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TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04
Route: GAVAGE                                                                                                     Time: 14:09:15

                                                     53 WEEK SSAC FINAL #1




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  TEFBINARYMIX

       Lock Date:  03/27/02

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     09/16/99 - 09/17/99

       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 004    300 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 006    300 NG /3000 UG

































                                                              Page   1


NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Inflammation                         |             1  1  1  1  1  1  1  1                                       |      8  1.0|
      Mixed Cell Focus                     |                   X                                                      |      1     |
      Mixed Cell Focus, Multiple           |                X     X     X  X                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |             +  +  +  +  +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |                   2              3                                       |      2  2.5|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Hypertrophy                          |             1        1  1     1                                          |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         |             +  +  +  +  +  +  +  +                                       |   8        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      C-Cell, Hyperplasia                  |                      2           1                                       |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             4  4  4     4  4  4  4                                       |      7  4.0|
      Cyst                                 |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Metaplasia, Squamous                 |             2  2  2     2  1  2  3                                       |      7  2.0|
      Endometrium, Hyperplasia, Cystic     |                2  2     2  2  1                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Pigmentation                         |             1  1  2  1  2  2  1  2                                       |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  |             +  +  +  +  +  +  +  +                                       |   8        |
      Atrophy                              |             1     1     1  1     2                                       |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |             +  +  +  +  +  +  +  +                                       |   8        |
      Cyst                                 |             1                                                            |      1  1.0|
      Hyperplasia                          |             1  1  1              1                                       |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |             +  +  +  +  +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      A     |
    0 NG /                                 | 0| 0| 1| 3| 4| 4| 4| 5| 7| 7| 7| 7| 8|                                   |      L     |
    0 UG                                   | 2| 6| 6| 8| 6| 7| 9| 0| 2| 3| 4| 5| 5|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Infiltration Cellular, Histiocyte    |                         1  2  1  1                                       |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300 NG /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Basophilic Focus                     | X                                                                        |      1     |
      Eosinophilic Focus                   |                   X                                                      |      1     |
      Eosinophilic Focus, Multiple         |    X                                                                     |      1     |
      Fatty Change, Diffuse                |                         1                                                |      1  1.0|
      Fatty Change, Focal                  | 1                                                                        |      1  1.0|
      Hepatodiaphragmatic Nodule           |                      X                                                   |      1     |
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Mixed Cell Focus                     |                X                                                         |      1     |
      Mixed Cell Focus, Multiple           |    X  X  X  X     X  X  X  X                                             |      8     |
      Pigmentation                         | 1  2  2  1  1  1  2  2  1  1                                             |     10  1.4|
      Toxic Hepatopathy                    |                   1  1     1                                             |      3  1.0|
      Bile Duct, Fibrosis                  |                      1                                                   |      1  1.0|
      Bile Duct, Hyperplasia               |                   1        1                                             |      2  1.0|
      Hepatocyte, Hypertrophy              | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Hepatocyte, Multinucleated           |                   1  1     1                                             |      3  1.0|
      Oval Cell, Hyperplasia               |                      1                                                   |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration, Cystic                 |          2                                                               |      1  2.0|
      Hyperplasia                          |    1  1  3                                                               |      3  1.7|
      Hypertrophy                          |       1  3        1  1  1                                                |      5  1.4|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicular Cell, Hypertrophy         | 1  1     1  1  1     1  1                                                |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300 NG /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 4  4  4  4  4     4  4     4                                             |      8  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Metaplasia, Squamous                 | 3  2  2  3  3  1  4  1     2                                             |      9  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3  2  3  2  2  2  2  2  3  2                                             |     10  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                          +                                             |   2        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |             1        1  1                                                |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    300 NG /                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
    100 UG                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
   Kidney                                  |          +                                                               |   1        |
      Mineralization                       |          2                                                               |      1  2.0|
      Nephropathy                          |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +        +  +  +  +                                       |   8        |
      Eosinophilic Focus                   |                         X                                                |      1     |
      Fatty Change, Diffuse                |                            1  1  1                                       |      3  1.0|
      Infiltration Cellular, Histiocyte    |             1                                                            |      1  1.0|
      Inflammation                         |       1  1  1  1        1  1  1  1                                       |      8  1.0|
      Mixed Cell Focus, Multiple           |                X                 X                                       |      2     |
      Pigmentation                         |       2  2  1  1        1  1  1  2                                       |      8  1.4|
      Hepatocyte, Hypertrophy              |       1  1  1  1        1  1  1  1                                       |      8  1.0|
      Hepatocyte, Multinucleated           |       1  1                                                               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +        +  +  +  +                                       |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +        +  +  +  +                                       |   8        |
      Degeneration, Cystic                 |          2                                                               |      1  2.0|
      Hyperplasia                          |                            1                                             |      1  1.0|
      Hypertrophy                          |       2  3              1     1  1                                       |      5  1.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +        +  +  +  +                                       |   8        |
      Follicular Cell, Hypertrophy         |       1     1  1        1     1  2                                       |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +        +  +  +  +                                       |   8        |
      Atrophy                              |          4  4  4        4  4  4  4                                       |      7  4.0|
      Cyst                                 |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +        +  +  +  +                                       |   8        |
      Metaplasia, Squamous                 |          4  2  2        3  2  4  4                                       |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +        +  +  +  +                                       |   8        |
      Atrophy                              |       2  3  3  2        2  2  3  2                                       |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           |          +  +  +              +  +                                       |   5        |
      Cyst                                 |          3                       3                                       |      2  3.0|
      Hyperplasia                          |          1                                                               |      1  1.0|
      Inflammation, Granulomatous          |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +        +  +  +  +                                       |   8        |
      Infiltration Cellular, Histiocyte    |             1                    1                                       |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |       1                                                                  |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                   |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                   |            |
                                           | 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7|                                   |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                   |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                   |      A     |
    300 NG /                               | 1| 2| 3| 3| 3| 3| 5| 6| 6| 6| 6| 7| 7|                                   |      L     |
    300 UG                                 | 5| 9| 2| 3| 4| 5| 9| 4| 7| 8| 9| 0| 7|                                   |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3|                                               |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |      A     |
    300 NG /                               | 0| 0| 0| 1| 7| 7| 7| 7| 8|                                               |      L     |
    3000 UG                                | 6| 8| 9| 0| 6| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |   9        |
      Basophilic Focus                     |                   X                                                      |      1     |
      Eosinophilic Focus                   |       X                                                                  |      1     |
      Fatty Change, Diffuse                | 1  2  2  2  1  2  2  1  2                                                |      9  1.7|
      Inflammation                         | 2  1  1  1  1  1  1  1  1                                                |      9  1.1|
      Mixed Cell Focus                     |             X  X     X                                                   |      3     |
      Mixed Cell Focus, Multiple           |    X     X              X                                                |      3     |
      Pigmentation                         | 3  2  2  2  2  2  2  2  2                                                |      9  2.1|
      Toxic Hepatopathy                    | 1     1  1     1     1  1                                                |      6  1.0|
      Bile Duct, Hyperplasia               |       1  2     1     1  2                                                |      5  1.4|
      Hepatocyte, Hypertrophy              | 3  2  3  3  1  2  2  3  3                                                |      9  2.4|
      Hepatocyte, Multinucleated           | 1  1     1  1  1     1  2                                                |      7  1.1|
      Oval Cell, Hyperplasia               |       1        1                                                         |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +                                                |   9        |
      Acinus, Atrophy                      |             1                                                            |      1  1.0|
      Acinus, Hyperplasia                  |                2                                                         |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    | 1     1  1     1     1  1                                                |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +                                                |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |   9        |
      Degeneration, Cystic                 |       2                                                                  |      1  2.0|
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Hypertrophy                          |    2     2        1                                                      |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3|                                               |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |      A     |
    300 NG /                               | 0| 0| 0| 1| 7| 7| 7| 7| 8|                                               |      L     |
    3000 UG                                | 6| 8| 9| 0| 6| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Vacuolization Cytoplasmic            |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |   9        |
      C-Cell, Hyperplasia                  |                      1                                                   |      1  1.0|
      Follicular Cell, Hypertrophy         | 1     1     1  2  1     1                                                |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +                                                |   9        |
      Atrophy                              | 4  4  4  4  4  4  4  4                                                   |      8  4.0|
      Inflammation, Suppurative            |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Inflammation, Suppurative            | 2  3  1     1  1     1                                                   |      6  1.5|
      Metaplasia, Squamous                 | 4  3  3     2  2  3  4                                                   |      7  3.0|
      Endometrium, Hyperplasia, Cystic     |             2  1                                                         |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Pigmentation                         | 2  1  2  2  1  2  2  2  2                                                |      9  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                          TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                     Date: 03/03/04    
Route: GAVAGE                                                                                                     Time: 14:09:15    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3|                                               |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |      A     |
    300 NG /                               | 0| 0| 0| 1| 7| 7| 7| 7| 8|                                               |      L     |
    3000 UG                                | 6| 8| 9| 0| 6| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              | 3  2  2  2  2  2  3  1  2                                                |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +                                                |   9        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |   9        |
      Infiltration Cellular, Histiocyte    | 1  1  1              1                                                   |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------