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https://ntp.niehs.nih.gov/go/19819

TDMS Study 05206-05 Pathology Tables

NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04
Route: DOSED FEED                                                                                                 Time: 08:19:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7758-99-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 PPM
                               Include 001    0 PPM
                               Include 006    500 PPM
                               Include 005    500 PPM
                               Include 010    1000 PPM
                               Include 009    1000 PPM
                               Include 014    2000 PPM
                               Include 013    2000 PPM
                               Include 018    4000 PPM
                               Include 017    4000 PPM
                               Include 022    8000 PPM
                               Include 021    8000 PPM

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10            9           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (10)                      (1)                                    (10)         
      Inflammation, Acute                              1 (10%)                                                                      
   Liver                                              (10)         (1)          (2)          (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       2 (20%)      1 (100%)     2 (100%)     2 (20%)                               
      Inflammation, Chronic Active                                                                         6 (60%)     10 (100%)    
      Inflammation, Focal                              2 (20%)                                                                      
   Mesentery                                                       (1)                                                              
      Fat, Necrosis                                                 1 (100%)                                                        
   Pancreas                                           (10)                      (1)                                    (10)         
      Atrophy                                          1 (10%)                                                          1 (10%)     
   Stomach, Forestomach                               (10)                      (10)         (10)         (10)         (10)         
      Cyst Epithelial Inclusion                                                                                         1 (10%)     
      Hyperplasia                                                                             7 (70%)     10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Inflammation, Chronic Active                                                                                      1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                      (1)                                    (10)         
      Inflammation, Chronic Active                     9 (90%)                                                         10 (100%)    
   Ovary                                              (10)         (1)          (1)                                    (10)         
      Cyst                                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (10)                      (1)                                    (10)         
      Gliosis                                          1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Cyst                                             1 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Cytoplasmic Alteration                                                     1 (10%)      9 (90%)     10 (100%)    10 (100%)    
      Mineralization                                                1 (10%)                                                         
      Nephropathy                                                                1 (10%)      1 (10%)                   2 (20%)     
      Pigmentation                                                                                                      2 (20%)     
      Proximal Convoluted Renal Tubule, Karyomegaly                                                                    10 (100%)    
      Renal Tubule, Degeneration                                                                                        3 (30%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)                      (10)         (10)         (10)         (10)         
      Hepatodiaphragmatic Nodule                       1 (10%)                   1 (10%)      1 (10%)                               
      Inflammation, Chronic Active                                                            1 (10%)     10 (100%)    10 (100%)    
   Pancreas                                           (10)                                                             (10)         
      Atrophy                                          2 (20%)                                                          1 (10%)     
   Stomach, Forestomach                               (10)         (1)          (10)         (10)         (10)         (10)         
      Hyperplasia                                                                            10 (100%)    10 (100%)    10 (100%)    
   Stomach, Glandular                                 (10)                      (10)         (10)         (10)         (10)         
      Mineralization                                                             1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                             (10)         
      Inflammation, Chronic Active                    10 (100%)                                                         5 (50%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (10)                                                             (10)         
      Cyst                                                                                                              1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (10)                                                             (10)         
      Inflammation, Chronic Active                     7 (70%)                                                          8 (80%)     
   Prostate                                           (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Inflammation, Chronic Active                     1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (9)          (10)         (10)         (10)         (10)         
      Cytoplasmic Alteration                                                                  3 (30%)     10 (100%)    10 (100%)    
      Nephropathy                                     10 (100%)     9 (100%)    10 (100%)     8 (80%)      9 (90%)      6 (60%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 05206-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                   CUPRIC SULFATE                                      Date: 10/15/04    
Route: DOSED FEED                                                                                                 Time: 08:19:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        500 PPM      1000 PPM     2000 PPM     4000 PPM     8000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Proximal Convoluted Renal Tubule, Karyomegaly                                                                    10 (100%)    
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------