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TDMS Study 96022-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 05/06/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:07:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                    FINAL #1 RATS CTRL. VS. HIGH                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25018 Dosing Accident                                                                        
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    0 NG /  0 UG                                                                  
                                       INCLUDE 006    4000 NG/500 UG                                                                
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 05/06/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:07:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF      TEF EVALUATION (PCB MIXTURE;PCB 126/P                                                                       
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Angiectasis                                                                                  
                                       Atrophy                                                                                      
                                       Degeneration Cystic                                                                          
                                       Hyperplasia                                                                                  
                                       Hypertrophy                                                                                  
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Blood Vessel: Aorta, Adventitia        Inflammation                                                                                 
Bone Marrow                            Atrophy                                                                                      
                                       Hyperplasia                                                                                  
Brain                                  Hemorrhage                                                                                   
Clitoral Gland                         Inflammation                                                                                 
Clitoral Gland: Duct                   Cyst                                                                                         
Esophagus: Muscularis                  Inflammation                                                                                 
Harderian Gland                        Inflammation                                                                                 
Heart                                  Cardiomyopathy                                                                               
Heart: Coronary Artery                 Inflammation Chronic                                                                         
Heart: Epicardium                      Inflammation                                                                                 
Heart: Myocardium                      Hemorrhage                                                                                   
                                       Necrosis                                                                                     
Intestine Large, Cecum                 Edema                                                                                        
                                       Inflammation                                                                                 
Intestine Large, Colon                 Parasite Metazoan                                                                            
Intestine Large, Rectum                Parasite Metazoan                                                                            
Kidney                                 Calculus Micro Observation Only                                                              
                                       Infarct                                                                                      
                                       Mineralization                                                                               
                                       Nephropathy                                                                                  
Kidney: Pelvis                         Inflammation                                                                                 
Kidney: Renal Tubule                   Hyperplasia                                                                                  
Kidney: Transitional Epithelium        Hyperplasia                                                                                  
Liver                                  Angiectasis                                                                                  
                                       Basophilic Focus                                                                             
                                       Cholangiofibrosis                                                                            
                                       Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
                                       Fatty Change Diffuse                                                                         
                                       Fatty Change Focal                                                                           
                                       Hematopoietic Cell Proliferation                                                             
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
                                       Mixed Cell Focus                                                                             
                                       Necrosis                                                                                     
                                       Pigmentation                                                                                 
                                       Toxic Hepatopathy                                                                            
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 05/06/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:07:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
Liver: Bile Duct                       Cyst                                                                                         
                                       Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Liver: Centrilobular                   Degeneration                                                                                 
                                       Fibrosis                                                                                     
Liver: Hepatocyte                      Glandular Structures                                                                         
                                       Hypertrophy                                                                                  
                                       Multinucleated                                                                               
Liver: Oval Cell                       Hyperplasia                                                                                  
Liver: Portal                          Fibrosis                                                                                     
Lung                                   Hemorrhage                                                                                   
                                       Infiltration Cellular Histiocyte                                                             
                                       Inflammation                                                                                 
                                       Metaplasia                                                                                   
Lung: Alveolar Epithelium              Hyperplasia                                                                                  
                                       Metaplasia Bronchiolar                                                                       
Lung: Serosa                           Fibrosis                                                                                     
Lymph Node, Mandibular                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node, Mesenteric                 Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Mediastinal                Ectasia                                                                                      
                                       Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
Lymph Node: Renal                      Hyperplasia                                                                                  
Mammary Gland                          Hyperplasia                                                                                  
                                       Inflammation Granulomatous                                                                   
Mesentery: Artery                      Inflammation Chronic                                                                         
Mesentery: Fat                         Necrosis                                                                                     
Nose                                   Inflammation                                                                                 
Nose: Respiratory Epithelium           Hyperplasia                                                                                  
Oral Mucosa: Gingival                  Hyperplasia                                                                                  
Ovary                                  Atrophy                                                                                      
                                       Cyst                                                                                         
Pancreas                               Edema                                                                                        
                                       Hemorrhage                                                                                   
                                       Inflammation Chronic                                                                         
Pancreas: Acinus                       Atrophy                                                                                      
                                       Hyperplasia                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Pancreas: Artery                       Inflammation Chronic                                                                         
Pituitary Gland                        Angiectasis                                                                                  
                                       Vacuolization Cytoplasmic                                                                    
Pituitary Gland: Pars Distalis         Hyperplasia                                                                                  
Spleen                                 Hematopoietic Cell Proliferation                                                             
                                       Pigmentation                                                                                 
Spleen: Lymphoid Follicle              Atrophy                                                                                      
Spleen: Red Pulp                       Atrophy                                                                                      
Stomach, Forestomach                   Hyperplasia                                                                                  
                                       Inflammation                                                                                 
                                       Mineralization                                                                               
                                       Ulcer                                                                                        
Stomach, Glandular                     Erosion                                                                                      
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                        TEF EVALUATION (PCB MIXTURE;PCB 126/PCB 118)                     DATE: 05/06/04       
EXPERIMENT: 96022 TEST: 02                                                                                     TIME: 10:07:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75411                              ROUTE: GAVAGE                                                  NTP C#: C96022       
PATHOLOGIST: MISSING                                                                                           CAS: TEFPCBMIX       
                                       Hemorrhage                                                                                   
                                       Mineralization                                                                               
Thymus                                 Atrophy                                                                                      
Thyroid Gland: C-Cell                  Hyperplasia                                                                                  
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Urinary Bladder                        Inflammation                                                                                 
Urinary Bladder: Transitional Epithelium                                                                                            
                                       Hyperplasia                                                                                  
Uterus                                 Inflammation                                                                                 
                                       Inflammation Chronic                                                                         
                                       Metaplasia                                                                                   
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P        
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              42/53 (79%)                                       6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              42/48.03                                          6/14.36                      | 
|POLY-3 PERCENT (g) |                              87.4%                                             41.8%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              482                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.008 **                   | 
|POLY 3             |                                                                                P=0.007N**                   | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.881N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.007N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         40/65 (62%)                  | 
|POLY-3 RATE (b)    |                              2/42.18                                           40/41.82                     | 
|POLY-3 PERCENT (g) |                              4.7%                                              95.7%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              649                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/53 (23%)                                       2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              12/43.80                                          2/10.85                      | 
|POLY-3 PERCENT (g) |                              27.4%                                             18.4%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              482                                               336                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.152                      | 
|POLY 3             |                                                                                P=0.716N                     | 
|POLY 1.5           |                                                                                P=0.166N                     | 
|POLY 6             |                                                                                P=0.973                      | 
|LOGISTIC REGRESSION|                                                                                P=0.396N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              13/53 (25%)                                       5/65 (8%)                    | 
|POLY-3 RATE (b)    |                              13/44.54                                          5/13.17                      | 
|POLY-3 PERCENT (g) |                              29.2%                                             38.0%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              362                                               321                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.626                      | 
|POLY 1.5           |                                                                                P=0.438N                     | 
|POLY 6             |                                                                                P=0.580                      | 
|LOGISTIC REGRESSION|                                                                                P=0.532N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.011N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/53 (85%)                                       27/65 (42%)                  | 
|POLY-3 RATE (b)    |                              45/48.89                                          27/31.15                     | 
|POLY-3 PERCENT (g) |                              92.1%                                             86.7%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.377N                     | 
|POLY 1.5           |                                                                                P=0.008N**                   | 
|POLY 6             |                                                                                P=0.757                      | 
|LOGISTIC REGRESSION|                                                                                P=0.527                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              1/42.24                                           4/13.13                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              30.5%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              628                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.077                      | 
|POLY 3             |                                                                                P=0.132                      | 
|POLY 1.5           |                                                                                P=0.105                      | 
|POLY 6             |                                                                                P=0.352                      | 
|LOGISTIC REGRESSION|                                                                                P=0.627N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.252                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              14/53 (26%)                                       12/65 (18%)                  | 
|POLY-3 RATE (b)    |                              14/44.09                                          12/18.81                     | 
|POLY-3 PERCENT (g) |                              31.8%                                             63.8%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.059                      | 
|POLY 1.5           |                                                                                P=0.257                      | 
|POLY 6             |                                                                                P=0.020 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.266                      | 
|COCH-ARM / FISHERS |                                                                                P=0.208N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              13/53 (25%)                                       0/64 (0%)                    | 
|POLY-3 RATE (b)    |                              13/42.77                                          0/9.22                       | 
|POLY-3 PERCENT (g) |                              30.4%                                             0.0%                         | 
|TERMINAL (d)       |                              10/27 (37%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              628                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.999N                     | 
|POLY 3             |                                                                                P=0.470N                     | 
|POLY 1.5           |                                                                                P=0.028N*                    | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.612N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Blood Vessel: Aorta, Adventitia                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.08                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.123                      | 
|POLY 3             |                                                                                P=0.582                      | 
|POLY 1.5           |                                                                                P=0.271                      | 
|POLY 6             |                                                                                P=0.995                      | 
|LOGISTIC REGRESSION|                                                                                P=0.609                      | 
|COCH-ARM / FISHERS |                                                                                P=0.306                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         12/66 (18%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           12/20.74                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              57.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.387                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              37/53 (70%)                                       49/66 (74%)                  | 
|POLY-3 RATE (b)    |                              37/51.61                                          49/50.11                     | 
|POLY-3 PERCENT (g) |                              71.7%                                             97.8%                        | 
|TERMINAL (d)       |                              14/27 (52%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.002 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.298                      | 
|COCH-ARM / FISHERS |                                                                                P=0.369                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         14/66 (21%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           14/22.64                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              61.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.402                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       31/66 (47%)                  | 
|POLY-3 RATE (b)    |                              49/52.29                                          31/35.89                     | 
|POLY-3 PERCENT (g) |                              93.7%                                             86.4%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.199N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.626                      | 
|LOGISTIC REGRESSION|                                                                                P<0.001N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland: Duct                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       61/66 (92%)                  | 
|POLY-3 RATE (b)    |                              40/50.23                                          61/61.31                     | 
|POLY-3 PERCENT (g) |                              79.6%                                             99.5%                        | 
|TERMINAL (d)       |                              20/27 (74%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.017 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.010 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Esophagus: Muscularis                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              3/42.85                                           2/10.61                      | 
|POLY-3 PERCENT (g) |                              7.0%                                              18.9%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.066                      | 
|POLY 3             |                                                                                P=0.751                      | 
|POLY 1.5           |                                                                                P=0.682                      | 
|POLY 6             |                                                                                P=0.989                      | 
|LOGISTIC REGRESSION|                                                                                P=0.783                      | 
|COCH-ARM / FISHERS |                                                                                P=0.397N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              24/53 (45%)                                       9/66 (14%)                   | 
|POLY-3 RATE (b)    |                              24/45.26                                          9/16.65                      | 
|POLY-3 PERCENT (g) |                              53.0%                                             54.1%                        | 
|TERMINAL (d)       |                              15/27 (56%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.701                      | 
|POLY 1.5           |                                                                                P=0.137N                     | 
|POLY 6             |                                                                                P=0.416                      | 
|LOGISTIC REGRESSION|                                                                                P=0.329N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              20/53 (38%)                                       19/65 (29%)                  | 
|POLY-3 RATE (b)    |                              20/45.03                                          19/24.56                     | 
|POLY-3 PERCENT (g) |                              44.4%                                             77.4%                        | 
|TERMINAL (d)       |                              11/27 (41%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               237                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.014 *                    | 
|POLY 1.5           |                                                                                P=0.140                      | 
|POLY 6             |                                                                                P=0.002 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.117                      | 
|COCH-ARM / FISHERS |                                                                                P=0.217N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Coronary Artery                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              1/41.89                                           9/16.16                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              55.7%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.007 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.019 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Epicardium                                                                                                                | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              1/42.60                                           6/13.78                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              43.5%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              482                                               362                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.017 *                    | 
|POLY 1.5           |                                                                                P=0.018 *                    | 
|POLY 6             |                                                                                P=0.036 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.087                      | 
|COCH-ARM / FISHERS |                                                                                P=0.096                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           3/12.08                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              24.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.084                      | 
|POLY 3             |                                                                                P=0.221                      | 
|POLY 1.5           |                                                                                P=0.104                      | 
|POLY 6             |                                                                                P=0.737                      | 
|LOGISTIC REGRESSION|                                                                                P=0.655                      | 
|COCH-ARM / FISHERS |                                                                                P=0.164                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Myocardium                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.19                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.229                      | 
|POLY 3             |                                                                                P=0.569                      | 
|POLY 1.5           |                                                                                P=0.268                      | 
|POLY 6             |                                                                                P=0.995                      | 
|LOGISTIC REGRESSION|                                                                                P=0.890                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.19                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               254                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.229                      | 
|POLY 3             |                                                                                P=0.570                      | 
|POLY 1.5           |                                                                                P=0.269                      | 
|POLY 6             |                                                                                P=0.994                      | 
|LOGISTIC REGRESSION|                                                                                P=0.865                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.20                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.243                      | 
|POLY 3             |                                                                                P=0.569                      | 
|POLY 1.5           |                                                                                P=0.268                      | 
|POLY 6             |                                                                                P=0.994                      | 
|LOGISTIC REGRESSION|                                                                                P=0.887                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              2/41.97                                           2/11.13                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              18.0%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              707                                               236                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.175                      | 
|POLY 3             |                                                                                P=0.691                      | 
|POLY 1.5           |                                                                                P=0.582                      | 
|POLY 6             |                                                                                P=0.978                      | 
|LOGISTIC REGRESSION|                                                                                P=0.807N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.610N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Rectum                                                                                                          | 
|     Parasite Metazoan                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/52 (6%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              3/41.84                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              7.2%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              567                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.987N                     | 
|POLY 3             |                                                                                P=0.935N                     | 
|POLY 1.5           |                                                                                P=0.469N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.613N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.083N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/53 (11%)                                        0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              6/42.65                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              14.1%                                             0.0%                         | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              586                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.985N                     | 
|POLY 3             |                                                                                P=0.778N                     | 
|POLY 1.5           |                                                                                P=0.214N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.561N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.007N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           1/10.26                      | 
|POLY-3 PERCENT (g) |                              4.8%                                              9.8%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.534                      | 
|POLY 3             |                                                                                P=0.926                      | 
|POLY 1.5           |                                                                                P=0.831                      | 
|POLY 6             |                                                                                P=1.000                      | 
|LOGISTIC REGRESSION|                                                                                P=0.732N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.423N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              46/53 (87%)                                       37/65 (57%)                  | 
|POLY-3 RATE (b)    |                              46/51.13                                          37/39.76                     | 
|POLY-3 PERCENT (g) |                              90.0%                                             93.1%                        | 
|TERMINAL (d)       |                              23/27 (85%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.467                      | 
|POLY 1.5           |                                                                                P=0.230N                     | 
|POLY 6             |                                                                                P=0.153                      | 
|LOGISTIC REGRESSION|                                                                                P=0.551N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              41/53 (77%)                                       43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              41/49.70                                          43/44.50                     | 
|POLY-3 PERCENT (g) |                              82.5%                                             96.6%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.014 *                    | 
|POLY 1.5           |                                                                                P=0.146                      | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.133                      | 
|COCH-ARM / FISHERS |                                                                                P=0.128N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis                                                                                                                   | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.25                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              9.5%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000                      | 
|POLY 3             |                                                                                P=0.883N                     | 
|POLY 1.5           |                                                                                P=0.364N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.876N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.038N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/42.10                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.980N                     | 
|POLY 1.5           |                                                                                P=0.642N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.966N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.200N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Transitional Epithelium                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.25                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              9.5%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.883N                     | 
|POLY 1.5           |                                                                                P=0.364N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.876N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.038N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/10.57                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.033 *                    | 
|POLY 3             |                                                                                P=0.613                      | 
|POLY 1.5           |                                                                                P=0.274                      | 
|POLY 6             |                                                                                P=0.999                      | 
|LOGISTIC REGRESSION|                                                                                P=0.300                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              27/53 (51%)                                       0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              27/45.63                                          0/9.28                       | 
|POLY-3 PERCENT (g) |                              59.2%                                             0.0%                         | 
|TERMINAL (d)       |                              16/27 (59%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.681N                     | 
|POLY 3             |                                                                                P=0.140N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.029N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         29/65 (45%)                  | 
|POLY-3 RATE (b)    |                              1/41.89                                           29/31.95                     | 
|POLY-3 PERCENT (g) |                              2.4%                                              90.8%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              5/42.17                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              11.9%                                             0.0%                         | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              651                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.826N                     | 
|POLY 1.5           |                                                                                P=0.277N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.931N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.016N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/53 (19%)                                       10/65 (15%)                  | 
|POLY-3 RATE (b)    |                              10/43.62                                          10/18.34                     | 
|POLY-3 PERCENT (g) |                              22.9%                                             54.5%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.060                      | 
|POLY 1.5           |                                                                                P=0.206                      | 
|POLY 6             |                                                                                P=0.024 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.333N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.398N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Diffuse                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         56/65 (86%)                  | 
|POLY-3 RATE (b)    |                              3/42.21                                           56/57.00                     | 
|POLY-3 PERCENT (g) |                              7.1%                                              98.3%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              639                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Fatty Change Focal                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              10/53 (19%)                                       6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              10/43.19                                          6/13.82                      | 
|POLY-3 PERCENT (g) |                              23.2%                                             43.4%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              586                                               329                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.356                      | 
|POLY 1.5           |                                                                                P=0.590                      | 
|POLY 6             |                                                                                P=0.309                      | 
|LOGISTIC REGRESSION|                                                                                P=0.228                      | 
|COCH-ARM / FISHERS |                                                                                P=0.106N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              27/53 (51%)                                       11/65 (17%)                  | 
|POLY-3 RATE (b)    |                              27/48.61                                          11/17.99                     | 
|POLY-3 PERCENT (g) |                              55.6%                                             61.1%                        | 
|TERMINAL (d)       |                              11/27 (41%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.587                      | 
|POLY 1.5           |                                                                                P=0.173N                     | 
|POLY 6             |                                                                                P=0.278                      | 
|LOGISTIC REGRESSION|                                                                                P=0.014N*                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.979N                     | 
|POLY 1.5           |                                                                                P=0.641N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.200N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         61/65 (94%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           61/61.04                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              99.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       64/65 (98%)                  | 
|POLY-3 RATE (b)    |                              49/51.05                                          64/64.15                     | 
|POLY-3 PERCENT (g) |                              96.0%                                             99.8%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.149                      | 
|POLY 1.5           |                                                                                P=0.121                      | 
|POLY 6             |                                                                                P=0.231                      | 
|LOGISTIC REGRESSION|                                                                                P=0.054                      | 
|COCH-ARM / FISHERS |                                                                                P=0.125                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/11.99                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              33.4%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               338                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.083                      | 
|POLY 1.5           |                                                                                P=0.040 *                    | 
|POLY 6             |                                                                                P=0.350                      | 
|LOGISTIC REGRESSION|                                                                                P=0.014 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.088                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              38/53 (72%)                                       3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              38/45.68                                          3/11.13                      | 
|POLY-3 PERCENT (g) |                              83.2%                                             27.0%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               429                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.005 **                   | 
|POLY 3             |                                                                                P=0.019N*                    | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.994N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.587N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         27/65 (42%)                  | 
|POLY-3 RATE (b)    |                              3/42.94                                           27/31.21                     | 
|POLY-3 PERCENT (g) |                              7.0%                                              86.5%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         60/65 (92%)                  | 
|POLY-3 RATE (b)    |                              5/43.23                                           60/60.56                     | 
|POLY-3 PERCENT (g) |                              11.6%                                             99.1%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Toxic Hepatopathy                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         64/65 (98%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           64/64.00                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              100.0%                       | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         14/65 (22%)                  | 
|POLY-3 RATE (b)    |                              4/42.10                                           14/19.17                     | 
|POLY-3 PERCENT (g) |                              9.5%                                              73.0%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              672                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.030 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              6/53 (11%)                                        4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              6/42.12                                           4/12.37                      | 
|POLY-3 PERCENT (g) |                              14.2%                                             32.3%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              665                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.457                      | 
|POLY 1.5           |                                                                                P=0.575                      | 
|POLY 6             |                                                                                P=0.582                      | 
|LOGISTIC REGRESSION|                                                                                P=0.362                      | 
|COCH-ARM / FISHERS |                                                                                P=0.251N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         60/65 (92%)                  | 
|POLY-3 RATE (b)    |                              5/42.04                                           60/60.13                     | 
|POLY-3 PERCENT (g) |                              11.9%                                             99.8%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              687                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         8/65 (12%)                   | 
|POLY-3 RATE (b)    |                              2/42.71                                           8/16.92                      | 
|POLY-3 PERCENT (g) |                              4.7%                                              47.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.004 **                   | 
|POLY 1.5           |                                                                                P=0.009 **                   | 
|POLY 6             |                                                                                P=0.003 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.493N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.091                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         57/65 (88%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           57/59.02                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              96.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Glandular Structures                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         25/65 (38%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           25/31.26                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              80.0%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.007 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         65/65 (100%)                 | 
|POLY-3 RATE (b)    |                              0/41.89                                           65/65.00                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              100.0%                       | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Multinucleated                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         48/65 (74%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           48/50.32                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              95.4%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Oval Cell                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         62/65 (95%)                  | 
|POLY-3 RATE (b)    |                              4/41.89                                           62/62.03                     | 
|POLY-3 PERCENT (g) |                              9.6%                                              100.0%                       | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Portal                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         58/65 (89%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           58/58.27                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              99.5%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/66 (6%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/12.86                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              31.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.016 *                    | 
|POLY 3             |                                                                                P=0.074                      | 
|POLY 1.5           |                                                                                P=0.040 *                    | 
|POLY 6             |                                                                                P=0.293                      | 
|LOGISTIC REGRESSION|                                                                                P=0.397                      | 
|COCH-ARM / FISHERS |                                                                                P=0.091                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       33/66 (50%)                  | 
|POLY-3 RATE (b)    |                              40/49.03                                          33/37.16                     | 
|POLY-3 PERCENT (g) |                              81.6%                                             88.8%                        | 
|TERMINAL (d)       |                              21/27 (78%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              362                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.268                      | 
|POLY 1.5           |                                                                                P=0.469N                     | 
|POLY 6             |                                                                                P=0.078                      | 
|LOGISTIC REGRESSION|                                                                                P=0.519                      | 
|COCH-ARM / FISHERS |                                                                                P=0.004N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              5/53 (9%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              5/43.02                                           2/11.03                      | 
|POLY-3 PERCENT (g) |                              11.6%                                             18.1%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.162                      | 
|POLY 3             |                                                                                P=0.798                      | 
|POLY 1.5           |                                                                                P=0.653N                     | 
|POLY 6             |                                                                                P=0.972                      | 
|LOGISTIC REGRESSION|                                                                                P=0.471N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.140N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         7/66 (11%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           7/14.88                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              47.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.002 **                   | 
|POLY 6             |                                                                                P=0.003 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.019 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.014 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              18/53 (34%)                                       4/66 (6%)                    | 
|POLY-3 RATE (b)    |                              18/43.48                                          4/12.41                      | 
|POLY-3 PERCENT (g) |                              41.4%                                             32.2%                        | 
|TERMINAL (d)       |                              13/27 (48%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               303                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.002 **                   | 
|POLY 3             |                                                                                P=0.637N                     | 
|POLY 1.5           |                                                                                P=0.089N                     | 
|POLY 6             |                                                                                P=0.841                      | 
|LOGISTIC REGRESSION|                                                                                P=0.586                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Metaplasia Bronchiolar                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              1/41.89                                           8/16.09                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              49.7%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.003 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.066                      | 
|COCH-ARM / FISHERS |                                                                                P=0.035 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Serosa                                                                                                                     | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              3/42.18                                           8/15.93                      | 
|POLY-3 PERCENT (g) |                              7.1%                                              50.2%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              649                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.009 **                   | 
|POLY 1.5           |                                                                                P=0.021 *                    | 
|POLY 6             |                                                                                P=0.007 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.084                      | 
|COCH-ARM / FISHERS |                                                                                P=0.188                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         1/66 (2%)                    | 
|POLY-3 RATE (b)    |                              3/42.29                                           1/10.25                      | 
|POLY-3 PERCENT (g) |                              7.1%                                              9.8%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              639                                               313                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.427                      | 
|POLY 3             |                                                                                P=0.927                      | 
|POLY 1.5           |                                                                                P=0.703N                     | 
|POLY 6             |                                                                                P=1.000                      | 
|LOGISTIC REGRESSION|                                                                                P=0.723N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.232N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         7/66 (11%)                   | 
|POLY-3 RATE (b)    |                              0/41.89                                           7/15.76                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              44.4%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.002 **                   | 
|POLY 6             |                                                                                P=0.002 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.363                      | 
|COCH-ARM / FISHERS |                                                                                P=0.014 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              45/53 (85%)                                       20/66 (30%)                  | 
|POLY-3 RATE (b)    |                              45/51.67                                          20/26.79                     | 
|POLY-3 PERCENT (g) |                              87.1%                                             74.7%                        | 
|TERMINAL (d)       |                              24/27 (89%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.179N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.705                      | 
|LOGISTIC REGRESSION|                                                                                P<0.001N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              1/41.89                                           2/11.14                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              18.0%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           245                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.183                      | 
|POLY 3             |                                                                                P=0.640                      | 
|POLY 1.5           |                                                                                P=0.448                      | 
|POLY 6             |                                                                                P=0.986                      | 
|LOGISTIC REGRESSION|                                                                                P=0.813                      | 
|COCH-ARM / FISHERS |                                                                                P=0.577                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         14/65 (22%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           14/22.13                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              63.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.136                      | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              3/42.49                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              7.1%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              639                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.939N                     | 
|POLY 1.5           |                                                                                P=0.484N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.661N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.088N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/28 (25%)                                        27/45 (60%)                  | 
|POLY-3 RATE (b)    |                              7/23.39                                           27/29.76                     | 
|POLY-3 PERCENT (g) |                              29.9%                                             90.7%                        | 
|TERMINAL (d)       |                              2/12 (17%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.140                      | 
|COCH-ARM / FISHERS |                                                                                P=0.003 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/28 (7%)                                         25/45 (56%)                  | 
|POLY-3 RATE (b)    |                              2/21.96                                           25/28.50                     | 
|POLY-3 PERCENT (g) |                              9.1%                                              87.7%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              586                                               174                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.042 *                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           2/7.29                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              27.4%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               611                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.474                      | 
|POLY 1.5           |                                                                                P=0.249                      | 
|POLY 6             |                                                                                P=0.948                      | 
|LOGISTIC REGRESSION|                                                                                P=0.004 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.377                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           2/8.07                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              24.8%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.036 *                    | 
|POLY 3             |                                                                                P=0.416                      | 
|POLY 1.5           |                                                                                P=0.244                      | 
|POLY 6             |                                                                                P=0.854                      | 
|LOGISTIC REGRESSION|                                                                                P=0.394                      | 
|COCH-ARM / FISHERS |                                                                                P=0.377                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         4/45 (9%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           4/10.12                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              39.5%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.020 *                    | 
|POLY 3             |                                                                                P=0.042 *                    | 
|POLY 1.5           |                                                                                P=0.041 *                    | 
|POLY 6             |                                                                                P=0.075                      | 
|LOGISTIC REGRESSION|                                                                                P=0.412                      | 
|COCH-ARM / FISHERS |                                                                                P=0.137                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         3/45 (7%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           3/8.86                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              33.9%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               342                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.004 **                   | 
|POLY 3             |                                                                                P=0.146                      | 
|POLY 1.5           |                                                                                P=0.101                      | 
|POLY 6             |                                                                                P=0.335                      | 
|LOGISTIC REGRESSION|                                                                                P=0.158                      | 
|COCH-ARM / FISHERS |                                                                                P=0.228                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Renal                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/28 (0%)                                         2/45 (4%)                    | 
|POLY-3 RATE (b)    |                              0/21.26                                           2/7.54                       | 
|POLY-3 PERCENT (g) |                              0.0%                                              26.5%                        | 
|TERMINAL (d)       |                              0/12 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               545                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.454                      | 
|POLY 1.5           |                                                                                P=0.247                      | 
|POLY 6             |                                                                                P=0.911                      | 
|LOGISTIC REGRESSION|                                                                                P=0.028 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.377                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              26/53 (49%)                                       0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              26/46.93                                          0/9.33                       | 
|POLY-3 PERCENT (g) |                              55.4%                                             0.0%                         | 
|TERMINAL (d)       |                              14/27 (52%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.399N                     | 
|POLY 3             |                                                                                P=0.187N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P<0.001N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              3/53 (6%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              3/42.81                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              7.0%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              555                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.958N                     | 
|POLY 3             |                                                                                P=0.940N                     | 
|POLY 1.5           |                                                                                P=0.482N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.377N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.086N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Artery                                                                                                                | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         3/63 (5%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           3/11.22                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              26.7%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.005 **                   | 
|POLY 3             |                                                                                P=0.245                      | 
|POLY 1.5           |                                                                                P=0.105                      | 
|POLY 6             |                                                                                P=0.801                      | 
|LOGISTIC REGRESSION|                                                                                P=0.113                      | 
|COCH-ARM / FISHERS |                                                                                P=0.157                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         3/63 (5%)                    | 
|POLY-3 RATE (b)    |                              1/41.89                                           3/11.49                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              26.1%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.009 **                   | 
|POLY 3             |                                                                                P=0.332                      | 
|POLY 1.5           |                                                                                P=0.223                      | 
|POLY 6             |                                                                                P=0.762                      | 
|LOGISTIC REGRESSION|                                                                                P=0.313                      | 
|COCH-ARM / FISHERS |                                                                                P=0.377                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              17/53 (32%)                                       11/66 (17%)                  | 
|POLY-3 RATE (b)    |                              17/45.19                                          11/17.92                     | 
|POLY-3 PERCENT (g) |                              37.6%                                             61.4%                        | 
|TERMINAL (d)       |                              10/27 (37%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               226                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.181                      | 
|POLY 1.5           |                                                                                P=0.525                      | 
|POLY 6             |                                                                                P=0.077                      | 
|LOGISTIC REGRESSION|                                                                                P=0.487                      | 
|COCH-ARM / FISHERS |                                                                                P=0.040N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/53 (15%)                                        9/66 (14%)                   | 
|POLY-3 RATE (b)    |                              8/43.10                                           9/16.16                      | 
|POLY-3 PERCENT (g) |                              18.6%                                             55.7%                        | 
|TERMINAL (d)       |                              5/27 (19%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               289                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.046 *                    | 
|POLY 1.5           |                                                                                P=0.140                      | 
|POLY 6             |                                                                                P=0.026 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.050                      | 
|COCH-ARM / FISHERS |                                                                                P=0.512N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Oral Mucosa: Gingival                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/53 (21%)                                       18/66 (27%)                  | 
|POLY-3 RATE (b)    |                              11/43.10                                          18/22.91                     | 
|POLY-3 PERCENT (g) |                              25.5%                                             78.6%                        | 
|TERMINAL (d)       |                              7/27 (26%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              582                                               222                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.003 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P=0.273                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              46/53 (87%)                                       9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              46/50.65                                          9/17.30                      | 
|POLY-3 PERCENT (g) |                              90.8%                                             52.0%                        | 
|TERMINAL (d)       |                              25/27 (93%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.014 *                    | 
|POLY 3             |                                                                                P=0.003N**                   | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.755N                     | 
|LOGISTIC REGRESSION|                                                                                P<0.001N**                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              19/53 (36%)                                       13/65 (20%)                  | 
|POLY-3 RATE (b)    |                              19/44.54                                          13/19.19                     | 
|POLY-3 PERCENT (g) |                              42.7%                                             67.7%                        | 
|TERMINAL (d)       |                              13/27 (48%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.128                      | 
|POLY 1.5           |                                                                                P=0.472                      | 
|POLY 6             |                                                                                P=0.042 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.199                      | 
|COCH-ARM / FISHERS |                                                                                P=0.043N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         19/65 (29%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           19/26.29                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              72.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.029 *                    | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.15                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               294                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.183                      | 
|POLY 3             |                                                                                P=0.572                      | 
|POLY 1.5           |                                                                                P=0.269                      | 
|POLY 6             |                                                                                P=0.995                      | 
|LOGISTIC REGRESSION|                                                                                P=0.782                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         6/65 (9%)                    | 
|POLY-3 RATE (b)    |                              1/42.38                                           6/14.33                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              41.9%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              582                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.016 *                    | 
|POLY 1.5           |                                                                                P=0.018 *                    | 
|POLY 6             |                                                                                P=0.032 *                    | 
|LOGISTIC REGRESSION|                                                                                P=0.278                      | 
|COCH-ARM / FISHERS |                                                                                P=0.096                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              1/53 (2%)                                         8/65 (12%)                   | 
|POLY-3 RATE (b)    |                              1/41.89                                           8/16.01                      | 
|POLY-3 PERCENT (g) |                              2.4%                                              50.0%                        | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           222                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P=0.003 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.099                      | 
|COCH-ARM / FISHERS |                                                                                P=0.033 *                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/42.36                                           0/9.28                       | 
|POLY-3 PERCENT (g) |                              4.7%                                              0.0%                         | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              639                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.981N                     | 
|POLY 1.5           |                                                                                P=0.644N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.773N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.200N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              0/41.89                                           43/44.52                     | 
|POLY-3 PERCENT (g) |                              0.0%                                              96.6%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               203                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P<0.001 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Artery                                                                                                                 | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         4/65 (6%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           4/12.01                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              33.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               329                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.083                      | 
|POLY 1.5           |                                                                                P=0.040 *                    | 
|POLY 6             |                                                                                P=0.348                      | 
|LOGISTIC REGRESSION|                                                                                P=0.016 *                    | 
|COCH-ARM / FISHERS |                                                                                P=0.088                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              23/53 (43%)                                       0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              23/44.91                                          0/9.27                       | 
|POLY-3 PERCENT (g) |                              51.2%                                             0.0%                         | 
|TERMINAL (d)       |                              15/27 (56%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.778N                     | 
|POLY 3             |                                                                                P=0.215N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.999N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.067N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/65 (0%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           0/9.27                       | 
|POLY-3 PERCENT (g) |                              4.8%                                              0.0%                         | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000N                     | 
|POLY 3             |                                                                                P=0.979N                     | 
|POLY 1.5           |                                                                                P=0.641N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                P=0.200N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              11/53 (21%)                                       1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              11/43.08                                          1/10.02                      | 
|POLY-3 PERCENT (g) |                              25.5%                                             10.0%                        | 
|TERMINAL (d)       |                              6/27 (22%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               456                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.289                      | 
|POLY 3             |                                                                                P=0.657N                     | 
|POLY 1.5           |                                                                                P=0.116N                     | 
|POLY 6             |                                                                                P=0.998                      | 
|LOGISTIC REGRESSION|                                                                                P=0.625N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              49/53 (92%)                                       43/65 (66%)                  | 
|POLY-3 RATE (b)    |                              49/51.71                                          43/45.37                     | 
|POLY-3 PERCENT (g) |                              94.8%                                             94.8%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.747                      | 
|POLY 1.5           |                                                                                P=0.148N                     | 
|POLY 6             |                                                                                P=0.430                      | 
|LOGISTIC REGRESSION|                                                                                P=0.337N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              52/53 (98%)                                       59/65 (91%)                  | 
|POLY-3 RATE (b)    |                              52/53.00                                          59/59.63                     | 
|POLY-3 PERCENT (g) |                              98.1%                                             99.0%                        | 
|TERMINAL (d)       |                              26/27 (96%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.671                      | 
|POLY 1.5           |                                                                                P=0.597N                     | 
|POLY 6             |                                                                                P=0.493                      | 
|LOGISTIC REGRESSION|                                                                                P=0.397N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.096N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              4/43.27                                           9/17.28                      | 
|POLY-3 PERCENT (g) |                              9.3%                                              52.1%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              564                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.007 **                   | 
|POLY 1.5           |                                                                                P=0.021 *                    | 
|POLY 6             |                                                                                P=0.004 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.682                      | 
|COCH-ARM / FISHERS |                                                                                P=0.216                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Red Pulp                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.23                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              17.8%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               209                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.269                      | 
|POLY 3             |                                                                                P=0.567                      | 
|POLY 1.5           |                                                                                P=0.268                      | 
|POLY 6             |                                                                                P=0.994                      | 
|LOGISTIC REGRESSION|                                                                                P=0.945                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         9/65 (14%)                   | 
|POLY-3 RATE (b)    |                              4/41.89                                           9/16.84                      | 
|POLY-3 PERCENT (g) |                              9.6%                                              53.4%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           217                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P=0.006 **                   | 
|POLY 1.5           |                                                                                P=0.021 *                    | 
|POLY 6             |                                                                                P=0.004 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.198                      | 
|COCH-ARM / FISHERS |                                                                                P=0.216                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           1/9.95                       | 
|POLY-3 PERCENT (g) |                              4.8%                                              10.1%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           482                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.186                      | 
|POLY 3             |                                                                                P=0.932                      | 
|POLY 1.5           |                                                                                P=0.832                      | 
|POLY 6             |                                                                                P=1.000                      | 
|LOGISTIC REGRESSION|                                                                                P=0.554                      | 
|COCH-ARM / FISHERS |                                                                                P=0.423N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/11.13                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.0%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.205                      | 
|POLY 3             |                                                                                P=0.573                      | 
|POLY 1.5           |                                                                                P=0.270                      | 
|POLY 6             |                                                                                P=0.995                      | 
|LOGISTIC REGRESSION|                                                                                P=0.817                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         1/65 (2%)                    | 
|POLY-3 RATE (b)    |                              2/41.89                                           1/9.95                       | 
|POLY-3 PERCENT (g) |                              4.8%                                              10.1%                        | 
|TERMINAL (d)       |                              2/27 (7%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           482                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.186                      | 
|POLY 3             |                                                                                P=0.932                      | 
|POLY 1.5           |                                                                                P=0.832                      | 
|POLY 6             |                                                                                P=1.000                      | 
|LOGISTIC REGRESSION|                                                                                P=0.554                      | 
|COCH-ARM / FISHERS |                                                                                P=0.423N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         2/65 (3%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           2/10.92                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              18.3%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               237                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.094                      | 
|POLY 3             |                                                                                P=0.588                      | 
|POLY 1.5           |                                                                                P=0.272                      | 
|POLY 6             |                                                                                P=0.996                      | 
|LOGISTIC REGRESSION|                                                                                P=0.580                      | 
|COCH-ARM / FISHERS |                                                                                P=0.301                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              0/53 (0%)                                         3/65 (5%)                    | 
|POLY-3 RATE (b)    |                              0/41.89                                           3/12.13                      | 
|POLY-3 PERCENT (g) |                              0.0%                                              24.7%                        | 
|TERMINAL (d)       |                              0/27 (0%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              ---                                               233                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.129                      | 
|POLY 3             |                                                                                P=0.220                      | 
|POLY 1.5           |                                                                                P=0.104                      | 
|POLY 6             |                                                                                P=0.736                      | 
|LOGISTIC REGRESSION|                                                                                P=0.814                      | 
|COCH-ARM / FISHERS |                                                                                P=0.164                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              12/53 (23%)                                       5/65 (8%)                    | 
|POLY-3 RATE (b)    |                              12/45.97                                          5/13.58                      | 
|POLY-3 PERCENT (g) |                              26.1%                                             36.8%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              313                                               267                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.053                      | 
|POLY 3             |                                                                                P=0.582                      | 
|POLY 1.5           |                                                                                P=0.508N                     | 
|POLY 6             |                                                                                P=0.555                      | 
|LOGISTIC REGRESSION|                                                                                P=0.033N*                    | 
|COCH-ARM / FISHERS |                                                                                P=0.021N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              40/53 (75%)                                       57/59 (97%)                  | 
|POLY-3 RATE (b)    |                              40/48.92                                          57/57.15                     | 
|POLY-3 PERCENT (g) |                              81.8%                                             99.7%                        | 
|TERMINAL (d)       |                              23/27 (85%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               91                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.002 **                   | 
|COCH-ARM / FISHERS |                                                                                P<0.001 **                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              7/53 (13%)                                        3/66 (5%)                    | 
|POLY-3 RATE (b)    |                              7/43.53                                           3/11.81                      | 
|POLY-3 PERCENT (g) |                              16.1%                                             25.4%                        | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              555                                               321                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.034 *                    | 
|POLY 3             |                                                                                P=0.689                      | 
|POLY 1.5           |                                                                                P=0.619N                     | 
|POLY 6             |                                                                                P=0.843                      | 
|LOGISTIC REGRESSION|                                                                                P=0.512N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.087N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              22/53 (42%)                                       37/66 (56%)                  | 
|POLY-3 RATE (b)    |                              22/47.33                                          37/40.35                     | 
|POLY-3 PERCENT (g) |                              46.5%                                             91.7%                        | 
|TERMINAL (d)       |                              9/27 (33%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               51                           | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P<0.001 **                   | 
|POLY 3             |                                                                                P<0.001 **                   | 
|POLY 1.5           |                                                                                P<0.001 **                   | 
|POLY 6             |                                                                                P<0.001 **                   | 
|LOGISTIC REGRESSION|                                                                                P=0.137                      | 
|COCH-ARM / FISHERS |                                                                                P=0.082                      | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              29/29 (100%)                                      25/25 (100%)                 | 
|POLY-3 RATE (b)    |                              29/29.00                                          25/25.00                     | 
|POLY-3 PERCENT (g) |                              100.0%                                            100.0%                       | 
|TERMINAL (d)       |                              16/16 (100%)                                      0/0 (0%)                     | 
|FIRST INCIDENCE    |                              534                                               245                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                (e)                          | 
|POLY 3             |                                                                                (e)                          | 
|POLY 1.5           |                                                                                (e)                          | 
|POLY 6             |                                                                                (e)                          | 
|LOGISTIC REGRESSION|                                                                                (e)                          | 
|COCH-ARM / FISHERS |                                                                                (e)                          | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              8/53 (15%)                                        0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              8/43.36                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              18.5%                                             0.0%                         | 
|TERMINAL (d)       |                              3/27 (11%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              362                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.642N                     | 
|POLY 3             |                                                                                P=0.688N                     | 
|POLY 1.5           |                                                                                P=0.126N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.136N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              4/42.40                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              9.4%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              672                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=1.000                      | 
|POLY 3             |                                                                                P=0.884N                     | 
|POLY 1.5           |                                                                                P=0.361N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.765N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.037N*                    | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              4/53 (8%)                                         2/66 (3%)                    | 
|POLY-3 RATE (b)    |                              4/41.89                                           2/10.47                      | 
|POLY-3 PERCENT (g) |                              9.6%                                              19.1%                        | 
|TERMINAL (d)       |                              4/27 (15%)                                        0/0 (0%)                     | 
|FIRST INCIDENCE    |                              726 (T)                                           415                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.006 **                   | 
|POLY 3             |                                                                                P=0.777                      | 
|POLY 1.5           |                                                                                P=0.758N                     | 
|POLY 6             |                                                                                P=0.983                      | 
|LOGISTIC REGRESSION|                                                                                P=0.119                      | 
|COCH-ARM / FISHERS |                                                                                P=0.242N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              2/53 (4%)                                         0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              2/42.77                                           0/9.33                       | 
|POLY-3 PERCENT (g) |                              4.7%                                              0.0%                         | 
|TERMINAL (d)       |                              1/27 (4%)                                         0/0 (0%)                     | 
|FIRST INCIDENCE    |                              362                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.642N                     | 
|POLY 3             |                                                                                P=0.982N                     | 
|POLY 1.5           |                                                                                P=0.645N                     | 
|POLY 6             |                                                                                P=1.000N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.191N                     | 
|COCH-ARM / FISHERS |                                                                                P=0.196N                     | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/06/04                           EXPERIMENT: 96022 TEST: 02                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(SPRAGUE-DAWLEY)  -       TEF EVALUATION (PCB MIXTURE;PCB 126/P         
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              23/53 (43%)                                       0/66 (0%)                    | 
|POLY-3 RATE (b)    |                              23/44.48                                          0/9.33                       | 
|POLY-3 PERCENT (g) |                              51.7%                                             0.0%                         | 
|TERMINAL (d)       |                              16/27 (59%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              555                                               ---                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.848N                     | 
|POLY 3             |                                                                                P=0.203N                     | 
|POLY 1.5           |                                                                                P<0.001N**                   | 
|POLY 6             |                                                                                P=0.999N                     | 
|LOGISTIC REGRESSION|                                                                                P=0.120N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
|                   |                                                                                                             | 
|                   |                                                      Females                                                | 
|Dose               |                              0 NG /                                            4000 NG/                     | 
|                   |                              0 UG                                              500 UG                       | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                                                                             | 
|-----------        |                                                                                                             | 
|OVERALL (a)        |                              32/53 (60%)                                       8/66 (12%)                   | 
|POLY-3 RATE (b)    |                              32/46.96                                          8/15.68                      | 
|POLY-3 PERCENT (g) |                              68.2%                                             51.0%                        | 
|TERMINAL (d)       |                              21/27 (78%)                                       0/0 (0%)                     | 
|FIRST INCIDENCE    |                              275                                               243                          | 
|-------------------|                                                                                                             | 
|STATISTICAL TESTS  |                                                                                                             | 
|-------------------|                                                                                                             | 
|LIFE TABLE         |                                                                                P=0.003 **                   | 
|POLY 3             |                                                                                P=0.367N                     | 
|POLY 1.5           |                                                                                P=0.004N**                   | 
|POLY 6             |                                                                                P=0.791                      | 
|LOGISTIC REGRESSION|                                                                                P=0.077N                     | 
|COCH-ARM / FISHERS |                                                                                P<0.001N**                   | 
|ORDER RESTRICTED   |                                                                                (e)                          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
                                                                                                                                   
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).