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TDMS Study 88138-03 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 08/23/04       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 08:33:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #2/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 08/23/04       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 08:33:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
Rats(FISCHER 344)                                                                                                                   
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Clitoral/Preputial Gland                                                           
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 08/23/04       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 08:33:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                      BENZOPHENONE                                                                                
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney: Renal Tubule                   Adenoma                                                                                      
                                       Carcinoma or Adenoma                                                                         
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma                                                               
Skin                                                                                                                                
Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthom
a, Trichoepitheliom                                                                                                                 
                                       Keratoacanthoma                                                                              
                                       Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma               
                                       Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                       
Testes                                 Adenoma                                                                                      
All Organs                             Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Mammary Gland                          Fibroadenoma                                                                                 
                                       Fibroma, Fibroadenoma or Adenoma                                                             
                                       Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                 
Skin                                   Fibroma                                                                                      
                                       Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Keratoacanthoma                                                                              
All Organs                             Histiocytic Sarcoma                                                                          
                                       Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                           
                                       Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                       BENZOPHENONE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/49 (10%)   8/50 (16%)   3/50 (6%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/42.42      5/41.31      8/44.47      3/32.72     |0/44.12      2/47.51      2/47.33      0/45.76      | 
|POLY-3 PERCENT (g) |     18.9%        12.1%        18.0%        9.2%        |0.0%         4.2%         4.2%         0.0%         | 
|TERMINAL (d)       |     4/22 (18%)   3/27 (11%)   6/31 (19%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     690          673          708          624         |---          725          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331      P=0.191N     P=0.342N     P=0.306     |P=0.499N     P=0.281      P=0.264      (e)          | 
|POLY 3             |     P=0.235N     P=0.290N     P=0.568N     P=0.199N    |P=0.482N     P=0.254      P=0.253      (e)          | 
|POLY 1.5           |     P=0.173N     P=0.295N     P=0.587N     P=0.144N    |P=0.486N     P=0.249      P=0.248      (e)          | 
|POLY 6             |     P=0.348N     P=0.275N     P=0.536N     P=0.325N    |P=0.484N     P=0.258      P=0.257      (e)          | 
|LOGISTIC REGRESSION|     P=0.477N     P=0.261N     P=0.460N     P=0.548N    |P=0.498N     P=0.259      P=0.251      (e)          | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.290N     P=0.607N     P=0.100N    |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.207N     (e)          (e)          (e)         |P=0.282N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/40.97      2/44.30      1/32.67     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         3.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      507         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072      (e)          P=0.316      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.156      (e)          P=0.249      P=0.450     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.199      (e)          P=0.243      P=0.475     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.103      (e)          P=0.258      P=0.408     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.267      (e)          P=0.316      P=0.527     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.247      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.187      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/49 (10%)   10/50 (20%)  4/50 (8%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     8/42.42      5/41.31      10/44.47     4/33.38     |0/44.12      2/47.51      2/47.33      0/45.76      | 
|POLY-3 PERCENT (g) |     18.9%        12.1%        22.5%        12.0%       |0.0%         4.2%         4.2%         0.0%         | 
|TERMINAL (d)       |     4/22 (18%)   3/27 (11%)   8/31 (26%)   0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     690          673          708          507         |---          725          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.191N     P=0.514N     P=0.198     |P=0.499N     P=0.281      P=0.264      (e)          | 
|POLY 3             |     P=0.405N     P=0.290N     P=0.439      P=0.310N    |P=0.482N     P=0.254      P=0.253      (e)          | 
|POLY 1.5           |     P=0.313N     P=0.295N     P=0.419      P=0.239N    |P=0.486N     P=0.249      P=0.248      (e)          | 
|POLY 6             |     P=0.526      P=0.275N     P=0.475      P=0.456N    |P=0.484N     P=0.258      P=0.257      (e)          | 
|LOGISTIC REGRESSION|     P=0.524      P=0.261N     P=0.569      P=0.480N    |P=0.498N     P=0.259      P=0.251      (e)          | 
|COCH-ARM / FISHERS |     P=0.227N     P=0.290N     P=0.398      P=0.178N    |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.353N     (e)          (e)          (e)         |P=0.282N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    1/49 (2%)   |3/50 (6%)    1/50 (2%)    5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/42.08      3/42.15      1/44.30      1/31.40     |3/44.25      1/47.49      5/47.22      6/46.49      | 
|POLY-3 PERCENT (g) |     0.0%         7.1%         2.3%         3.2%        |6.8%         2.1%         10.6%        12.9%        | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |2/32 (6%)    1/38 (3%)    5/37 (14%)   3/34 (9%)    | 
|FIRST INCIDENCE    |     ---          543          729 (T)      726         |697          729 (T)      729 (T)      624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.254      P=0.143      P=0.568      P=0.114     |P=0.081      P=0.256N     P=0.433      P=0.271      | 
|POLY 3             |     P=0.461      P=0.118      P=0.510      P=0.442     |P=0.083      P=0.280N     P=0.393      P=0.267      | 
|POLY 1.5           |     P=0.520      P=0.118      P=0.505      P=0.469     |P=0.082      P=0.288N     P=0.383      P=0.261      | 
|POLY 6             |     P=0.388      P=0.122      P=0.519      P=0.399     |P=0.082      P=0.276N     P=0.398      P=0.269      | 
|LOGISTIC REGRESSION|     P=0.501      P=0.122      P=0.568      P=0.142     |P=0.082      P=0.274N     P=0.401      P=0.250      | 
|COCH-ARM / FISHERS |     P=0.585      P=0.121      P=0.500      P=0.495     |P=0.080      P=0.309N     P=0.357      P=0.243      | 
|ORDER RESTRICTED   |     P=0.262      (e)          (e)          (e)         |P=0.105      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    1/49 (2%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.08      3/41.64      3/45.29      1/31.91     |1/44.14      2/47.49      2/47.30      1/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         7.2%         6.6%         3.1%        |2.3%         4.2%         4.2%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    2/38 (5%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      709          543          569         |724          729 (T)      709          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.360      P=0.375      P=0.371      P=0.533     |P=0.559N     P=0.549      P=0.529      P=0.760N     | 
|POLY 3             |     P=0.529      P=0.301      P=0.332      P=0.696     |P=0.544N     P=0.525      P=0.524      P=0.753N     | 
|POLY 1.5           |     P=0.573N     P=0.301      P=0.320      P=0.726     |P=0.546N     P=0.518      P=0.517      P=0.754N     | 
|POLY 6             |     P=0.420      P=0.307      P=0.353      P=0.638     |P=0.547N     P=0.531      P=0.529      P=0.754N     | 
|LOGISTIC REGRESSION|     P=0.512N     P=0.335      P=0.278      P=0.779N    |P=0.561N     P=0.534      P=0.528      P=0.762      | 
|COCH-ARM / FISHERS |     P=0.509N     P=0.309      P=0.309      P=0.747     |P=0.556N     P=0.500      P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.410      (e)          (e)          (e)         |P=0.558N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral/Preputial Gland                                                                                                         | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   4/50 (8%)    2/49 (4%)   |4/50 (8%)    3/50 (6%)    6/50 (12%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     1/42.08      6/42.23      4/45.29      2/31.92     |4/44.27      3/47.49      6/47.30      7/46.49      | 
|POLY-3 PERCENT (g) |     2.4%         14.2%        8.8%         6.3%        |9.0%         6.3%         12.7%        15.1%        | 
|TERMINAL (d)       |     1/22 (5%)    4/27 (15%)   2/31 (7%)    0/2 (0%)    |2/32 (6%)    3/38 (8%)    5/37 (14%)   4/34 (12%)   | 
|FIRST INCIDENCE    |     729 (T)      543          543          569         |697          729 (T)      709          624          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.174      P=0.088      P=0.250      P=0.100     |P=0.134      P=0.423N     P=0.447      P=0.290      | 
|POLY 3             |     P=0.440      P=0.055      P=0.201      P=0.405     |P=0.142      P=0.462N     P=0.412      P=0.290      | 
|POLY 1.5           |     P=0.528      P=0.055      P=0.191      P=0.448     |P=0.140      P=0.473N     P=0.400      P=0.283      | 
|POLY 6             |     P=0.322      P=0.058      P=0.220      P=0.335     |P=0.141      P=0.455N     P=0.419      P=0.292      | 
|LOGISTIC REGRESSION|     P=0.579      P=0.057      P=0.165      P=0.381     |P=0.136      P=0.449N     P=0.421      P=0.276      | 
|COCH-ARM / FISHERS |     P=0.530N     P=0.056      P=0.181      P=0.492     |P=0.132      P=0.500N     P=0.370      P=0.262      | 
|ORDER RESTRICTED   |     P=0.200      (e)          (e)          (e)         |P=0.204      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.26      0/41.56      1/44.30      1/32.24     |0/44.12      0/47.49      2/47.41      1/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.3%         3.1%        |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     680          ---          729 (T)      669         |---          ---          701          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281      P=0.500N     P=0.704N     P=0.519     |P=0.240      (e)          P=0.257      P=0.512      | 
|POLY 3             |     P=0.459      P=0.503N     P=0.750N     P=0.697     |P=0.248      (e)          P=0.254      P=0.507      | 
|POLY 1.5           |     P=0.498      P=0.503N     P=0.755N     P=0.729     |P=0.249      (e)          P=0.249      P=0.506      | 
|POLY 6             |     P=0.418      P=0.501N     P=0.742N     P=0.635     |P=0.244      (e)          P=0.257      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.463      P=0.500N     P=0.752N     P=0.719     |P=0.247      (e)          P=0.240      P=0.512      | 
|COCH-ARM / FISHERS |     P=0.539      P=0.500N     P=0.753N     P=0.753N    |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.451      (e)          (e)          (e)         |P=0.182      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.16      1/41.56      2/44.46      4/33.18     |0/44.12      0/47.49      2/47.41      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         2.4%         4.5%         12.1%       |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    1/27 (4%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     709          729 (T)      687          537         |---          ---          701          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.722N     P=0.591      P=0.015 *   |P=0.242      (e)          P=0.257      P=0.514      | 
|POLY 3             |     P=0.046 *    P=0.758      P=0.519      P=0.114     |P=0.250      (e)          P=0.254      P=0.508      | 
|POLY 1.5           |     P=0.056      P=0.758      P=0.510      P=0.143     |P=0.250      (e)          P=0.249      P=0.506      | 
|POLY 6             |     P=0.036 *    P=0.761      P=0.534      P=0.075     |P=0.247      (e)          P=0.257      P=0.508      | 
|LOGISTIC REGRESSION|     P=0.047 *    P=0.754N     P=0.526      P=0.142     |P=0.239      (e)          P=0.240      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.072      P=0.753N     P=0.500      P=0.181     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.047 *    (e)          (e)          (e)         |P=0.182      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.16      2/41.56      2/44.46      4/33.18     |0/44.12      0/47.49      2/47.41      1/45.95      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         4.5%         12.1%       |0.0%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     709          729 (T)      687          537         |---          ---          701          679          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.563      P=0.591      P=0.015 *   |P=0.242      (e)          P=0.257      P=0.514      | 
|POLY 3             |     P=0.073      P=0.495      P=0.519      P=0.114     |P=0.250      (e)          P=0.254      P=0.508      | 
|POLY 1.5           |     P=0.090      P=0.495      P=0.510      P=0.143     |P=0.250      (e)          P=0.249      P=0.506      | 
|POLY 6             |     P=0.057      P=0.500      P=0.534      P=0.075     |P=0.247      (e)          P=0.257      P=0.508      | 
|LOGISTIC REGRESSION|     P=0.065      P=0.525      P=0.526      P=0.142     |P=0.239      (e)          P=0.240      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.113      P=0.500      P=0.500      P=0.181     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.060      (e)          (e)          (e)         |P=0.182      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.28      0/41.56      1/44.30      0/32.01     |0/44.12      0/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         2.3%         0.0%        |0.0%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          ---          729 (T)      ---         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.347N     P=0.223N     P=0.409N     P=0.632N    |P=0.700      (e)          P=0.529      (e)          | 
|POLY 3             |     P=0.204N     P=0.241N     P=0.484N     P=0.304N    |P=0.698      (e)          P=0.514      (e)          | 
|POLY 1.5           |     P=0.198N     P=0.241N     P=0.491N     P=0.270N    |P=0.698      (e)          P=0.510      (e)          | 
|POLY 6             |     P=0.221N     P=0.238N     P=0.470N     P=0.369N    |P=0.693      (e)          P=0.516      (e)          | 
|LOGISTIC REGRESSION|     P=0.264N     P=0.239N     P=0.469N     P=0.420N    |(e)          (e)          P=0.529      (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.247N     P=0.500N     P=0.247N    |P=0.694      (e)          P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.122N     (e)          (e)          (e)         |P=0.393      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.28      0/41.56      2/44.30      0/32.01     |0/44.12      1/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         4.5%         0.0%        |0.0%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          ---          729 (T)      ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.223N     P=0.589N     P=0.632N    |P=0.594N     P=0.534      P=0.529      (e)          | 
|POLY 3             |     P=0.306N     P=0.241N     P=0.677N     P=0.304N    |P=0.583N     P=0.515      P=0.514      (e)          | 
|POLY 1.5           |     P=0.277N     P=0.241N     P=0.685N     P=0.270N    |P=0.585N     P=0.510      P=0.510      (e)          | 
|POLY 6             |     P=0.366N     P=0.238N     P=0.664N     P=0.369N    |P=0.584N     P=0.518      P=0.516      (e)          | 
|LOGISTIC REGRESSION|     P=0.408N     P=0.239N     P=0.653N     P=0.420N    |(e)          P=0.534      P=0.529      (e)          | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.247N     P=0.691N     P=0.247N    |P=0.595N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.409N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.28      0/41.56      2/44.30      0/32.01     |0/44.12      1/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         4.5%         0.0%        |0.0%         2.1%         2.1%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     676          ---          729 (T)      ---         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.223N     P=0.589N     P=0.632N    |P=0.594N     P=0.534      P=0.529      (e)          | 
|POLY 3             |     P=0.306N     P=0.241N     P=0.677N     P=0.304N    |P=0.583N     P=0.515      P=0.514      (e)          | 
|POLY 1.5           |     P=0.277N     P=0.241N     P=0.685N     P=0.270N    |P=0.585N     P=0.510      P=0.510      (e)          | 
|POLY 6             |     P=0.366N     P=0.238N     P=0.664N     P=0.369N    |P=0.584N     P=0.518      P=0.516      (e)          | 
|LOGISTIC REGRESSION|     P=0.408N     P=0.239N     P=0.653N     P=0.420N    |(e)          P=0.534      P=0.529      (e)          | 
|COCH-ARM / FISHERS |     P=0.248N     P=0.247N     P=0.691N     P=0.247N    |P=0.595N     P=0.500      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.409N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/42.46      1/41.07      0/44.30      0/32.01     |4/44.12      0/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     9.4%         2.4%         0.0%         0.0%        |9.1%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/22 (9%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |4/32 (13%)   0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     666          704          ---          ---         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033N*    P=0.153N     P=0.038N*    P=0.405N    |P=0.034N*    P=0.043N*    P=0.137N     P=0.055N     | 
|POLY 3             |     P=0.017N*    P=0.188N     P=0.055N     P=0.105N    |P=0.040N*    P=0.051N     P=0.159N     P=0.056N     | 
|POLY 1.5           |     P=0.018N*    P=0.189N     P=0.057N     P=0.080N    |P=0.039N*    P=0.054N     P=0.165N     P=0.057N     | 
|POLY 6             |     P=0.015N*    P=0.182N     P=0.050N     P=0.163N    |P=0.040N*    P=0.050N     P=0.155N     P=0.056N     | 
|LOGISTIC REGRESSION|     P=0.022N*    P=0.184N     P=0.056N     P=0.185N    |P=0.034N*    (e)          P=0.137N     (e)          | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.187N     P=0.059N     P=0.059N    |P=0.039N*    P=0.059N     P=0.181N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.017N*    (e)          (e)          (e)         |P=0.005N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/40.97      1/44.46      2/32.43     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         6.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          687          637         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.008 **   (e)          P=0.549      P=0.067     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.048 *    (e)          P=0.511      P=0.184     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.058      (e)          P=0.506      P=0.209     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.040 *    (e)          P=0.520      P=0.148     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.052      (e)          P=0.500      P=0.154     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.071      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.045 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    1/50 (2%)    2/50 (4%)   |4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/42.46      1/41.07      1/44.46      2/32.43     |4/44.12      0/47.49      1/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     9.4%         2.4%         2.3%         6.2%        |9.1%         0.0%         2.1%         0.0%         | 
|TERMINAL (d)       |     2/22 (9%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |4/32 (13%)   0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     666          704          687          637         |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556      P=0.153N     P=0.117N     P=0.389     |P=0.034N*    P=0.043N*    P=0.137N     P=0.055N     | 
|POLY 3             |     P=0.332N     P=0.188N     P=0.164N     P=0.467N    |P=0.040N*    P=0.051N     P=0.159N     P=0.056N     | 
|POLY 1.5           |     P=0.326N     P=0.189N     P=0.171N     P=0.402N    |P=0.039N*    P=0.054N     P=0.165N     P=0.057N     | 
|POLY 6             |     P=0.325N     P=0.182N     P=0.153N     P=0.582N    |P=0.040N*    P=0.050N     P=0.155N     P=0.056N     | 
|LOGISTIC REGRESSION|     P=0.418N     P=0.184N     P=0.167N     P=0.648N    |P=0.034N*    (e)          P=0.137N     (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.187N     P=0.181N     P=0.339N    |P=0.039N*    P=0.059N     P=0.181N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.203N     (e)          (e)          (e)         |P=0.005N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |2/45.06      2/47.84      3/47.49      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         4.2%         6.3%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    1/38 (3%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |288          633          679          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.194N     P=0.653N     P=0.543      P=0.233N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.199N     P=0.672N     P=0.524      P=0.234N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.198N     P=0.679N     P=0.516      P=0.234N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.203N     P=0.666N     P=0.531      P=0.235N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.292N     P=0.459      P=0.317      P=0.433N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.199N     P=0.691N     P=0.500      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.169N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 9       
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    3/50 (6%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |2/45.06      3/47.84      3/47.49      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         6.3%         6.3%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |1/32 (3%)    2/38 (5%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |288          633          679          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.160N     P=0.554      P=0.543      P=0.233N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.527      P=0.524      P=0.234N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.162N     P=0.518      P=0.516      P=0.234N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.165N     P=0.535      P=0.531      P=0.235N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.235N     P=0.285      P=0.317      P=0.433N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.164N     P=0.500      P=0.500      P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.144N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroadenoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |27/50 (54%)  24/50 (48%)  15/50 (30%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/42.26      2/41.83      0/44.30      1/32.63     |27/46.22     24/47.99     15/47.97     7/46.28      | 
|POLY-3 PERCENT (g) |     4.7%         4.8%         0.0%         3.1%        |58.4%        50.0%        31.3%        15.1%        | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |19/32 (59%)  18/38 (47%)  12/37 (32%)  3/34 (9%)    | 
|FIRST INCIDENCE    |     681          657          ---          529         |528          693          609          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.655N     P=0.181N     P=0.679     |P<0.001N**   P=0.147N     P=0.005N**   P<0.001N**   | 
|POLY 3             |     P=0.307N     P=0.691      P=0.227N     P=0.589N    |P<0.001N**   P=0.269N     P=0.006N**   P<0.001N**   | 
|POLY 1.5           |     P=0.306N     P=0.690      P=0.232N     P=0.545N    |P<0.001N**   P=0.283N     P=0.007N**   P<0.001N**   | 
|POLY 6             |     P=0.296N     P=0.693N     P=0.218N     P=0.661N    |P<0.001N**   P=0.275N     P=0.006N**   P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.283N     P=0.692      P=0.224N     P=0.479N    |P<0.001N**   P=0.224N     P=0.007N**   P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.691N     P=0.247N     P=0.500N    |P<0.001N**   P=0.345N     P=0.013N*    P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.331N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 10      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma or Adenoma                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |28/50 (56%)  25/50 (50%)  17/50 (34%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/42.26      2/41.83      0/44.30      1/32.63     |28/47.16     25/48.34     17/48.16     7/46.28      | 
|POLY-3 PERCENT (g) |     4.7%         4.8%         0.0%         3.1%        |59.4%        51.7%        35.3%        15.1%        | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |19/32 (59%)  18/38 (47%)  13/37 (35%)  3/34 (9%)    | 
|FIRST INCIDENCE    |     681          657          ---          529         |288          633          609          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.655N     P=0.181N     P=0.679     |P<0.001N**   P=0.153N     P=0.010N*    P<0.001N**   | 
|POLY 3             |     P=0.307N     P=0.691      P=0.227N     P=0.589N    |P<0.001N**   P=0.291N     P=0.013N*    P<0.001N**   | 
|POLY 1.5           |     P=0.306N     P=0.690      P=0.232N     P=0.545N    |P<0.001N**   P=0.304N     P=0.015N*    P<0.001N**   | 
|POLY 6             |     P=0.296N     P=0.693N     P=0.218N     P=0.661N    |P<0.001N**   P=0.292N     P=0.013N*    P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.283N     P=0.692      P=0.224N     P=0.479N    |P<0.001N**   P=0.306N     P=0.021N*    P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.691N     P=0.247N     P=0.500N    |P<0.001N**   P=0.344N     P=0.022N*    P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.331N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |28/50 (56%)  25/50 (50%)  17/50 (34%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/42.26      2/41.83      0/44.30      1/32.63     |28/47.16     25/48.34     17/48.16     7/46.28      | 
|POLY-3 PERCENT (g) |     4.7%         4.8%         0.0%         3.1%        |59.4%        51.7%        35.3%        15.1%        | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |19/32 (59%)  18/38 (47%)  13/37 (35%)  3/34 (9%)    | 
|FIRST INCIDENCE    |     681          657          ---          529         |288          633          609          686          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.527N     P=0.655N     P=0.181N     P=0.679     |P<0.001N**   P=0.153N     P=0.010N*    P<0.001N**   | 
|POLY 3             |     P=0.307N     P=0.691      P=0.227N     P=0.589N    |P<0.001N**   P=0.291N     P=0.013N*    P<0.001N**   | 
|POLY 1.5           |     P=0.306N     P=0.690      P=0.232N     P=0.545N    |P<0.001N**   P=0.304N     P=0.015N*    P<0.001N**   | 
|POLY 6             |     P=0.296N     P=0.693N     P=0.218N     P=0.661N    |P<0.001N**   P=0.292N     P=0.013N*    P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.283N     P=0.692      P=0.224N     P=0.479N    |P<0.001N**   P=0.306N     P=0.021N*    P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.296N     P=0.691N     P=0.247N     P=0.500N    |P<0.001N**   P=0.344N     P=0.022N*    P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.331N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 11      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Papilloma Squamous or Papilloma                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.56      0/44.30      2/32.72     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         0.0%         6.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          593         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161      P=0.572      P=0.432N     P=0.173     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.417      P=0.496      P=0.490N     P=0.413     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.439      P=0.495      P=0.495N     P=0.456     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.407      P=0.501      P=0.481N     P=0.344     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.386      P=0.572      (e)          P=0.456     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.470      P=0.500      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.298      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       | 
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.56      0/44.30      2/32.72     |0/44.12      1/47.64      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         0.0%         6.1%        |0.0%         2.1%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          593         |---          690          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.161      P=0.572      P=0.432N     P=0.173     |P=0.581N     P=0.523      (e)          (e)          | 
|POLY 3             |     P=0.417      P=0.496      P=0.490N     P=0.413     |P=0.553N     P=0.515      (e)          (e)          | 
|POLY 1.5           |     P=0.439      P=0.495      P=0.495N     P=0.456     |P=0.557N     P=0.511      (e)          (e)          | 
|POLY 6             |     P=0.407      P=0.501      P=0.481N     P=0.344     |P=0.550N     P=0.519      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.386      P=0.572      (e)          P=0.456     |P=0.575N     P=0.487      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.470      P=0.500      P=0.500N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.298      (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 12      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  6/50 (12%)   12/50 (24%)  5/50 (10%)  |17/50 (34%)  17/50 (34%)  11/50 (22%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     10/43.58     6/42.41      12/45.83     5/33.77     |17/45.66     17/48.82     11/47.80     13/46.21     | 
|POLY-3 PERCENT (g) |     23.0%        14.2%        26.2%        14.8%       |37.2%        34.8%        23.0%        28.1%        | 
|TERMINAL (d)       |     1/22 (5%)    3/27 (11%)   6/31 (19%)   0/2 (0%)    |12/32 (38%)  11/38 (29%)  8/37 (22%)   10/34 (29%)  | 
|FIRST INCIDENCE    |     584          535          499          569         |430          613          644          659          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.225      P=0.160N     P=0.539N     P=0.359     |P=0.158N     P=0.382N     P=0.075N     P=0.219N     | 
|POLY 3             |     P=0.384N     P=0.219N     P=0.456      P=0.272N    |P=0.157N     P=0.488N     P=0.100N     P=0.239N     | 
|POLY 1.5           |     P=0.284N     P=0.217N     P=0.433      P=0.194N    |P=0.154N     P=0.520N     P=0.109N     P=0.239N     | 
|POLY 6             |     P=0.529      P=0.219N     P=0.492      P=0.439N    |P=0.168N     P=0.457N     P=0.093N     P=0.246N     | 
|LOGISTIC REGRESSION|     P=0.263N     P=0.212N     P=0.410      P=0.214N    |P=0.150N     P=0.575N     P=0.117N     P=0.227N     | 
|COCH-ARM / FISHERS |     P=0.192N     P=0.207N     P=0.405      P=0.131N    |P=0.158N     P=0.583N     P=0.133N     P=0.257N     | 
|ORDER RESTRICTED   |     P=0.311N     (e)          (e)          (e)         |P=0.177N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      3/41.98      1/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         7.2%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          609          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.660N     P=0.146      P=0.568      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.454N     P=0.118      P=0.510      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.413N     P=0.117      P=0.505      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.531N     P=0.121      P=0.519      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.469N     P=0.119      P=0.568      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.121      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.281N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 13      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Adenoma, Basosquamous Tumor Benign, or                                                                           | 
|     Trichoepithelioma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      3/41.98      2/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         7.2%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          609          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556      P=0.146      P=0.316      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.534N     P=0.118      P=0.249      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.474N     P=0.117      P=0.243      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.531      P=0.121      P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.575N     P=0.119      P=0.316      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.121      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      | 
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.08      3/41.98      2/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     0.0%         7.2%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          609          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.556      P=0.146      P=0.316      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.534N     P=0.118      P=0.249      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.474N     P=0.117      P=0.243      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.531      P=0.121      P=0.258      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.575N     P=0.119      P=0.316      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.121      P=0.247      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 14      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       | 
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  8/50 (16%)   5/50 (10%)   3/50 (6%)   |3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     11/43.14     8/42.85      5/44.53      3/33.02     |3/44.48      0/47.49      2/47.33      1/45.76      | 
|POLY-3 PERCENT (g) |     25.5%        18.7%        11.2%        9.1%        |6.7%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     4/22 (18%)   4/27 (15%)   4/31 (13%)   0/2 (0%)    |1/32 (3%)    0/38 (0%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     584          590          669          537         |634          ---          701          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.234N     P=0.225N     P=0.031N*    P=0.592     |P=0.337N     P=0.106N     P=0.457N     P=0.296N     | 
|POLY 3             |     P=0.027N*    P=0.307N     P=0.070N     P=0.061N    |P=0.344N     P=0.107N     P=0.472N     P=0.295N     | 
|POLY 1.5           |     P=0.018N*    P=0.312N     P=0.077N     P=0.036N*   |P=0.341N     P=0.111N     P=0.480N     P=0.296N     | 
|POLY 6             |     P=0.043N*    P=0.290N     P=0.061N     P=0.141N    |P=0.349N     P=0.106N     P=0.468N     P=0.299N     | 
|LOGISTIC REGRESSION|     P=0.026N*    P=0.314N     P=0.064N     P=0.103N    |P=0.335N     P=0.120N     P=0.494N     P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.011N*    P=0.306N     P=0.086N     P=0.020N*   |P=0.337N     P=0.121N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.047N*    (e)          (e)          (e)         |P=0.172N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    3/50 (6%)    2/50 (4%)   |3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/42.40      3/41.77      3/44.46      2/32.95     |3/44.14      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     11.8%        7.2%         6.8%         6.1%        |6.8%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/22 (14%)   0/27 (0%)    2/31 (7%)    0/2 (0%)    |2/32 (6%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     680          704          687          555         |724          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.584      P=0.286N     P=0.213N     P=0.542     |P=0.045N*    P=0.099N     P=0.105N     P=0.119N     | 
|POLY 3             |     P=0.245N     P=0.364N     P=0.330N     P=0.329N    |P=0.048N*    P=0.106N     P=0.107N     P=0.112N     | 
|POLY 1.5           |     P=0.214N     P=0.364N     P=0.343N     P=0.270N    |P=0.047N*    P=0.110N     P=0.111N     P=0.114N     | 
|POLY 6             |     P=0.288N     P=0.355N     P=0.309N     P=0.443N    |P=0.049N*    P=0.104N     P=0.105N     P=0.113N     | 
|LOGISTIC REGRESSION|     P=0.278N     P=0.349N     P=0.300N     P=0.345N    |P=0.046N*    P=0.103N     P=0.107N     P=0.121N     | 
|COCH-ARM / FISHERS |     P=0.179N     P=0.357N     P=0.357N     P=0.218N    |P=0.047N*    P=0.121N     P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.308N     (e)          (e)          (e)         |P=0.007N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 15      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    3/50 (6%)    2/50 (4%)   |4/50 (8%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/42.42      3/41.77      3/44.46      2/32.95     |4/44.16      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     14.2%        7.2%         6.8%         6.1%        |9.1%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/22 (14%)   0/27 (0%)    2/31 (7%)    0/2 (0%)    |2/32 (6%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     680          704          687          555         |724          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.498N     P=0.187N     P=0.127N     P=0.581     |P=0.020N*    P=0.051N     P=0.055N     P=0.065N     | 
|POLY 3             |     P=0.158N     P=0.248N     P=0.218N     P=0.228N    |P=0.020N*    P=0.052N     P=0.052N     P=0.056N     | 
|POLY 1.5           |     P=0.136N     P=0.249N     P=0.230N     P=0.177N    |P=0.019N*    P=0.054N     P=0.055N     P=0.057N     | 
|POLY 6             |     P=0.188N     P=0.240N     P=0.199N     P=0.337N    |P=0.020N*    P=0.050N     P=0.051N     P=0.056N     | 
|LOGISTIC REGRESSION|     P=0.195N     P=0.232N     P=0.188N     P=0.280N    |P=0.019N*    P=0.051N     P=0.053N     P=0.062N     | 
|COCH-ARM / FISHERS |     P=0.112N     P=0.243N     P=0.243N     P=0.134N    |P=0.020N*    P=0.059N     P=0.059N     P=0.059N     | 
|ORDER RESTRICTED   |     P=0.186N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Keratoacanthoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  3/50 (6%)    3/50 (6%)    3/50 (6%)   |3/50 (6%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     10/43.06     3/42.43      3/44.53      3/33.02     |3/44.48      0/47.49      2/47.33      0/45.76      | 
|POLY-3 PERCENT (g) |     23.2%        7.1%         6.7%         9.1%        |6.7%         0.0%         4.2%         0.0%         | 
|TERMINAL (d)       |     4/22 (18%)   0/27 (0%)    2/31 (7%)    0/2 (0%)    |1/32 (3%)    0/38 (0%)    1/37 (3%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     584          590          669          537         |634          ---          701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.259N     P=0.030N*    P=0.014N*    P=0.565     |P=0.125N     P=0.106N     P=0.457N     P=0.120N     | 
|POLY 3             |     P=0.047N*    P=0.035N*    P=0.028N*    P=0.093N    |P=0.128N     P=0.107N     P=0.472N     P=0.114N     | 
|POLY 1.5           |     P=0.040N*    P=0.036N*    P=0.031N*    P=0.059N    |P=0.127N     P=0.111N     P=0.480N     P=0.114N     | 
|POLY 6             |     P=0.053N     P=0.032N*    P=0.024N*    P=0.191N    |P=0.131N     P=0.106N     P=0.468N     P=0.115N     | 
|LOGISTIC REGRESSION|     P=0.044N*    P=0.038N*    P=0.029N*    P=0.137N    |P=0.126N     P=0.120N     P=0.494N     P=0.119N     | 
|COCH-ARM / FISHERS |     P=0.033N*    P=0.036N*    P=0.036N*    P=0.036N*   |P=0.126N     P=0.121N     P=0.500N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.027N*    (e)          (e)          (e)         |P=0.034N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 16      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.64      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      710          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.568      P=0.432N     P=0.934N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.202N     P=0.496      P=0.490N     P=0.554N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.198N     P=0.496      P=0.495N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.210N     P=0.503      P=0.481N     P=0.598N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.315N     P=0.527      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.226N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.16      2/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/22 (0%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     709          729 (T)      ---          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.371N     P=0.563      P=0.460N     P=0.909N    |P=0.195      (e)          (e)          P=0.512      | 
|POLY 3             |     P=0.202N     P=0.495      P=0.490N     P=0.554N    |P=0.200      (e)          (e)          P=0.507      | 
|POLY 1.5           |     P=0.198N     P=0.495      P=0.495N     P=0.528N    |P=0.200      (e)          (e)          P=0.506      | 
|POLY 6             |     P=0.211N     P=0.500      P=0.482N     P=0.599N    |P=0.198      (e)          (e)          P=0.506      | 
|LOGISTIC REGRESSION|     P=0.313N     P=0.525      P=0.485N     P=0.717N    |(e)          (e)          (e)          P=0.512      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.226N     (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 17      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           | 
|     Carcinoma or Keratoacanthoma                                                                                                | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  5/50 (10%)   3/50 (6%)    3/50 (6%)   |3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     11/43.14     5/42.43      3/44.53      3/33.02     |3/44.48      0/47.49      2/47.33      1/45.76      | 
|POLY-3 PERCENT (g) |     25.5%        11.8%        6.7%         9.1%        |6.7%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     4/22 (18%)   2/27 (7%)    2/31 (7%)    0/2 (0%)    |1/32 (3%)    0/38 (0%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     584          590          669          537         |634          ---          701          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.063N     P=0.008N**   P=0.592     |P=0.337N     P=0.106N     P=0.457N     P=0.296N     | 
|POLY 3             |     P=0.021N*    P=0.086N     P=0.015N*    P=0.061N    |P=0.344N     P=0.107N     P=0.472N     P=0.295N     | 
|POLY 1.5           |     P=0.017N*    P=0.087N     P=0.017N*    P=0.036N*   |P=0.341N     P=0.111N     P=0.480N     P=0.296N     | 
|POLY 6             |     P=0.025N*    P=0.080N     P=0.013N*    P=0.141N    |P=0.349N     P=0.106N     P=0.468N     P=0.299N     | 
|LOGISTIC REGRESSION|     P=0.023N*    P=0.089N     P=0.016N*    P=0.103N    |P=0.335N     P=0.120N     P=0.494N     P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.086N     P=0.020N*    P=0.020N*   |P=0.337N     P=0.121N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.019N*    (e)          (e)          (e)         |P=0.172N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  5/50 (10%)   3/50 (6%)    3/50 (6%)   |3/50 (6%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     11/43.14     5/42.43      3/44.53      3/33.02     |3/44.48      0/47.49      2/47.33      1/45.76      | 
|POLY-3 PERCENT (g) |     25.5%        11.8%        6.7%         9.1%        |6.7%         0.0%         4.2%         2.2%         | 
|TERMINAL (d)       |     4/22 (18%)   2/27 (7%)    2/31 (7%)    0/2 (0%)    |1/32 (3%)    0/38 (0%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     584          590          669          537         |634          ---          701          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.063N     P=0.008N**   P=0.592     |P=0.337N     P=0.106N     P=0.457N     P=0.296N     | 
|POLY 3             |     P=0.021N*    P=0.086N     P=0.015N*    P=0.061N    |P=0.344N     P=0.107N     P=0.472N     P=0.295N     | 
|POLY 1.5           |     P=0.017N*    P=0.087N     P=0.017N*    P=0.036N*   |P=0.341N     P=0.111N     P=0.480N     P=0.296N     | 
|POLY 6             |     P=0.025N*    P=0.080N     P=0.013N*    P=0.141N    |P=0.349N     P=0.106N     P=0.468N     P=0.299N     | 
|LOGISTIC REGRESSION|     P=0.023N*    P=0.089N     P=0.016N*    P=0.103N    |P=0.335N     P=0.120N     P=0.494N     P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.013N*    P=0.086N     P=0.020N*    P=0.020N*   |P=0.337N     P=0.121N     P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.019N*    (e)          (e)          (e)         |P=0.172N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 18      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  46/50 (92%)  46/50 (92%)  48/50 (96%) |                                                    | 
|POLY-3 RATE (b)    |     45/48.31     46/46.96     46/48.16     48/48.92    |                                                    | 
|POLY-3 PERCENT (g) |     93.2%        98.0%        95.5%        98.1%       |                                                    | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 31/31 (100%) 2/2 (100%)  |                                                    | 
|FIRST INCIDENCE    |     495          484          486          487         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.292N     P=0.055N     P<0.001 **  |                                                    | 
|POLY 3             |     P=0.172      P=0.219      P=0.473      P=0.203     |                                                    | 
|POLY 1.5           |     P=0.177      P=0.311      P=0.486      P=0.211     |                                                    | 
|POLY 6             |     P=0.156      P=0.178      P=0.466      P=0.196     |                                                    | 
|LOGISTIC REGRESSION|     P=0.040 *    P=0.294      P=0.590      P=0.079     |                                                    | 
|COCH-ARM / FISHERS |     P=0.170      P=0.500      P=0.500      P=0.218     |                                                    | 
|ORDER RESTRICTED   |     P=0.084      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  6/50 (12%)   9/50 (18%)   4/50 (8%)   |4/50 (8%)    6/50 (12%)   3/50 (6%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     10/42.92     6/41.62      9/44.62      4/33.08     |4/44.14      6/47.51      3/47.22      6/46.55      | 
|POLY-3 PERCENT (g) |     23.3%        14.4%        20.2%        12.1%       |9.1%         12.6%        6.4%         12.9%        | 
|TERMINAL (d)       |     5/22 (23%)   5/27 (19%)   6/31 (19%)   0/2 (0%)    |3/32 (9%)    5/38 (13%)   3/37 (8%)    3/34 (9%)    | 
|FIRST INCIDENCE    |     638          715          691          621         |724          725          729 (T)      480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.314      P=0.128N     P=0.248N     P=0.318     |P=0.392      P=0.476      P=0.430N     P=0.398      | 
|POLY 3             |     P=0.197N     P=0.221N     P=0.462N     P=0.171N    |P=0.415      P=0.417      P=0.463N     P=0.403      | 
|POLY 1.5           |     P=0.141N     P=0.218N     P=0.480N     P=0.115N    |P=0.409      P=0.403      P=0.474N     P=0.395      | 
|POLY 6             |     P=0.300N     P=0.219N     P=0.431N     P=0.307N    |P=0.414      P=0.426      P=0.457N     P=0.405      | 
|LOGISTIC REGRESSION|     P=0.395N     P=0.191N     P=0.406N     P=0.354N    |P=0.398      P=0.433      P=0.459N     P=0.378      | 
|COCH-ARM / FISHERS |     P=0.093N     P=0.207N     P=0.500N     P=0.074N    |P=0.388      P=0.370      P=0.500N     P=0.370      | 
|ORDER RESTRICTED   |     P=0.174N     (e)          (e)          (e)         |P=0.439      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 19      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.56      2/44.30      1/32.09     |0/44.12      1/47.49      1/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         4.5%         3.1%        |0.0%         2.1%         2.1%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    1/38 (3%)    1/37 (3%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      708         |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.220      P=0.572      P=0.620      P=0.354     |P=0.385      P=0.534      P=0.529      P=0.512      | 
|POLY 3             |     P=0.533      P=0.496      P=0.518      P=0.697     |P=0.396      P=0.515      P=0.514      P=0.507      | 
|POLY 1.5           |     P=0.597      P=0.495      P=0.509      P=0.729     |P=0.394      P=0.510      P=0.510      P=0.506      | 
|POLY 6             |     P=0.444      P=0.501      P=0.533      P=0.635     |P=0.393      P=0.518      P=0.516      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.277      P=0.572      P=0.620      P=0.442     |(e)          P=0.534      P=0.529      P=0.512      | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.500      P=0.500      P=0.753N    |P=0.384      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.545      (e)          (e)          (e)         |P=0.335      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  8/50 (16%)   10/50 (20%)  5/50 (10%)  |4/50 (8%)    7/50 (14%)   4/50 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     11/42.92     8/41.62      10/44.62     5/33.16     |4/44.14      7/47.51      4/47.22      7/46.55      | 
|POLY-3 PERCENT (g) |     25.6%        19.2%        22.4%        15.1%       |9.1%         14.7%        8.5%         15.0%        | 
|TERMINAL (d)       |     6/22 (27%)   7/27 (26%)   7/31 (23%)   0/2 (0%)    |3/32 (9%)    6/38 (16%)   4/37 (11%)   4/34 (12%)   | 
|FIRST INCIDENCE    |     638          715          691          621         |724          725          729 (T)      480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210      P=0.183N     P=0.230N     P=0.181     |P=0.300      P=0.364      P=0.570N     P=0.291      | 
|POLY 3             |     P=0.205N     P=0.327N     P=0.459N     P=0.201N    |P=0.325      P=0.305      P=0.606N     P=0.292      | 
|POLY 1.5           |     P=0.143N     P=0.322N     P=0.479N     P=0.135N    |P=0.319      P=0.292      P=0.617N     P=0.285      | 
|POLY 6             |     P=0.318N     P=0.327N     P=0.426N     P=0.359N    |P=0.324      P=0.314      P=0.599N     P=0.293      | 
|LOGISTIC REGRESSION|     P=0.492N     P=0.276N     P=0.390N     P=0.492N    |P=0.305      P=0.319      P=0.603N     P=0.272      | 
|COCH-ARM / FISHERS |     P=0.091N     P=0.306N     P=0.500N     P=0.086N    |P=0.297      P=0.262      P=0.643N     P=0.262      | 
|ORDER RESTRICTED   |     P=0.221N     (e)          (e)          (e)         |P=0.305      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 20      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/42.42      2/41.70      3/44.71      3/33.80     |0/44.12      0/47.49      0/47.22      1/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         4.8%         6.7%         8.9%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/22 (5%)    0/27 (0%)    2/31 (7%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     634          709          613          487         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.100      P=0.654N     P=0.594      P=0.275     |P=0.195      (e)          (e)          P=0.512      | 
|POLY 3             |     P=0.272      P=0.688      P=0.524      P=0.398     |P=0.200      (e)          (e)          P=0.507      | 
|POLY 1.5           |     P=0.318      P=0.688      P=0.513      P=0.448     |P=0.200      (e)          (e)          P=0.506      | 
|POLY 6             |     P=0.211      P=0.693      P=0.543      P=0.314     |P=0.198      (e)          (e)          P=0.506      | 
|LOGISTIC REGRESSION|     P=0.446      P=0.692      P=0.499      P=0.675N    |(e)          (e)          (e)          P=0.512      | 
|COCH-ARM / FISHERS |     P=0.371      P=0.691N     P=0.500      P=0.500     |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.377      (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/50 (12%)   9/50 (18%)   10/50 (20%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |                                                        |6/44.12      9/47.99      10/47.66     10/46.21     | 
|POLY-3 PERCENT (g) |                                                        |13.6%        18.8%        21.0%        21.6%        | 
|TERMINAL (d)       |                                                        |6/32 (19%)   7/38 (18%)   8/37 (22%)   8/34 (24%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      633          633          653          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.203      P=0.413      P=0.300      P=0.243      | 
|POLY 3             |                                                        |P=0.218      P=0.350      P=0.257      P=0.234      | 
|POLY 1.5           |                                                        |P=0.215      P=0.330      P=0.240      P=0.228      | 
|POLY 6             |                                                        |P=0.215      P=0.368      P=0.270      P=0.236      | 
|LOGISTIC REGRESSION|                                                        |P=0.204      P=0.350      P=0.258      P=0.219      | 
|COCH-ARM / FISHERS |                                                        |P=0.198      P=0.288      P=0.207      P=0.207      | 
|ORDER RESTRICTED   |                                                        |P=0.268      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 21      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/42.08      0/41.56      0/44.30      0/32.01     |0/44.12      0/47.49      1/47.84      2/46.97      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.1%         4.3%         | 
|TERMINAL (d)       |     0/22 (0%)    0/27 (0%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.074      (e)          P=0.512      P=0.254      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.074      (e)          P=0.516      P=0.251      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.073      (e)          P=0.511      P=0.248      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.074      (e)          P=0.520      P=0.253      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.007 **   (e)          P=0.275      P=0.068      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.083      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           | 
|     Undifferentiated                                                                                                            | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  41/50 (82%)  39/50 (78%)  24/50 (48%) |19/50 (38%)  25/50 (50%)  30/50 (60%)  29/50 (58%)  | 
|POLY-3 RATE (b)    |     27/48.36     41/49.82     39/48.01     24/40.48    |19/44.91     25/48.56     30/48.94     29/48.68     | 
|POLY-3 PERCENT (g) |     55.8%        82.3%        81.2%        59.3%       |42.3%        51.5%        61.3%        59.6%        | 
|TERMINAL (d)       |     6/22 (27%)   20/27 (74%)  25/31 (81%)  2/2 (100%)  |13/32 (41%)  19/38 (50%)  21/37 (57%)  20/34 (59%)  | 
|FIRST INCIDENCE    |     425          344          494          487         |637          613          609          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.086      P=0.317      P=0.003 **  |P=0.052      P=0.383      P=0.115      P=0.084      | 
|POLY 3             |     P=0.508      P=0.003 **   P=0.005 **   P=0.454     |P=0.058      P=0.247      P=0.048 *    P=0.068      | 
|POLY 1.5           |     P=0.292N     P=0.002 **   P=0.006 **   P=0.540N    |P=0.047 *    P=0.216      P=0.037 *    P=0.056      | 
|POLY 6             |     P=0.135      P=0.004 **   P=0.004 **   P=0.196     |P=0.066      P=0.271      P=0.060      P=0.078      | 
|LOGISTIC REGRESSION|     P=0.062N     P=0.002 **   P=0.008 **   P=0.139N    |P=0.034 *    P=0.250      P=0.042 *    P=0.045 *    | 
|COCH-ARM / FISHERS |     P=0.091N     P=0.002 **   P=0.010 *    P=0.345N    |P=0.029 *    P=0.157      P=0.022 *    P=0.036 *    | 
|ORDER RESTRICTED   |     P=0.025 *    (e)          (e)          (e)         |P=0.057      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 22      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Benign, Malignant, NOS                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.65      3/42.03      2/44.77      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         7.1%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     549          590          624          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286N     P=0.547      P=0.635N     P=0.466N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.203N     P=0.493      P=0.677N     P=0.306N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.169N     P=0.493      P=0.685N     P=0.271N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.270N     P=0.500      P=0.661N     P=0.372N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.122N     P=0.508      P=0.670      P=0.194N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.500      P=0.691N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.190N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Mesothelioma: Malignant                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/42.65      3/42.03      2/44.77      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     4.7%         7.1%         4.5%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    2/27 (7%)    0/31 (0%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     549          590          624          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286N     P=0.547      P=0.635N     P=0.466N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.203N     P=0.493      P=0.677N     P=0.306N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.169N     P=0.493      P=0.685N     P=0.271N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.270N     P=0.500      P=0.661N     P=0.372N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.122N     P=0.508      P=0.670      P=0.194N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.134N     P=0.500      P=0.691N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.190N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 23      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.64      1/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      710          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.557N     P=0.568      P=0.684N     P=0.934N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.304N     P=0.496      P=0.749N     P=0.554N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.278N     P=0.496      P=0.755N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.354N     P=0.503      P=0.740N     P=0.598N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.480N     P=0.527      P=0.684N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.283N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/42.08      2/41.64      1/44.30      0/32.01     |0/44.12      0/47.49      0/47.22      0/45.76      | 
|POLY-3 PERCENT (g) |     2.4%         4.8%         2.3%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/22 (5%)    1/27 (4%)    1/31 (3%)    0/2 (0%)    |0/32 (0%)    0/38 (0%)    0/37 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      710          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.557N     P=0.568      P=0.684N     P=0.934N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.304N     P=0.496      P=0.749N     P=0.554N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.278N     P=0.496      P=0.755N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.354N     P=0.503      P=0.740N     P=0.598N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.480N     P=0.527      P=0.684N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.500      P=0.753N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.283N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 24      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     49/50 (98%)  47/50 (94%)  49/50 (98%)  50/50 (100%)|42/50 (84%)  40/50 (80%)  37/50 (74%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     49/49.20     47/47.56     49/49.31     50/50.00    |42/48.73     40/49.18     37/49.11     33/48.18     | 
|POLY-3 PERCENT (g) |     99.6%        98.8%        99.4%        100.0%      |86.2%        81.3%        75.4%        68.5%        | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 31/31 (100%) 2/2 (100%)  |27/32 (84%)  30/38 (79%)  28/37 (76%)  22/34 (65%)  | 
|FIRST INCIDENCE    |     495          484          486          487         |288          613          609          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.165N     P=0.046N*    P<0.001 **  |P=0.052N     P=0.119N     P=0.068N     P=0.059N     | 
|POLY 3             |     P=0.655      P=0.932N     P=0.991N     P=1.000     |P=0.016N*    P=0.351N     P=0.130N     P=0.028N*    | 
|POLY 1.5           |     P=0.349      P=0.576N     P=0.891N     P=0.891     |P=0.015N*    P=0.358N     P=0.136N     P=0.026N*    | 
|POLY 6             |     P=1.000      P=1.000N     P=1.000N     P=1.000     |P=0.020N*    P=0.358N     P=0.131N     P=0.034N*    | 
|LOGISTIC REGRESSION|     P=0.406      P=0.633N     P=0.712N     (e)         |P=0.014N*    P=0.335N     P=0.137N     P=0.027N*    | 
|COCH-ARM / FISHERS |     P=0.200      P=0.309N     P=0.753N     P=0.500     |P=0.017N*    P=0.398N     P=0.163N     P=0.032N*    | 
|ORDER RESTRICTED   |     P=0.232      (e)          (e)          (e)         |P=0.021N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  42/50 (84%)  40/50 (80%)  26/50 (52%) |20/50 (40%)  29/50 (58%)  32/50 (64%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     33/49.44     42/49.82     40/48.38     26/41.59    |20/44.93     29/48.98     32/49.71     32/49.17     | 
|POLY-3 PERCENT (g) |     66.7%        84.3%        82.7%        62.5%       |44.5%        59.2%        64.4%        65.1%        | 
|TERMINAL (d)       |     9/22 (41%)   21/27 (78%)  25/31 (81%)  2/2 (100%)  |13/32 (41%)  22/38 (58%)  21/37 (57%)  22/34 (65%)  | 
|FIRST INCIDENCE    |     425          344          494          487         |637          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.004 **   P=0.268      P=0.479N     P=0.006 **  |P=0.038 *    P=0.224      P=0.096      P=0.047 *    | 
|POLY 3             |     P=0.275N     P=0.033 *    P=0.053      P=0.417N    |P=0.041 *    P=0.109      P=0.039 *    P=0.033 *    | 
|POLY 1.5           |     P=0.094N     P=0.032 *    P=0.063      P=0.243N    |P=0.031 *    P=0.087      P=0.026 *    P=0.024 *    | 
|POLY 6             |     P=0.393      P=0.035 *    P=0.047 *    P=0.456     |P=0.051      P=0.129      P=0.054      P=0.041 *    | 
|LOGISTIC REGRESSION|     P=0.008N**   P=0.015 *    P=0.064      P=0.017N*   |P=0.018 *    P=0.101      P=0.023 *    P=0.018 *    | 
|COCH-ARM / FISHERS |     P=0.019N*    P=0.032 *    P=0.088      P=0.111N    |P=0.016 *    P=0.055      P=0.014 *    P=0.014 *    | 
|ORDER RESTRICTED   |     P=0.059N     (e)          (e)          (e)         |P=0.029 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  08/23/04                           EXPERIMENT: 88138 TEST: 03                                            Page 25      
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                       BENZOPHENONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 PPM        312 PPM      625 PPM      1250 PPM    |0 PPM        312 PPM      625 PPM      1250 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|46/50 (92%)  46/50 (92%)  45/50 (90%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     50/50.00     50/50.00     50/50.00     50/50.00    |46/48.75     46/50.00     45/50.00     44/50.00     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |94.4%        92.0%        90.0%        88.0%        | 
|TERMINAL (d)       |     22/22 (100%) 27/27 (100%) 31/31 (100%) 2/2 (100%)  |30/32 (94%)  34/38 (90%)  32/37 (87%)  28/34 (82%)  | 
|FIRST INCIDENCE    |     425          344          486          487         |288          609          528          480          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.349N     P=0.159N     P=0.173N     P=0.309N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.167N     P=0.473N     P=0.330N     P=0.221N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.197N     P=0.531N     P=0.384N     P=0.265N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.144N     P=0.420N     P=0.285N     P=0.185N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.268N     P=0.549N     P=0.422N     P=0.340N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.270N     P=0.643N     P=0.500N     P=0.370N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.210N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).