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TDMS Study 88138-03 Pathology Tables

NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04
Route: DOSED FEED                                                                                                 Time: 08:33:36

                                                         FINAL #2/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  119-61-9

       Lock Date:  04/26/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           10            9           13                                     
    Natural Death                                      2            2            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           38           37           34                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                                       1 (2%)                                             
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
   Mesentery                                          (12)         (18)         (10)         (6)                                    
      Histiocytic Sarcoma                                                                     1 (17%)                               
   Oral Mucosa                                        (4)          (8)          (4)          (4)                                    
      Gingival, Squamous Cell Carcinoma                             1 (13%)                                                         
   Pancreas                                           (50)         (50)         (50)         (50)                                   
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Schwannoma Malignant                                                                    1 (2%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Tooth                                                                        (3)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Endocardium, Schwannoma Malignant                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                                       2 (4%)       2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    2 (4%)       1 (2%)                                
   Parathyroid Gland                                  (47)         (48)         (44)         (48)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          17 (34%)     17 (34%)     11 (22%)     13 (26%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Bilateral, C-Cell, Carcinoma                                               1 (2%)                                             
      C-Cell, Adenoma                                  4 (8%)       6 (12%)      3 (6%)       6 (12%)                               
      C-Cell, Carcinoma                                             1 (2%)                    1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)                    5 (10%)      6 (12%)                               
      Carcinoma                                        1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Bilateral, Adenoma                               1 (2%)       1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Benign                                                             1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Polyp Stromal                                    6 (12%)      9 (18%)     10 (20%)     10 (20%)                               
      Cervix, Histiocytic Sarcoma                                                             1 (2%)                                
      Cervix, Schwannoma Malignant                                                            1 (2%)                                
   Vagina                                                          (1)          (1)                                                 
      Schwannoma Malignant                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node                                         (8)          (8)          (11)         (12)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                          1 (9%)                                             
   Lymph Node, Mandibular                                          (1)          (1)          (1)                                    
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
   Spleen                                             (49)         (50)         (50)         (50)                                   
   Thymus                                             (50)         (49)         (46)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                          2 (4%)       2 (4%)       3 (6%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Fibroadenoma                                    21 (42%)     20 (40%)     12 (24%)      7 (14%)                               
      Fibroadenoma, Multiple                           6 (12%)      4 (8%)       3 (6%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Keratoacanthoma                                  3 (6%)                    2 (4%)                                             
      Lipoma                                                        1 (2%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     3 (6%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (3)          (1)                                    
      Histiocytic Sarcoma                                                        1 (33%)      1 (100%)                              
      Rhabdomyosarcoma                                                           1 (33%)                                            
      Sarcoma                                                                    1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)                    1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Iris, Melanoma Benign                            1 (2%)                                                                       
   Zymbal's Gland                                                               (1)          (1)                                    
      Carcinoma                                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Renal Tubule, Adenoma, Multiple                                            2 (4%)       1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       2 (4%)                                
      Leukemia Mononuclear                            19 (38%)     25 (50%)     30 (60%)     29 (58%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          46          45          44                                       
     Total Primary Neoplasms                           93          95          97          85                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          40          37          33                                       
     Total Benign Neoplasms                            71          62          59          48                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          29          32          32                                       
     Total Malignant Neoplasms                         22          33          38          37                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      1           1                                       
     Total Metastatic Neoplasm                                                  4           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                25           12           16           44                                     
    Natural Death                                      3           11            3            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           27           31            2                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Leiomyoma                                                                  1 (2%)                                             
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)                                   
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)                                   
   Intestine Small, Ileum                             (50)         (50)         (50)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           2 (4%)                    1 (2%)                                             
   Mesentery                                          (9)          (12)         (8)          (4)                                    
   Oral Mucosa                                        (8)          (8)          (5)          (7)                                    
      Gingival, Squamous Cell Papilloma                             1 (13%)                                                         
      Pharyngeal, Squamous Cell Papilloma                                                     1 (14%)                               
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Mixed Tumor Benign                               1 (2%)                                                                       
   Salivary Glands                                    (49)         (50)         (50)         (49)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
   Tongue                                             (1)          (1)                       (1)                                    
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                  1 (100%)                              
   Tooth                                              (3)          (5)          (2)          (3)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
   Heart                                              (50)         (50)         (50)         (50)                                   
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Medulla                                    (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Malignant                                                 2 (4%)       1 (2%)                                
      Pheochromocytoma Benign                          8 (16%)      5 (10%)      6 (12%)      3 (6%)                                
      Bilateral, Pheochromocytoma Benign                                         2 (4%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    1 (2%)       1 (2%)                                
   Parathyroid Gland                                  (49)         (45)         (48)         (49)                                   
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Pars Distalis, Adenoma                          10 (20%)      6 (12%)     12 (24%)      5 (10%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Bilateral, C-Cell, Adenoma                                                 3 (6%)                                             
      C-Cell, Adenoma                                 10 (20%)      6 (12%)      6 (12%)      4 (8%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Follicular Cell, Adenoma                         2 (4%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                                       3 (6%)       1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)       3 (6%)       3 (6%)       1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (49)                                   
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           43 (86%)     41 (82%)     40 (80%)     42 (84%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Interstitial Cell, Adenoma                       2 (4%)       5 (10%)      6 (12%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)         (50)                                   
   Lymph Node                                         (19)         (20)         (16)         (19)                                   
   Lymph Node, Mandibular                             (5)          (1)          (2)                                                 
   Lymph Node, Mesenteric                             (50)         (50)         (50)         (50)                                   
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)         (50)                                   
   Thymus                                             (48)         (48)         (48)         (48)                                   
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (50)         (50)                                   
      Fibroadenoma                                     2 (4%)       2 (4%)                    1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            3 (6%)       1 (2%)                                             
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Keratoacanthoma                                 10 (20%)      3 (6%)       3 (6%)       3 (6%)                                
      Osteosarcoma                                     1 (2%)       2 (4%)                                                          
      Schwannoma Malignant                                                                    1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       2 (4%)                                                          
      Trichoepithelioma                                                          1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     5 (10%)      3 (6%)       3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chordoma                                         1 (2%)                                                                       
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (2)          (2)          (1)                                                 
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                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)       2 (4%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Osteosarcoma, Metastatic, Skin                                2 (4%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        2 (4%)       1 (2%)                                
      Mediastinum, Myxosarcoma                                                                1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
   Trachea                                            (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Pelvis, Transitional Epithelium, Carcinoma                                              1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            27 (54%)     41 (82%)     39 (78%)     24 (48%)                               
      Mesothelioma Malignant                           2 (4%)       3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88138-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            BENZOPHENONE                                       Date: 08/23/04  
Route: DOSED FEED                                                                                                 Time: 08:33:36  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50                                       
     Total Primary Neoplasms                          139         139         143         109                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          47          49          50                                       
     Total Benign Neoplasms                           103          86          92          77                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          42          40          26                                       
     Total Malignant Neoplasms                         36          53          51          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           5           4           1                                       
     Total Metastatic Neoplasm                          9          12           6           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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