P=0.425                      | 
|LOGISTIC REGRESSION|                                                                                P=0.536                      | 
|COCH-ARM / FISHERS |                                                                                P=0.478                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              14/53 (26%)                                       16/50 (32%)                  | 
|POLY-3 RATE (b)    |                              14/44.09                                          16/26.74                     | 
|POLY-3 PERCENT (g) |                              31.8%                                             59.9%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        5/10 (50%)                   | 
|FIRST INCIDENCE    |                              564                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.003 **                   | 
|POLY 3             |                                                                                P=0.024 *                    | 
|POLY 1.5           |                                                                                P=0.059                      | 
|POLY 6             |                                                                                P=0.015 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.033 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.342                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              13/53 (25%)                                       8/49 (16%)                   | 
|POLY-3 RATE (b)    |                              13/42.77                                          8/23.03                      | 
|POLY-3 PERCENT (g) |                              30.4%                                             34.7%                        | 
|TERMINAL (d)       |                              10/27 (37%)                                       3/9 (33%)                    | 
|FIRST INCIDENCE    |                              628                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.180                      | 
|POLY 3             |                                                                                P=0.523                      | 
|POLY 1.5           |                                                                                P=0.621N                     | 
|POLY 6             |                                                                                P=0.452                      | 
|LOGISTIC REGRESSION|                                                                                P=0.448                      | 
|COCH-ARM / FISHERS |                                                                                P=0.219N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/22.98                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              8.7%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               240                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.185                      | 
|POLY 3             |                                                                                P=0.225                      | 
|POLY 1.5           |                                                                                P=0.215                      | 
|POLY 6             |                                                                                P=0.239                      | 
|LOGISTIC REGRESSION|                                                                                P=0.898                      | 
|COCH-ARM / FISHERS |                                                                                P=0.233                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/22.99                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              8.7%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               240                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.193                      | 
|POLY 3             |                                                                                P=0.225                      | 
|POLY 1.5           |                                                                                P=0.215                      | 
|POLY 6             |                                                                                P=0.239                      | 
|LOGISTIC REGRESSION|                                                                                P=0.951                      | 
|COCH-ARM / FISHERS |                                                                                P=0.233                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/24.94                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              16.0%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.051                      | 
|POLY 3             |                                                                                P=0.031 *                    | 
|POLY 1.5           |                                                                                P=0.035 *                    | 
|POLY 6             |                                                                                P=0.029 *                    | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.052                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              37/53 (70%)                                       40/50 (80%)                  | 
|POLY-3 RATE (b)    |                              37/51.61                                          40/46.05                     | 
|POLY-3 PERCENT (g) |                              71.7%                                             86.9%                        | 
|TERMINAL (d)       |                              14/27 (52%)                                       5/10 (50%)                   | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.054                      | 
|POLY 1.5           |                                                                                P=0.061                      | 
|POLY 6             |                                                                                P=0.062                      | 
|LOGISTIC REGRESSION|                                                                                P=0.555                      | 
|COCH-ARM / FISHERS |                                                                                P=0.168                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         8/50 (16%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           8/28.75                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              27.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.583                      | 
|COCH-ARM / FISHERS |                                                                                P=0.002 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       30/50 (60%)                  | 
|POLY-3 RATE (b)    |                              49/52.29                                          30/33.33                     | 
|POLY-3 PERCENT (g) |                              93.7%                                             90.0%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       9/10 (90%)                   | 
|FIRST INCIDENCE    |                              275                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.037 *                    | 
|POLY 3             |                                                                                P=0.468N                     | 
|POLY 1.5           |                                                                                P=0.076N                     | 
|POLY 6             |                                                                                P=0.741N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.100N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       40/50 (80%)                  | 
|POLY-3 RATE (b)    |                              40/50.23                                          40/43.50                     | 
|POLY-3 PERCENT (g) |                              79.6%                                             92.0%                        | 
|TERMINAL (d)       |                              20/27 (74%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              313                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.070                      | 
|POLY 1.5           |                                                                                P=0.125                      | 
|POLY 6             |                                                                                P=0.039 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.310                      | 
|COCH-ARM / FISHERS |                                                                                P=0.377                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              3/42.85                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              7.0%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              534                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.317N                     | 
|POLY 3             |                                                                                P=0.430N                     | 
|POLY 1.5           |                                                                                P=0.311N                     | 
|POLY 6             |                                                                                P=0.533N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.180N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.132N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              24/53 (45%)                                       12/50 (24%)                  | 
|POLY-3 RATE (b)    |                              24/45.26                                          12/26.40                     | 
|POLY-3 PERCENT (g) |                              53.0%                                             45.5%                        | 
|TERMINAL (d)       |                              15/27 (56%)                                       5/10 (50%)                   | 
|FIRST INCIDENCE    |                              313                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.387                      | 
|POLY 3             |                                                                                P=0.396N                     | 
|POLY 1.5           |                                                                                P=0.210N                     | 
|POLY 6             |                                                                                P=0.545N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.183N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.019N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              20/53 (38%)                                       15/50 (30%)                  | 
|POLY-3 RATE (b)    |                              20/45.03                                          15/28.08                     | 
|POLY-3 PERCENT (g) |                              44.4%                                             53.4%                        | 
|TERMINAL (d)       |                              11/27 (41%)                                       3/10 (30%)                   | 
|FIRST INCIDENCE    |                              534                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.065                      | 
|POLY 3             |                                                                                P=0.338                      | 
|POLY 1.5           |                                                                                P=0.489                      | 
|POLY 6             |                                                                                P=0.273                      | 
|LOGISTIC REGRESSION|                                                                                P=0.523                      | 
|COCH-ARM / FISHERS |                                                                                P=0.268N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Coronary Artery                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         6/50 (12%)                   | 
|POLY-3 RATE (b)    |                              1/41.89                                           6/24.90                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              24.1%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           273                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.005 **                   | 
|POLY 3             |                                                                                P=0.015 *                    | 
|POLY 1.5           |                                                                                P=0.020 *                    | 
|POLY 6             |                                                                                P=0.013 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.071                      | 
|COCH-ARM / FISHERS |                                                                                P=0.048 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              2/41.97                                           1/21.06                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              4.8%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              707                                               726 (T)                      | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.652                      | 
|POLY 3             |                                                                                P=0.820N                     | 
|POLY 1.5           |                                                                                P=0.739N                     | 
|POLY 6             |                                                                                P=0.825                      | 
|LOGISTIC REGRESSION|                                                                                P=0.674                      | 
|COCH-ARM / FISHERS |                                                                                P=0.522N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/52 (6%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              3/41.84                                           1/22.02                      | 
|POLY-3 PERCENT (g) |                              7.2%                                              4.5%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              567                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.594N                     | 
|POLY 3             |                                                                                P=0.656N                     | 
|POLY 1.5           |                                                                                P=0.550N                     | 
|POLY 6             |                                                                                P=0.733N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.287N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.324N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum: Artery                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/52 (0%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              0/41.24                                           4/21.71                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.4%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         2/10 (20%)                   | 
|FIRST INCIDENCE    |                              ---                                               607                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.030 *                    | 
|POLY 1.5           |                                                                                P=0.033 *                    | 
|POLY 6             |                                                                                P=0.030 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.007 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.054                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/53 (11%)                                        0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              6/42.65                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              14.1%                                             0.0%                         | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/10 (0%)                    | 
|FIRST INCIDENCE    |                              586                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.132N                     | 
|POLY 3             |                                                                                P=0.169N                     | 
|POLY 1.5           |                                                                                P=0.094N                     | 
|POLY 6             |                                                                                P=0.249N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.093N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.016N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.474N                     | 
|POLY 3             |                                                                                P=0.579N                     | 
|POLY 1.5           |                                                                                P=0.464N                     | 
|POLY 6             |                                                                                P=0.667N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.262N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              46/53 (87%)                                       32/50 (64%)                  | 
|POLY-3 RATE (b)    |                              46/51.13                                          32/39.76                     | 
|POLY-3 PERCENT (g) |                              90.0%                                             80.5%                        | 
|TERMINAL (d)       |                              23/27 (85%)                                       7/10 (70%)                   | 
|FIRST INCIDENCE    |                              313                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.020 *                    | 
|POLY 3             |                                                                                P=0.157N                     | 
|POLY 1.5           |                                                                                P=0.065N                     | 
|POLY 6             |                                                                                P=0.283N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.021N*                    | 
|COCH-ARM / FISHERS |                                                                                P=0.006N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              41/53 (77%)                                       34/50 (68%)                  | 
|POLY-3 RATE (b)    |                              41/49.70                                          34/34.66                     | 
|POLY-3 PERCENT (g) |                              82.5%                                             98.1%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.021 *                    | 
|POLY 1.5           |                                                                                P=0.112                      | 
|POLY 6             |                                                                                P=0.020 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.045 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.199N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.25                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              9.5%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.255N                     | 
|POLY 3             |                                                                                P=0.306N                     | 
|POLY 1.5           |                                                                                P=0.205N                     | 
|POLY 6             |                                                                                P=0.400N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.211N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.066N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              2/42.10                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.477N                     | 
|POLY 3             |                                                                                P=0.582N                     | 
|POLY 1.5           |                                                                                P=0.465N                     | 
|POLY 6             |                                                                                P=0.673N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.430N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.262N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.25                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              9.5%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.255N                     | 
|POLY 3             |                                                                                P=0.306N                     | 
|POLY 1.5           |                                                                                P=0.205N                     | 
|POLY 6             |                                                                                P=0.400N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.211N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.066N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/21.49                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              ---                                               601                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.029 *                    | 
|POLY 1.5           |                                                                                P=0.032 *                    | 
|POLY 6             |                                                                                P=0.029 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.005 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.052                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              27/53 (51%)                                       5/50 (10%)                   | 
|POLY-3 RATE (b)    |                              27/45.63                                          5/21.73                      | 
|POLY-3 PERCENT (g) |                              59.2%                                             23.0%                        | 
|TERMINAL (d)       |                              16/27 (59%)                                       3/10 (30%)                   | 
|FIRST INCIDENCE    |                              534                                               601                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.053N                     | 
|POLY 3             |                                                                                P=0.013N*                    | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.051N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.006N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         27/50 (54%)                  | 
|POLY-3 RATE (b)    |                              1/41.89                                           27/33.72                     | 
|POLY-3 PERCENT (g) |                              2.4%                                              80.1%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         8/10 (80%)                   | 
|FIRST INCIDENCE    |                              726 (T)                                           201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              5/42.17                                           1/21.06                      | 
|POLY-3 PERCENT (g) |                              11.9%                                             4.8%                         | 
|TERMINAL (d)       |                              4/27 (15%)                                        1/10 (10%)                   | 
|FIRST INCIDENCE    |                              651                                               726 (T)                      | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.448N                     | 
|POLY 3             |                                                                                P=0.442N                     | 
|POLY 1.5           |                                                                                P=0.317N                     | 
|POLY 6             |                                                                                P=0.542N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.416N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.116N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/53 (19%)                                       15/50 (30%)                  | 
|POLY-3 RATE (b)    |                              10/43.62                                          15/28.06                     | 
|POLY-3 PERCENT (g) |                              22.9%                                             53.5%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        3/10 (30%)                   | 
|FIRST INCIDENCE    |                              534                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.010 *                    | 
|POLY 1.5           |                                                                                P=0.021 *                    | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.040 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.138                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         35/50 (70%)                  | 
|POLY-3 RATE (b)    |                              3/42.21                                           35/43.37                     | 
|POLY-3 PERCENT (g) |                              7.1%                                              80.7%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         7/10 (70%)                   | 
|FIRST INCIDENCE    |                              639                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/53 (19%)                                       14/50 (28%)                  | 
|POLY-3 RATE (b)    |                              10/43.19                                          14/24.02                     | 
|POLY-3 PERCENT (g) |                              23.2%                                             58.3%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        7/10 (70%)                   | 
|FIRST INCIDENCE    |                              586                                               282                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.007 **                   | 
|POLY 1.5           |                                                                                P=0.022 *                    | 
|POLY 6             |                                                                                P=0.003 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.003 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.194                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              27/53 (51%)                                       22/50 (44%)                  | 
|POLY-3 RATE (b)    |                              27/48.61                                          22/29.47                     | 
|POLY-3 PERCENT (g) |                              55.6%                                             74.6%                        | 
|TERMINAL (d)       |                              11/27 (41%)                                       8/10 (80%)                   | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.010 *                    | 
|POLY 3             |                                                                                P=0.087                      | 
|POLY 1.5           |                                                                                P=0.221                      | 
|POLY 6             |                                                                                P=0.047 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.348                      | 
|COCH-ARM / FISHERS |                                                                                P=0.306N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           1/21.15                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              4.7%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           703                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.660                      | 
|POLY 3             |                                                                                P=0.818N                     | 
|POLY 1.5           |                                                                                P=0.737N                     | 
|POLY 6             |                                                                                P=0.825                      | 
|LOGISTIC REGRESSION|                                                                                P=0.675                      | 
|COCH-ARM / FISHERS |                                                                                P=0.522N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         34/50 (68%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           34/44.64                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              76.2%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         4/10 (40%)                   | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       48/50 (96%)                  | 
|POLY-3 RATE (b)    |                              49/51.05                                          48/48.82                     | 
|POLY-3 PERCENT (g) |                              96.0%                                             98.3%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              313                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.460                      | 
|POLY 1.5           |                                                                                P=0.408                      | 
|POLY 6             |                                                                                P=0.541                      | 
|LOGISTIC REGRESSION|                                                                                P=0.208                      | 
|COCH-ARM / FISHERS |                                                                                P=0.367                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/22.97                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              8.7%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               232                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.179                      | 
|POLY 3             |                                                                                P=0.225                      | 
|POLY 1.5           |                                                                                P=0.215                      | 
|POLY 6             |                                                                                P=0.239                      | 
|LOGISTIC REGRESSION|                                                                                P=0.882                      | 
|COCH-ARM / FISHERS |                                                                                P=0.233                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              38/53 (72%)                                       20/50 (40%)                  | 
|POLY-3 RATE (b)    |                              38/45.68                                          20/26.46                     | 
|POLY-3 PERCENT (g) |                              83.2%                                             75.6%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              534                                               282                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.082                      | 
|POLY 3             |                                                                                P=0.349N                     | 
|POLY 1.5           |                                                                                P=0.095N                     | 
|POLY 6             |                                                                                P=0.599N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.536                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         6/50 (12%)                   | 
|POLY-3 RATE (b)    |                              3/42.94                                           6/25.40                      | 
|POLY-3 PERCENT (g) |                              7.0%                                              23.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              564                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.051                      | 
|POLY 3             |                                                                                P=0.083                      | 
|POLY 1.5           |                                                                                P=0.108                      | 
|POLY 6             |                                                                                P=0.071                      | 
|LOGISTIC REGRESSION|                                                                                P=0.499                      | 
|COCH-ARM / FISHERS |                                                                                P=0.216                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         50/50 (100%)                 | 
|POLY-3 RATE (b)    |                              5/43.23                                           50/50.00                     | 
|POLY-3 PERCENT (g) |                              11.6%                                             100.0%                       | 
|TERMINAL (d)       |                              2/27 (7%)                                         10/10 (100%)                 | 
|FIRST INCIDENCE    |                              534                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         50/50 (100%)                 | 
|POLY-3 RATE (b)    |                              0/41.89                                           50/50.00                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              100.0%                       | 
|TERMINAL (d)       |                              0/27 (0%)                                         10/10 (100%)                 | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         21/50 (42%)                  | 
|POLY-3 RATE (b)    |                              4/42.10                                           21/25.42                     | 
|POLY-3 PERCENT (g) |                              9.5%                                              82.6%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        9/10 (90%)                   | 
|FIRST INCIDENCE    |                              672                                               474                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/53 (11%)                                        12/50 (24%)                  | 
|POLY-3 RATE (b)    |                              6/42.12                                           12/24.42                     | 
|POLY-3 PERCENT (g) |                              14.2%                                             49.2%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        3/10 (30%)                   | 
|FIRST INCIDENCE    |                              665                                               383                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.004 **                   | 
|POLY 1.5           |                                                                                P=0.009 **                   | 
|POLY 6             |                                                                                P=0.003 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.075                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         37/50 (74%)                  | 
|POLY-3 RATE (b)    |                              5/42.04                                           37/44.10                     | 
|POLY-3 PERCENT (g) |                              11.9%                                             83.9%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        5/10 (50%)                   | 
|FIRST INCIDENCE    |                              687                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         6/50 (12%)                   | 
|POLY-3 RATE (b)    |                              2/42.71                                           6/25.86                      | 
|POLY-3 PERCENT (g) |                              4.7%                                              23.2%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              564                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.036 *                    | 
|POLY 3             |                                                                                P=0.042 *                    | 
|POLY 1.5           |                                                                                P=0.056                      | 
|POLY 6             |                                                                                P=0.034 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.609                      | 
|COCH-ARM / FISHERS |                                                                                P=0.117                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         43/50 (86%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           43/50.00                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              86.0%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Glandular Structures                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         9/50 (18%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           9/29.71                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              30.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.563                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         36/50 (72%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           36/45.73                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              78.7%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         5/10 (50%)                   | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         38/50 (76%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           38/44.81                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              84.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         5/10 (50%)                   | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         43/50 (86%)                  | 
|POLY-3 RATE (b)    |                              4/41.89                                           43/48.43                     | 
|POLY-3 PERCENT (g) |                              9.6%                                              88.8%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        5/10 (50%)                   | 
|FIRST INCIDENCE    |                              726 (T)                                           201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         42/50 (84%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           42/48.26                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              87.0%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         5/10 (50%)                   | 
|FIRST INCIDENCE    |                              ---                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         3/50 (6%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           3/23.69                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              12.7%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.063                      | 
|POLY 3             |                                                                                P=0.083                      | 
|POLY 1.5           |                                                                                P=0.085                      | 
|POLY 6             |                                                                                P=0.084                      | 
|LOGISTIC REGRESSION|                                                                                P=0.467                      | 
|COCH-ARM / FISHERS |                                                                                P=0.111                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       24/50 (48%)                  | 
|POLY-3 RATE (b)    |                              40/49.03                                          24/32.50                     | 
|POLY-3 PERCENT (g) |                              81.6%                                             73.8%                        | 
|TERMINAL (d)       |                              21/27 (78%)                                       6/10 (60%)                   | 
|FIRST INCIDENCE    |                              362                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.078                      | 
|POLY 3             |                                                                                P=0.312N                     | 
|POLY 1.5           |                                                                                P=0.131N                     | 
|POLY 6             |                                                                                P=0.420N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.190N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.004N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         6/50 (12%)                   | 
|POLY-3 RATE (b)    |                              5/43.02                                           6/23.16                      | 
|POLY-3 PERCENT (g) |                              11.6%                                             25.9%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        2/10 (20%)                   | 
|FIRST INCIDENCE    |                              534                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.071                      | 
|POLY 3             |                                                                                P=0.185                      | 
|POLY 1.5           |                                                                                P=0.244                      | 
|POLY 6             |                                                                                P=0.156                      | 
|LOGISTIC REGRESSION|                                                                                P=0.248                      | 
|COCH-ARM / FISHERS |                                                                                P=0.459                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/22.05                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         2/10 (20%)                   | 
|FIRST INCIDENCE    |                              ---                                               561                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.029 *                    | 
|POLY 1.5           |                                                                                P=0.032 *                    | 
|POLY 6             |                                                                                P=0.029 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.011 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.052                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Keratin Cyst                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         9/50 (18%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           9/23.33                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              38.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              ---                                               525                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         8/50 (16%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           8/22.72                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              35.2%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         4/10 (40%)                   | 
|FIRST INCIDENCE    |                              ---                                               541                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.002 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              18/53 (34%)                                       5/50 (10%)                   | 
|POLY-3 RATE (b)    |                              18/43.48                                          5/22.02                      | 
|POLY-3 PERCENT (g) |                              41.4%                                             22.7%                        | 
|TERMINAL (d)       |                              13/27 (48%)                                       3/10 (30%)                   | 
|FIRST INCIDENCE    |                              534                                               383                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.311N                     | 
|POLY 3             |                                                                                P=0.161N                     | 
|POLY 1.5           |                                                                                P=0.062N                     | 
|POLY 6             |                                                                                P=0.282N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.156N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.003N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         15/50 (30%)                  | 
|POLY-3 RATE (b)    |                              1/41.89                                           15/27.99                     | 
|POLY-3 PERCENT (g) |                              2.4%                                              53.6%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              726 (T)                                           226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Serosa                                                                                                                     | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              3/42.18                                           1/22.01                      | 
|POLY-3 PERCENT (g) |                              7.1%                                              4.5%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              649                                               273                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.622N                     | 
|POLY 3             |                                                                                P=0.660N                     | 
|POLY 1.5           |                                                                                P=0.557N                     | 
|POLY 6             |                                                                                P=0.731N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.366N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.331N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         11/49 (22%)                  | 
|POLY-3 RATE (b)    |                              3/42.29                                           11/24.51                     | 
|POLY-3 PERCENT (g) |                              7.1%                                              44.9%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              639                                               247                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.014 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/49 (8%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/24.84                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              16.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               230                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.035 *                    | 
|POLY 3             |                                                                                P=0.030 *                    | 
|POLY 1.5           |                                                                                P=0.034 *                    | 
|POLY 6             |                                                                                P=0.028 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.677                      | 
|COCH-ARM / FISHERS |                                                                                P=0.050                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/53 (85%)                                       28/49 (57%)                  | 
|POLY-3 RATE (b)    |                              45/51.67                                          28/32.76                     | 
|POLY-3 PERCENT (g) |                              87.1%                                             85.5%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.039 *                    | 
|POLY 3             |                                                                                P=0.597N                     | 
|POLY 1.5           |                                                                                P=0.192N                     | 
|POLY 6             |                                                                                P=0.492                      | 
|LOGISTIC REGRESSION|                                                                                P=0.096N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.002N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         10/50 (20%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           10/28.48                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              35.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.030 *                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              3/42.49                                           2/22.10                      | 
|POLY-3 PERCENT (g) |                              7.1%                                              9.1%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              639                                               541                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.491                      | 
|POLY 3             |                                                                                P=0.672                      | 
|POLY 1.5           |                                                                                P=0.703                      | 
|POLY 6             |                                                                                P=0.659                      | 
|LOGISTIC REGRESSION|                                                                                P=0.695                      | 
|COCH-ARM / FISHERS |                                                                                P=0.528N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/28 (25%)                                        3/22 (14%)                   | 
|POLY-3 RATE (b)    |                              7/23.39                                           3/10.39                      | 
|POLY-3 PERCENT (g) |                              29.9%                                             28.9%                        | 
|TERMINAL (d)       |                              2/12 (17%)                                        0/2 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.599                      | 
|POLY 3             |                                                                                P=0.719N                     | 
|POLY 1.5           |                                                                                P=0.566N                     | 
|POLY 6             |                                                                                P=0.702                      | 
|LOGISTIC REGRESSION|                                                                                P=0.287N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.263N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/28 (7%)                                         11/22 (50%)                  | 
|POLY-3 RATE (b)    |                              2/21.96                                           11/16.43                     | 
|POLY-3 PERCENT (g) |                              9.1%                                              67.0%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/2 (0%)                     | 
|FIRST INCIDENCE    |                              586                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.010 *                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         4/22 (18%)                   | 
|POLY-3 RATE (b)    |                              0/21.26                                           4/10.38                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              38.5%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/2 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               594                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.015 *                    | 
|POLY 1.5           |                                                                                P=0.018 *                    | 
|POLY 6             |                                                                                P=0.013 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.008 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.032 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         3/22 (14%)                   | 
|POLY-3 RATE (b)    |                              0/21.26                                           3/11.01                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              27.3%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/2 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               230                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.048 *                    | 
|POLY 3             |                                                                                P=0.061                      | 
|POLY 1.5           |                                                                                P=0.065                      | 
|POLY 6             |                                                                                P=0.061                      | 
|LOGISTIC REGRESSION|                                                                                P=0.241                      | 
|COCH-ARM / FISHERS |                                                                                P=0.079                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         3/22 (14%)                   | 
|POLY-3 RATE (b)    |                              0/21.26                                           3/11.01                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              27.3%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/2 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               230                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.048 *                    | 
|POLY 3             |                                                                                P=0.061                      | 
|POLY 1.5           |                                                                                P=0.065                      | 
|POLY 6             |                                                                                P=0.061                      | 
|LOGISTIC REGRESSION|                                                                                P=0.241                      | 
|COCH-ARM / FISHERS |                                                                                P=0.079                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         2/22 (9%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           2/9.18                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              21.8%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         1/2 (50%)                    | 
|FIRST INCIDENCE    |                              ---                                               636                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.033 *                    | 
|POLY 3             |                                                                                P=0.225                      | 
|POLY 1.5           |                                                                                P=0.200                      | 
|POLY 6             |                                                                                P=0.285                      | 
|LOGISTIC REGRESSION|                                                                                P=0.039 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.189                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         3/22 (14%)                   | 
|POLY-3 RATE (b)    |                              0/21.26                                           3/9.93                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              30.2%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/2 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               601                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.020 *                    | 
|POLY 3             |                                                                                P=0.062                      | 
|POLY 1.5           |                                                                                P=0.063                      | 
|POLY 6             |                                                                                P=0.064                      | 
|LOGISTIC REGRESSION|                                                                                P=0.025 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.079                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              26/53 (49%)                                       11/50 (22%)                  | 
|POLY-3 RATE (b)    |                              26/46.93                                          11/23.96                     | 
|POLY-3 PERCENT (g) |                              55.4%                                             45.9%                        | 
|TERMINAL (d)       |                              14/27 (52%)                                       4/10 (40%)                   | 
|FIRST INCIDENCE    |                              313                                               282                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.531                      | 
|POLY 3             |                                                                                P=0.369N                     | 
|POLY 1.5           |                                                                                P=0.144N                     | 
|POLY 6             |                                                                                P=0.559N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.161N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.004N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              3/42.81                                           1/21.06                      | 
|POLY-3 PERCENT (g) |                              7.0%                                              4.8%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              555                                               726 (T)                      | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.654N                     | 
|POLY 3             |                                                                                P=0.693N                     | 
|POLY 1.5           |                                                                                P=0.578N                     | 
|POLY 6             |                                                                                P=0.774N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.524N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.331N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         7/43 (16%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           7/21.52                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              32.5%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/9 (11%)                    | 
|FIRST INCIDENCE    |                              ---                                               451                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.003 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              17/53 (32%)                                       11/50 (22%)                  | 
|POLY-3 RATE (b)    |                              17/45.19                                          11/25.60                     | 
|POLY-3 PERCENT (g) |                              37.6%                                             43.0%                        | 
|TERMINAL (d)       |                              10/27 (37%)                                       1/10 (10%)                   | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.184                      | 
|POLY 3             |                                                                                P=0.473                      | 
|POLY 1.5           |                                                                                P=0.614                      | 
|POLY 6             |                                                                                P=0.420                      | 
|LOGISTIC REGRESSION|                                                                                P=0.549N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.177N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         5/50 (10%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           5/22.14                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              22.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              ---                                               593                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P=0.010 *                    | 
|POLY 1.5           |                                                                                P=0.012 *                    | 
|POLY 6             |                                                                                P=0.009 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.003 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.024 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/53 (15%)                                        10/50 (20%)                  | 
|POLY-3 RATE (b)    |                              8/43.10                                           10/24.54                     | 
|POLY-3 PERCENT (g) |                              18.6%                                             40.7%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        1/10 (10%)                   | 
|FIRST INCIDENCE    |                              564                                               474                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.014 *                    | 
|POLY 3             |                                                                                P=0.066                      | 
|POLY 1.5           |                                                                                P=0.107                      | 
|POLY 6             |                                                                                P=0.054                      | 
|LOGISTIC REGRESSION|                                                                                P=0.055                      | 
|COCH-ARM / FISHERS |                                                                                P=0.346                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/53 (21%)                                       18/50 (36%)                  | 
|POLY-3 RATE (b)    |                              11/43.10                                          18/29.52                     | 
|POLY-3 PERCENT (g) |                              25.5%                                             61.0%                        | 
|TERMINAL (d)       |                              7/27 (26%)                                        3/10 (30%)                   | 
|FIRST INCIDENCE    |                              582                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.002 **                   | 
|POLY 1.5           |                                                                                P=0.005 **                   | 
|POLY 6             |                                                                                P=0.002 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.006 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.067                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              46/53 (87%)                                       15/50 (30%)                  | 
|POLY-3 RATE (b)    |                              46/50.65                                          15/27.64                     | 
|POLY-3 PERCENT (g) |                              90.8%                                             54.3%                        | 
|TERMINAL (d)       |                              25/27 (93%)                                       6/10 (60%)                   | 
|FIRST INCIDENCE    |                              275                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.173N                     | 
|POLY 3             |                                                                                P<0.001N**                   | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.003N**                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              19/53 (36%)                                       7/50 (14%)                   | 
|POLY-3 RATE (b)    |                              19/44.54                                          7/22.45                      | 
|POLY-3 PERCENT (g) |                              42.7%                                             31.2%                        | 
|TERMINAL (d)       |                              13/27 (48%)                                       2/10 (20%)                   | 
|FIRST INCIDENCE    |                              313                                               525                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.532N                     | 
|POLY 3             |                                                                                P=0.327N                     | 
|POLY 1.5           |                                                                                P=0.156N                     | 
|POLY 6             |                                                                                P=0.455N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.241N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.009N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         12/50 (24%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           12/31.74                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              37.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.081                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         5/50 (10%)                   | 
|POLY-3 RATE (b)    |                              1/42.38                                           5/22.51                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              22.2%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         2/10 (20%)                   | 
|FIRST INCIDENCE    |                              582                                               541                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.008 **                   | 
|POLY 3             |                                                                                P=0.034 *                    | 
|POLY 1.5           |                                                                                P=0.042 *                    | 
|POLY 6             |                                                                                P=0.031 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.024 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.090                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         8/50 (16%)                   | 
|POLY-3 RATE (b)    |                              1/41.89                                           8/24.21                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              33.0%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              726 (T)                                           258                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.002 **                   | 
|POLY 1.5           |                                                                                P=0.003 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.004 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.012 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              2/42.36                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              4.7%                                              0.0%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              639                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.473N                     | 
|POLY 3             |                                                                                P=0.586N                     | 
|POLY 1.5           |                                                                                P=0.467N                     | 
|POLY 6             |                                                                                P=0.681N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.371N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.262N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         41/50 (82%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           41/41.99                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              97.7%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         10/10 (100%)                 | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         10/50 (20%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           10/24.82                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              40.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         3/10 (30%)                   | 
|FIRST INCIDENCE    |                              ---                                               401                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              23/53 (43%)                                       3/50 (6%)                    | 
|POLY-3 RATE (b)    |                              23/44.91                                          3/21.06                      | 
|POLY-3 PERCENT (g) |                              51.2%                                             14.3%                        | 
|TERMINAL (d)       |                              15/27 (56%)                                       3/10 (30%)                   | 
|FIRST INCIDENCE    |                              564                                               726 (T)                      | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.024N*                    | 
|POLY 3             |                                                                                P=0.012N*                    | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.048N*                    | 
|LOGISTIC REGRESSION|                                                                                P=0.005N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         3/50 (6%)                    | 
|POLY-3 RATE (b)    |                              1/42.21                                           3/23.88                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              12.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              639                                               258                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.135                      | 
|POLY 3             |                                                                                P=0.204                      | 
|POLY 1.5           |                                                                                P=0.218                      | 
|POLY 6             |                                                                                P=0.198                      | 
|LOGISTIC REGRESSION|                                                                                P=0.758N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.287                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cytoplasmic Alteration                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/22.03                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              9.1%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         1/10 (10%)                   | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.129                      | 
|POLY 3             |                                                                                P=0.230                      | 
|POLY 1.5           |                                                                                P=0.216                      | 
|POLY 6             |                                                                                P=0.249                      | 
|LOGISTIC REGRESSION|                                                                                P=0.308                      | 
|COCH-ARM / FISHERS |                                                                                P=0.233                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.474N                     | 
|POLY 3             |                                                                                P=0.579N                     | 
|POLY 1.5           |                                                                                P=0.464N                     | 
|POLY 6             |                                                                                P=0.667N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.262N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/53 (21%)                                       8/50 (16%)                   | 
|POLY-3 RATE (b)    |                              11/43.08                                          8/22.16                      | 
|POLY-3 PERCENT (g) |                              25.5%                                             36.1%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        5/10 (50%)                   | 
|FIRST INCIDENCE    |                              564                                               601                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.107                      | 
|POLY 3             |                                                                                P=0.345                      | 
|POLY 1.5           |                                                                                P=0.480                      | 
|POLY 6             |                                                                                P=0.271                      | 
|LOGISTIC REGRESSION|                                                                                P=0.185                      | 
|COCH-ARM / FISHERS |                                                                                P=0.357N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       45/50 (90%)                  | 
|POLY-3 RATE (b)    |                              49/51.71                                          45/46.08                     | 
|POLY-3 PERCENT (g) |                              94.8%                                             97.7%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.417                      | 
|POLY 1.5           |                                                                                P=0.467                      | 
|POLY 6             |                                                                                P=0.499                      | 
|LOGISTIC REGRESSION|                                                                                P=0.465                      | 
|COCH-ARM / FISHERS |                                                                                P=0.463N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              52/53 (98%)                                       41/50 (82%)                  | 
|POLY-3 RATE (b)    |                              52/53.00                                          41/43.06                     | 
|POLY-3 PERCENT (g) |                              98.1%                                             95.2%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.427N                     | 
|POLY 1.5           |                                                                                P=0.119N                     | 
|POLY 6             |                                                                                P=0.817N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.070N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.006N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              4/43.27                                           4/23.68                      | 
|POLY-3 PERCENT (g) |                              9.3%                                              16.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              564                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.272                      | 
|POLY 3             |                                                                                P=0.381                      | 
|POLY 1.5           |                                                                                P=0.439                      | 
|POLY 6             |                                                                                P=0.348                      | 
|LOGISTIC REGRESSION|                                                                                P=0.550N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.609                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              4/41.89                                           2/22.11                      | 
|POLY-3 PERCENT (g) |                              9.6%                                              9.1%                         | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           474                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.584                      | 
|POLY 3             |                                                                                P=0.720N                     | 
|POLY 1.5           |                                                                                P=0.623N                     | 
|POLY 6             |                                                                                P=0.743                      | 
|LOGISTIC REGRESSION|                                                                                P=0.654N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.367N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           2/21.77                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              9.2%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           593                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.358                      | 
|POLY 3             |                                                                                P=0.562                      | 
|POLY 1.5           |                                                                                P=0.583                      | 
|POLY 6             |                                                                                P=0.557                      | 
|LOGISTIC REGRESSION|                                                                                P=0.431                      | 
|COCH-ARM / FISHERS |                                                                                P=0.669                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         2/50 (4%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           2/21.61                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              9.3%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           593                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.350                      | 
|POLY 3             |                                                                                P=0.562                      | 
|POLY 1.5           |                                                                                P=0.582                      | 
|POLY 6             |                                                                                P=0.557                      | 
|LOGISTIC REGRESSION|                                                                                P=0.405                      | 
|COCH-ARM / FISHERS |                                                                                P=0.669                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/53 (23%)                                       1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              12/45.97                                          1/21.72                      | 
|POLY-3 PERCENT (g) |                              26.1%                                             4.6%                         | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/10 (0%)                    | 
|FIRST INCIDENCE    |                              313                                               504                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.073N                     | 
|POLY 3             |                                                                                P=0.083N                     | 
|POLY 1.5           |                                                                                P=0.030N*                    | 
|POLY 6             |                                                                                P=0.157N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.003N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       45/46 (98%)                  | 
|POLY-3 RATE (b)    |                              40/48.92                                          45/45.07                     | 
|POLY-3 PERCENT (g) |                              81.8%                                             99.8%                        | 
|TERMINAL (d)       |                              23/27 (85%)                                       10/10 (100%)                 | 
|FIRST INCIDENCE    |                              275                                               201                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P=0.004 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Infiltration Cellular Lymphoid                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/49 (4%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/21.97                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              9.1%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/9 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.182                      | 
|POLY 3             |                                                                                P=0.228                      | 
|POLY 1.5           |                                                                                P=0.214                      | 
|POLY 6             |                                                                                P=0.246                      | 
|LOGISTIC REGRESSION|                                                                                P=0.890                      | 
|COCH-ARM / FISHERS |                                                                                P=0.228                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/53 (13%)                                        6/49 (12%)                   | 
|POLY-3 RATE (b)    |                              7/43.53                                           6/21.98                      | 
|POLY-3 PERCENT (g) |                              16.1%                                             27.3%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        2/9 (22%)                    | 
|FIRST INCIDENCE    |                              555                                               258                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.143                      | 
|POLY 3             |                                                                                P=0.308                      | 
|POLY 1.5           |                                                                                P=0.401                      | 
|POLY 6             |                                                                                P=0.258                      | 
|LOGISTIC REGRESSION|                                                                                P=0.373                      | 
|COCH-ARM / FISHERS |                                                                                P=0.561N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              22/53 (42%)                                       29/49 (59%)                  | 
|POLY-3 RATE (b)    |                              22/47.33                                          29/35.78                     | 
|POLY-3 PERCENT (g) |                              46.5%                                             81.1%                        | 
|TERMINAL (d)       |                              9/27 (33%)                                        6/9 (67%)                    | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.002 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.039 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.056                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              29/29 (100%)                                      23/23 (100%)                 | 
|POLY-3 RATE (b)    |                              29/29.00                                          23/23.00                     | 
|POLY-3 PERCENT (g) |                              100.0%                                            100.0%                       | 
|TERMINAL (d)       |                              16/16 (100%)                                      7/7 (100%)                   | 
|FIRST INCIDENCE    |                              534                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                (e)                          | 
|POLY 3             |                                                                                (e)                          | 
|POLY 1.5           |                                                                                (e)                          | 
|POLY 6             |                                                                                (e)                          | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                (e)                          | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/53 (15%)                                        1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              8/43.36                                           1/21.51                      | 
|POLY-3 PERCENT (g) |                              18.5%                                             4.7%                         | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/10 (0%)                    | 
|FIRST INCIDENCE    |                              362                                               594                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.210N                     | 
|POLY 3             |                                                                                P=0.210N                     | 
|POLY 1.5           |                                                                                P=0.118N                     | 
|POLY 6             |                                                                                P=0.296N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.081N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.019N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/50 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.40                                           0/21.06                      | 
|POLY-3 PERCENT (g) |                              9.4%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.255N                     | 
|POLY 3             |                                                                                P=0.309N                     | 
|POLY 1.5           |                                                                                P=0.206N                     | 
|POLY 6             |                                                                                P=0.405N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.196N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.066N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         4/50 (8%)                    | 
|POLY-3 RATE (b)    |                              4/41.89                                           4/22.63                      | 
|POLY-3 PERCENT (g) |                              9.6%                                              17.7%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/10 (0%)                    | 
|FIRST INCIDENCE    |                              726 (T)                                           541                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.177                      | 
|POLY 3             |                                                                                P=0.376                      | 
|POLY 1.5           |                                                                                P=0.430                      | 
|POLY 6             |                                                                                P=0.354                      | 
|LOGISTIC REGRESSION|                                                                                P=0.278                      | 
|COCH-ARM / FISHERS |                                                                                P=0.609                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/50 (2%)                    | 
|POLY-3 RATE (b)    |                              2/42.77                                           1/21.74                      | 
|POLY-3 PERCENT (g) |                              4.7%                                              4.6%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/10 (0%)                    | 
|FIRST INCIDENCE    |                              362                                               494                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.726                      | 
|POLY 3             |                                                                                P=0.815N                     | 
|POLY 1.5           |                                                                                P=0.737N                     | 
|POLY 6             |                                                                                P=0.824                      | 
|LOGISTIC REGRESSION|                                                                                P=0.434N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.522N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              23/53 (43%)                                       8/50 (16%)                   | 
|POLY-3 RATE (b)    |                              23/44.48                                          8/23.38                      | 
|POLY-3 PERCENT (g) |                              51.7%                                             34.2%                        | 
|TERMINAL (d)       |                              16/27 (59%)                                       3/10 (30%)                   | 
|FIRST INCIDENCE    |                              555                                               494                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.457N                     | 
|POLY 3             |                                                                                P=0.176N                     | 
|POLY 1.5           |                                                                                P=0.065N                     | 
|POLY 6             |                                                                                P=0.276N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.176N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.002N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 96022 TEST: 02                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500UG ST                     | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              32/53 (60%)                                       17/50 (34%)                  | 
|POLY-3 RATE (b)    |                              32/46.96                                          17/24.95                     | 
|POLY-3 PERCENT (g) |                              68.2%                                             68.2%                        | 
|TERMINAL (d)       |                              21/27 (78%)                                       8/10 (80%)                   | 
|FIRST INCIDENCE    |                              275                                               273                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.156                      | 
|POLY 3             |                                                                                P=0.661                      | 
|POLY 1.5           |                                                                                P=0.307N                     | 
|POLY 6             |                                                                                P=0.497                      | 
|LOGISTIC REGRESSION|                                                                                P=0.525N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.006N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).