National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19252

TDMS Study 96017-05 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                           DATE: 04/14/04  
EXPERIMENT: 96017 TEST: 05                                                                                        TIME: 09:02:49    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96017      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)          DATE: 04/14/04    
EXPERIMENT: 96017 TEST: 05                                                                                        TIME:  9:35:15    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96017      
CONT: N01-ES-85420                                                                                                CAS: 631-64-1     
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    15.8   107.8      16.4    109.5    1.04      7.5     16.7    109.7    1.06     76.1     17.1    108.4    1.08    157.8       
  2    18.0   139.6      17.9    143.4    0.99      6.2     17.9    144.6    0.99     61.9     18.8    142.2    1.04    132.2       
  3    18.6   173.7      18.2    173.3    0.98      5.2     18.2    179.2    0.98     50.8     18.7    177.7    1.01    105.5       
  4    18.4   202.7      18.1    204.5    0.98      4.4     18.2    206.3    0.99     44.1     18.2    206.3    0.99     88.4       
  5    19.2   227.3      18.9    227.3    0.98      4.2     18.3    229.4    0.95     39.8     18.3    229.7    0.95     79.6       
  6    18.6   254.4      18.3    253.0    0.98      3.6     18.2    254.5    0.98     35.8     18.2    255.1    0.98     71.4       
  7    18.7   270.5      18.3    268.4    0.98      3.4     17.8    267.6    0.95     33.2     17.9    271.5    0.96     65.9       
  8    18.3   286.2      17.9    282.7    0.98      3.2     17.0    283.0    0.93     30.0     17.4    284.9    0.95     61.1       
  9    18.1   302.8      18.8    296.4    1.04      3.2     17.8    296.2    0.98     30.1     17.0    298.6    0.94     57.1       
 10    18.2   319.1      17.7    313.9    0.97      2.8     17.2    310.7    0.95     27.7     16.8    312.7    0.92     53.8       
 11    17.3   325.3      17.3    318.6    1.00      2.7     16.5    314.0    0.95     26.3     16.4    315.7    0.95     51.9       
 12    17.0   336.9      17.2    328.7    1.01      2.6     16.2    323.1    0.95     25.0     15.7    324.5    0.92     48.3       
 13    16.8   349.7      17.4    338.1    1.04      2.6     16.3    329.7    0.97     24.7     16.0    330.8    0.95     48.3       
 17    17.6   373.9      17.6    368.2    1.00      2.4     16.4    359.7    0.93     22.8     16.7    356.9    0.95     46.7       
 21    15.8   397.5      16.1    391.9    1.02      2.1     15.4    381.6    0.97     20.2     15.3    376.9    0.97     40.6       
 25    16.7   417.8      17.3    412.5    1.04      2.1     17.0    401.3    1.02     21.2     16.0    397.9    0.96     40.2       
 29    16.3   433.7      16.5    429.5    1.01      1.9     16.0    415.9    0.98     19.3     15.6    413.0    0.96     37.7       
 33    15.9   452.4      15.6    445.4    0.98      1.8     14.8    432.2    0.93     17.1     15.0    426.8    0.94     35.2       
 37    15.6   466.8      15.3    457.6    0.98      1.7     15.2    442.0    0.97     17.1     14.4    438.2    0.92     32.9       
 41    16.4   473.1      16.2    466.9    0.99      1.7     15.9    452.2    0.97     17.6     15.4    445.1    0.94     34.6       
 45    15.9   483.6      15.8    474.8    0.99      1.7     15.6    462.1    0.98     16.9     14.8    452.0    0.93     32.6       
 49    16.4   493.6      16.7    483.5    1.02      1.7     15.7    468.1    0.96     16.8     15.2    457.4    0.93     33.1       
 53    15.3   503.4      15.4    491.4    1.01      1.6     15.3    475.1    1.00     16.1     14.6    461.9    0.95     31.5       
 57    18.7   509.1      18.9    497.5    1.01      1.9     18.0    483.1    0.96     18.7     16.9    467.3    0.90     36.3       
 61    16.7   515.9      17.0    501.4    1.02      1.7     16.0    484.5    0.96     16.5     14.5    466.9    0.87     31.1       
 65    15.4   519.4      15.3    501.3    0.99      1.5     14.9    485.1    0.97     15.4     13.9    462.3    0.90     30.1       
 69    15.7   522.1      15.2    506.9    0.97      1.5     14.8    488.6    0.94     15.2     13.9    467.2    0.89     29.8       
 73    16.3   522.9      15.5    503.9    0.95      1.5     15.2    490.9    0.93     15.5     14.0    468.7    0.86     29.9       
 77    16.1   521.7      16.5    508.4    1.02      1.6     16.6    486.1    1.03     17.0     14.0    461.7    0.87     30.3       
 81    16.1   521.5      16.8    508.7    1.04      1.6     15.2    486.9    0.94     15.6     14.0    457.0    0.87     30.7       
 85    17.1   511.8      17.7    506.4    1.04      1.7     16.8    473.6    0.98     17.7     15.0    448.8    0.88     33.3       
 89    18.3   516.3      18.7    502.5    1.02      1.9     18.0    479.2    0.98     18.8     16.0    441.1    0.87     36.2       
 93    17.5   520.5      17.1    491.8    0.98      1.7     15.9    477.4    0.91     16.7     14.3    450.3    0.82     31.8       
 97    16.7   515.3      16.8    496.4    1.01      1.7     16.3    463.1    0.98     17.5     15.0    445.0    0.90     33.8       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                        
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101    18.1   509.3      18.7    503.6     1.03     1.9     17.1    456.7     0.94    18.8     14.9    435.4     0.82    34.3       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   17.9   253.5      17.9    250.6     1.00     4.0     17.4    249.8     0.97    38.9     17.4    250.6     0.97    78.6       
SD(D)   0.9               0.7              0.02     1.5      0.8              0.03    15.7      1.0              0.05    34.3       
CV(E)   5.3               3.9              2.5     38.2      4.5              3.3     40.4      5.9              4.8     43.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   16.3   443.6      16.3    436.7     1.00     1.9     15.8    423.9     0.97    18.8     15.4    418.2     0.94    37.1       
SD(D)   0.6               0.7              0.02     0.2      0.7              0.03     2.2      0.7              0.02     4.7       
CV(E)   3.6               4.5              1.9     13.1      4.2              2.8     11.7      4.4              1.6     12.7       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   16.8   516.1      16.9    501.6     1.01     1.7     16.2    479.2     0.96    16.9     14.7    456.4     0.88    32.2       
SD(D)   1.1               1.3              0.03     0.1      1.1              0.03     1.3      0.9              0.04     2.3       
CV(E)   6.6               7.8              2.8      7.9      6.8              3.3      7.9      6.2              4.0      7.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                      
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1    12.4    91.5      12.3     92.3     0.99     6.7     12.8     92.2     1.03    69.3     13.3     94.9     1.07   140.2       
  2    13.3   112.0      13.1    114.2     0.98     5.7     13.4    115.9     1.01    57.9     13.7    118.7     1.03   115.8       
  3    13.1   126.1      12.6    126.4     0.96     5.0     12.8    129.5     0.98    49.4     12.6    132.0     0.96    95.5       
  4    13.3   140.3      12.1    140.3     0.91     4.3     13.0    145.0     0.98    44.8     12.1    147.4     0.91    82.2       
  5    13.4   151.5      13.2    150.0     0.99     4.4     13.1    154.2     0.98    42.6     12.8    155.5     0.96    82.1       
  6    13.8   159.6      12.7    159.1     0.92     4.0     13.0    163.1     0.94    39.8     12.5    163.2     0.91    76.6       
  7    13.1   167.2      12.5    166.1     0.95     3.8     12.6    170.4     0.96    36.9     12.5    170.9     0.95    73.0       
  8    13.3   170.7      12.5    169.5     0.94     3.7     12.1    173.6     0.91    34.7     11.8    173.4     0.89    68.2       
  9    12.3   175.7      12.8    174.3     1.04     3.7     12.3    177.9     1.00    34.5     12.0    178.6     0.98    67.1       
 10    12.4   181.2      11.7    180.5     0.94     3.2     11.4    184.1     0.92    31.0     11.7    182.8     0.94    64.0       
 11    11.9   184.7      11.3    182.8     0.95     3.1     11.1    184.1     0.93    30.1     10.8    184.1     0.91    58.6       
 12    11.9   190.1      11.1    186.9     0.93     3.0     10.9    188.7     0.92    28.9     10.7    188.5     0.90    56.6       
 13    11.3   192.3      11.3    188.8     1.00     3.0     10.7    189.9     0.95    28.2     10.0    188.8     0.88    53.2       
 17    12.1   206.8      11.9    203.7     0.98     2.9     11.3    205.1     0.93    27.6     10.9    207.1     0.90    52.4       
 21    10.8   218.8      10.5    218.9     0.97     2.4      9.7    218.5     0.90    22.2      9.3    215.2     0.86    43.2       
 25    11.6   220.1      11.6    217.7     1.00     2.7     10.8    219.7     0.93    24.5      9.9    218.0     0.85    45.5       
 29    11.4   228.8      11.2    224.8     0.98     2.5      9.9    228.2     0.87    21.8      9.9    224.9     0.87    43.8       
 33    10.9   238.7      10.8    235.4     0.99     2.3     10.1    235.7     0.93    21.4      9.5    236.4     0.87    40.1       
 37    11.0   243.8      10.6    242.1     0.96     2.2      9.5    241.5     0.86    19.7      8.8    240.8     0.80    36.7       
 41    11.1   250.9      10.9    251.0     0.98     2.2     10.4    249.8     0.94    20.9      9.8    243.4     0.88    40.3       
 45    10.9   257.5      10.8    256.8     0.99     2.1     10.4    252.4     0.95    20.6      9.8    249.3     0.90    39.4       
 49    11.6   265.4      11.4    265.4     0.98     2.1     10.7    259.4     0.92    20.6     10.1    253.8     0.87    39.9       
 53    10.9   275.7      10.9    276.0     1.00     2.0     10.1    271.8     0.93    18.6      9.6    259.8     0.88    37.1       
 57    13.9   287.3      13.9    286.4     1.00     2.4     13.0    277.7     0.94    23.4     12.0    268.3     0.86    44.9       
 61    11.8   294.2      11.9    294.6     1.01     2.0     11.6    288.4     0.98    20.1     10.2    272.4     0.86    37.5       
 65    11.4   306.2      10.6    305.3     0.93     1.7     10.2    291.8     0.89    17.5     10.0    280.7     0.88    35.7       
 69    11.6   311.5      11.3    313.3     0.97     1.8     11.2    298.3     0.97    18.9     10.4    288.2     0.90    36.1       
 73    12.2   317.2      11.4    319.0     0.93     1.8     11.2    306.8     0.92    18.2     10.1    292.4     0.83    34.5       
 77    13.0   326.0      12.1    324.2     0.93     1.9     11.7    315.5     0.90    18.5     11.5    293.7     0.88    39.1       
 81    13.1   331.6      12.9    328.8     0.98     2.0     12.3    316.5     0.94    19.4     10.8    295.7     0.82    36.4       
 85    14.0   333.9      14.1    333.0     1.01     2.1     13.4    315.5     0.96    21.2     11.8    301.1     0.84    39.3       
 89    15.5   342.2      15.4    338.3     0.99     2.3     14.0    323.5     0.90    21.7     12.8    304.0     0.83    42.2       
 93    13.8   345.9      13.7    346.6     0.99     2.0     12.6    325.6     0.91    19.3     10.7    306.7     0.78    34.9       
 97    14.2   350.3      12.7    347.0     0.89     1.8     13.6    331.7     0.96    20.5     10.8    302.5     0.76    35.8       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                      
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101    15.8   350.5      14.1    339.5     0.89     2.1     14.3    335.7     0.91    21.4     11.7    306.4     0.74    38.1       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN   12.7   157.1      12.2    156.3     0.96     4.1     12.2    159.1     0.96    40.6     12.0    159.9     0.95    79.5       
SD(D)   0.8               0.7              0.04     1.1      0.9              0.04    12.2      1.1              0.06    25.0       
CV(E)   5.9               5.8              3.8     27.1      7.5              3.9     30.1      8.8              6.0     31.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN   11.3   236.7      11.1    235.1     0.98     2.4     10.3    234.5     0.92    22.1      9.8    232.1     0.87    42.4       
SD(D)   0.4               0.5              0.01     0.3      0.6              0.03     2.5      0.6              0.03     4.6       
CV(E)   3.9               4.2              1.1     11.5      5.4              3.4     11.1      5.7              3.4     10.9       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN   13.2   321.0      12.7    319.4     0.96     2.0     12.3    307.6     0.93    19.9     11.0    290.1     0.84    37.8       
SD(D)   1.5               1.5              0.04     0.2      1.4              0.03     1.7      0.9              0.05     3.0       
CV(E)  11.7              11.5              4.4     10.1     11.3              3.0      8.4      8.6              6.0      7.9       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               DIAGNOSTIC TRAILER REPORT                                                                                            
               WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE                                                                   
               CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                      
=========================================================================================================                           
           0 MG/L                  50 MG/L                  500 MG/L               1000    MG/L                                     
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B              107.8  50                109.5  50                109.7  50                108.4  50                               
  1  15.8  7367  107.8  50    16.4  7347  109.5  50    16.7  7339  109.7  50    17.1  7271  108.4  50                               
  2  18.0  7860  139.6  50    17.9  7868  143.4  50    17.9  7862  144.6  50    18.8  7944  142.2  50                               
  3  18.6  8318  173.7  50    18.2  8385  173.3  50    18.2  8372  179.2  50    18.7  8387  177.7  50                               
  4  18.4  7365  202.7  50    18.1  7799  204.5  50    18.2  7371  206.3  49    18.2  8477  206.3  50                               
  5  19.2  7650  227.3  50    18.9  7765  227.3  50    18.3  7805  229.4  49    18.3  7755  229.7  50                               
  6  18.6  8320  254.4  50    18.3  7732  253.0  50    18.2  7702  254.5  49    18.2  8407  255.1  50                               
  7  18.7  7899  270.5  50    18.3  8273  268.4  50    17.8  7850  267.6  49    17.9  8376  271.5  50                               
  8  18.3  7698  286.2  50    17.9  8263  282.7  50    17.0  7680  283.0  49    17.4  7830  284.9  50                               
  9  18.1  8457  302.8  50    18.8  7905  296.4  50    17.8  7761  296.2  49    17.0  8025  298.6  50                               
 10  18.2  8436  319.1  50    17.7  7273  313.9  50    17.2  7598  310.7  49    16.8  7723  312.7  50                               
 11  17.3  8073  325.3  50    17.3  7370  318.6  50    16.5  6923  314.0  49    16.4  7046  315.7  50                               
 12  17.0  7817  336.9  50    17.2  7732  328.7  50    16.2  7127  323.1  49    15.7  7909  324.5  50                               
 13  16.8  8144  349.7  50    17.4  8117  338.1  50    16.3  7948  329.7  49    16.0  7887  330.8  50                               
 17  17.6  8240  373.9  50    17.6  8252  368.2  50    16.4  7648  359.7  49    16.7  8004  356.9  50                               
 21  15.8  8146  397.5  50    16.1  8224  391.9  50    15.4  7263  381.6  49    15.3  8095  376.9  50                               
 25  16.7  7601  417.8  50    17.3  7881  412.5  50    17.0  7574  401.3  49    16.0  8039  397.9  50                               
 29  16.3  7502  433.7  50    16.5  8076  429.5  50    16.0  7627  415.9  49    15.6  8071  413.0  50                               
 33  15.9  7873  452.4  49    15.6  8157  445.4  50    14.8  7814  432.2  49    15.0  7461  426.8  50                               
 37  15.6  7897  466.8  49    15.3  8058  457.6  50    15.2  7745  442.0  49    14.4  8023  438.2  50                               
 41  16.4  8152  473.1  49    16.2  8089  466.9  50    15.9  7862  452.2  48    15.4  8220  445.1  50                               
 45  15.9  7952  483.6  49    15.8  8115  474.8  50    15.6  7792  462.1  48    14.8  8047  452.0  50                               
 49  16.4  7749  493.6  49    16.7  7691  483.5  50    15.7  7203  468.1  48    15.2  7194  457.4  50                               
 53  15.3  8036  503.4  49    15.4  7926  491.4  50    15.3  7615  475.1  48    14.6  7978  461.9  49                               
 57  18.7  7393  509.1  49    18.9  8049  497.5  50    18.0  7642  483.1  48    16.9  6937  467.3  48                               
 61  16.7  7836  515.9  49    17.0  8003  501.4  50    16.0  7554  484.5  47    14.5  7369  466.9  48                               
 65  15.4  7767  519.4  47    15.3  7641  501.3  48    14.9  7424  485.1  45    13.9  7497  462.3  47                               
 69  15.7  7618  522.1  47    15.2  7756  506.9  47    14.8  7422  488.6  45    13.9  7251  467.2  47                               
 73  16.3  7634  522.9  47    15.5  7618  503.9  47    15.2  7246  490.9  45    14.0  7454  468.7  47                               
 77  16.1  7181  521.7  45    16.5  7099  508.4  45    16.6  6593  486.1  44    14.0  7109  461.7  44                               
 81  16.1  7348  521.5  45    16.8  7244  508.7  44    15.2  6518  486.9  42    14.0  6886  457.0  43                               
 85  17.1  7185  511.8  45    17.7  6667  506.4  44    16.8  5912  473.6  40    15.0  6215  448.8  41                               
 89  18.3  6888  516.3  43    18.7  5466  502.5  41    18.0  5134  479.2  34    16.0  6178  441.1  40                               
 93  17.5  6249  520.5  40    17.1  5298  491.8  38    15.9  5532  477.4  34    14.3  5697  450.3  35                               
 97  16.7  5773  515.3  39    16.8  5439  496.4  35    16.3  5337  463.1  34    15.0  4787  445.0  32                               
101  18.1  5691  509.3  36    18.7  4379  503.6  30    17.1  4763  456.7  31    14.9  4676  435.4  30                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          253.5                    250.6                    249.8                    250.6                                   
14 TO 52         443.6                    436.7                    423.9                    418.2                                   
 > 52            516.1                    501.6                    479.2                    456.4                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
               DIAGNOSTIC TRAILER REPORT                                                                                            
               WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE                                                                 
               CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                      
=========================================================================================================                           
           0 MG/L                  50 MG/L                  500 MG/L               1000    MG/L                                     
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               91.5  50                 92.3  50                 92.2  50                 94.9  50                               
  1  12.4  7375   91.5  50    12.3  7349   92.3  50    12.8  7353   92.2  50    13.3  7280   94.9  50                               
  2  13.3  8287  112.0  50    13.1  7568  114.2  50    13.4  7937  115.9  50    13.7  7829  118.7  50                               
  3  13.1  8388  126.1  50    12.6  8379  126.4  50    12.8  7911  129.5  50    12.6  8390  132.0  50                               
  4  13.3  7664  140.3  50    12.1  7948  140.3  50    13.0  8126  145.0  50    12.1  8369  147.4  50                               
  5  13.4  7498  151.5  50    13.2  8310  150.0  50    13.1  8315  154.2  50    12.8  8210  155.5  50                               
  6  13.8  8096  159.6  50    12.7  7309  159.1  50    13.0  8097  163.1  50    12.5  7568  163.2  50                               
  7  13.1  7724  167.2  50    12.5  8047  166.1  50    12.6  8430  170.4  50    12.5  8322  170.9  50                               
  8  13.3  8270  170.7  50    12.5  7571  169.5  50    12.1  7790  173.6  50    11.8  8230  173.4  50                               
  9  12.3  8525  175.7  50    12.8  7912  174.3  50    12.3  8159  177.9  50    12.0  8474  178.6  50                               
 10  12.4  7867  181.2  50    11.7  7955  180.5  50    11.4  7384  184.1  50    11.7  6937  182.8  50                               
 11  11.9  7890  184.7  50    11.3  7532  182.8  50    11.1  5636  184.1  50    10.8  6970  184.1  50                               
 12  11.9  7901  190.1  50    11.1  7792  186.9  50    10.9  8394  188.7  50    10.7  7929  188.5  50                               
 13  11.3  8173  192.3  50    11.3  8039  188.8  50    10.7  7324  189.9  50    10.0  8119  188.8  50                               
 17  12.1  8238  206.8  50    11.9  7761  203.7  50    11.3  7888  205.1  50    10.9  8026  207.1  50                               
 21  10.8  8159  218.8  50    10.5  7890  218.9  50     9.7  6683  218.5  50     9.3  8505  215.2  50                               
 25  11.6  7693  220.1  49    11.6  7392  217.7  50    10.8  7376  219.7  50     9.9  8095  218.0  50                               
 29  11.4  7642  228.8  49    11.2  7925  224.8  50     9.9  8011  228.2  50     9.9  8135  224.9  50                               
 33  10.9  7961  238.7  49    10.8  8156  235.4  50    10.1  8043  235.7  50     9.5  8154  236.4  50                               
 37  11.0  7901  243.8  49    10.6  8058  242.1  50     9.5  8049  241.5  50     8.8  7908  240.8  49                               
 41  11.1  8153  250.9  49    10.9  8307  251.0  50    10.4  7735  249.8  50     9.8  8061  243.4  49                               
 45  10.9  7594  257.5  49    10.8  8110  256.8  50    10.4  8115  252.4  50     9.8  7865  249.3  49                               
 49  11.6  7826  265.4  49    11.4  7398  265.4  50    10.7  8126  259.4  50    10.1  7137  253.8  49                               
 53  10.9  8036  275.7  49    10.9  8140  276.0  50    10.1  8140  271.8  50     9.6  7987  259.8  49                               
 57  13.9  8134  287.3  49    13.9  7869  286.4  49    13.0  8280  277.7  50    12.0  8019  268.3  49                               
 61  11.8  8097  294.2  49    11.9  8097  294.6  49    11.6  8038  288.4  50    10.2  7470  272.4  48                               
 65  11.4  8127  306.2  49    10.6  8122  305.3  49    10.2  7575  291.8  48    10.0  7392  280.7  48                               
 69  11.6  8099  311.5  49    11.3  8092  313.3  49    11.2  7920  298.3  48    10.4  7814  288.2  48                               
 73  12.2  8006  317.2  49    11.4  8059  319.0  49    11.2  7807  306.8  47    10.1  7670  292.4  48                               
 77  13.0  7128  326.0  48    12.1  7218  324.2  46    11.7  7314  315.5  46    11.5  6835  293.7  48                               
 81  13.1  7891  331.6  48    12.9  7109  328.8  46    12.3  7314  316.5  46    10.8  7805  295.7  48                               
 85  14.0  6864  333.9  48    14.1  6714  333.0  46    13.4  7068  315.5  46    11.8  6601  301.1  45                               
 89  15.5  6904  342.2  43    15.4  7370  338.3  46    14.0  7217  323.5  45    12.8  6185  304.0  44                               
 93  13.8  6458  345.9  39    13.7  7614  346.6  46    12.6  6784  325.6  41    10.7  6254  306.7  40                               
 97  14.2  5985  350.3  37    12.7  6458  347.0  45    13.6  6307  331.7  39    10.8  5796  302.5  36                               
101  15.8  5692  350.5  35    14.1  6449  339.5  40    14.3  5957  335.7  37    11.7  5030  306.4  32                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13          157.1                    156.3                    159.1                    159.9                                   
14 TO 52         236.7                    235.1                    234.5                    232.1                                   
 > 52            321.0                    319.4                    307.6                    290.1                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.