National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19839

TDMS Study 88138-03 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                                    BENZOPHENONE                                              DATE: 07/21/03  
EXPERIMENT: 88138 TEST: 03                                                                                        TIME: 15:06:19    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  C88138B     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                BENZOPHENONE                                                DATE: 07/21/03    
EXPERIMENT: 88138 TEST: 03                                                                                        TIME: 15:21:50    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED FEED                                             NTP:  88138B      
CONT: N01-ES-55388                                                                                                CAS: 119-61-9     
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                         
                                                CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                            
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    17.6   108.3      17.9    109.4    1.02       51     17.0    108.6    0.97       98     14.6    110.0    0.83      166       
  2    18.2   144.0      19.0    148.1    1.04       40     19.0    146.0    1.04       81     21.0    141.8    1.15      185       
  6    19.5   265.9      19.4    268.2    0.99       23     20.0    266.3    1.03       47     19.9    263.8    1.02       94       
 10    18.8   319.3      18.3    317.9    0.97       18     18.7    319.4    0.99       37     18.8    316.3    1.00       74       
 14    16.9   351.8      17.1    351.5    1.01       15     16.5    350.4    0.98       29     18.8    352.6    1.11       67       
 18    17.2   379.4      17.4    380.1    1.01       14     17.6    371.5    1.02       30     17.3    372.0    1.01       58       
 22    18.9   393.8      18.4    391.6    0.97       15     19.0    388.2    1.01       31     18.5    387.7    0.98       60       
 26    19.1   416.1      19.1    413.0    1.00       14     17.8    407.0    0.93       27     17.1    406.5    0.90       53       
 30    18.3   426.1      17.8    427.0    0.97       13     18.1    423.6    0.99       27     19.8    423.0    1.08       59       
 34    17.5   442.4      17.2    442.5    0.98       12     16.7    437.5    0.95       24     18.3    436.2    1.05       53       
 38    17.6   452.7      18.0    455.4    1.02       12     18.7    448.9    1.06       26     18.3    447.1    1.04       51       
 41    18.5   456.6      18.6    460.2    1.01       13     18.7    456.7    1.01       26     18.4    450.2    0.99       51       
 46    18.0   471.5      17.9    463.1    0.99       12     17.5    468.3    0.97       23     18.9    462.2    1.05       51       
 50    17.6   478.1      17.7    475.5    1.01       12     18.2    473.2    1.03       24     17.7    464.7    1.01       48       
 54    20.3   482.3      20.0    478.5    0.99       13     19.9    478.7    0.98       26     19.3    466.1    0.95       52       
 58    17.5   489.2      17.7    488.3    1.01       11     16.9    485.7    0.97       22     16.2    470.6    0.93       43       
 62    17.8   493.9      17.2    492.8    0.97       11     17.6    491.2    0.99       22     17.7    471.6    0.99       47       
 66    17.1   498.6      17.3    494.7    1.01       11     17.3    497.2    1.01       22     17.4    472.2    1.02       46       
 70    16.3   492.4      17.1    494.3    1.05       11     17.5    484.5    1.07       23     16.9    458.0    1.04       46       
 74    17.3   497.6      16.7    491.4    0.97       11     17.2    490.0    0.99       22     16.1    449.4    0.93       45       
 78    18.5   498.6      18.6    492.6    1.01       12     17.2    483.7    0.93       22     14.7    435.5    0.79       42       
 82    18.6   500.2      18.5    496.2    0.99       12     17.4    479.4    0.94       23     15.8    424.2    0.85       47       
 86    16.7   501.7      16.0    493.8    0.96       10     16.7    480.7    1.00       22     14.8    410.5    0.89       45       
 90    17.1   496.7      16.8    486.1    0.98       11     16.9    471.0    0.99       22     15.9    384.4    0.93       52       
 94    15.7   486.9      16.6    481.8    1.06       11     16.3    462.5    1.04       22     14.4    378.7    0.92       48       
 98    16.6   478.2      16.2    478.4    0.98       11     16.0    443.8    0.96       23     14.9    343.3    0.90       54       
102    16.5   476.7      16.3    459.5    0.99       11     15.2    422.1    0.92       23     15.1    305.6    0.92       62       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   18.5   209.4      18.6    210.9    1.01       33     18.7    210.1    1.01       66     18.6    208.0    1.00      130       
SD(D)   0.8               0.7             0.03       15      1.2             0.03       29      2.8             0.13       54       
CV(E)   4.4               3.6             3.0      46.7      6.5             3.4      43.9     15.1            13.3      41.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   18.0   426.9      17.9    426.0    1.00       13     17.9    422.5    1.00       27     18.3    420.2    1.02       55       
SD(D)   0.7               0.7             0.02        1      0.8             0.04        3      0.8             0.06        6       
CV(E)   4.0               3.6             1.7       9.8      4.7             3.9       9.6      4.4             5.9      10.4       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   17.4   491.8      17.3    486.8    1.00       11     17.1    474.7    0.98       23     16.1    420.8    0.93       48       
SD(D)   1.2               1.1             0.03        1      1.1             0.04        1      1.4             0.07        5       
CV(E)   7.0               6.5             3.1       6.6      6.3             4.4       4.9      8.8             7.1      11.0       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                       
                                                CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                            
==================================================================================================================================  
           0 PPM                      312 PPM                            625 PPM                            1250 PPM                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    12.9   100.9      13.0    100.6     1.01      40     12.9     99.8     1.00      81     11.5     99.7     0.89     144       
  2    13.2   119.9      13.1    120.0     0.99      34     13.0    118.9     0.98      68     13.8    117.7     1.05     146       
  6    12.4   169.4      12.2    168.6     0.98      23     12.4    164.7     1.00      47     11.3    161.2     0.91      87       
 10    12.5   189.4      11.8    186.4     0.94      20     12.0    183.8     0.96      41     11.5    179.0     0.92      80       
 14    10.9   201.9      10.0    194.6     0.92      16     10.5    191.4     0.96      34     10.1    187.4     0.93      67       
 18    11.1   213.5      10.2    204.8     0.92      15     10.4    200.6     0.94      33     10.0    193.4     0.90      65       
 22    12.2   218.8      11.3    210.4     0.93      17     10.8    206.0     0.89      33     10.4    197.9     0.85      65       
 26    10.8   223.5      10.6    213.7     0.98      16     10.2    209.8     0.94      30      9.6    201.6     0.89      59       
 30    10.9   233.6      10.9    222.1     1.00      15     10.0    216.4     0.92      29     10.0    209.9     0.92      60       
 34    10.9   240.5      10.3    227.2     0.94      14     10.1    221.2     0.93      29      9.6    212.9     0.88      57       
 38    12.2   248.7      11.4    234.9     0.93      15     11.3    228.3     0.93      31     10.5    219.2     0.86      60       
 41    11.2   254.0      11.9    240.2     1.06      15     11.4    232.9     1.02      30     10.9    222.3     0.97      61       
 46    12.2   264.1      11.2    249.2     0.92      14     11.2    237.4     0.92      30     10.9    222.0     0.89      61       
 50    12.6   274.6      12.1    258.1     0.96      15     11.6    244.7     0.92      30     10.6    231.1     0.84      57       
 54    12.6   283.2      12.8    267.5     1.02      15     12.3    252.6     0.98      30     11.3    235.9     0.90      60       
 58    11.8   290.4      11.8    273.2     1.00      13     11.4    257.9     0.97      28     10.1    239.1     0.86      53       
 62    13.2   302.2      13.5    289.6     1.02      15     13.1    272.3     0.99      30     11.7    250.1     0.89      58       
 66    13.2   313.4      12.6    297.6     0.95      13     11.7    278.6     0.89      26     11.3    256.1     0.86      55       
 70    12.7   318.3      12.5    305.8     0.98      13     12.4    286.8     0.98      27     11.7    264.5     0.92      55       
 74    13.4   327.6      12.6    313.3     0.94      12     12.1    293.9     0.90      26     11.8    271.6     0.88      54       
 78    12.8   331.2      12.7    317.0     0.99      13     12.4    300.2     0.97      26     11.8    275.8     0.92      54       
 82    13.6   337.6      13.3    324.1     0.98      13     13.2    309.0     0.97      27     12.1    283.5     0.89      53       
 86    12.8   343.6      12.3    327.9     0.96      12     12.4    313.4     0.97      25     11.8    287.3     0.92      51       
 90    13.3   346.6      12.9    331.7     0.97      12     12.1    312.4     0.91      24     11.2    287.2     0.84      49       
 94    13.9   345.8      13.3    332.6     0.96      13     13.0    315.3     0.94      26     11.7    288.9     0.84      51       
 98    13.1   348.7      12.8    336.7     0.98      12     12.0    314.3     0.92      24     11.2    291.4     0.85      48       
102    12.6   344.5      13.3    337.0     1.06      12     12.0    313.0     0.95      24     13.0    294.8     1.03      55       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   12.7   144.9      12.5    143.9     0.98      29     12.6    141.8     0.99      59     12.0    139.4     0.94     115       
SD(D)   0.4               0.6              0.03      10      0.5              0.02      19      1.2              0.07      36       
CV(E)   3.2               5.1              2.8     33.1      4.0              1.9     31.7      9.8              7.4     31.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.5   237.3      11.0    225.5     0.96      15     10.7    218.9     0.94      31     10.3    209.8     0.89      61       
SD(D)   0.7               0.7              0.05       1      0.6              0.04       2      0.5              0.04       4       
CV(E)   6.2               6.5              4.9      5.5      5.4              3.8      6.0      4.5              4.4      5.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   13.0   325.6      12.8    311.8     0.99      13     12.3    293.8     0.95      26     11.6    271.2     0.89      54       
SD(D)   0.5               0.5              0.03       1      0.5              0.03       2      0.6              0.05       3       
CV(E)   4.1               3.8              3.2      7.5      4.3              3.6      8.0      5.6              5.7      6.3       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                 
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              108.3  50                109.4  50                108.6  50                110.0  50                               
  1  17.6  3511  108.3  50    17.9  3517  109.4  50    17.0  3512  108.6  50    14.6  3507  110.0  50                               
  2  18.2  4781  144.0  50    19.0  4797  148.1  50    19.0  4741  146.0  50    21.0  4715  141.8  50                               
  5  19.2  3728               19.4  3738               19.7  3738               19.8  3739                                          
  6  19.5  4653  265.9  50    19.4  4675  268.2  50    20.0  4689  266.3  50    19.9  4695  263.8  50                               
  9  18.4  3694               18.0  3700               18.6  3678               19.1  3662                                          
 10  18.8  4685  319.3  50    18.3  4700  317.9  50    18.7  4747  319.4  50    18.8  4755  316.3  50                               
 13  18.0  3471               18.3  3478               18.2  3493               19.7  3494                                          
 14  16.9  5056  351.8  50    17.1  5053  351.5  50    16.5  5044  350.4  50    18.8  5050  352.6  50                               
 17  16.7  3719               16.9  3734               17.1  3739               16.5  3744                                          
 18  17.2  4632  379.4  50    17.4  4638  380.1  50    17.6  4659  371.5  50    17.3  4671  372.0  50                               
 21  18.3  3650               18.2  3638               17.9  3399               17.5  3593                                          
 22  18.9  4871  393.8  50    18.4  4904  391.6  50    19.0  4790  388.2  50    18.5  4516  387.7  50                               
 25  19.1  3561               19.1  3604               18.1  3622               17.6  3654                                          
 26  19.1  4798  416.1  50    19.1  4803  413.0  50    17.8  4821  407.0  50    17.1  4842  406.5  50                               
 29  18.6  3727               17.6  3719               18.3  3717               19.2  3711                                          
 30  18.3  4923  426.1  50    17.8  4740  427.0  50    18.1  4811  423.6  50    19.8  4668  423.0  50                               
 33  18.1  3656               18.0  3477               17.9  3561               19.5  3563                                          
 34  17.5  4802  442.4  50    17.2  4867  442.5  50    16.7  4942  437.5  50    18.3  4952  436.2  50                               
 37  17.4  3654               18.0  3705               18.2  3496               18.2  3727                                          
 38  17.6  4373  452.7  50    18.0  4697  455.4  50    18.7  4777  448.9  50    18.3  4868  447.1  50                               
 40  17.4  3493               18.3  3474               18.9  3467               18.9  3443                                          
 41  18.5  4781  456.6  50    18.6  4804  460.2  50    18.7  4851  456.7  50    18.4  4867  450.2  50                               
 45  18.7  3424               18.3  3214               19.0  3572               20.3  3583                                          
 46  18.0  4817  471.5  50    17.9  4561  463.1  50    17.5  4984  468.3  50    18.9  5005  462.2  50                               
 49  17.8  2787               17.8  3533               18.3  3168               18.3  3600                                          
 50  17.6  4650  478.1  50    17.7  4465  475.5  50    18.2  4534  473.2  50    17.7  4883  464.7  50                               
 53  18.8  3684               18.3  3643               19.2  3670               18.7  3662                                          
 54  20.3  4694  482.3  50    20.0  4668  478.5  49    19.9  4910  478.7  50    19.3  4932  466.1  50                               
 57  18.2  3596               18.2  3416               18.5  3500               17.4  3290                                          
 58  17.5  4845  489.2  50    17.7  4746  488.3  48    16.9  5026  485.7  50    16.2  5038  470.6  50                               
 61  17.3  3695               17.3  3541               17.8  3748               17.1  3744                                          
 62  17.8  4709  493.9  49    17.2  4591  492.8  48    17.6  4755  491.2  50    17.7  4809  471.6  50                               
 65  17.6  3462               17.6  3386               18.0  3527               17.4  3535                                          
 66  17.1  4568  498.6  49    17.3  4699  494.7  48    17.3  4622  497.2  50    17.4  4657  472.2  50                               
 69  17.2  3542               17.5  3240               17.2  3395               16.2  3600                                          
 70  16.3  4433  492.4  49    17.1  4600  494.3  47    17.5  4535  484.5  50    16.9  4821  458.0  50                               
 73  19.1  1744               17.1  3204               17.5  3336               16.1  3152                                          
 74  17.3  4603  497.6  47    16.7  4520  491.4  46    17.2  4535  490.0  47    16.1  4600  449.4  47                               
 77  17.1  3529               17.0  3346               16.5  3375               15.3  3299                                          
 78  18.5  4345  498.6  47    18.6  4093  492.6  44    17.2  4430  483.7  47    14.7  4034  435.5  42                               
 81  18.5  3254               18.1  3112               17.3  3260               15.6  2542                                          
 82  18.6  4268  500.2  45    18.5  4099  496.2  43    17.4  4335  479.4  45    15.8  3767  424.2  39                               
 85  18.0  3028               17.0  3000               17.0  3139               15.7  2558                                          
 86  16.7  4204  501.7  43    16.0  4109  493.8  42    16.7  4312  480.7  44    14.8  3415  410.5  34                               
 89  17.3  3090               16.7  2785               17.4  2795               14.8  1890                                          
 90  17.1  3921  496.7  43    16.8  3550  486.1  40    16.9  4139  471.0  43    15.9  1832  384.4  27                               
 93  14.7  2304               17.0  2304               16.2  3057               13.6  1022                                          
 94  15.7  3703  486.9  39    16.6  3623  481.8  38    16.3  3978  462.5  42    14.4  1519  378.7  16                               
 97  17.1  2153               17.1  2518               16.5  2799               15.5   503                                          
=========================================================================================================                           
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                 
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS                              
==========================================================================================================                          
 98  16.6  2871  478.2  34    16.2  3371  478.4  35    16.0  3876  443.8  41    14.9   594  343.3  11                               
101  17.7  1827               16.2  2108               15.2  2329               14.4   426                                          
102  16.5  2574  476.7  27    16.3  2675  459.5  31    15.2  3558  422.1  37    15.1   576  305.6   8                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          209.4                    210.9                    210.1                    208.0                                   
14 TO 52         426.9                    426.0                    422.5                    420.2                                   
 > 52            491.8                    486.8                    474.7                    420.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                               
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B              100.9  50                100.6  50                 99.8  50                 99.7  50                               
  1  12.9  3515  100.9  50    13.0  3506  100.6  50    12.9  3510   99.8  50    11.5  3505   99.7  50                               
  2  13.2  4755  119.9  50    13.1  4808  120.0  50    13.0  4820  118.9  50    13.8  4775  117.7  50                               
  5  12.3  3500               12.6  3535               12.1  3555               12.3  3561                                          
  6  12.4  4795  169.4  50    12.2  4785  168.6  50    12.4  4787  164.7  50    11.3  4804  161.2  50                               
  9  11.9  3745               11.6  3745               11.7  3740               11.6  3740                                          
 10  12.5  4675  189.4  50    11.8  4687  186.4  50    12.0  4690  183.8  50    11.5  4697  179.0  50                               
 13  11.4  3511               10.7  3506               10.7  3500               10.4  3497                                          
 14  10.9  4826  201.9  50    10.0  4845  194.6  50    10.5  4858  191.4  50    10.1  4872  187.4  50                               
 17  11.5  3531               10.7  3535               10.7  3555               10.2  3562                                          
 18  11.1  4770  213.5  50    10.2  4770  204.8  50    10.4  4772  200.6  50    10.0  4775  193.4  50                               
 21  11.4  3610               11.4  3605               10.9  3600               10.4  3600                                          
 22  12.2  4816  218.8  50    11.3  4842  210.4  50    10.8  4838  206.0  50    10.4  4903  197.9  50                               
 25  11.5  3545               11.2  3555               10.8  3567               10.1  3576                                          
 26  10.8  5000  223.5  50    10.6  5020  213.7  50    10.2  5010  209.8  50     9.6  4983  201.6  50                               
 29  11.7  3505               11.2  3504               10.4  3510               10.5  3515                                          
 30  10.9  4921  233.6  50    10.9  4930  222.1  50    10.0  4858  216.4  50    10.0  4844  209.9  50                               
 33  11.9  3510               11.0  3485               10.6  3460               10.4  3444                                          
 34  10.9  4881  240.5  50    10.3  4931  227.2  50    10.1  4989  221.2  50     9.6  5025  212.9  50                               
 37  11.7  3700               11.2  3677               11.2  3610               10.7  3610                                          
 38  12.2  4757  248.7  50    11.4  4826  234.9  50    11.3  4847  228.3  50    10.5  4862  219.2  50                               
 40  11.5  3596               11.2  3604               11.3  3611               10.3  3620                                          
 41  11.2  4937  254.0  50    11.9  4896  240.2  50    11.4  4784  232.9  50    10.9  4799  222.3  50                               
 45  12.5  3145               11.7  3539               11.1  3655               10.9  3570                                          
 46  12.2  4752  264.1  49    11.2  4768  249.2  50    11.2  4783  237.4  50    10.9  4351  222.0  50                               
 49  12.3  3518               11.4  3705               11.1  3705               10.6  3625                                          
 50  12.6  4565  274.6  49    12.1  4679  258.1  50    11.6  4693  244.7  50    10.6  4707  231.1  50                               
 53  11.9  3446               12.2  3555               11.8  3515               11.0  3514                                          
 54  12.6  4591  283.2  48    12.8  4830  267.5  50    12.3  4896  252.6  50    11.3  4910  235.9  50                               
 57  12.4  3432               12.6  3550               11.8  3570               10.9  3569                                          
 58  11.8  4773  290.4  48    11.8  4970  273.2  50    11.4  5002  257.9  50    10.1  4975  239.1  50                               
 61  12.6  3448               12.6  3620               12.0  3620               11.4  3620                                          
 62  13.2  4450  302.2  48    13.5  4615  289.6  50    13.1  4624  272.3  50    11.7  4634  250.1  50                               
 65  13.3  3290               12.7  3500               12.2  3500               12.1  3500                                          
 66  13.2  4555  313.4  47    12.6  4855  297.6  50    11.7  4944  278.6  50    11.3  4956  256.1  50                               
 69  13.6  3252               13.4  3490               13.4  3515               12.2  3535                                          
 70  12.7  4611  318.3  47    12.5  4858  305.8  50    12.4  4835  286.8  50    11.7  4719  264.5  49                               
 73  13.4  3375               12.7  3590               12.5  3595               11.8  3512                                          
 74  13.4  4380  327.6  47    12.6  4675  313.3  50    12.1  4699  293.9  50    11.8  4629  271.6  49                               
 77  14.2  2978               13.2  3557               12.7  3491               11.7  3477                                          
 78  12.8  4463  331.2  46    12.7  4788  317.0  50    12.4  4760  300.2  49    11.8  4618  275.8  48                               
 81  14.0  3221               13.3  3580               13.1  3508               12.1  3083                                          
 82  13.6  4241  337.6  45    13.3  4729  324.1  50    13.2  4648  309.0  49    12.1  4567  283.5  48                               
 85  13.4  3131               12.7  3480               12.7  3411               12.1  3274                                          
 86  12.8  4277  343.6  45    12.3  4771  327.9  50    12.4  4747  313.4  49    11.8  4573  287.3  47                               
 89  13.3  3127               12.9  3346               12.6  3418               11.6  3364                                          
 90  13.3  4078  346.6  43    12.9  4472  331.7  47    12.1  4687  312.4  48    11.2  4594  287.2  46                               
 93  12.7  3037               12.5  3414               11.8  3420               11.5  3353                                          
 94  13.9  3832  345.8  41    13.3  4315  332.6  46    13.0  4327  315.3  46    11.7  4245  288.9  45                               
 97  13.8  2840               13.4  3195               13.0  2910               11.7  3053                                          
=========================================================================================================                           
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                               
                                  CHRONIC DOSED FEED STUDY OF BENZOPHENONE                                                          
=========================================================================================================                           
           0 PPM                   312 PPM                  625 PPM                  1250 PPM                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS   FEED HOURS  WGT   WGTS                              
==========================================================================================================                          
 98  13.1  3573  348.7  40    12.8  4365  336.7  45    12.0  4361  314.3  44    11.2  4158  291.4  41                               
101  12.7  2692               13.1  2988               12.0  2992               12.2  2703                                          
102  12.6  3777  344.5  37    13.3  4000  337.0  41    12.0  3925  313.0  40    13.0  3649  294.8  37                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          144.9                    143.9                    141.8                    139.4                                   
14 TO 52         237.3                    225.5                    218.9                    209.8                                   
 > 52            325.6                    311.8                    293.8                    271.2                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.