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https://ntp.niehs.nih.gov/go/15409

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 13:32:35

                                                     31 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     04/14/99 - 04/15/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 002    10 NG / 10 UG
                               Include 003    100 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 007    1000 NG/1000 UG
































                                                              Page   1


NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9|                          |      L     |
    0 UG                                   | 9| 5| 8| 1| 2| 3| 4| 5| 2| 1| 6| 7| 8| 9| 0| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Inflammation                         |          1  1  1  1  1        1  1  1  1  1                              |     10  1.0|
      Mixed Cell Focus                     |                                        X                                 |      1     |
      Mixed Cell Focus, Multiple           |                                           X                              |      1     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Inflammation, Chronic Active         |                                        1                                 |      1  1.0|
      Acinus, Atrophy                      |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +  +  +        +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +  +  +        +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Hypertrophy                          |                               1  1  1                                    |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +  +  +  +        +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +  +  +  +        +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +  +  +  +        +  +  +  +  +                              |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +  +  +        +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9|                          |      L     |
    0 UG                                   | 9| 5| 8| 1| 2| 3| 4| 5| 2| 1| 6| 7| 8| 9| 0| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Atrophy                              |          4  4  4              4     4  4                                 |      6  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
      Metaplasia, Squamous                 |          2  1  2              1     2  2                                 |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |          +  +  +  +  +        +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Pigmentation                         |          1  1  1  1  1        1  1  1  1  1                              |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Atrophy                              |             1  1  1           2  1  1                                    |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |          +  +  +  +  +        +  +  +  +  +                              |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |          +  +  +  +  +        +  +  +  +  +                              |  10        |
      Infiltration Cellular, Histiocyte    |                   1                    1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      A     |
    0 NG /                                 | 1| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 8| 9|                          |      L     |
    0 UG                                   | 9| 5| 8| 1| 2| 3| 4| 5| 2| 1| 6| 7| 8| 9| 0| 8|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    10 NG /                                | 3| 3| 3| 3| 4| 7| 7| 7| 7| 8|                                            |      L     |
    10 UG                                  | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Clear Cell Focus                     |                            X                                             |      1     |
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Mixed Cell Focus, Multiple           |                         X                                                |      1     |
      Hepatocyte, Hypertrophy              | 1                    1     1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
      Acinus, Atrophy                      |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration, Cystic                 |       1                                                                  |      1  1.0|
      Hypertrophy                          |             1     1                                                      |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicular Cell, Hypertrophy         | 1  1  1     1  1                                                         |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    4  4  4  4  4  4  4                                                   |      7  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
      Metaplasia, Squamous                 |    3  1  1  3  2  2  2                                                   |      7  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    10 NG /                                | 3| 3| 3| 3| 4| 7| 7| 7| 7| 8|                                            |      L     |
    10 UG                                  | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    1     1  1  1  2                                                      |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Histiocyte    |                      1                                                   |      1  1.0|
      Inflammation                         |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    100 NG /                               | 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|                          |      L     |
    100 UG                                 | 1| 6| 7| 8| 9| 0| 5| 6| 7| 8| 9| 0| 1| 5| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Inflammation                         |    1  1  1  1  1     1  1  1  2  1                                       |     10  1.1|
      Mixed Cell Focus                     |    X  X                                                                  |      2     |
      Mixed Cell Focus, Multiple           |             X                                                            |      1     |
      Pigmentation                         |                      1        1  1                                       |      3  1.0|
      Hepatocyte, Hypertrophy              |    1     1  1  1           1                                             |      5  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Degeneration, Cystic                 |                2                                                         |      1  2.0|
      Hypertrophy                          |                2                 1                                       |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Follicular Cell, Hypertrophy         |       1     1        1     1     1                                       |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Atrophy                              |    4  4  4  4  4     4     4  4  4                                       |      9  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Metaplasia, Squamous                 |    2     2  2  1              2                                          |      5  1.8|
      Endometrium, Hyperplasia, Cystic     |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |      A     |
    100 NG /                               | 2| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7|                          |      L     |
    100 UG                                 | 1| 6| 7| 8| 9| 0| 5| 6| 7| 8| 9| 0| 1| 5| 5| 6|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   1        |
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |                            3                                             |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
      Atrophy                              |    1     1  1        1        1  1                                       |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +     +  +  +  +  +                                       |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8|                          |      L     |
    300 UG                                 | 9| 2| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 9| 3| 9|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Fatty Change, Diffuse                |             1                                                            |      1  1.0|
      Inflammation                         |       1  1  1  1  1     1  1  1  1  1                                    |     10  1.0|
      Mixed Cell Focus                     |       X  X              X                                                |      3     |
      Mixed Cell Focus, Multiple           |             X                 X     X                                    |      3     |
      Pigmentation                         |       1  1  1  1  1     1  1  1  1  1                                    |     10  1.0|
      Bile Duct, Hyperplasia               |                               1                                          |      1  1.0|
      Hepatocyte, Hypertrophy              |       1  1  1  1  1     1  1  1  1  1                                    |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Basophilic Focus                     |                                  X                                       |      1     |
      Inflammation, Chronic Active         |                                  1                                       |      1  1.0|
      Acinus, Atrophy                      |                                  1                                       |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Hyperplasia                          |                1                                                         |      1  1.0|
      Hypertrophy                          |       1     1                 1     1                                    |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Follicular Cell, Hypertrophy         |             1  1  1     1  1     1  1                                    |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Atrophy                              |       4  4  4  4  4     4  4  4  4  4                                    |     10  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                          |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 7| 8| 8|                          |      L     |
    300 UG                                 | 9| 2| 6| 7| 8| 9| 0| 1| 1| 2| 3| 4| 5| 9| 3| 9|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Metaplasia, Squamous                 |       2  2  2  3  2        2  3  2  2                                    |      9  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Atrophy                              |       1  1     1        1  1  1     1                                    |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +     +  +  +  +  +                                    |  10        |
      Hemorrhage                           |                            1                                             |      1  1.0|
      Infiltration Cellular, Histiocyte    |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  |                               +                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    1000 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 8| 8| 8| 8| 8| 9|                          |      L     |
    1000 UG                                | 5| 6| 8| 4| 6| 7| 8| 9| 0| 2| 1| 6| 7| 8| 9| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Fatty Change, Diffuse                |             2  1  2  3  3        1  2  1  3  3                           |     10  2.1|
      Inflammation                         |             1  1  2  2  1        1  2  2  2  2                           |     10  1.6|
      Mixed Cell Focus                     |             X                             X                              |      2     |
      Mixed Cell Focus, Multiple           |                X        X           X                                    |      3     |
      Pigmentation                         |             1  1  1  1  1        1  2  2  1  1                           |     10  1.2|
      Toxic Hepatopathy                    |                      1  1        1        1  1                           |      5  1.0|
      Bile Duct, Hyperplasia               |                         1        1                                       |      2  1.0|
      Bile Duct, Inflammation, Chronic     |                                                                          |            |
          Active, Focal                    |                         2                                                |      1  2.0|
      Hepatocyte, Hypertrophy              |             3  4  3  3  3        3  3  3  3  4                           |     10  3.2|
      Hepatocyte, Multinucleated           |             1  1  1     1        1  2  2  1  1                           |      9  1.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Acinus, Vacuolization Cytoplasmic    |                1                       1     1                           |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Hyperplasia                          |                         3           2                                    |      2  2.5|
      Hypertrophy                          |                                     1                                    |      1  1.0|
      Vacuolization Cytoplasmic            |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Follicular Cell, Hypertrophy         |             1  1  2  1  2           1  2     1                           |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 13:32:35    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                          |            |
                             DAY ON TEST   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                          |            |
                                           | 2| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1|                          |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                          |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                          |      A     |
    1000 NG/                               | 0| 0| 0| 1| 1| 1| 1| 1| 2| 4| 8| 8| 8| 8| 8| 9|                          |      L     |
    1000 UG                                | 5| 6| 8| 4| 6| 7| 8| 9| 0| 2| 1| 6| 7| 8| 9| 0|                          |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Atrophy                              |                   4     4        4  4  4  4                              |      6  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Metaplasia, Squamous                 |                   2              1  2     2                              |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Atrophy                              |             1  4  2  1  1        1  1  1  4  3                           |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +        +  +  +  +  +                           |  10        |
      Infiltration Cellular, Histiocyte    |             1  1     1                       1                           |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------