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TDMS Study 96017-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                           DATE: 04/14/04  
EXPERIMENT: 96017 TEST: 05                                                                                        TIME: 08:34:38    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96017      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)          DATE: 04/14/04    
EXPERIMENT: 96017 TEST: 05                                                                                        TIME:  8:48:04    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: DOSED WATER                                            NTP:  C96017      
CONT: N01-ES-85420                                                                                                CAS: 631-64-1     
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
             TWO YEAR DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                       
==========================================================================================================                          
WEEK     0 MG/L                 50 MG/L                  500 MG/L                 1000    MG/L                                      
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B       107.8       50       109.5    101.6    50     109.7    101.8    50     108.4    100.6    50                               
  1       107.8       50       109.5    101.6    50     109.7    101.8    50     108.4    100.6    50                               
  2       139.6       50       143.4    102.7    50     144.6    103.6    50     142.2    101.9    50                               
  3       173.7       50       173.3     99.8    50     179.2    103.2    50     177.7    102.3    50                               
  4       202.7       50       204.5    100.9    50     206.3    101.8    49     206.3    101.8    50                               
  5       227.3       50       227.3    100.0    50     229.4    100.9    49     229.7    101.1    50                               
  6       254.4       50       253.0     99.4    50     254.5    100.0    49     255.1    100.3    50                               
  7       270.5       50       268.4     99.2    50     267.6     98.9    49     271.5    100.4    50                               
  8       286.2       50       282.7     98.8    50     283.0     98.9    49     284.9     99.5    50                               
  9       302.8       50       296.4     97.9    50     296.2     97.8    49     298.6     98.6    50                               
 10       319.1       50       313.9     98.4    50     310.7     97.4    49     312.7     98.0    50                               
 11       325.3       50       318.6     97.9    50     314.0     96.5    49     315.7     97.0    50                               
 12       336.9       50       328.7     97.6    50     323.1     95.9    49     324.5     96.3    50                               
 13       349.7       50       338.1     96.7    50     329.7     94.3    49     330.8     94.6    50                               
 17       373.9       50       368.2     98.5    50     359.7     96.2    49     356.9     95.5    50                               
 21       397.5       50       391.9     98.6    50     381.6     96.0    49     376.9     94.8    50                               
 25       417.8       50       412.5     98.7    50     401.3     96.1    49     397.9     95.2    50                               
 29       433.7       50       429.5     99.0    50     415.9     95.9    49     413.0     95.2    50                               
 33       452.4       49       445.4     98.5    50     432.2     95.5    49     426.8     94.3    50                               
 37       466.8       49       457.6     98.0    50     442.0     94.7    49     438.2     93.9    50                               
 41       473.1       49       466.9     98.7    50     452.2     95.6    48     445.1     94.1    50                               
 45       483.6       49       474.8     98.2    50     462.1     95.6    48     452.0     93.5    50                               
 49       493.6       49       483.5     98.0    50     468.1     94.8    48     457.4     92.7    50                               
 53       503.4       49       491.4     97.6    50     475.1     94.4    48     461.9     91.8    49                               
 57       509.1       49       497.5     97.7    50     483.1     94.9    48     467.3     91.8    48                               
 61       515.9       49       501.4     97.2    50     484.5     93.9    47     466.9     90.5    48                               
 65       519.4       47       501.3     96.5    48     485.1     93.4    45     462.3     89.0    47                               
 69       522.1       47       506.9     97.1    47     488.6     93.6    45     467.2     89.5    47                               
 73       522.9       47       503.9     96.4    47     490.9     93.9    45     468.7     89.6    47                               
 77       521.7       45       508.4     97.5    45     486.1     93.2    44     461.7     88.5    44                               
 81       521.5       45       508.7     97.5    44     486.9     93.4    42     457.0     87.6    43                               
 85       511.8       45       506.4     98.9    44     473.6     92.5    40     448.8     87.7    41                               
 89       516.3       43       502.5     97.3    41     479.2     92.8    34     441.1     85.4    40                               
 93       520.5       40       491.8     94.5    38     477.4     91.7    34     450.3     86.5    35                               
 97       515.3       39       496.4     96.3    35     463.1     89.9    34     445.0     86.4    32                               
101       509.3       36       503.6     98.9    30     456.7     89.7    31     435.4     85.5    30                               
TERM. SAC.            34                         24                       30                       28                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
             TWO YEAR DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                       
==========================================================================================================                          
WEEK     0 MG/L                 50 MG/L                  500 MG/L                 1000    MG/L                                      
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        91.5       50        92.3    100.9    50      92.2    100.8    50      94.9    103.7    50                               
  1        91.5       50        92.3    100.9    50      92.2    100.8    50      94.9    103.7    50                               
  2       112.0       50       114.2    102.0    50     115.9    103.5    50     118.7    106.0    50                               
  3       126.1       50       126.4    100.2    50     129.5    102.7    50     132.0    104.7    50                               
  4       140.3       50       140.3    100.0    50     145.0    103.3    50     147.4    105.1    50                               
  5       151.5       50       150.0     99.0    50     154.2    101.8    50     155.5    102.6    50                               
  6       159.6       50       159.1     99.7    50     163.1    102.2    50     163.2    102.3    50                               
  7       167.2       50       166.1     99.3    50     170.4    101.9    50     170.9    102.2    50                               
  8       170.7       50       169.5     99.3    50     173.6    101.7    50     173.4    101.6    50                               
  9       175.7       50       174.3     99.2    50     177.9    101.3    50     178.6    101.7    50                               
 10       181.2       50       180.5     99.6    50     184.1    101.6    50     182.8    100.9    50                               
 11       184.7       50       182.8     99.0    50     184.1     99.7    50     184.1     99.7    50                               
 12       190.1       50       186.9     98.3    50     188.7     99.3    50     188.5     99.2    50                               
 13       192.3       50       188.8     98.2    50     189.9     98.8    50     188.8     98.2    50                               
 17       206.8       50       203.7     98.5    50     205.1     99.2    50     207.1    100.1    50                               
 21       218.8       50       218.9    100.0    50     218.5     99.9    50     215.2     98.4    50                               
 25       220.1       49       217.7     98.9    50     219.7     99.8    50     218.0     99.0    50                               
 29       228.8       49       224.8     98.3    50     228.2     99.7    50     224.9     98.3    50                               
 33       238.7       49       235.4     98.6    50     235.7     98.7    50     236.4     99.0    50                               
 37       243.8       49       242.1     99.3    50     241.5     99.1    50     240.8     98.8    49                               
 41       250.9       49       251.0    100.0    50     249.8     99.6    50     243.4     97.0    49                               
 45       257.5       49       256.8     99.7    50     252.4     98.0    50     249.3     96.8    49                               
 49       265.4       49       265.4    100.0    50     259.4     97.7    50     253.8     95.6    49                               
 53       275.7       49       276.0    100.1    50     271.8     98.6    50     259.8     94.2    49                               
 57       287.3       49       286.4     99.7    49     277.7     96.7    50     268.3     93.4    49                               
 61       294.2       49       294.6    100.1    49     288.4     98.0    50     272.4     92.6    48                               
 65       306.2       49       305.3     99.7    49     291.8     95.3    48     280.7     91.7    48                               
 69       311.5       49       313.3    100.6    49     298.3     95.8    48     288.2     92.5    48                               
 73       317.2       49       319.0    100.6    49     306.8     96.7    47     292.4     92.2    48                               
 77       326.0       48       324.2     99.4    46     315.5     96.8    46     293.7     90.1    48                               
 81       331.6       48       328.8     99.2    46     316.5     95.4    46     295.7     89.2    48                               
 85       333.9       48       333.0     99.7    46     315.5     94.5    46     301.1     90.2    45                               
 89       342.2       43       338.3     98.9    46     323.5     94.5    45     304.0     88.8    44                               
 93       345.9       39       346.6    100.2    46     325.6     94.1    41     306.7     88.7    40                               
 97       350.3       37       347.0     99.1    45     331.7     94.7    39     302.5     86.4    36                               
101       350.5       35       339.5     96.9    40     335.7     95.8    37     306.4     87.4    32                               
TERM. SAC.            35                         39                       35                       32                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.