Share This:
https://ntp.niehs.nih.gov/go/16116

TDMS Study 88138-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 10/25/04       
EXPERIMENT: 88138 TEST: 02                                                                                     TIME: 13:32:15       
TEST TYPE:  SUBCHRON 90-DAY                                                                                    PAGE:       1        
CONT: NO1-ES-15320                              ROUTE: DOSED FEED                                              NTP C#: C88138       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 10/25/04       
EXPERIMENT: 88138 TEST: 02                                                                                     TIME: 13:32:15       
TEST TYPE:  SUBCHRON 90-DAY                                                                                                         
CONT: NO1-ES-15320                              ROUTE: DOSED FEED                                              NTP C#: C88138       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Heart: Myocardium                      Mineralization                                                                               
Liver                                  Inflammation Chronic                                                                         
Liver: Centrilobular                   Hypertrophy                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Nose                                   Inflammation Chronic                                                                         
Spleen: Lymphoid Follicle              Depletion Cellular                                                                           
Thymus                                 Atrophy                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Inflammation Chronic                                                                         
Liver: Centrilobular                   Hypertrophy                                                                                  
Liver: Hepatocyte                      Vacuolization Cytoplasmic                                                                    
Nose                                   Inflammation Chronic                                                                         
Thymus                                 Atrophy                                                                                      
===============================================================                                                                     
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 1       
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                       BENZOPHENONE    
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.02           0/0.00           0/0.00           0/10.00          2/3.32          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             60.3%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              75              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.034 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.063         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.078         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.050         | 
|LOGISTIC REGRESSION|        P=0.034 *        (e)              (e)              (e)              (e)              P=0.055         | 
|COCH-ARM / FISHERS |        P=0.082          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/10 (20%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/0.00           2/7.83          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             25.5%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         2/6 (33%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              92 (T)          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.065          (e)              (e)              (e)              (e)              P=0.128         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.171         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.185         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.152         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              P=0.128         | 
|COCH-ARM / FISHERS |        P=0.132          (e)              (e)              (e)              (e)              P=0.237         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        5/10 (50%)       4/10 (40%)       8/10 (80%)       8/10 (80%)       5/10 (50%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        5/10.00          4/9.02           8/10.00          8/10.00          5/10.00          1/3.40          | 
|POLY-3 PERCENT (g) |        50.0%            44.3%            80.0%            80.0%            50.0%            29.4%           | 
|TERMINAL (d)       |        5/10 (50%)       4/9 (44%)        8/10 (80%)       8/10 (80%)       5/10 (50%)       0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.249          P=0.584N         P=0.180          P=0.180          P=0.669          P=0.500         | 
|POLY 3             |        P=0.420N         P=0.580N         P=0.174          P=0.174          P=0.664          P=0.491N        | 
|POLY 1.5           |        P=0.276N         P=0.569N         P=0.174          P=0.174          P=0.664          P=0.357N        | 
|POLY 6             |        P=0.562N         P=0.582N         P=0.174          P=0.174          P=0.664          P=0.657N        | 
|LOGISTIC REGRESSION|        P=0.163N         P=0.586N         P=0.180          P=0.180          P=0.669          P=0.151N        | 
|COCH-ARM / FISHERS |        P=0.012N*        P=0.500N         P=0.175          P=0.175          P=0.672N         P=0.070N        | 
|ORDER RESTRICTED   |        P=0.395N         (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        8/10 (80%)       9/10 (90%)       9/10 (90%)       9/10 (90%)       9/10 (90%)       3/10 (30%)      | 
|POLY-3 RATE (b)    |        8/10.00          9/10.00          9/10.00          9/10.00          9/10.00          3/8.22          | 
|POLY-3 PERCENT (g) |        80.0%            90.0%            90.0%            90.0%            90.0%            36.5%           | 
|TERMINAL (d)       |        8/10 (80%)       9/10 (90%)       9/10 (90%)       9/10 (90%)       9/10 (90%)       2/6 (33%)       | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           78              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.090N         P=0.500          P=0.500          P=0.500          P=0.500          P=0.253N        | 
|POLY 3             |        P=0.006N**       P=0.500          P=0.500          P=0.500          P=0.500          P=0.067N        | 
|POLY 1.5           |        P=0.003N**       P=0.500          P=0.500          P=0.500          P=0.500          P=0.054N        | 
|POLY 6             |        P=0.014N*        P=0.500          P=0.500          P=0.500          P=0.500          P=0.091N        | 
|LOGISTIC REGRESSION|        P=0.012N*        P=0.500          P=0.500          P=0.500          P=0.500          P=0.094N        | 
|COCH-ARM / FISHERS |        P<0.001N**       P=0.500          P=0.500          P=0.500          P=0.500          P=0.035N*       | 
|ORDER RESTRICTED   |        P=0.003N**       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       8/10 (80%)       10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        3/10.00          8/9.02           10/10.00         10/10.00         10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        30.0%            88.7%            100.0%           100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        3/10 (30%)       8/9 (89%)        10/10 (100%)     10/10 (100%)     10/10 (100%)     0/0 (0%)        | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.019 *        P=0.003 **       P=0.003 **       P=0.003 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.008 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.007 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.017 *        P=0.003 **       P=0.003 **       P=0.003 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.004 **       P=0.035 *        P=0.002 **       P=0.002 **       P=0.002 **       P=0.002 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        3/10 (30%)       9/10 (90%)       10/10 (100%)     10/10 (100%)     10/10 (100%)     10/10 (100%)    | 
|POLY-3 RATE (b)    |        3/10.00          9/10.00          10/10.00         10/10.00         10/10.00         10/10.00        | 
|POLY-3 PERCENT (g) |        30.0%            90.0%            100.0%           100.0%           100.0%           100.0%          | 
|TERMINAL (d)       |        3/10 (30%)       9/10 (90%)       10/10 (100%)     10/10 (100%)     10/10 (100%)     6/6 (100%)      | 
|FIRST INCIDENCE    |        92 (T)           92 (T)           92 (T)           92 (T)           92 (T)           13              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       P=0.013 *        P=0.003 **       P=0.003 **       P=0.003 **       P<0.001 **      | 
|POLY 3             |        P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 1.5           |        P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|POLY 6             |        P<0.001 **       P=0.003 **       P<0.001 **       P<0.001 **       P<0.001 **       P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       P=0.013 *        P=0.003 **       P=0.003 **       P=0.003 **       (e)             | 
|COCH-ARM / FISHERS |        P=0.006 **       P=0.010 *        P=0.002 **       P=0.002 **       P=0.002 **       P=0.002 **      | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        0/10 (0%)        3/10 (30%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/9.02           0/10.00          0/10.00          0/10.00          3/3.97          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             75.7%           | 
|TERMINAL (d)       |        0/10 (0%)        0/9 (0%)         0/10 (0%)        0/10 (0%)        0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              65              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.011 *       | 
|POLY 3             |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.008 **      | 
|POLY 1.5           |        P=0.002 **       (e)              (e)              (e)              (e)              P=0.011 *       | 
|POLY 6             |        P=0.007 **       (e)              (e)              (e)              (e)              P=0.005 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              P=0.012 *       | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.105         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       9/10 (90%)       1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/10.00          0/10.00          2/10.00          9/10.00          1/8.22          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             20.0%            90.0%            12.2%           | 
|TERMINAL (d)       |        0/10 (0%)        0/10 (0%)        0/10 (0%)        2/10 (20%)       9/10 (90%)       0/6 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              92 (T)           92 (T)           78              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.006 **       (e)              (e)              P=0.234          P<0.001 **       P=0.479         | 
|POLY 3             |        P<0.001 **       (e)              (e)              P=0.227          P<0.001 **       P=0.461         | 
|POLY 1.5           |        P<0.001 **       (e)              (e)              P=0.227          P<0.001 **       P=0.470         | 
|POLY 6             |        P<0.001 **       (e)              (e)              P=0.227          P<0.001 **       P=0.449         | 
|LOGISTIC REGRESSION|        P=0.020 *        (e)              (e)              P=0.234          P<0.001 **       P=0.563         | 
|COCH-ARM / FISHERS |        P=0.039 *        (e)              (e)              P=0.237          P<0.001 **       P=0.500         | 
|ORDER RESTRICTED   |        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.02           0/0.00           0/0.00           0/10.00          1/2.86          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             35.0%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              75              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.022 *        (e)              (e)              (e)              (e)              P=0.261         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.303         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.334         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.271         | 
|LOGISTIC REGRESSION|        P=0.190          (e)              (e)              (e)              (e)              P=0.370         | 
|COCH-ARM / FISHERS |        P=0.256          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/0.00           5/8.61          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             58.1%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/6 (50%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              78              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.010 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.003 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.002 **      | 
|LOGISTIC REGRESSION|        P=0.006 **       (e)              (e)              (e)              (e)              P=0.013 *       | 
|COCH-ARM / FISHERS |        P=0.010 *        (e)              (e)              (e)              (e)              P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        5/10 (50%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.02           0/0.00           0/0.00           0/10.00          5/7.40          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             67.6%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.019 *       | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.002 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.003 **       (e)              (e)              (e)              (e)              P=0.016 *       | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Depletion Cellular                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         1/10 (10%)      | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/0.00           1/8.83          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             11.3%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/6 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              13              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P=0.107          (e)              (e)              (e)              (e)              P=0.500         | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P=0.475         | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P=0.486         | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P=0.458         | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.304          (e)              (e)              (e)              (e)              P=0.500         | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  10/25/04                           EXPERIMENT: 88138 TEST: 02                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                       BENZOPHENONE     
                                         Terminal Sacrifice at 14 weeks                                                             
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Males                                                  | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/8 (0%)         0/1 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        7/8 (88%)       | 
|POLY-3 RATE (b)    |        0/8.00           0/0.02           0/0.00           0/0.00           0/10.00          7/7.54          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             92.8%           | 
|TERMINAL (d)       |        0/8 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         0/10 (0%)        0/0 (0%)        | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              4               | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        P<0.001 **       (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P<0.001 **       (e)              (e)              (e)              (e)              P<0.001 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |        0%               0.125%           0.25%            0.5%             1.0%             2.0%            | 
|                   |                                                                                                             | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         5/7 (71%)       | 
|POLY-3 RATE (b)    |        0/10.00          0/0.00           0/0.00           0/0.00           0/0.00           5/7.00          | 
|POLY-3 PERCENT (g) |        0.0%             0.0%             0.0%             0.0%             0.0%             71.4%           | 
|TERMINAL (d)       |        0/10 (0%)        0/0 (0%)         0/0 (0%)         0/0 (0%)         0/0 (0%)         3/5 (60%)       | 
|FIRST INCIDENCE    |        ---              ---              ---              ---              ---              13              | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |        P<0.001 **       (e)              (e)              (e)              (e)              P=0.006 **      | 
|POLY 3             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 1.5           |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|POLY 6             |        (e)              (e)              (e)              (e)              (e)              P<0.001 **      | 
|LOGISTIC REGRESSION|        (e)              (e)              (e)              (e)              (e)              (e)             | 
|COCH-ARM / FISHERS |        P=0.002 **       (e)              (e)              (e)              (e)              P=0.003 **      | 
|ORDER RESTRICTED   |        (e)              (e)              (e)              (e)              (e)              (e)             | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).