TDMS Study 96022-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 04/29/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:11:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 RATS_CTRL VS STOP GRP.
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 NG / 0 UG
INCLUDE 007 4000 NG/500UG ST
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 04/29/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:11:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TEF EVALUATION (PCB MIXTURE;PCB 126/P
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Atrophy
Degeneration Cystic
Hyperplasia
Hypertrophy
Inflammation
Necrosis
Vacuolization Cytoplasmic
Adrenal Medulla Hyperplasia
Blood Vessel: Aorta, Adventitia Hemorrhage
Inflammation
Bone Marrow Atrophy
Hyperplasia
Brain Hemorrhage
Clitoral Gland Inflammation
Clitoral Gland: Duct Cyst
Esophagus: Muscularis Inflammation
Harderian Gland Inflammation
Heart Cardiomyopathy
Heart: Coronary Artery Inflammation Chronic
Intestine Large, Colon Parasite Metazoan
Intestine Large, Rectum Parasite Metazoan
Intestine Large, Rectum: Artery Inflammation Chronic
Kidney Calculus Micro Observation Only
Infarct
Mineralization
Nephropathy
Kidney: Pelvis Inflammation
Kidney: Renal Tubule Hyperplasia
Kidney: Transitional Epithelium Hyperplasia
Liver Angiectasis
Basophilic Focus
Cholangiofibrosis
Clear Cell Focus
Eosinophilic Focus
Fatty Change Diffuse
Fatty Change Focal
Hematopoietic Cell Proliferation
Hepatodiaphragmatic Nodule
Hyperplasia
Inflammation
Metaplasia
Mixed Cell Focus
Necrosis
Pigmentation
Toxic Hepatopathy
Liver: Bile Duct Cyst
Fibrosis
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 04/29/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:11:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Hyperplasia
Liver: Centrilobular Degeneration
Fibrosis
Liver: Hepatocyte Glandular Structures
Hypertrophy
Multinucleated
Liver: Oval Cell Hyperplasia
Liver: Portal Fibrosis
Lung Hemorrhage
Infiltration Cellular Histiocyte
Inflammation
Inflammation Granulomatous
Keratin Cyst
Metaplasia
Lung: Alveolar Epithelium Hyperplasia
Metaplasia Bronchiolar
Lung: Serosa Fibrosis
Lymph Node, Mandibular Ectasia
Hemorrhage
Hyperplasia
Lymph Node, Mesenteric Hemorrhage
Hyperplasia
Lymph Node: Mediastinal Ectasia
Hemorrhage
Hyperplasia
Lymph Node: Pancreatic Hemorrhage
Hyperplasia
Lymph Node: Renal Hemorrhage
Hyperplasia
Mammary Gland Hyperplasia
Inflammation Granulomatous
Mesentery: Artery Inflammation Chronic
Nose Inflammation
Nose: Olfactory Epithelium Metaplasia
Nose: Respiratory Epithelium Hyperplasia
Oral Mucosa: Gingival Hyperplasia
Ovary Atrophy
Cyst
Pancreas Edema
Inflammation Chronic
Pancreas: Acinus Atrophy
Hyperplasia
Vacuolization Cytoplasmic
Pancreas: Artery Inflammation Chronic
Pituitary Gland Angiectasis
Cyst
Cytoplasmic Alteration
Vacuolization Cytoplasmic
Pituitary Gland: Pars Distalis Hyperplasia
Spleen Hematopoietic Cell Proliferation
Pigmentation
Spleen: Lymphoid Follicle Atrophy
Stomach, Forestomach Hyperplasia
Inflammation
Ulcer
Stomach, Glandular Mineralization
Thymus Atrophy
Thyroid Gland Infiltration Cellular Lymphoid
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118) DATE: 04/29/04
EXPERIMENT: 96022 TEST: 02 TIME: 10:11:57
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96022
PATHOLOGIST: MISSING CAS: TEFPCBMIX
Thyroid Gland: C-Cell Hyperplasia
Thyroid Gland: Follicular Cell Hypertrophy
Urinary Bladder Inflammation
Urinary Bladder: Transitional Epithelium
Hyperplasia
Uterus Inflammation
Inflammation Chronic
Metaplasia
Uterus: Endometrium Hyperplasia Cystic
===============================================================
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/53 (79%) 21/50 (42%) |
|POLY-3 RATE (b) | 42/48.03 21/28.18 |
|POLY-3 PERCENT (g) | 87.4% 74.5% |
|TERMINAL (d) | 26/27 (96%) 9/10 (90%) |
|FIRST INCIDENCE | 482 232 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.190 |
|POLY 3 | P=0.134N |
|POLY 1.5 | P=0.017N* |
|POLY 6 | P=0.364N |
|LOGISTIC REGRESSION| P=0.169N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 12/50 (24%) |
|POLY-3 RATE (b) | 2/42.18 12/30.21 |
|POLY-3 PERCENT (g) | 4.7% 39.7% |
|TERMINAL (d) | 1/27 (4%) 1/10 (10%) |
|FIRST INCIDENCE | 649 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.102 |
|COCH-ARM / FISHERS | P=0.003 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/53 (23%) 9/50 (18%) |
|POLY-3 RATE (b) | 12/43.80 9/22.95 |
|POLY-3 PERCENT (g) | 27.4% 39.2% |
|TERMINAL (d) | 6/27 (22%) 4/10 (40%) |
|FIRST INCIDENCE | 482 504 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.098 |
|POLY 3 | P=0.303 |
|POLY 1.5 | P=0.438 |
|POLY 6 | P=0.236 |
|LOGISTIC REGRESSION| P=0.233 |
|COCH-ARM / FISHERS | P=0.368N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 10/50 (20%) |
|POLY-3 RATE (b) | 13/44.54 10/25.67 |
|POLY-3 PERCENT (g) | 29.2% 39.0% |
|TERMINAL (d) | 5/27 (19%) 4/10 (40%) |
|FIRST INCIDENCE | 362 258 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.109 |
|POLY 3 | P=0.331 |
|POLY 1.5 | P=0.454 |
|POLY 6 | P=0.259 |
|LOGISTIC REGRESSION| P=0.582 |
|COCH-ARM / FISHERS | P=0.377N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 29/50 (58%) |
|POLY-3 RATE (b) | 45/48.89 29/31.75 |
|POLY-3 PERCENT (g) | 92.1% 91.3% |
|TERMINAL (d) | 26/27 (96%) 10/10 (100%) |
|FIRST INCIDENCE | 275 230 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009 ** |
|POLY 3 | P=0.700N |
|POLY 1.5 | P=0.243N |
|POLY 6 | P=0.725 |
|LOGISTIC REGRESSION| P=0.452 |
|COCH-ARM / FISHERS | P=0.002N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/22.11 |
|POLY-3 PERCENT (g) | 0.0% 9.1% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 279 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.110 |
|POLY 3 | P=0.230 |
|POLY 1.5 | P=0.216 |
|POLY 6 | P=0.247 |
|LOGISTIC REGRESSION| P=0.288 |
|COCH-ARM / FISHERS | P=0.233 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 2/50 (4%) |
|POLY-3 RATE (b) | 1/42.24 2/22.01 |
|POLY-3 PERCENT (g) | 2.4% 9.1% |
|TERMINAL (d) | 0/27 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 628 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.253 |
|POLY 3 | P=0.417 |
|POLY 1.5 | P=0.422 |
|POLY 6 | P=0.425 |
|LOGISTIC REGRESSION| P=0.536 |
|COCH-ARM / FISHERS | P=0.478 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 16/50 (32%) |
|POLY-3 RATE (b) | 14/44.09 16/26.74 |
|POLY-3 PERCENT (g) | 31.8% 59.9% |
|TERMINAL (d) | 6/27 (22%) 5/10 (50%) |
|FIRST INCIDENCE | 564 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** |
|POLY 3 | P=0.024 * |
|POLY 1.5 | P=0.059 |
|POLY 6 | P=0.015 * |
|LOGISTIC REGRESSION| P=0.033 * |
|COCH-ARM / FISHERS | P=0.342 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 8/49 (16%) |
|POLY-3 RATE (b) | 13/42.77 8/23.03 |
|POLY-3 PERCENT (g) | 30.4% 34.7% |
|TERMINAL (d) | 10/27 (37%) 3/9 (33%) |
|FIRST INCIDENCE | 628 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180 |
|POLY 3 | P=0.523 |
|POLY 1.5 | P=0.621N |
|POLY 6 | P=0.452 |
|LOGISTIC REGRESSION| P=0.448 |
|COCH-ARM / FISHERS | P=0.219N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta, Adventitia |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/22.98 |
|POLY-3 PERCENT (g) | 0.0% 8.7% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 240 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.185 |
|POLY 3 | P=0.225 |
|POLY 1.5 | P=0.215 |
|POLY 6 | P=0.239 |
|LOGISTIC REGRESSION| P=0.898 |
|COCH-ARM / FISHERS | P=0.233 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta, Adventitia |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/22.99 |
|POLY-3 PERCENT (g) | 0.0% 8.7% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 240 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.193 |
|POLY 3 | P=0.225 |
|POLY 1.5 | P=0.215 |
|POLY 6 | P=0.239 |
|LOGISTIC REGRESSION| P=0.951 |
|COCH-ARM / FISHERS | P=0.233 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/41.89 4/24.94 |
|POLY-3 PERCENT (g) | 0.0% 16.0% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051 |
|POLY 3 | P=0.031 * |
|POLY 1.5 | P=0.035 * |
|POLY 6 | P=0.029 * |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.052 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 37/53 (70%) 40/50 (80%) |
|POLY-3 RATE (b) | 37/51.61 40/46.05 |
|POLY-3 PERCENT (g) | 71.7% 86.9% |
|TERMINAL (d) | 14/27 (52%) 5/10 (50%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.054 |
|POLY 1.5 | P=0.061 |
|POLY 6 | P=0.062 |
|LOGISTIC REGRESSION| P=0.555 |
|COCH-ARM / FISHERS | P=0.168 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 8/50 (16%) |
|POLY-3 RATE (b) | 0/41.89 8/28.75 |
|POLY-3 PERCENT (g) | 0.0% 27.8% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.583 |
|COCH-ARM / FISHERS | P=0.002 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 30/50 (60%) |
|POLY-3 RATE (b) | 49/52.29 30/33.33 |
|POLY-3 PERCENT (g) | 93.7% 90.0% |
|TERMINAL (d) | 24/27 (89%) 9/10 (90%) |
|FIRST INCIDENCE | 275 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.037 * |
|POLY 3 | P=0.468N |
|POLY 1.5 | P=0.076N |
|POLY 6 | P=0.741N |
|LOGISTIC REGRESSION| P=0.100N |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Clitoral Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 40/50 (80%) |
|POLY-3 RATE (b) | 40/50.23 40/43.50 |
|POLY-3 PERCENT (g) | 79.6% 92.0% |
|TERMINAL (d) | 20/27 (74%) 10/10 (100%) |
|FIRST INCIDENCE | 313 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.070 |
|POLY 1.5 | P=0.125 |
|POLY 6 | P=0.039 * |
|LOGISTIC REGRESSION| P=0.310 |
|COCH-ARM / FISHERS | P=0.377 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Esophagus: Muscularis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/42.85 0/21.06 |
|POLY-3 PERCENT (g) | 7.0% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 534 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.317N |
|POLY 3 | P=0.430N |
|POLY 1.5 | P=0.311N |
|POLY 6 | P=0.533N |
|LOGISTIC REGRESSION| P=0.180N |
|COCH-ARM / FISHERS | P=0.132N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 24/53 (45%) 12/50 (24%) |
|POLY-3 RATE (b) | 24/45.26 12/26.40 |
|POLY-3 PERCENT (g) | 53.0% 45.5% |
|TERMINAL (d) | 15/27 (56%) 5/10 (50%) |
|FIRST INCIDENCE | 313 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.387 |
|POLY 3 | P=0.396N |
|POLY 1.5 | P=0.210N |
|POLY 6 | P=0.545N |
|LOGISTIC REGRESSION| P=0.183N |
|COCH-ARM / FISHERS | P=0.019N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 20/53 (38%) 15/50 (30%) |
|POLY-3 RATE (b) | 20/45.03 15/28.08 |
|POLY-3 PERCENT (g) | 44.4% 53.4% |
|TERMINAL (d) | 11/27 (41%) 3/10 (30%) |
|FIRST INCIDENCE | 534 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.065 |
|POLY 3 | P=0.338 |
|POLY 1.5 | P=0.489 |
|POLY 6 | P=0.273 |
|LOGISTIC REGRESSION| P=0.523 |
|COCH-ARM / FISHERS | P=0.268N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Heart: Coronary Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 6/50 (12%) |
|POLY-3 RATE (b) | 1/41.89 6/24.90 |
|POLY-3 PERCENT (g) | 2.4% 24.1% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 273 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** |
|POLY 3 | P=0.015 * |
|POLY 1.5 | P=0.020 * |
|POLY 6 | P=0.013 * |
|LOGISTIC REGRESSION| P=0.071 |
|COCH-ARM / FISHERS | P=0.048 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/41.97 1/21.06 |
|POLY-3 PERCENT (g) | 4.8% 4.8% |
|TERMINAL (d) | 1/27 (4%) 1/10 (10%) |
|FIRST INCIDENCE | 707 726 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.652 |
|POLY 3 | P=0.820N |
|POLY 1.5 | P=0.739N |
|POLY 6 | P=0.825 |
|LOGISTIC REGRESSION| P=0.674 |
|COCH-ARM / FISHERS | P=0.522N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/52 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/41.84 1/22.02 |
|POLY-3 PERCENT (g) | 7.2% 4.5% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 567 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.594N |
|POLY 3 | P=0.656N |
|POLY 1.5 | P=0.550N |
|POLY 6 | P=0.733N |
|LOGISTIC REGRESSION| P=0.287N |
|COCH-ARM / FISHERS | P=0.324N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Intestine Large, Rectum: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/52 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/41.24 4/21.71 |
|POLY-3 PERCENT (g) | 0.0% 18.4% |
|TERMINAL (d) | 0/27 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- 607 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.030 * |
|POLY 1.5 | P=0.033 * |
|POLY 6 | P=0.030 * |
|LOGISTIC REGRESSION| P=0.007 ** |
|COCH-ARM / FISHERS | P=0.054 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney |
| Calculus Micro Observation Only |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/53 (11%) 0/50 (0%) |
|POLY-3 RATE (b) | 6/42.65 0/21.06 |
|POLY-3 PERCENT (g) | 14.1% 0.0% |
|TERMINAL (d) | 4/27 (15%) 0/10 (0%) |
|FIRST INCIDENCE | 586 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.132N |
|POLY 3 | P=0.169N |
|POLY 1.5 | P=0.094N |
|POLY 6 | P=0.249N |
|LOGISTIC REGRESSION| P=0.093N |
|COCH-ARM / FISHERS | P=0.016N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/41.89 0/21.06 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.474N |
|POLY 3 | P=0.579N |
|POLY 1.5 | P=0.464N |
|POLY 6 | P=0.667N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.262N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 46/53 (87%) 32/50 (64%) |
|POLY-3 RATE (b) | 46/51.13 32/39.76 |
|POLY-3 PERCENT (g) | 90.0% 80.5% |
|TERMINAL (d) | 23/27 (85%) 7/10 (70%) |
|FIRST INCIDENCE | 313 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020 * |
|POLY 3 | P=0.157N |
|POLY 1.5 | P=0.065N |
|POLY 6 | P=0.283N |
|LOGISTIC REGRESSION| P=0.021N* |
|COCH-ARM / FISHERS | P=0.006N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 41/53 (77%) 34/50 (68%) |
|POLY-3 RATE (b) | 41/49.70 34/34.66 |
|POLY-3 PERCENT (g) | 82.5% 98.1% |
|TERMINAL (d) | 24/27 (89%) 10/10 (100%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.021 * |
|POLY 1.5 | P=0.112 |
|POLY 6 | P=0.020 * |
|LOGISTIC REGRESSION| P=0.045 * |
|COCH-ARM / FISHERS | P=0.199N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/42.25 0/21.06 |
|POLY-3 PERCENT (g) | 9.5% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.255N |
|POLY 3 | P=0.306N |
|POLY 1.5 | P=0.205N |
|POLY 6 | P=0.400N |
|LOGISTIC REGRESSION| P=0.211N |
|COCH-ARM / FISHERS | P=0.066N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/42.10 0/21.06 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.477N |
|POLY 3 | P=0.582N |
|POLY 1.5 | P=0.465N |
|POLY 6 | P=0.673N |
|LOGISTIC REGRESSION| P=0.430N |
|COCH-ARM / FISHERS | P=0.262N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Kidney: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/42.25 0/21.06 |
|POLY-3 PERCENT (g) | 9.5% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.255N |
|POLY 3 | P=0.306N |
|POLY 1.5 | P=0.205N |
|POLY 6 | P=0.400N |
|LOGISTIC REGRESSION| P=0.211N |
|COCH-ARM / FISHERS | P=0.066N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/41.89 4/21.49 |
|POLY-3 PERCENT (g) | 0.0% 18.6% |
|TERMINAL (d) | 0/27 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** |
|POLY 3 | P=0.029 * |
|POLY 1.5 | P=0.032 * |
|POLY 6 | P=0.029 * |
|LOGISTIC REGRESSION| P=0.005 ** |
|COCH-ARM / FISHERS | P=0.052 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 5/50 (10%) |
|POLY-3 RATE (b) | 27/45.63 5/21.73 |
|POLY-3 PERCENT (g) | 59.2% 23.0% |
|TERMINAL (d) | 16/27 (59%) 3/10 (30%) |
|FIRST INCIDENCE | 534 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053N |
|POLY 3 | P=0.013N* |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.051N |
|LOGISTIC REGRESSION| P=0.006N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 27/50 (54%) |
|POLY-3 RATE (b) | 1/41.89 27/33.72 |
|POLY-3 PERCENT (g) | 2.4% 80.1% |
|TERMINAL (d) | 1/27 (4%) 8/10 (80%) |
|FIRST INCIDENCE | 726 (T) 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 1/50 (2%) |
|POLY-3 RATE (b) | 5/42.17 1/21.06 |
|POLY-3 PERCENT (g) | 11.9% 4.8% |
|TERMINAL (d) | 4/27 (15%) 1/10 (10%) |
|FIRST INCIDENCE | 651 726 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.448N |
|POLY 3 | P=0.442N |
|POLY 1.5 | P=0.317N |
|POLY 6 | P=0.542N |
|LOGISTIC REGRESSION| P=0.416N |
|COCH-ARM / FISHERS | P=0.116N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 15/50 (30%) |
|POLY-3 RATE (b) | 10/43.62 15/28.06 |
|POLY-3 PERCENT (g) | 22.9% 53.5% |
|TERMINAL (d) | 6/27 (22%) 3/10 (30%) |
|FIRST INCIDENCE | 534 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.010 * |
|POLY 1.5 | P=0.021 * |
|POLY 6 | P=0.007 ** |
|LOGISTIC REGRESSION| P=0.040 * |
|COCH-ARM / FISHERS | P=0.138 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 35/50 (70%) |
|POLY-3 RATE (b) | 3/42.21 35/43.37 |
|POLY-3 PERCENT (g) | 7.1% 80.7% |
|TERMINAL (d) | 2/27 (7%) 7/10 (70%) |
|FIRST INCIDENCE | 639 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 14/50 (28%) |
|POLY-3 RATE (b) | 10/43.19 14/24.02 |
|POLY-3 PERCENT (g) | 23.2% 58.3% |
|TERMINAL (d) | 5/27 (19%) 7/10 (70%) |
|FIRST INCIDENCE | 586 282 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.007 ** |
|POLY 1.5 | P=0.022 * |
|POLY 6 | P=0.003 ** |
|LOGISTIC REGRESSION| P=0.003 ** |
|COCH-ARM / FISHERS | P=0.194 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 22/50 (44%) |
|POLY-3 RATE (b) | 27/48.61 22/29.47 |
|POLY-3 PERCENT (g) | 55.6% 74.6% |
|TERMINAL (d) | 11/27 (41%) 8/10 (80%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.010 * |
|POLY 3 | P=0.087 |
|POLY 1.5 | P=0.221 |
|POLY 6 | P=0.047 * |
|LOGISTIC REGRESSION| P=0.348 |
|COCH-ARM / FISHERS | P=0.306N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/41.89 1/21.15 |
|POLY-3 PERCENT (g) | 4.8% 4.7% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 703 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.660 |
|POLY 3 | P=0.818N |
|POLY 1.5 | P=0.737N |
|POLY 6 | P=0.825 |
|LOGISTIC REGRESSION| P=0.675 |
|COCH-ARM / FISHERS | P=0.522N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 34/50 (68%) |
|POLY-3 RATE (b) | 0/41.89 34/44.64 |
|POLY-3 PERCENT (g) | 0.0% 76.2% |
|TERMINAL (d) | 0/27 (0%) 4/10 (40%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 48/50 (96%) |
|POLY-3 RATE (b) | 49/51.05 48/48.82 |
|POLY-3 PERCENT (g) | 96.0% 98.3% |
|TERMINAL (d) | 26/27 (96%) 10/10 (100%) |
|FIRST INCIDENCE | 313 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.460 |
|POLY 1.5 | P=0.408 |
|POLY 6 | P=0.541 |
|LOGISTIC REGRESSION| P=0.208 |
|COCH-ARM / FISHERS | P=0.367 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/22.97 |
|POLY-3 PERCENT (g) | 0.0% 8.7% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 232 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.179 |
|POLY 3 | P=0.225 |
|POLY 1.5 | P=0.215 |
|POLY 6 | P=0.239 |
|LOGISTIC REGRESSION| P=0.882 |
|COCH-ARM / FISHERS | P=0.233 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 38/53 (72%) 20/50 (40%) |
|POLY-3 RATE (b) | 38/45.68 20/26.46 |
|POLY-3 PERCENT (g) | 83.2% 75.6% |
|TERMINAL (d) | 26/27 (96%) 10/10 (100%) |
|FIRST INCIDENCE | 534 282 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.082 |
|POLY 3 | P=0.349N |
|POLY 1.5 | P=0.095N |
|POLY 6 | P=0.599N |
|LOGISTIC REGRESSION| P=0.536 |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 6/50 (12%) |
|POLY-3 RATE (b) | 3/42.94 6/25.40 |
|POLY-3 PERCENT (g) | 7.0% 23.6% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 564 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051 |
|POLY 3 | P=0.083 |
|POLY 1.5 | P=0.108 |
|POLY 6 | P=0.071 |
|LOGISTIC REGRESSION| P=0.499 |
|COCH-ARM / FISHERS | P=0.216 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 50/50 (100%) |
|POLY-3 RATE (b) | 5/43.23 50/50.00 |
|POLY-3 PERCENT (g) | 11.6% 100.0% |
|TERMINAL (d) | 2/27 (7%) 10/10 (100%) |
|FIRST INCIDENCE | 534 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver |
| Toxic Hepatopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 50/50 (100%) |
|POLY-3 RATE (b) | 0/41.89 50/50.00 |
|POLY-3 PERCENT (g) | 0.0% 100.0% |
|TERMINAL (d) | 0/27 (0%) 10/10 (100%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 21/50 (42%) |
|POLY-3 RATE (b) | 4/42.10 21/25.42 |
|POLY-3 PERCENT (g) | 9.5% 82.6% |
|TERMINAL (d) | 3/27 (11%) 9/10 (90%) |
|FIRST INCIDENCE | 672 474 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/53 (11%) 12/50 (24%) |
|POLY-3 RATE (b) | 6/42.12 12/24.42 |
|POLY-3 PERCENT (g) | 14.2% 49.2% |
|TERMINAL (d) | 5/27 (19%) 3/10 (30%) |
|FIRST INCIDENCE | 665 383 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.004 ** |
|POLY 1.5 | P=0.009 ** |
|POLY 6 | P=0.003 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.075 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 37/50 (74%) |
|POLY-3 RATE (b) | 5/42.04 37/44.10 |
|POLY-3 PERCENT (g) | 11.9% 83.9% |
|TERMINAL (d) | 4/27 (15%) 5/10 (50%) |
|FIRST INCIDENCE | 687 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 6/50 (12%) |
|POLY-3 RATE (b) | 2/42.71 6/25.86 |
|POLY-3 PERCENT (g) | 4.7% 23.2% |
|TERMINAL (d) | 0/27 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 564 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.036 * |
|POLY 3 | P=0.042 * |
|POLY 1.5 | P=0.056 |
|POLY 6 | P=0.034 * |
|LOGISTIC REGRESSION| P=0.609 |
|COCH-ARM / FISHERS | P=0.117 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 43/50 (86%) |
|POLY-3 RATE (b) | 0/41.89 43/50.00 |
|POLY-3 PERCENT (g) | 0.0% 86.0% |
|TERMINAL (d) | 0/27 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Glandular Structures |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 9/50 (18%) |
|POLY-3 RATE (b) | 0/41.89 9/29.71 |
|POLY-3 PERCENT (g) | 0.0% 30.3% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.563 |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 36/50 (72%) |
|POLY-3 RATE (b) | 0/41.89 36/45.73 |
|POLY-3 PERCENT (g) | 0.0% 78.7% |
|TERMINAL (d) | 0/27 (0%) 5/10 (50%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Multinucleated |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 38/50 (76%) |
|POLY-3 RATE (b) | 0/41.89 38/44.81 |
|POLY-3 PERCENT (g) | 0.0% 84.8% |
|TERMINAL (d) | 0/27 (0%) 5/10 (50%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Oval Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 43/50 (86%) |
|POLY-3 RATE (b) | 4/41.89 43/48.43 |
|POLY-3 PERCENT (g) | 9.6% 88.8% |
|TERMINAL (d) | 4/27 (15%) 5/10 (50%) |
|FIRST INCIDENCE | 726 (T) 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Liver: Portal |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 42/50 (84%) |
|POLY-3 RATE (b) | 0/41.89 42/48.26 |
|POLY-3 PERCENT (g) | 0.0% 87.0% |
|TERMINAL (d) | 0/27 (0%) 5/10 (50%) |
|FIRST INCIDENCE | --- 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/50 (6%) |
|POLY-3 RATE (b) | 0/41.89 3/23.69 |
|POLY-3 PERCENT (g) | 0.0% 12.7% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.063 |
|POLY 3 | P=0.083 |
|POLY 1.5 | P=0.085 |
|POLY 6 | P=0.084 |
|LOGISTIC REGRESSION| P=0.467 |
|COCH-ARM / FISHERS | P=0.111 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 24/50 (48%) |
|POLY-3 RATE (b) | 40/49.03 24/32.50 |
|POLY-3 PERCENT (g) | 81.6% 73.8% |
|TERMINAL (d) | 21/27 (78%) 6/10 (60%) |
|FIRST INCIDENCE | 362 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.078 |
|POLY 3 | P=0.312N |
|POLY 1.5 | P=0.131N |
|POLY 6 | P=0.420N |
|LOGISTIC REGRESSION| P=0.190N |
|COCH-ARM / FISHERS | P=0.004N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 6/50 (12%) |
|POLY-3 RATE (b) | 5/43.02 6/23.16 |
|POLY-3 PERCENT (g) | 11.6% 25.9% |
|TERMINAL (d) | 3/27 (11%) 2/10 (20%) |
|FIRST INCIDENCE | 534 267 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.071 |
|POLY 3 | P=0.185 |
|POLY 1.5 | P=0.244 |
|POLY 6 | P=0.156 |
|LOGISTIC REGRESSION| P=0.248 |
|COCH-ARM / FISHERS | P=0.459 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/41.89 4/22.05 |
|POLY-3 PERCENT (g) | 0.0% 18.1% |
|TERMINAL (d) | 0/27 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- 561 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.029 * |
|POLY 1.5 | P=0.032 * |
|POLY 6 | P=0.029 * |
|LOGISTIC REGRESSION| P=0.011 * |
|COCH-ARM / FISHERS | P=0.052 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Keratin Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 9/50 (18%) |
|POLY-3 RATE (b) | 0/41.89 9/23.33 |
|POLY-3 PERCENT (g) | 0.0% 38.6% |
|TERMINAL (d) | 0/27 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- 525 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 8/50 (16%) |
|POLY-3 RATE (b) | 0/41.89 8/22.72 |
|POLY-3 PERCENT (g) | 0.0% 35.2% |
|TERMINAL (d) | 0/27 (0%) 4/10 (40%) |
|FIRST INCIDENCE | --- 541 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.002 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 18/53 (34%) 5/50 (10%) |
|POLY-3 RATE (b) | 18/43.48 5/22.02 |
|POLY-3 PERCENT (g) | 41.4% 22.7% |
|TERMINAL (d) | 13/27 (48%) 3/10 (30%) |
|FIRST INCIDENCE | 534 383 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.311N |
|POLY 3 | P=0.161N |
|POLY 1.5 | P=0.062N |
|POLY 6 | P=0.282N |
|LOGISTIC REGRESSION| P=0.156N |
|COCH-ARM / FISHERS | P=0.003N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 15/50 (30%) |
|POLY-3 RATE (b) | 1/41.89 15/27.99 |
|POLY-3 PERCENT (g) | 2.4% 53.6% |
|TERMINAL (d) | 1/27 (4%) 3/10 (30%) |
|FIRST INCIDENCE | 726 (T) 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lung: Serosa |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/42.18 1/22.01 |
|POLY-3 PERCENT (g) | 7.1% 4.5% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 649 273 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.622N |
|POLY 3 | P=0.660N |
|POLY 1.5 | P=0.557N |
|POLY 6 | P=0.731N |
|LOGISTIC REGRESSION| P=0.366N |
|COCH-ARM / FISHERS | P=0.331N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 11/49 (22%) |
|POLY-3 RATE (b) | 3/42.29 11/24.51 |
|POLY-3 PERCENT (g) | 7.1% 44.9% |
|TERMINAL (d) | 1/27 (4%) 3/10 (30%) |
|FIRST INCIDENCE | 639 247 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.014 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 4/49 (8%) |
|POLY-3 RATE (b) | 0/41.89 4/24.84 |
|POLY-3 PERCENT (g) | 0.0% 16.1% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 230 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.035 * |
|POLY 3 | P=0.030 * |
|POLY 1.5 | P=0.034 * |
|POLY 6 | P=0.028 * |
|LOGISTIC REGRESSION| P=0.677 |
|COCH-ARM / FISHERS | P=0.050 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 28/49 (57%) |
|POLY-3 RATE (b) | 45/51.67 28/32.76 |
|POLY-3 PERCENT (g) | 87.1% 85.5% |
|TERMINAL (d) | 24/27 (89%) 10/10 (100%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.039 * |
|POLY 3 | P=0.597N |
|POLY 1.5 | P=0.192N |
|POLY 6 | P=0.492 |
|LOGISTIC REGRESSION| P=0.096N |
|COCH-ARM / FISHERS | P=0.002N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 10/50 (20%) |
|POLY-3 RATE (b) | 0/41.89 10/28.48 |
|POLY-3 PERCENT (g) | 0.0% 35.1% |
|TERMINAL (d) | 0/27 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.030 * |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 2/50 (4%) |
|POLY-3 RATE (b) | 3/42.49 2/22.10 |
|POLY-3 PERCENT (g) | 7.1% 9.1% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 639 541 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.491 |
|POLY 3 | P=0.672 |
|POLY 1.5 | P=0.703 |
|POLY 6 | P=0.659 |
|LOGISTIC REGRESSION| P=0.695 |
|COCH-ARM / FISHERS | P=0.528N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/28 (25%) 3/22 (14%) |
|POLY-3 RATE (b) | 7/23.39 3/10.39 |
|POLY-3 PERCENT (g) | 29.9% 28.9% |
|TERMINAL (d) | 2/12 (17%) 0/2 (0%) |
|FIRST INCIDENCE | 275 254 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.599 |
|POLY 3 | P=0.719N |
|POLY 1.5 | P=0.566N |
|POLY 6 | P=0.702 |
|LOGISTIC REGRESSION| P=0.287N |
|COCH-ARM / FISHERS | P=0.263N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/28 (7%) 11/22 (50%) |
|POLY-3 RATE (b) | 2/21.96 11/16.43 |
|POLY-3 PERCENT (g) | 9.1% 67.0% |
|TERMINAL (d) | 0/12 (0%) 0/2 (0%) |
|FIRST INCIDENCE | 586 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.010 * |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 4/22 (18%) |
|POLY-3 RATE (b) | 0/21.26 4/10.38 |
|POLY-3 PERCENT (g) | 0.0% 38.5% |
|TERMINAL (d) | 0/12 (0%) 0/2 (0%) |
|FIRST INCIDENCE | --- 594 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** |
|POLY 3 | P=0.015 * |
|POLY 1.5 | P=0.018 * |
|POLY 6 | P=0.013 * |
|LOGISTIC REGRESSION| P=0.008 ** |
|COCH-ARM / FISHERS | P=0.032 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 3/22 (14%) |
|POLY-3 RATE (b) | 0/21.26 3/11.01 |
|POLY-3 PERCENT (g) | 0.0% 27.3% |
|TERMINAL (d) | 0/12 (0%) 0/2 (0%) |
|FIRST INCIDENCE | --- 230 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.048 * |
|POLY 3 | P=0.061 |
|POLY 1.5 | P=0.065 |
|POLY 6 | P=0.061 |
|LOGISTIC REGRESSION| P=0.241 |
|COCH-ARM / FISHERS | P=0.079 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 3/22 (14%) |
|POLY-3 RATE (b) | 0/21.26 3/11.01 |
|POLY-3 PERCENT (g) | 0.0% 27.3% |
|TERMINAL (d) | 0/12 (0%) 0/2 (0%) |
|FIRST INCIDENCE | --- 230 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.048 * |
|POLY 3 | P=0.061 |
|POLY 1.5 | P=0.065 |
|POLY 6 | P=0.061 |
|LOGISTIC REGRESSION| P=0.241 |
|COCH-ARM / FISHERS | P=0.079 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 2/22 (9%) |
|POLY-3 RATE (b) | 0/21.26 2/9.18 |
|POLY-3 PERCENT (g) | 0.0% 21.8% |
|TERMINAL (d) | 0/12 (0%) 1/2 (50%) |
|FIRST INCIDENCE | --- 636 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.033 * |
|POLY 3 | P=0.225 |
|POLY 1.5 | P=0.200 |
|POLY 6 | P=0.285 |
|LOGISTIC REGRESSION| P=0.039 * |
|COCH-ARM / FISHERS | P=0.189 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/28 (0%) 3/22 (14%) |
|POLY-3 RATE (b) | 0/21.26 3/9.93 |
|POLY-3 PERCENT (g) | 0.0% 30.2% |
|TERMINAL (d) | 0/12 (0%) 0/2 (0%) |
|FIRST INCIDENCE | --- 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020 * |
|POLY 3 | P=0.062 |
|POLY 1.5 | P=0.063 |
|POLY 6 | P=0.064 |
|LOGISTIC REGRESSION| P=0.025 * |
|COCH-ARM / FISHERS | P=0.079 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 26/53 (49%) 11/50 (22%) |
|POLY-3 RATE (b) | 26/46.93 11/23.96 |
|POLY-3 PERCENT (g) | 55.4% 45.9% |
|TERMINAL (d) | 14/27 (52%) 4/10 (40%) |
|FIRST INCIDENCE | 313 282 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.531 |
|POLY 3 | P=0.369N |
|POLY 1.5 | P=0.144N |
|POLY 6 | P=0.559N |
|LOGISTIC REGRESSION| P=0.161N |
|COCH-ARM / FISHERS | P=0.004N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Mammary Gland |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/50 (2%) |
|POLY-3 RATE (b) | 3/42.81 1/21.06 |
|POLY-3 PERCENT (g) | 7.0% 4.8% |
|TERMINAL (d) | 1/27 (4%) 1/10 (10%) |
|FIRST INCIDENCE | 555 726 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.654N |
|POLY 3 | P=0.693N |
|POLY 1.5 | P=0.578N |
|POLY 6 | P=0.774N |
|LOGISTIC REGRESSION| P=0.524N |
|COCH-ARM / FISHERS | P=0.331N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 7/43 (16%) |
|POLY-3 RATE (b) | 0/41.89 7/21.52 |
|POLY-3 PERCENT (g) | 0.0% 32.5% |
|TERMINAL (d) | 0/27 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- 451 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P=0.003 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 11/50 (22%) |
|POLY-3 RATE (b) | 17/45.19 11/25.60 |
|POLY-3 PERCENT (g) | 37.6% 43.0% |
|TERMINAL (d) | 10/27 (37%) 1/10 (10%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.184 |
|POLY 3 | P=0.473 |
|POLY 1.5 | P=0.614 |
|POLY 6 | P=0.420 |
|LOGISTIC REGRESSION| P=0.549N |
|COCH-ARM / FISHERS | P=0.177N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 5/50 (10%) |
|POLY-3 RATE (b) | 0/41.89 5/22.14 |
|POLY-3 PERCENT (g) | 0.0% 22.6% |
|TERMINAL (d) | 0/27 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- 593 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** |
|POLY 3 | P=0.010 * |
|POLY 1.5 | P=0.012 * |
|POLY 6 | P=0.009 ** |
|LOGISTIC REGRESSION| P=0.003 ** |
|COCH-ARM / FISHERS | P=0.024 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 10/50 (20%) |
|POLY-3 RATE (b) | 8/43.10 10/24.54 |
|POLY-3 PERCENT (g) | 18.6% 40.7% |
|TERMINAL (d) | 5/27 (19%) 1/10 (10%) |
|FIRST INCIDENCE | 564 474 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.014 * |
|POLY 3 | P=0.066 |
|POLY 1.5 | P=0.107 |
|POLY 6 | P=0.054 |
|LOGISTIC REGRESSION| P=0.055 |
|COCH-ARM / FISHERS | P=0.346 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Oral Mucosa: Gingival |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 18/50 (36%) |
|POLY-3 RATE (b) | 11/43.10 18/29.52 |
|POLY-3 PERCENT (g) | 25.5% 61.0% |
|TERMINAL (d) | 7/27 (26%) 3/10 (30%) |
|FIRST INCIDENCE | 582 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.002 ** |
|POLY 1.5 | P=0.005 ** |
|POLY 6 | P=0.002 ** |
|LOGISTIC REGRESSION| P=0.006 ** |
|COCH-ARM / FISHERS | P=0.067 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 46/53 (87%) 15/50 (30%) |
|POLY-3 RATE (b) | 46/50.65 15/27.64 |
|POLY-3 PERCENT (g) | 90.8% 54.3% |
|TERMINAL (d) | 25/27 (93%) 6/10 (60%) |
|FIRST INCIDENCE | 275 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.173N |
|POLY 3 | P<0.001N** |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.003N** |
|LOGISTIC REGRESSION| P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 19/53 (36%) 7/50 (14%) |
|POLY-3 RATE (b) | 19/44.54 7/22.45 |
|POLY-3 PERCENT (g) | 42.7% 31.2% |
|TERMINAL (d) | 13/27 (48%) 2/10 (20%) |
|FIRST INCIDENCE | 313 525 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.532N |
|POLY 3 | P=0.327N |
|POLY 1.5 | P=0.156N |
|POLY 6 | P=0.455N |
|LOGISTIC REGRESSION| P=0.241N |
|COCH-ARM / FISHERS | P=0.009N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 12/50 (24%) |
|POLY-3 RATE (b) | 0/41.89 12/31.74 |
|POLY-3 PERCENT (g) | 0.0% 37.8% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.081 |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 5/50 (10%) |
|POLY-3 RATE (b) | 1/42.38 5/22.51 |
|POLY-3 PERCENT (g) | 2.4% 22.2% |
|TERMINAL (d) | 0/27 (0%) 2/10 (20%) |
|FIRST INCIDENCE | 582 541 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** |
|POLY 3 | P=0.034 * |
|POLY 1.5 | P=0.042 * |
|POLY 6 | P=0.031 * |
|LOGISTIC REGRESSION| P=0.024 * |
|COCH-ARM / FISHERS | P=0.090 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 8/50 (16%) |
|POLY-3 RATE (b) | 1/41.89 8/24.21 |
|POLY-3 PERCENT (g) | 2.4% 33.0% |
|TERMINAL (d) | 1/27 (4%) 3/10 (30%) |
|FIRST INCIDENCE | 726 (T) 258 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.002 ** |
|POLY 1.5 | P=0.003 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.004 ** |
|COCH-ARM / FISHERS | P=0.012 * |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/42.36 0/21.06 |
|POLY-3 PERCENT (g) | 4.7% 0.0% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 639 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.473N |
|POLY 3 | P=0.586N |
|POLY 1.5 | P=0.467N |
|POLY 6 | P=0.681N |
|LOGISTIC REGRESSION| P=0.371N |
|COCH-ARM / FISHERS | P=0.262N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 41/50 (82%) |
|POLY-3 RATE (b) | 0/41.89 41/41.99 |
|POLY-3 PERCENT (g) | 0.0% 97.7% |
|TERMINAL (d) | 0/27 (0%) 10/10 (100%) |
|FIRST INCIDENCE | --- 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 10/50 (20%) |
|POLY-3 RATE (b) | 0/41.89 10/24.82 |
|POLY-3 PERCENT (g) | 0.0% 40.3% |
|TERMINAL (d) | 0/27 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- 401 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 3/50 (6%) |
|POLY-3 RATE (b) | 23/44.91 3/21.06 |
|POLY-3 PERCENT (g) | 51.2% 14.3% |
|TERMINAL (d) | 15/27 (56%) 3/10 (30%) |
|FIRST INCIDENCE | 564 726 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.024N* |
|POLY 3 | P=0.012N* |
|POLY 1.5 | P<0.001N** |
|POLY 6 | P=0.048N* |
|LOGISTIC REGRESSION| P=0.005N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/50 (6%) |
|POLY-3 RATE (b) | 1/42.21 3/23.88 |
|POLY-3 PERCENT (g) | 2.4% 12.6% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 639 258 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.135 |
|POLY 3 | P=0.204 |
|POLY 1.5 | P=0.218 |
|POLY 6 | P=0.198 |
|LOGISTIC REGRESSION| P=0.758N |
|COCH-ARM / FISHERS | P=0.287 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/22.03 |
|POLY-3 PERCENT (g) | 0.0% 9.1% |
|TERMINAL (d) | 0/27 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 |
|POLY 3 | P=0.230 |
|POLY 1.5 | P=0.216 |
|POLY 6 | P=0.249 |
|LOGISTIC REGRESSION| P=0.308 |
|COCH-ARM / FISHERS | P=0.233 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/41.89 0/21.06 |
|POLY-3 PERCENT (g) | 4.8% 0.0% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.474N |
|POLY 3 | P=0.579N |
|POLY 1.5 | P=0.464N |
|POLY 6 | P=0.667N |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | P=0.262N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 8/50 (16%) |
|POLY-3 RATE (b) | 11/43.08 8/22.16 |
|POLY-3 PERCENT (g) | 25.5% 36.1% |
|TERMINAL (d) | 6/27 (22%) 5/10 (50%) |
|FIRST INCIDENCE | 564 601 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.107 |
|POLY 3 | P=0.345 |
|POLY 1.5 | P=0.480 |
|POLY 6 | P=0.271 |
|LOGISTIC REGRESSION| P=0.185 |
|COCH-ARM / FISHERS | P=0.357N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 49/53 (92%) 45/50 (90%) |
|POLY-3 RATE (b) | 49/51.71 45/46.08 |
|POLY-3 PERCENT (g) | 94.8% 97.7% |
|TERMINAL (d) | 26/27 (96%) 10/10 (100%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.417 |
|POLY 1.5 | P=0.467 |
|POLY 6 | P=0.499 |
|LOGISTIC REGRESSION| P=0.465 |
|COCH-ARM / FISHERS | P=0.463N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 52/53 (98%) 41/50 (82%) |
|POLY-3 RATE (b) | 52/53.00 41/43.06 |
|POLY-3 PERCENT (g) | 98.1% 95.2% |
|TERMINAL (d) | 26/27 (96%) 10/10 (100%) |
|FIRST INCIDENCE | 275 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P=0.427N |
|POLY 1.5 | P=0.119N |
|POLY 6 | P=0.817N |
|LOGISTIC REGRESSION| P=0.070N |
|COCH-ARM / FISHERS | P=0.006N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 4/43.27 4/23.68 |
|POLY-3 PERCENT (g) | 9.3% 16.9% |
|TERMINAL (d) | 0/27 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 564 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.272 |
|POLY 3 | P=0.381 |
|POLY 1.5 | P=0.439 |
|POLY 6 | P=0.348 |
|LOGISTIC REGRESSION| P=0.550N |
|COCH-ARM / FISHERS | P=0.609 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 2/50 (4%) |
|POLY-3 RATE (b) | 4/41.89 2/22.11 |
|POLY-3 PERCENT (g) | 9.6% 9.1% |
|TERMINAL (d) | 4/27 (15%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 474 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.584 |
|POLY 3 | P=0.720N |
|POLY 1.5 | P=0.623N |
|POLY 6 | P=0.743 |
|LOGISTIC REGRESSION| P=0.654N |
|COCH-ARM / FISHERS | P=0.367N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/41.89 2/21.77 |
|POLY-3 PERCENT (g) | 4.8% 9.2% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 593 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.358 |
|POLY 3 | P=0.562 |
|POLY 1.5 | P=0.583 |
|POLY 6 | P=0.557 |
|LOGISTIC REGRESSION| P=0.431 |
|COCH-ARM / FISHERS | P=0.669 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/41.89 2/21.61 |
|POLY-3 PERCENT (g) | 4.8% 9.3% |
|TERMINAL (d) | 2/27 (7%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 593 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.350 |
|POLY 3 | P=0.562 |
|POLY 1.5 | P=0.582 |
|POLY 6 | P=0.557 |
|LOGISTIC REGRESSION| P=0.405 |
|COCH-ARM / FISHERS | P=0.669 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/53 (23%) 1/50 (2%) |
|POLY-3 RATE (b) | 12/45.97 1/21.72 |
|POLY-3 PERCENT (g) | 26.1% 4.6% |
|TERMINAL (d) | 3/27 (11%) 0/10 (0%) |
|FIRST INCIDENCE | 313 504 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.073N |
|POLY 3 | P=0.083N |
|POLY 1.5 | P=0.030N* |
|POLY 6 | P=0.157N |
|LOGISTIC REGRESSION| P=0.003N** |
|COCH-ARM / FISHERS | P<0.001N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 40/53 (75%) 45/46 (98%) |
|POLY-3 RATE (b) | 40/48.92 45/45.07 |
|POLY-3 PERCENT (g) | 81.8% 99.8% |
|TERMINAL (d) | 23/27 (85%) 10/10 (100%) |
|FIRST INCIDENCE | 275 201 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P<0.001 ** |
|POLY 6 | P=0.004 ** |
|LOGISTIC REGRESSION| P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Infiltration Cellular Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/41.89 2/21.97 |
|POLY-3 PERCENT (g) | 0.0% 9.1% |
|TERMINAL (d) | 0/27 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- 226 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.182 |
|POLY 3 | P=0.228 |
|POLY 1.5 | P=0.214 |
|POLY 6 | P=0.246 |
|LOGISTIC REGRESSION| P=0.890 |
|COCH-ARM / FISHERS | P=0.228 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 6/49 (12%) |
|POLY-3 RATE (b) | 7/43.53 6/21.98 |
|POLY-3 PERCENT (g) | 16.1% 27.3% |
|TERMINAL (d) | 3/27 (11%) 2/9 (22%) |
|FIRST INCIDENCE | 555 258 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.143 |
|POLY 3 | P=0.308 |
|POLY 1.5 | P=0.401 |
|POLY 6 | P=0.258 |
|LOGISTIC REGRESSION| P=0.373 |
|COCH-ARM / FISHERS | P=0.561N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 29/49 (59%) |
|POLY-3 RATE (b) | 22/47.33 29/35.78 |
|POLY-3 PERCENT (g) | 46.5% 81.1% |
|TERMINAL (d) | 9/27 (33%) 6/9 (67%) |
|FIRST INCIDENCE | 275 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** |
|POLY 3 | P<0.001 ** |
|POLY 1.5 | P=0.002 ** |
|POLY 6 | P<0.001 ** |
|LOGISTIC REGRESSION| P=0.039 * |
|COCH-ARM / FISHERS | P=0.056 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Tooth: Peridontal Tissue |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/29 (100%) 23/23 (100%) |
|POLY-3 RATE (b) | 29/29.00 23/23.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% |
|TERMINAL (d) | 16/16 (100%) 7/7 (100%) |
|FIRST INCIDENCE | 534 209 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) |
|POLY 3 | (e) |
|POLY 1.5 | (e) |
|POLY 6 | (e) |
|LOGISTIC REGRESSION| (e) |
|COCH-ARM / FISHERS | (e) |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 1/50 (2%) |
|POLY-3 RATE (b) | 8/43.36 1/21.51 |
|POLY-3 PERCENT (g) | 18.5% 4.7% |
|TERMINAL (d) | 3/27 (11%) 0/10 (0%) |
|FIRST INCIDENCE | 362 594 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.210N |
|POLY 3 | P=0.210N |
|POLY 1.5 | P=0.118N |
|POLY 6 | P=0.296N |
|LOGISTIC REGRESSION| P=0.081N |
|COCH-ARM / FISHERS | P=0.019N* |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Urinary Bladder: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 0/50 (0%) |
|POLY-3 RATE (b) | 4/42.40 0/21.06 |
|POLY-3 PERCENT (g) | 9.4% 0.0% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 672 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.255N |
|POLY 3 | P=0.309N |
|POLY 1.5 | P=0.206N |
|POLY 6 | P=0.405N |
|LOGISTIC REGRESSION| P=0.196N |
|COCH-ARM / FISHERS | P=0.066N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 4/50 (8%) |
|POLY-3 RATE (b) | 4/41.89 4/22.63 |
|POLY-3 PERCENT (g) | 9.6% 17.7% |
|TERMINAL (d) | 4/27 (15%) 0/10 (0%) |
|FIRST INCIDENCE | 726 (T) 541 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.177 |
|POLY 3 | P=0.376 |
|POLY 1.5 | P=0.430 |
|POLY 6 | P=0.354 |
|LOGISTIC REGRESSION| P=0.278 |
|COCH-ARM / FISHERS | P=0.609 |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/42.77 1/21.74 |
|POLY-3 PERCENT (g) | 4.7% 4.6% |
|TERMINAL (d) | 1/27 (4%) 0/10 (0%) |
|FIRST INCIDENCE | 362 494 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.726 |
|POLY 3 | P=0.815N |
|POLY 1.5 | P=0.737N |
|POLY 6 | P=0.824 |
|LOGISTIC REGRESSION| P=0.434N |
|COCH-ARM / FISHERS | P=0.522N |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 8/50 (16%) |
|POLY-3 RATE (b) | 23/44.48 8/23.38 |
|POLY-3 PERCENT (g) | 51.7% 34.2% |
|TERMINAL (d) | 16/27 (59%) 3/10 (30%) |
|FIRST INCIDENCE | 555 494 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.457N |
|POLY 3 | P=0.176N |
|POLY 1.5 | P=0.065N |
|POLY 6 | P=0.276N |
|LOGISTIC REGRESSION| P=0.176N |
|COCH-ARM / FISHERS | P=0.002N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
Date: 04/29/04 EXPERIMENT: 96022 TEST: 02 Page 58
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (PCB MIXTURE;PCB 126/P
Terminal Sacrifice at 104 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 4000 NG/ |
| | 0 UG 500UG ST |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 32/53 (60%) 17/50 (34%) |
|POLY-3 RATE (b) | 32/46.96 17/24.95 |
|POLY-3 PERCENT (g) | 68.2% 68.2% |
|TERMINAL (d) | 21/27 (78%) 8/10 (80%) |
|FIRST INCIDENCE | 275 273 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.156 |
|POLY 3 | P=0.661 |
|POLY 1.5 | P=0.307N |
|POLY 6 | P=0.497 |
|LOGISTIC REGRESSION| P=0.525N |
|COCH-ARM / FISHERS | P=0.006N** |
|ORDER RESTRICTED | (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).