National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20247

TDMS Study 99022-02 Pathology Tables

NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04
Route: IN-UTERO                                                                                                   Time: 14:01:32

                                                   FINAL #2; REVISION #1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  30516-87-1

       Lock Date:  06/20/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Merge     006   006,016
                               Merge     007   007,017
                               Merge     008   008,018
                               Merge     009   009,019
                               Merge     010   010,020
                               Merge     001   001,011
                               Merge     002   002,012
                               Merge     003   003,013
                               Merge     004   004,014
                               Merge     005   005,015

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           40           42                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           18           11           11           15                        
    Natural Death                                     14           13           15            9            8                        
    Accidently Killed                                               1                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                 1                                                   1                        
    Terminal Sacrifice                                19           17           24           19           18                        
    Natural Death                                                   1                         1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           40           42                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (49)         (49)         (39)         (42)                      
      Edema                                                         1 (2%)       1 (2%)                    1 (2%)                   
   Intestine Large, Cecum                             (47)         (48)         (45)         (38)         (40)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Edema                                            3 (6%)       3 (6%)       4 (9%)       4 (11%)      8 (20%)                  
   Intestine Small, Duodenum                          (50)         (50)         (48)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Erosion                                          1 (2%)       1 (2%)                                 2 (5%)                   
      Ulcer                                                                      2 (4%)                    1 (2%)                   
      Epithelium, Hyperplasia                         12 (24%)      7 (14%)     12 (25%)      4 (10%)      9 (21%)                  
   Intestine Small, Jejunum                           (46)         (49)         (46)         (40)         (40)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Epithelium, Hyperplasia                                       1 (2%)       1 (2%)                    1 (3%)                   
   Intestine Small, Ileum                             (47)         (48)         (45)         (38)         (40)                      
      Amyloid Deposition                               1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                 1 (3%)                                
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                                           1 (2%)                    1 (2%)                   
      Cyst                                             2 (4%)                    1 (2%)       1 (3%)                                
      Eosinophilic Focus                               1 (2%)       2 (4%)       3 (6%)       1 (3%)       3 (7%)                   
      Hematopoietic Cell Proliferation                 8 (16%)      5 (10%)      5 (10%)      5 (13%)      8 (19%)                  
      Hyperplasia, Lymphoid                                                                   3 (8%)                                
      Infiltration Cellular, Mixed Cell                7 (14%)      6 (12%)      6 (12%)      9 (23%)      9 (21%)                  
      Necrosis, Focal                                  6 (12%)      8 (16%)      5 (10%)      4 (10%)      6 (14%)                  
      Regeneration                                                  1 (2%)                                 1 (2%)                   
      Thrombosis                                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hypertrophy                          1 (2%)       6 (12%)      3 (6%)       2 (5%)       2 (5%)                   
      Hepatocyte, Vacuolization Cytoplasmic                         1 (2%)       3 (6%)                    2 (5%)                   
      Kupffer Cell, Hyperplasia                        1 (2%)                    1 (2%)       1 (3%)       2 (5%)                   
      Kupffer Cell, Pigmentation                       4 (8%)       4 (8%)       2 (4%)       6 (15%)      6 (14%)                  
   Mesentery                                          (4)          (8)          (7)          (3)          (5)                       
      Angiectasis                                                                1 (14%)                                            
      Hemorrhage                                       1 (25%)      1 (13%)                   1 (33%)                               
      Thrombosis                                       1 (25%)                                                                      
      Fat, Necrosis                                                 5 (63%)      4 (57%)      2 (67%)      3 (60%)                  
   Pancreas                                           (50)         (49)         (49)         (40)         (41)                      
      Atrophy                                                       1 (2%)                    1 (3%)                                
      Edema                                                         2 (4%)       1 (2%)                    1 (2%)                   
      Necrosis, Focal                                  1 (2%)                                                                       
      Acinus, Cytoplasmic Alteration                                4 (8%)                    2 (5%)       4 (10%)                  
   Salivary Glands                                    (50)         (49)         (49)         (40)         (42)                      
      Hyperplasia, Lymphoid                            2 (4%)       6 (12%)      3 (6%)       1 (3%)       4 (10%)                  
   Stomach, Forestomach                               (50)         (50)         (49)         (40)         (42)                      
      Edema                                            1 (2%)       5 (10%)      3 (6%)       2 (5%)       4 (10%)                  
      Erosion                                                                                              2 (5%)                   
      Epithelium, Hyperplasia                          4 (8%)       3 (6%)                    2 (5%)       4 (10%)                  
   Stomach, Glandular                                 (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Cyst                                                          2 (4%)                                                          
      Edema                                                         2 (4%)       1 (2%)                    2 (5%)                   
      Erosion                                          1 (2%)       2 (4%)       1 (2%)                                             
      Infiltration Cellular, Mixed Cell                                                                    1 (2%)                   
      Glands, Hyperplasia, Cystic                      6 (12%)     12 (24%)      8 (16%)     10 (25%)      6 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (2)                                                 
      Inflammation, Chronic                            1 (33%)                                                                      
   Heart                                              (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Cardiomyopathy                                   3 (6%)       2 (4%)       6 (12%)      1 (3%)       2 (5%)                   
      Inflammation, Chronic                            7 (14%)      1 (2%)       2 (4%)       2 (5%)       2 (5%)                   
      Mineralization                                   2 (4%)       3 (6%)       2 (4%)       1 (3%)       2 (5%)                   
      Thrombosis                                                                 3 (6%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Cortex                                     (50)         (49)         (50)         (38)         (42)                      
      Accessory Adrenal Cortical Nodule               10 (20%)      8 (16%)     11 (22%)      7 (18%)      6 (14%)                  
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperplasia, Diffuse                                          2 (4%)                                 1 (2%)                   
      Hypertrophy, Focal                                                                                   1 (2%)                   
      Capsule, Hyperplasia                             1 (2%)       1 (2%)                    2 (5%)       2 (5%)                   
   Adrenal Medulla                                    (50)         (49)         (50)         (38)         (42)                      
      Hyperplasia                                      1 (2%)       3 (6%)       1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (49)         (40)         (41)                      
      Hyperplasia                                      2 (4%)       5 (10%)      6 (12%)      7 (18%)     10 (24%)                  
   Pituitary Gland                                    (50)         (49)         (50)         (40)         (42)                      
      Pars Distalis, Angiectasis                                                 1 (2%)       1 (3%)       2 (5%)                   
      Pars Distalis, Cyst                              3 (6%)                                 3 (8%)                                
      Pars Distalis, Hyperplasia, Focal                3 (6%)       4 (8%)       1 (2%)       2 (5%)       4 (10%)                  
      Pars Intermedia, Hyperplasia                     1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                 1 (3%)                                
      Degeneration, Cystic                            26 (52%)     18 (37%)     39 (78%)     24 (60%)     29 (69%)                  
      Follicular Cell, Hyperplasia                     4 (8%)       2 (4%)       5 (10%)      4 (10%)      1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (40)         (42)                      
      Cyst                                            22 (44%)     18 (36%)     25 (50%)     14 (35%)     12 (29%)                  
      Infiltration Cellular, Lymphocyte                                                       1 (3%)                                
      Inflammation, Chronic                           23 (46%)     19 (38%)     17 (34%)     14 (35%)     16 (38%)                  
   Ovary                                              (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                               1 (2%)                                              1 (2%)                   
      Angiectasis                                      1 (2%)       1 (2%)       4 (8%)       3 (8%)       4 (10%)                  
      Cyst                                            38 (76%)     35 (70%)     37 (76%)     28 (70%)     29 (69%)                  
      Hematocyst                                       1 (2%)                                                                       
      Hemorrhage                                       2 (4%)       2 (4%)       7 (14%)      5 (13%)      4 (10%)                  
      Thrombosis                                                                 2 (4%)       1 (3%)       1 (2%)                   
      Bilateral, Cyst                                                                         1 (3%)                                
      Corpus Luteum, Hyperplasia                       1 (2%)                    1 (2%)       1 (3%)       1 (2%)                   
   Uterus                                             (50)         (50)         (49)         (40)         (42)                      
      Angiectasis                                      1 (2%)                    4 (8%)                    1 (2%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                                                                    1 (2%)                   
      Inflammation, Chronic                            1 (2%)       1 (2%)                                 1 (2%)                   
      Thrombosis                                       2 (4%)                    3 (6%)                    1 (2%)                   
      Endometrium, Hyperplasia, Cystic                22 (44%)     27 (54%)     29 (59%)     24 (60%)     22 (52%)                  
   Vagina                                             (49)         (49)         (47)         (40)         (41)                      
      Cyst                                             2 (4%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (40)         (42)                      
      Hyperplasia                                     33 (66%)     24 (48%)     30 (60%)     22 (55%)     26 (62%)                  
      Myelofibrosis                                                 1 (2%)                                 1 (2%)                   
   Lymph Node                                         (14)         (23)         (16)         (12)         (16)                      
      Hematopoietic Cell Proliferation                 1 (7%)       1 (4%)       2 (13%)                                            
      Hemorrhage                                                                 1 (6%)                                             
      Hyperplasia, Lymphoid                            1 (7%)       3 (13%)                   1 (8%)                                
      Hyperplasia, Plasma Cell                         2 (14%)                                             1 (6%)                   
      Pigmentation                                                                                         1 (6%)                   
      Bronchial, Hemorrhage                                         1 (4%)                                                          
      Iliac, Hematopoietic Cell Proliferation          1 (7%)       1 (4%)       1 (6%)                                             
      Iliac, Hemorrhage                                                                                    1 (6%)                   
      Iliac, Hyperplasia, Lymphoid                                  2 (9%)       2 (13%)                                            
      Inguinal, Hematopoietic Cell Proliferation                    1 (4%)                                 1 (6%)                   
      Inguinal, Hyperplasia, Lymphoid                  2 (14%)      4 (17%)      2 (13%)      1 (8%)       2 (13%)                  
      Inguinal, Hyperplasia, Plasma Cell               1 (7%)                                                                       
      Inguinal, Pigmentation                                        1 (4%)                                                          
      Lumbar, Hematopoietic Cell Proliferation         1 (7%)                                                                       
      Lumbar, Hyperplasia, Lymphoid                                 1 (4%)                                 1 (6%)                   
      Mediastinal, Hematopoietic Cell Proliferation    1 (7%)                                                                       
      Mediastinal, Hemorrhage                          1 (7%)       1 (4%)       2 (13%)                   1 (6%)                   
      Mediastinal, Hyperplasia, Lymphoid               1 (7%)       2 (9%)                    1 (8%)                                
      Mediastinal, Pigmentation                                     1 (4%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                                                       1 (8%)                                
      Popliteal, Hyperplasia                                                     1 (6%)                                             
      Popliteal, Hyperplasia, Lymphoid                                                        1 (8%)                                
      Renal, Ectasia                                                1 (4%)                                                          
      Renal, Hematopoietic Cell Proliferation                       1 (4%)                                                          
      Renal, Hemorrhage                                             2 (9%)       1 (6%)                                             
      Renal, Hyperplasia, Lymphoid                                  3 (13%)      2 (13%)                                            
   Lymph Node, Mandibular                             (49)         (47)         (49)         (40)         (42)                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Amyloid Deposition                               1 (2%)                                                                       
      Atrophy                                          2 (4%)       2 (4%)       1 (2%)                    4 (10%)                  
      Ectasia                                          2 (4%)       1 (2%)                    3 (8%)       2 (5%)                   
      Hematopoietic Cell Proliferation                 7 (14%)      3 (6%)       2 (4%)       4 (10%)      6 (14%)                  
      Hemorrhage                                       3 (6%)       4 (9%)       5 (10%)      5 (13%)      7 (17%)                  
      Hyperplasia, Lymphoid                            9 (18%)     10 (21%)     17 (35%)     10 (25%)      4 (10%)                  
      Hyperplasia, Plasma Cell                         5 (10%)                                             3 (7%)                   
      Infiltration Cellular, Plasma Cell               2 (4%)                                                                       
      Pigmentation                                     5 (10%)      4 (9%)       2 (4%)       4 (10%)      6 (14%)                  
   Lymph Node, Mesenteric                             (50)         (48)         (46)         (40)         (42)                      
      Atrophy                                          2 (4%)       4 (8%)       2 (4%)       1 (3%)       5 (12%)                  
      Ectasia                                          2 (4%)       3 (6%)       2 (4%)       3 (8%)       1 (2%)                   
      Hematopoietic Cell Proliferation                 6 (12%)      6 (13%)      2 (4%)       3 (8%)       8 (19%)                  
      Hemorrhage                                      12 (24%)     10 (21%)      9 (20%)      9 (23%)     11 (26%)                  
      Hyperplasia, Lymphoid                            6 (12%)      7 (15%)      9 (20%)     10 (25%)      7 (17%)                  
      Pigmentation                                     2 (4%)       7 (15%)      3 (7%)       2 (5%)       4 (10%)                  
   Spleen                                             (50)         (50)         (49)         (40)         (42)                      
      Amyloid Deposition                                                                      1 (3%)                                
      Hematopoietic Cell Proliferation                31 (62%)     21 (42%)     32 (65%)     26 (65%)     29 (69%)                  
      Pigmentation                                    13 (26%)     24 (48%)     12 (24%)     10 (25%)     12 (29%)                  
      Lymphoid Follicle, Atrophy                       4 (8%)       6 (12%)      5 (10%)      6 (15%)      4 (10%)                  
      Lymphoid Follicle, Hyperplasia                   7 (14%)      3 (6%)       7 (14%)      6 (15%)      7 (17%)                  
   Thymus                                             (49)         (44)         (46)         (36)         (42)                      
      Atrophy                                          7 (14%)      3 (7%)       5 (11%)      2 (6%)       4 (10%)                  
      Hemorrhage                                       1 (2%)       4 (9%)       2 (4%)                    3 (7%)                   
      Hyperplasia, Lymphoid                            7 (14%)      3 (7%)       3 (7%)       7 (19%)      2 (5%)                   
      Thrombosis                                                                              1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (40)         (42)                      
      Hyperplasia                                      9 (18%)      9 (18%)      8 (16%)      6 (15%)      7 (17%)                  
   Skin                                               (50)         (50)         (49)         (40)         (42)                      
      Cyst Epithelial Inclusion                                                               1 (3%)       2 (5%)                   
      Edema                                            3 (6%)       7 (14%)      7 (14%)      6 (15%)      5 (12%)                  
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (3%)       1 (2%)                   
      Ulcer                                            8 (16%)      5 (10%)      1 (2%)       5 (13%)      3 (7%)                   
      Epidermis, Hyperplasia                           7 (14%)      5 (10%)      3 (6%)       4 (10%)      3 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
   Bone                                               (50)         (50)         (50)         (40)         (42)                      
      Fibrous Osteodystrophy                           2 (4%)       7 (14%)      9 (18%)      6 (15%)      4 (10%)                  
      Hyperostosis                                                               1 (2%)       1 (3%)                                
      Myelofibrosis                                                                           1 (3%)                                
      Cranium, Hyperostosis                                         1 (2%)                                                          
      Femur, Callus                                                                                        1 (2%)                   
      Femur, Hyperostosis                                                                     1 (3%)                                
   Skeletal Muscle                                    (5)          (2)          (1)          (1)          (4)                       
      Inflammation, Chronic                            1 (20%)                   1 (100%)                                           
      Thrombosis                                                                                           1 (25%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (40)         (42)                      
      Compression                                                   1 (2%)                                                          
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Peripheral Nerve                                   (7)          (5)          (3)          (5)          (6)                       
      Atrophy                                                       1 (20%)      1 (33%)      1 (20%)                               
   Spinal Cord                                        (50)         (50)         (50)         (40)         (42)                      
      Cyst Epithelial Inclusion                                                  1 (2%)       1 (3%)       1 (2%)                   
      Necrosis                                         1 (2%)       1 (2%)                    1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (40)         (42)                      
      Amyloid Deposition                                                                                   1 (2%)                   
      Edema                                            1 (2%)       3 (6%)       4 (8%)       1 (3%)       3 (7%)                   
      Fibrosis, Focal                                                            1 (2%)                                             
      Foreign Body                                     3 (6%)                                                                       
      Hemorrhage                                       7 (14%)      6 (12%)      6 (12%)      2 (5%)       8 (19%)                  
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       3 (6%)       4 (10%)      1 (2%)                   
      Infiltration Cellular, Histiocyte               12 (24%)     11 (22%)     21 (42%)     12 (30%)     10 (24%)                  
      Infiltration Cellular, Mixed Cell                2 (4%)                                 1 (3%)       1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                 2 (5%)       2 (5%)                   
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)      10 (20%)      3 (8%)       2 (5%)                   
   Nose                                               (50)         (50)         (50)         (40)         (42)                      
      Foreign Body                                     2 (4%)                                                                       
      Inflammation, Chronic                           11 (22%)      2 (4%)       7 (14%)      2 (5%)       4 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE FEMALE                         0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (2)          (1)          (2)                       
      Atrophy                                                                    1 (50%)      1 (100%)                              
      Cataract                                                                                             1 (50%)                  
      Inflammation, Chronic                                                      1 (50%)                                            
   Harderian Gland                                    (49)         (49)         (50)         (40)         (41)                      
      Atrophy                                                                    1 (2%)                    1 (2%)                   
      Hyperplasia, Focal                                                         1 (2%)       2 (5%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (40)         (42)                      
      Amyloid Deposition                               2 (4%)                    1 (2%)                    2 (5%)                   
      Cyst                                             2 (4%)       7 (14%)      5 (10%)      7 (18%)      5 (12%)                  
      Hydronephrosis                                   2 (4%)       7 (14%)      5 (10%)      5 (13%)      3 (7%)                   
      Infarct                                                       1 (2%)       3 (6%)       2 (5%)                                
      Infiltration Cellular, Mixed Cell               10 (20%)     20 (40%)     15 (30%)     14 (35%)     15 (36%)                  
      Inflammation, Chronic                            3 (6%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                              2 (5%)                   
      Nephropathy                                     29 (58%)     31 (62%)     41 (82%)     26 (65%)     33 (79%)                  
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)       2 (4%)       2 (4%)       3 (8%)       3 (7%)                   
      Renal Tubule, Dilatation                         1 (2%)       3 (6%)                    1 (3%)                                
      Renal Tubule, Necrosis                                                     1 (2%)       1 (3%)                                
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)       1 (2%)       2 (5%)       2 (5%)                   
   Urinary Bladder                                    (50)         (50)         (49)         (40)         (42)                      
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       3 (6%)       2 (5%)       3 (7%)                   
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           37           32                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                24           20           25           23           12                        
    Natural Death                                      7            9           11            5           10                        
    Accidently Killed                                                            1            1            2                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           20           13            7            7                        
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                                                          1                        
  Other                                                                                       1                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           37           32                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (50)         (49)         (37)         (32)                      
      Edema                                                                      2 (4%)       1 (3%)                                
   Intestine Large, Cecum                             (49)         (49)         (48)         (35)         (30)                      
      Edema                                           13 (27%)     11 (22%)      8 (17%)     14 (40%)      2 (7%)                   
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
   Intestine Small, Duodenum                          (49)         (50)         (49)         (36)         (32)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)       4 (8%)       1 (3%)       1 (3%)                   
   Intestine Small, Jejunum                           (49)         (50)         (46)         (36)         (29)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Epithelium, Hyperplasia                          4 (8%)       2 (4%)                    1 (3%)       1 (3%)                   
   Intestine Small, Ileum                             (49)         (48)         (47)         (35)         (30)                      
      Amyloid Deposition                               1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                                                                                   1 (3%)                   
      Angiectasis                                      1 (2%)       1 (2%)                                 1 (3%)                   
      Basophilic Focus                                 2 (4%)       4 (8%)       2 (4%)       2 (5%)                                
      Cholangiofibrosis                                                          1 (2%)                                             
      Clear Cell Focus                                 1 (2%)       1 (2%)                                                          
      Cyst                                                                       2 (4%)       1 (3%)                                
      Eosinophilic Focus                               3 (6%)       2 (4%)       2 (4%)       1 (3%)       2 (6%)                   
      Hematopoietic Cell Proliferation                 9 (18%)      7 (14%)     12 (24%)      6 (16%)      5 (16%)                  
      Hemorrhage                                                    1 (2%)       1 (2%)                    1 (3%)                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infarct                                                                                              1 (3%)                   
      Infiltration Cellular, Mixed Cell               10 (20%)      7 (14%)      2 (4%)       5 (14%)      2 (6%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis, Focal                                  8 (16%)      9 (18%)      7 (14%)      4 (11%)      3 (9%)                   
      Regeneration                                                               1 (2%)                    1 (3%)                   
      Tension Lipidosis                                                          1 (2%)                    1 (3%)                   
      Centrilobular, Necrosis                          2 (4%)                    1 (2%)                                             
      Hepatocyte, Hypertrophy                         15 (30%)     15 (30%)      9 (18%)      6 (16%)     15 (47%)                  
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)       1 (2%)       2 (4%)                    1 (3%)                   
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                                                                        1 (3%)                   
      Kupffer Cell, Hyperplasia                        2 (4%)                                 1 (3%)       1 (3%)                   
      Kupffer Cell, Pigmentation                       2 (4%)       3 (6%)                    2 (5%)       3 (9%)                   
   Mesentery                                          (1)          (2)                       (3)          (1)                       
      Hemorrhage                                                    1 (50%)                                1 (100%)                 
      Fat, Necrosis                                                 1 (50%)                   3 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (37)         (31)                      
      Atrophy                                                                    1 (2%)                                             
      Cyst                                                                                                 1 (3%)                   
      Edema                                            1 (2%)                    2 (4%)       2 (5%)                                
      Infiltration Cellular, Mixed Cell                                                                    1 (3%)                   
      Acinus, Cytoplasmic Alteration                   1 (2%)       2 (4%)       1 (2%)       1 (3%)       1 (3%)                   
   Salivary Glands                                    (50)         (50)         (50)         (37)         (32)                      
      Atrophy                                          1 (2%)                                 1 (3%)                                
      Hyperplasia, Lymphoid                                                                                1 (3%)                   
      Infiltration Cellular, Lymphoid                  1 (2%)                                              5 (16%)                  
      Infiltration Cellular, Mixed Cell                1 (2%)                    1 (2%)       2 (5%)                                
   Stomach, Forestomach                               (49)         (50)         (50)         (37)         (32)                      
      Diverticulum                                                                            1 (3%)                                
      Edema                                            1 (2%)                    2 (4%)       1 (3%)                                
      Ulcer                                            1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)                    1 (2%)       1 (3%)       1 (3%)                   
   Stomach, Glandular                                 (49)         (50)         (50)         (37)         (32)                      
      Edema                                                         1 (2%)       2 (4%)       2 (5%)                                
      Erosion                                          2 (4%)       2 (4%)       1 (2%)                    1 (3%)                   
      Glands, Hyperplasia, Cystic                      9 (18%)     13 (26%)     10 (20%)     15 (41%)      6 (19%)                  
   Tooth                                                           (1)                                                              
      Malformation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (1)          (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
   Heart                                              (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Cardiomyopathy                                  12 (24%)      7 (14%)     19 (38%)     13 (35%)      7 (22%)                  
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       5 (10%)      3 (6%)       2 (5%)       1 (3%)                   
      Mineralization                                                2 (4%)       1 (2%)       1 (3%)                                
      Thrombosis                                       2 (4%)       4 (8%)       5 (10%)      3 (8%)       3 (9%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (37)         (32)                      
      Accessory Adrenal Cortical Nodule                8 (16%)      9 (18%)      7 (14%)      6 (16%)      6 (19%)                  
      Amyloid Deposition                               1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)       5 (10%)      3 (6%)       2 (5%)                                
      Hypertrophy, Focal                               6 (12%)      5 (10%)      4 (8%)       4 (11%)      4 (13%)                  
      Capsule, Hyperplasia                             2 (4%)       2 (4%)       1 (2%)       3 (8%)       2 (6%)                   
   Adrenal Medulla                                    (50)         (50)         (49)         (37)         (32)                      
      Hyperplasia                                      2 (4%)                    1 (2%)                    1 (3%)                   
   Islets, Pancreatic                                 (50)         (50)         (50)         (36)         (31)                      
      Hyperplasia                                     15 (30%)     13 (26%)     12 (24%)      6 (17%)      6 (19%)                  
   Pituitary Gland                                    (48)         (49)         (49)         (36)         (31)                      
      Pars Distalis, Cyst                              1 (2%)       2 (4%)       3 (6%)       2 (6%)       1 (3%)                   
   Thyroid Gland                                      (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               1 (2%)                                                                       
      Degeneration, Cystic                            29 (58%)     23 (46%)     33 (66%)     15 (41%)     15 (47%)                  
      Follicular Cell, Hyperplasia                     3 (6%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (2)          (2)          (1)          (1)                       
      Bilateral, Dilatation                                         1 (50%)                                                         
   Epididymis                                         (50)         (50)         (50)         (37)         (32)                      
      Atypia Cellular                                  1 (2%)       3 (6%)       3 (6%)       3 (8%)       3 (9%)                   
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Spermatocele                                                               2 (4%)                    1 (3%)                   
   Penis                                                           (2)          (1)          (3)          (1)                       
      Inflammation, Chronic Active                                  2 (100%)     1 (100%)     1 (33%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (50)         (50)         (50)         (37)         (32)                      
      Cyst                                             6 (12%)      7 (14%)      6 (12%)      6 (16%)      2 (6%)                   
      Inflammation, Chronic                           11 (22%)     11 (22%)     18 (36%)      8 (22%)      9 (28%)                  
   Prostate                                           (50)         (50)         (50)         (37)         (32)                      
      Inflammation, Chronic                            8 (16%)      3 (6%)      12 (24%)      6 (16%)      5 (16%)                  
   Seminal Vesicle                                    (50)         (50)         (50)         (37)         (32)                      
      Degeneration                                                  1 (2%)                    1 (3%)       1 (3%)                   
      Dilatation                                       2 (4%)                                              3 (9%)                   
      Inflammation, Chronic                            2 (4%)       3 (6%)                    3 (8%)                                
   Testes                                             (50)         (50)         (50)         (37)         (32)                      
      Germinal Epithelium, Atrophy                     4 (8%)       7 (14%)      5 (10%)      3 (8%)       4 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (37)         (32)                      
      Hyperplasia                                     43 (86%)     29 (58%)     35 (70%)     27 (73%)     24 (75%)                  
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Myelofibrosis                                                                                        1 (3%)                   
   Lymph Node                                         (12)         (10)         (15)         (6)          (2)                       
      Hematopoietic Cell Proliferation                 3 (25%)      2 (20%)      1 (7%)                                             
      Hyperplasia, Lymphoid                            1 (8%)       3 (30%)      2 (13%)      2 (33%)                               
      Hyperplasia, Plasma Cell                         3 (25%)                                             2 (100%)                 
      Bronchial, Hyperplasia, Lymphoid                              1 (10%)                                                         
      Iliac, Hyperplasia, Lymphoid                                               1 (7%)       1 (17%)                               
      Iliac, Pigmentation                                                        1 (7%)                                             
      Inguinal, Hematopoietic Cell Proliferation       1 (8%)                    1 (7%)       1 (17%)                               
      Inguinal, Hyperplasia, Lymphoid                  2 (17%)      1 (10%)      6 (40%)      1 (17%)                               
      Inguinal, Hyperplasia, Plasma Cell               2 (17%)                                                                      
      Inguinal, Pigmentation                                                     1 (7%)                                             
      Lumbar, Pigmentation                                                       1 (7%)                                             
      Mediastinal, Hemorrhage                          1 (8%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         3 (20%)                                            
      Renal, Hyperplasia, Lymphoid                     1 (8%)                                 1 (17%)                               
      Renal, Hyperplasia, Plasma Cell                  1 (8%)                                                                       
   Lymph Node, Mandibular                             (50)         (50)         (49)         (37)         (32)                      
      Atrophy                                                                    1 (2%)       3 (8%)                                
      Ectasia                                          2 (4%)                    1 (2%)       1 (3%)       2 (6%)                   
      Hematopoietic Cell Proliferation                 7 (14%)                   6 (12%)      4 (11%)      5 (16%)                  
      Hemorrhage                                                                 3 (6%)                                             
      Hyperplasia, Lymphoid                           11 (22%)      7 (14%)      9 (18%)      6 (16%)      9 (28%)                  
      Hyperplasia, Plasma Cell                        11 (22%)      9 (18%)      6 (12%)      3 (8%)       4 (13%)                  
      Pigmentation                                                  1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (36)         (32)                      
      Atrophy                                          1 (2%)                    2 (4%)       3 (8%)                                
      Ectasia                                          2 (4%)       7 (14%)      3 (6%)       6 (17%)      2 (6%)                   
      Hematopoietic Cell Proliferation                12 (24%)      3 (6%)       8 (16%)      3 (8%)       4 (13%)                  
      Hemorrhage                                       7 (14%)     14 (29%)     17 (35%)      8 (22%)      9 (28%)                  
      Hyperplasia, Lymphoid                           15 (30%)     16 (33%)      9 (18%)     10 (28%)      6 (19%)                  
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)       3 (6%)                                             
      Pigmentation                                     1 (2%)       1 (2%)       1 (2%)                    1 (3%)                   
   Spleen                                             (49)         (50)         (50)         (37)         (32)                      
      Hematopoietic Cell Proliferation                31 (63%)     29 (58%)     27 (54%)     18 (49%)     20 (63%)                  
      Pigmentation                                     2 (4%)       3 (6%)       4 (8%)       2 (5%)                                
      Lymphoid Follicle, Atrophy                       4 (8%)       5 (10%)      5 (10%)      7 (19%)      2 (6%)                   
      Lymphoid Follicle, Hyperplasia                                6 (12%)      5 (10%)      2 (5%)       1 (3%)                   
   Thymus                                             (48)         (45)         (47)         (33)         (32)                      
      Atrophy                                         15 (31%)     12 (27%)     15 (32%)     13 (39%)      7 (22%)                  
      Cyst                                             2 (4%)       1 (2%)       2 (4%)       1 (3%)       1 (3%)                   
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       6 (13%)      1 (3%)       6 (19%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (37)         (32)                      
      Cyst Epithelial Inclusion                                     2 (4%)                    1 (3%)                                
      Edema                                           10 (20%)      2 (4%)       7 (14%)      7 (19%)      1 (3%)                   
      Ulcer                                           14 (28%)     14 (28%)     13 (26%)      7 (19%)      6 (19%)                  
      Epidermis, Hyperplasia                          13 (26%)     12 (24%)     12 (24%)      8 (22%)      5 (16%)                  
      Epidermis, Inflammation                          1 (2%)                    1 (2%)                                             
      Epidermis, Ulcer                                                           1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (37)         (32)                      
      Fibrous Osteodystrophy                                                     1 (2%)       1 (3%)       1 (3%)                   
      Fracture                                                                                             1 (3%)                   
      Femur, Osteopetrosis                                          1 (2%)                                 2 (6%)                   
      Scapula, Osteopetrosis                                                                               1 (3%)                   
   Skeletal Muscle                                    (1)          (2)          (1)          (3)          (2)                       
      Hemorrhage                                       1 (100%)                                                                     
      Pigmentation                                                                            1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)         (50)         (37)         (32)                      
      Hydrocephalus                                                 1 (2%)                                                          
      Necrosis                                                                                             1 (3%)                   
   Spinal Cord                                        (50)         (50)         (50)         (37)         (32)                      
      Cyst Epithelial Inclusion                        1 (2%)                                              1 (3%)                   
      Demyelination                                                                                        1 (3%)                   
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Necrosis                                         1 (2%)       1 (2%)                                 1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (37)         (32)                      
      Congestion                                                                              1 (3%)                                
      Edema                                                         1 (2%)       2 (4%)       4 (11%)                               
      Fibrosis, Focal                                                            1 (2%)                                             
      Foreign Body                                     1 (2%)                    1 (2%)       1 (3%)       1 (3%)                   
      Hemorrhage                                       5 (10%)      3 (6%)       7 (14%)      5 (14%)      2 (6%)                   
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (3%)       1 (3%)                   
      Infiltration Cellular, Histiocyte               12 (24%)     16 (32%)     13 (26%)     16 (43%)     14 (44%)                  
      Inflammation, Chronic                            2 (4%)       1 (2%)       5 (10%)      2 (5%)       1 (3%)                   
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 6 (12%)      3 (6%)                    1 (3%)       4 (13%)                  
   Nose                                               (50)         (50)         (50)         (36)         (32)                      
      Foreign Body                                     1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            5 (10%)      5 (10%)      5 (10%)      3 (8%)       4 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (49)         (37)         (32)                      
      Hyperplasia, Focal                               2 (4%)                    1 (2%)       1 (3%)       1 (3%)                   
      Hypertrophy, Focal                                            1 (2%)                                                          
      Inflammation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (37)         (32)                      
      Amyloid Deposition                               3 (6%)                                                                       
      Cyst                                            27 (54%)     23 (46%)     26 (52%)     24 (65%)     17 (53%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   14                                                              
                                                                                                                                   
NTP Experiment-Test: 99022-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: PERINATAL EXPOS                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                          Date: 09/09/04    
Route: IN-UTERO                                                                                                   Time: 14:01:32    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         SWISS MICE MALE                           0            50           100          200          300                          
                                                   MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY     MG/KG/DY                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                  30 (60%)     20 (40%)     17 (34%)     16 (43%)     14 (44%)                  
      Infarct                                          1 (2%)                                 1 (3%)       1 (3%)                   
      Infiltration Cellular, Mixed Cell                9 (18%)     11 (22%)     17 (34%)      9 (24%)     12 (38%)                  
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)       2 (5%)                                
      Inflammation, Suppurative                        4 (8%)                                                                       
      Metaplasia, Osseous                              1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                1 (2%)                    1 (3%)                                
      Nephropathy                                     40 (80%)     40 (80%)     42 (84%)     30 (81%)     23 (72%)                  
      Renal Tubule, Dilatation                                      1 (2%)       5 (10%)      2 (5%)       1 (3%)                   
      Renal Tubule, Necrosis                           3 (6%)                                 1 (3%)                                
      Renal Tubule, Pigmentation                                    1 (2%)       2 (4%)       2 (5%)                                
   Ureter                                                          (3)          (1)          (1)                                    
      Dilatation                                                    2 (67%)      1 (100%)     1 (100%)                              
   Urethra                                            (1)          (4)          (5)          (3)          (3)                       
      Angiectasis                                      1 (100%)                  3 (60%)      1 (33%)      1 (33%)                  
      Inflammation, Chronic                            1 (100%)     1 (25%)      3 (60%)      1 (33%)                               
      Bulbourethral Gland, Cyst                                     1 (25%)      2 (40%)      1 (33%)      2 (67%)                  
   Urinary Bladder                                    (50)         (50)         (50)         (37)         (32)                      
      Edema                                                                      1 (2%)                    2 (6%)                   
      Hemorrhage                                                                 3 (6%)       2 (5%)       2 (6%)                   
      Inflammation, Chronic                            4 (8%)                    2 (4%)       1 (3%)       1 (3%)                   
      Transitional Epithelium, Hyperplasia             4 (8%)       1 (2%)       3 (6%)       1 (3%)       1 (3%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.