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TDMS Study 88138-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:28:34       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1 RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Columbus                                        BENZOPHENONE                                     DATE: 07/21/03       
EXPERIMENT: 88138 TEST: 03                                                                                     TIME: 15:28:34       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-55388                              ROUTE: DOSED FEED                                              NTP C#: 88138B       
PATHOLOGIST: MISSING                                                                                           CAS: 119-61-9        
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 0 PPM                                    |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      425   495   506   549   553   582   584   632   634   638                 |                                                 
 |      645   662   666   676   676   680   680   681   690   693                 |                                                 
 |      694   704   704   709   709   715   725   726                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 312 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      344   373   484   499   526   535   543   590   609   610                 |                                                 
 |      624   641   653   657   673   698   698   702   704   709                 |                                                 
 |      710   715   715                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 625 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      486   494   499   543   543   590   613   624   669   687                 |                                                 
 |      690   691   705   708   708   708   708   711   726                       |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 1250 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 48     CENSORED DEATHS 0    TERMINAL 2         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      487   488   507   529   529   529   537   537   540   549                 |                                                 
 |      555   569   569   582   593   593   601   604   604   613                 |                                                 
 |      617   621   621   624   624   632   634   634   634   635                 |                                                 
 |      637   639   641   641   653   662   669   675   680   681                 |                                                 
 |      691   694   708   708   708   708   708   726                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE RATS                                                                                      
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0 PPM      |   100.0 100.0 100.0 100.0  98.0  98.0  94.0  86.0  76.0  44.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |312 PPM    |   100.0 100.0 100.0  98.0  96.0  94.0  86.0  84.0  72.0  54.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |625 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  90.0  88.0  84.0  62.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1250 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0  82.0  62.0  28.0   4.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0 PPM        312 PPM      625 PPM      1250 PPM |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       44.0%        54.0%        62.0%         4.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P<0.001      P=0.517N     P=0.099N     P<0.001  |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       644.0        609.2        637.0        617.1    |                                                 
 |NATURAL DEATHS (C)      |       (14.6)       (22.5)       (19.5)       ( 9.2)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       681.4        673.9        694.0        621.6    |                                                 
 |(STANDARD ERROR)        |       (10.1)       (13.3)       ( 9.7)       ( 9.3)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 0 PPM                                    |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      288   358   430   528   543   613   624   634   637   673                 |                                                 
 |      697   708   708   724   724   724   724   725                             |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 312 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      609   613   613   633   653   690   693   697   697   710                 |                                                 
 |      725   725                                                                 |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 625 PPM                                  |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      528   609   633   644   662   679   690   699   701   704                 |                                                 
 |      709   709   728                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 1250 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      480   528   581   624   638   653   659   679   679   681                 |                                                 
 |      686   687   701   709   714   725                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                                   BENZOPHENONE                                                                                     
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE RATS                                                                                     
                       FIRST TERMINAL SACRIFICE AT 729 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |0 PPM      |   100.0 100.0 100.0  96.0  96.0  94.0  90.0  90.0  82.0  64.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |312 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  90.0  76.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |625 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  90.0  74.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |1250 PPM   |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  94.0  86.0  68.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
 ==================================================================================                                                 
 |                           SURVIVAL SUMMARY STATISTICS                          |                                                 
 |                                                                                |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                                  DOSE                          |                                                 
 |                                                                                |                                                 
 |                                0 PPM        312 PPM      625 PPM      1250 PPM |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |SURVIVAL AT END OF STUDY|       64.0%        76.0%        74.0%        68.0%    |                                                 
 |(KAPLAN-MEIER)          |                                                       |                                                 
 |                        |                                                       |                                                 
 |SIGNIFICANCE (B)        |       P=0.985N     P=0.246N     P=0.354N     P=0.809N |                                                 
 |(LIFE TABLE)            |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN DAY OF             |       614.6        671.5        668.8        651.5    |                                                 
 |NATURAL DEATHS (C)      |       (31.7)       (12.9)       (15.2)       (17.1)   |                                                 
 |(STANDARD ERROR)        |                                                       |                                                 
 |                        |                                                       |                                                 
 |MEAN LIFE SPAN (D)      |       687.8        715.2        713.4        704.2    |                                                 
 |(STANDARD ERROR)        |       (13.7)       ( 4.6)       ( 5.4)       ( 7.4)   |                                                 
 |                        |                                                       |                                                 
 ==================================================================================                                                 
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                                            BENZOPHENONE                                                            
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 PPM            = 1                                                        
                                                        312 PPM          = 2                                                        
                                                        625 PPM          = 3                                                        
                                                        1250 PPM         = 4                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
  100 + 1                                                      2           1         3                                              
      |                                                        2   2       1         31                                             
      |                                                            2                 2121   4 31                                    
      |                                                                                2    2                                       
   90 +                                                                                     2231    1 3                             
      |                                                                                     422       3  3                          
      |                                                                                      42     1 2 23 31     3                 
      |                                                                                       44        22  11    3  3              
   80 +                                                                                        44        2 2 11                     
      |                                                                                         4 4        2 21  1                  
      |                                                                                           4 4        2 2 111 3 33           
      |                                                                                             4 4        2   2                
P  70 +                                                                                                            11 2             
E     |                                                                                               44                            
R     |                                                                                                44           11223 3         
C     |                                                                                                 44             22 3 3       
E  60 +                                                                                                  44          11             
N     |                                                                                                               1122          
T     |                                                                                                   44           112  2       
      |                                                                                                                             
S  50 +                                                                                                    44           11          
U     |                                                                                                                  11         
R     |                                                                                                                   1 1       
V     |                                                                                                                             
I  40 +                                                                                                                             
V     |                                                                                                     44                      
A     |                                                                                                                             
L     |                                                                                                      4 4                    
   30 +                                                                                                        4 4                  
      |                                                                                                          44                 
      |                                                                                                           444               
      |                                                                                                                             
   20 +                                                                                                             44              
      |                                                                                                              44             
      |                                                                                                               4 4           
      |                                                                                                                             
   10 +                                                                                                                             
      |                                                                                                                             
      |                                                                                                                 4 4 4       
      |                                                                                                                             
    0 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 22 obs hidden.                                                                                                                
                                                                                                                                   
                                                            BENZOPHENONE                                                            
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        0 PPM            = 1                                                        
                                                        312 PPM          = 2                                                        
                                                        625 PPM          = 3                                                        
                                                        1250 PPM         = 4                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
      |                                                                                                                             
      |                                                                                                                             
  100 + 1                                             1                             4       3           2                           
      |                                                                                                                             
      |                                               1          1                  4       3           22                          
      |                                                          1          1               4      4    3   3                       
   95 +                                                                                                                             
      |                                                                     1               1      4     2 423                      
      |                                                                                     1 1            423 2 3                  
      |                                                                                                                             
P  90 +                                                                                       1          1   4 2 3 3 2              
E     |                                                                                                                             
R     |                                                                                                  1 1   4 4 3 3              
C     |                                                                                                    11    4 4 22             
E  85 +                                                                                                                             
N     |                                                                                                               33            
T     |                                                                                                     1      14 2 2           
      |                                                                                                                             
S  80 +                                                                                                            1  132 2         
U     |                                                                                                                             
R     |                                                                                                             441 1           
V     |                                                                                                              4 43 2 2       
I  75 +                                                                                                                             
V     |                                                                                                                41 1 3       
A     |                                                                                                                             
L     |                                                                                                                             
   70 +                                                                                                                 4 4         
      |                                                                                                                             
      |                                                                                                                   4 4       
      |                                                                                                                             
   65 +                                                                                                                             
      |                                                                                                                   1 1       
      |                                                                                                                             
      |                                                                                                                             
   60 +                                                                                                                             
      |                                                                                                                             
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110 
                                                                                                                                    
                                                                   WEEK                                                             
                                                                                                                                    
NOTE: 15 obs hidden.