National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20245

TDMS Study 99022-02 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                  AZT TRANSPLACENTAL CARCINOGENESIS STUDY                                DATE: 10/08/03  
EXPERIMENT: 99022 TEST: 02                                                                                        TIME: 16:01:05    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: PERINATAL EXPOS                          ROUTE: IN-UTERO                                               NTP:  C99022      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       MERGE   001   001,011                    0       MG/KG/DY                                    
                                       MERGE   002   002,012                    50      MG/KG/DY                                    
                                       MERGE   003   003,013                    100     MG/KG/DY                                    
                                       MERGE   004   004,014                    200     MG/KG/DY                                    
                                       MERGE   005   005,015                    300     MG/KG/DY                                    
                                       MERGE   006   006,016                    0       MG/KG/DY                                    
                                       MERGE   007   007,017                    50      MG/KG/DY                                    
                                       MERGE   008   008,018                    100     MG/KG/DY                                    
                                       MERGE   009   009,019                    200     MG/KG/DY                                    
                                       MERGE   010   010,020                    300     MG/KG/DY                                    
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      AZT TRANSPLACENTAL CARCINOGENESIS STUDY                     DATE: 10/08/03    
EXPERIMENT: 99022 TEST: 02                                                                                        TIME: 16:09:47    
SPECIES: MICE, SWISS                                                                                                                
TEST TYPE: PERINATAL EXPOSURE                       ROUTE: IN-UTERO                                               NTP:  C99022      
CONT: N01-ES-15328                                                                                                CAS: 30516-87-1   
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                         
                            PERINATAL EXPOSURE IN-UTERO STUDY OF AZT TRANSPLACENTAL CARCINOGENESIS STUDY                            
=================================================================================================================================== 
WEEK     0       MG/KG/DY       50      MG/KG/DY         100     MG/KG/DY         200     MG/KG/DY         300     MG/KG/DY         
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  5        28.1       49*       26.3     93.6    44*     26.4     94.0    48*     26.9     95.7    37      25.6     91.1    32      
  9        40.3       50        37.6     93.3    49      38.1     94.5    50      38.7     96.0    37      36.9     91.6    30      
 13        44.6       50        42.6     95.5    49      42.9     96.2    50      43.7     98.0    37      41.4     92.8    30      
 17        48.8       48        46.4     95.1    49      46.6     95.5    50      45.8     93.9    37      44.7     91.6    30      
 21        49.6       48        48.4     97.6    49      48.2     97.2    50      47.5     95.8    37      46.1     92.9    30      
 25        52.6       48        50.1     95.2    46      50.6     96.2    49      50.6     96.2    34      47.6     90.5    30      
 29        53.3       48        51.3     96.2    46      50.7     95.1    48      50.9     95.5    34      48.9     91.7    29      
 33        54.8       48        51.7     94.3    46      51.2     93.4    47      52.0     94.9    34      48.8     89.1    27*     
 37        54.1       47*       51.3     94.8    38*     51.1     94.5    43*     51.6     95.4    34      49.5     91.5    28      
 41        55.4       48        53.1     95.8    43      52.6     94.9    45      52.3     94.4    34      50.7     91.5    28      
 45        56.1       47        53.3     95.0    40*     53.4     95.2    44      52.2     93.0    32      51.5     91.8    28      
 49        56.0       43*       53.5     95.5    36*     52.5     93.8    39*     52.7     94.1    29      52.5     93.8    25      
 53        56.3       44        55.1     97.9    38      53.3     94.7    41      53.9     95.7    28      52.0     92.4    25      
 57        56.0       42        54.9     98.0    35*     54.6     97.5    39      53.3     95.2    27      53.3     95.2    24      
 61        56.3       40        55.0     97.7    34*     54.2     96.3    38      52.2     92.7    26      53.4     94.8    23      
 65        56.5       39        54.7     96.8    32*     53.7     95.0    37      52.6     93.1    24*     53.6     94.9    23      
 69        55.4       36        54.8     98.9    29*     54.2     97.8    35      52.0     93.9    25      52.4     94.6    22      
 73        55.7       33        55.3     99.3    30      55.0     98.7    31      51.1     91.7    23      53.8     96.6    20      
 77        53.6       14*       55.2    103.0    16*     54.0    100.7    13*     52.4     97.8    11*     51.8     96.6    16*     
 81        54.8       30        52.2     95.3    28      55.4    101.1    25      49.5     90.3    19      53.5     97.6    17      
 85        54.2       28        55.0    101.5    24      54.1     99.8    23      49.0     90.4    17      51.6     95.2    16      
 89        55.4       24        53.1     95.8    23      53.3     96.2    18      48.6     87.7    13      50.5     91.2    15      
 93        54.5       21        52.2     95.8    21      52.8     96.9    14      50.2     92.1     8      51.9     95.2    10      
TERM. SAC.            19                         21                       13                        7                        8      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                         MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                       
                            PERINATAL EXPOSURE IN-UTERO STUDY OF AZT TRANSPLACENTAL CARCINOGENESIS STUDY                            
=================================================================================================================================== 
WEEK     0       MG/KG/DY       50      MG/KG/DY         100     MG/KG/DY         200     MG/KG/DY         300     MG/KG/DY         
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  5        21.4       48*       20.2     94.4    45*     20.4     95.3    46*     22.3    104.2    40      19.4     90.7    42      
  9        30.2       50        28.5     94.4    50      28.7     95.0    50      30.6    101.3    40      28.4     94.0    40      
 13        35.2       50        33.2     94.3    50      33.5     95.2    50      35.5    100.9    40      34.1     96.9    40      
 17        39.9       49        36.9     92.5    50      37.4     93.7    50      39.9    100.0    40      39.9    100.0    40      
 21        41.9       49        38.8     92.6    50      39.7     94.7    50      41.9    100.0    40      41.8     99.8    40      
 25        45.3       49        42.3     93.4    45*     42.8     94.5    50      45.4    100.2    40      45.3    100.0    40      
 29        46.7       48        44.1     94.4    50      44.4     95.1    48      46.3     99.1    40      46.3     99.1    40      
 33        48.7       24*       46.6     95.7    24*     42.1     86.4    23*     48.6     99.8    17*     45.4     93.2    24*     
 37        48.2       46        46.9     97.3    48      48.2    100.0    47      49.5    102.7    40      50.0    103.7    39      
 41        51.3       46        49.7     96.9    48      49.9     97.3    47      51.2     99.8    40      51.2     99.8    39      
 45        52.7       21*       52.7    100.0    24*     49.4     93.7    22*     54.4    103.2    17*     49.1     93.2    24*     
 49        51.1       45        50.5     98.8    46      51.9    101.6    44      52.1    102.0    40      51.8    101.4    37      
 53        53.1       44        51.9     97.7    43      53.2    100.2    43      52.9     99.6    39      52.6     99.1    37      
 57        55.3       20*       55.2     99.8    22*     53.0     95.8    21*     55.8    100.9    16*     49.7     89.9    23*     
 61        54.7       22*       53.6     98.0    17*     58.4    106.8    21*     53.5     97.8    22*     62.9    115.0    14*     
 65        54.8       40        55.2    100.7    38      56.2    102.6    41      53.1     96.9    38      52.8     96.4    36      
 69        55.6       39        54.5     98.0    34      55.9    100.5    40      52.1     93.7    38      54.0     97.1    31      
 73        56.7       38        54.4     95.9    30*     57.3    101.1    38      52.6     92.8    36      55.3     97.5    29      
 77        55.9       17*       52.8     94.5    18*     57.1    102.1    18*     52.6     94.1    15*     46.5     83.2    14*     
 80                                                                               50.4       NA     1*                              
 81        56.3       35        55.3     98.2    24      57.8    102.7    35      55.4     98.4    27*     56.7    100.7    26      
 85        56.2       30        55.4     98.6    21      57.7    102.7    32      53.5     95.2    27      55.8     99.3    24      
 89        56.2       24        55.6     98.9    20      57.8    102.8    29      51.9     92.3    23*     56.5    100.5    21      
 93        54.4       22        56.6    104.0    19      57.2    105.1    27      50.2     92.3    22      58.3    107.2    19      
TERM. SAC.            20                         18                       24                       20                       19      
=================================================================================================================================== 
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
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