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https://ntp.niehs.nih.gov/go/19256

TDMS Study 96017-05 Pathology Tables

NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04
Route: DOSED WATER                                                                                                Time: 08:50:24

                                                          FINAL#1 RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  631-64-1

       Lock Date:  11/15/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11            6            6            4                                     
    Moribund Sacrifice                                 4            5            9           14                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                35           38           34           32                                     
    Moribund Sacrifice                                              1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (49)         (49)         (48)                                   
      Edema                                                                                   2 (4%)                                
      Inflammation                                                                            1 (2%)                                
   Intestine Large, Rectum                            (49)         (50)         (50)         (48)                                   
      Inflammation                                                  1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (47)         (45)         (48)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                36 (72%)     41 (82%)     29 (58%)     15 (30%)                               
      Clear Cell Focus                                 8 (16%)      4 (8%)      14 (28%)     18 (36%)                               
      Degeneration, Cystic                                                                    1 (2%)                                
      Eosinophilic Focus                               4 (8%)       4 (8%)       5 (10%)      9 (18%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       3 (6%)       9 (18%)      2 (4%)       5 (10%)                               
      Inflammation, Chronic                            2 (4%)       3 (6%)       3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                      8 (16%)                   1 (2%)       2 (4%)                                
      Mixed Cell Focus                                 1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Necrosis, Focal                                  1 (2%)                                 1 (2%)                                
      Bile Duct, Hyperplasia                          17 (34%)     15 (30%)     15 (30%)     19 (38%)                               
      Centrilobular, Necrosis                          1 (2%)       1 (2%)                    1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic            3 (6%)       2 (4%)                    1 (2%)                                
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
        Cytoplasmic                                    1 (2%)                                                                       
      Serosa, Fibrosis                                 2 (4%)       2 (4%)                                                          
   Mesentery                                          (12)         (15)         (15)         (8)                                    
      Accessory Spleen                                 1 (8%)                    1 (7%)                                             
      Fat, Necrosis                                    9 (75%)     12 (80%)     14 (93%)      6 (75%)                               
   Pancreas                                           (47)         (50)         (49)         (48)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                         19 (40%)     15 (30%)     20 (41%)     23 (48%)                               
      Cyst                                             1 (2%)                    1 (2%)       1 (2%)                                
      Acinus, Hyperplasia, Focal                       1 (2%)       2 (4%)                    2 (4%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Inflammation                                                               1 (2%)       2 (4%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Edema                                            2 (4%)       5 (10%)                   1 (2%)                                
      Erosion                                          1 (2%)       1 (2%)                    1 (2%)                                
      Ulcer                                            3 (6%)       5 (10%)                   1 (2%)                                
      Epithelium, Hyperplasia                                       6 (12%)                   2 (4%)                                
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Edema                                            1 (2%)       2 (4%)                    2 (4%)                                
      Erosion                                                       1 (2%)                    2 (4%)                                
      Ulcer                                                         1 (2%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  37 (74%)     29 (58%)     34 (68%)     35 (70%)                               
      Mineralization                                   1 (2%)                                                                       
      Thrombosis                                       2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Valve, Inflammation, Suppurative                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Accessory Adrenal Cortical Nodule               17 (35%)      8 (16%)      6 (12%)      6 (12%)                               
      Degeneration, Fatty                             14 (29%)     19 (38%)     15 (30%)     14 (29%)                               
      Hyperplasia, Focal                               8 (16%)      6 (12%)      4 (8%)       5 (10%)                               
      Hypertrophy, Focal                              18 (37%)     19 (38%)     21 (42%)     17 (35%)                               
      Necrosis                                         3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Hyperplasia                                      5 (10%)      1 (2%)       2 (4%)       4 (8%)                                
   Islets, Pancreatic                                 (47)         (49)         (49)         (48)                                   
      Metaplasia, Hepatocyte                                        1 (2%)                    3 (6%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Pars Distalis, Angiectasis                      32 (64%)     24 (48%)     23 (46%)     23 (47%)                               
      Pars Distalis, Cyst                             20 (40%)     24 (48%)     20 (40%)     18 (37%)                               
      Pars Distalis, Hyperplasia, Focal               11 (22%)      9 (18%)      8 (16%)      6 (12%)                               
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
      Pars Intermedia, Cyst                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             23 (46%)      6 (12%)     18 (36%)     18 (37%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (49)                                   
      Cyst                                            12 (24%)      4 (8%)       8 (17%)     13 (27%)                               
      Hyperplasia                                      1 (2%)       4 (8%)                    2 (4%)                                
      Inflammation, Chronic                            3 (6%)       2 (4%)       5 (10%)      3 (6%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             8 (16%)      9 (18%)     14 (28%)      8 (16%)                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             3 (6%)                    1 (2%)       3 (6%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hydrometra                                       1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)       2 (4%)                                
      Cervix, Cyst                                                                            1 (2%)                                
      Cervix, Inflammation, Suppurative                                                       1 (2%)                                
      Endometrium, Hyperplasia, Cystic                 2 (4%)       1 (2%)                                                          
   Vagina                                             (1)          (4)          (6)          (20)                                   
      Cyst                                                                       3 (50%)     10 (50%)                               
      Inflammation                                                  1 (25%)      1 (17%)      9 (45%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Depletion Cellular                               1 (2%)                                                                       
      Hyperplasia                                      5 (10%)      8 (16%)      5 (10%)      3 (6%)                                
      Myelofibrosis                                                 1 (2%)                    2 (4%)                                
   Lymph Node                                         (13)         (13)         (9)          (21)                                   
      Deep Cervical, Hemorrhage                        1 (8%)                                                                       
      Deep Cervical, Hyperplasia                                                              1 (5%)                                
      Mediastinal, Congestion                                                    2 (22%)                                            
      Mediastinal, Hyperplasia, Lymphoid               7 (54%)      4 (31%)      3 (33%)      5 (24%)                               
      Pancreatic, Hyperplasia, Lymphoid                2 (15%)      4 (31%)      2 (22%)      3 (14%)                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Pigmentation                         1 (8%)                                                                       
   Lymph Node, Mandibular                             (2)                       (1)          (3)                                    
      Hyperplasia, Lymphoid                            1 (50%)                   1 (100%)                                           
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (48)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                 3 (6%)                                
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
   Spleen                                             (47)         (49)         (50)         (48)                                   
      Fibrosis                                                      3 (6%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 5 (11%)     16 (33%)      7 (14%)      5 (10%)                               
      Necrosis                                                      2 (4%)                                                          
      Pigmentation                                     8 (17%)      9 (18%)      6 (12%)      1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   1 (2%)                    1 (2%)       1 (2%)                                
   Thymus                                             (49)         (49)         (50)         (50)                                   
      Hemorrhage                                       2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                            45 (90%)     48 (96%)     41 (82%)     37 (74%)                               
      Galactocele                                                   1 (2%)       1 (2%)                                             
      Hyperplasia                                      2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
      Hyperplasia, Atypical                            5 (10%)      2 (4%)       4 (8%)       4 (8%)                                
      Hyperplasia, Lobular                                                                    1 (2%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                     2 (4%)                    1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                            1 (2%)       3 (6%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      6 (12%)      9 (18%)      7 (14%)      5 (10%)                               
      Hemorrhage                                       1 (2%)       5 (10%)      2 (4%)       3 (6%)                                
      Necrosis                                                      2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                          (1)          (1)                                                 
      Inflammation, Chronic, Suppurative                                         1 (100%)                                           
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       4 (8%)       2 (4%)       5 (10%)      3 (6%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)                                
      Infiltration Cellular, Histiocyte               45 (90%)     47 (94%)     46 (92%)     45 (90%)                               
      Inflammation, Chronic                           31 (62%)     31 (62%)     40 (80%)     36 (72%)                               
      Alveolar Epithelium, Hyperplasia                 3 (6%)       7 (14%)     13 (26%)     14 (28%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                  2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            2 (4%)       3 (6%)       4 (8%)       6 (12%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Respiratory Epithelium, Hyperplasia                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Cataract                                         2 (4%)       2 (4%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 (2%)       1 (2%)                                             
      Infarct                                                       2 (4%)                    2 (4%)                                
      Inflammation, Chronic                                                                   2 (4%)                                
      Nephropathy                                     18 (36%)     32 (64%)     37 (74%)     40 (80%)                               
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Transitional Epithelium, Hyperplasia                                       2 (4%)       2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4           15           12           12                                     
    Natural Death                                     12           11            8            9                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           24           27           28                                     
    Moribund Sacrifice                                                           1                                                  
    Natural Death                                                                2                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (50)                                   
      Edema                                                         1 (2%)       1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
      Polyp, Inflammatory                                                                     1 (2%)                                
   Intestine Large, Cecum                             (45)         (47)         (46)         (47)                                   
      Congestion                                                    1 (2%)                                                          
      Edema                                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Basophilic Focus                                14 (28%)      4 (8%)       1 (2%)       1 (2%)                                
      Cholangiofibrosis                                1 (2%)                                                                       
      Clear Cell Focus                                18 (36%)     19 (38%)     16 (32%)     21 (42%)                               
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             3 (6%)       9 (18%)     11 (22%)     15 (30%)                               
      Eosinophilic Focus                              16 (32%)      4 (8%)       3 (6%)       9 (18%)                               
      Hepatodiaphragmatic Nodule                       2 (4%)       1 (2%)       2 (4%)       5 (10%)                               
      Inflammation, Granulomatous                      6 (12%)      1 (2%)                    1 (2%)                                
      Mixed Cell Focus                                 8 (16%)      1 (2%)       5 (10%)      2 (4%)                                
      Necrosis, Focal                                                            3 (6%)       2 (4%)                                
      Regeneration                                                  1 (2%)       1 (2%)                                             
      Bile Duct, Hyperplasia                          43 (86%)     42 (84%)     35 (70%)     38 (76%)                               
      Centrilobular, Necrosis                                       1 (2%)       1 (2%)       5 (10%)                               
      Hepatocyte, Vacuolization Cytoplasmic           14 (28%)      6 (12%)     12 (24%)     12 (24%)                               
      Hepatocyte, Midzonal, Vacuolization                                                                                           
        Cytoplasmic                                                              1 (2%)                                             
      Serosa, Fibrosis                                 1 (2%)                                                                       
      Serosa, Inflammation                             1 (2%)                                                                       
   Mesentery                                          (10)         (14)         (11)         (17)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Accessory Spleen                                              1 (7%)       1 (9%)                                             
      Fat, Necrosis                                    8 (80%)      7 (50%)      7 (64%)      5 (29%)                               
   Pancreas                                           (48)         (50)         (48)         (49)                                   
      Atrophy                                         23 (48%)     28 (56%)     25 (52%)     23 (47%)                               
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Acinus, Hyperplasia, Focal                       3 (6%)       5 (10%)      1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Edema                                            2 (4%)       5 (10%)      5 (10%)      2 (4%)                                
      Erosion                                                       4 (8%)       3 (6%)       1 (2%)                                
      Ulcer                                            2 (4%)       5 (10%)      5 (10%)      3 (6%)                                
      Epithelium, Hyperplasia                          7 (14%)      5 (10%)      5 (10%)      1 (2%)                                
   Stomach, Glandular                                 (50)         (48)         (48)         (50)                                   
      Edema                                                         5 (10%)      3 (6%)       1 (2%)                                
      Erosion                                                       6 (13%)      4 (8%)       1 (2%)                                
      Hyperplasia, Focal                                                         1 (2%)                                             
      Ulcer                                                         3 (6%)       4 (8%)       2 (4%)                                
   Tongue                                             (1)                                                                           
      Hyperplasia                                      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  45 (90%)     41 (82%)     43 (86%)     41 (82%)                               
      Thrombosis                                                    4 (8%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule               26 (53%)     18 (36%)     20 (41%)     14 (28%)                               
      Degeneration, Fatty                              5 (10%)     12 (24%)      9 (18%)      4 (8%)                                
      Hyperplasia, Focal                               6 (12%)      4 (8%)       2 (4%)       6 (12%)                               
      Hypertrophy, Focal                              10 (20%)     12 (24%)     13 (27%)      8 (16%)                               
      Necrosis                                                      1 (2%)                    1 (2%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (50)                                   
      Hyperplasia                                      6 (12%)      8 (16%)      7 (14%)      8 (16%)                               
      Necrosis                                                      1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (50)         (48)         (50)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
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         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Angiectasis                      16 (32%)     14 (29%)     13 (27%)      9 (18%)                               
      Pars Distalis, Cyst                              1 (2%)       2 (4%)       5 (10%)      1 (2%)                                
      Pars Distalis, Hemorrhage                        1 (2%)       1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                                                              2 (4%)                                
      Pars Distalis, Hyperplasia, Focal                6 (12%)     10 (20%)      4 (8%)       3 (6%)                                
      Pars Intermedia, Angiectasis                                               1 (2%)                                             
      Pars Intermedia, Cyst                                         1 (2%)       2 (4%)                                             
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      Ultimobranchial Cyst                             5 (10%)                   2 (4%)       3 (6%)                                
      C-Cell, Hyperplasia                              9 (18%)     13 (26%)     15 (31%)      4 (8%)                                
      Follicle, Cyst                                   4 (8%)       2 (4%)       2 (4%)       2 (4%)                                
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (49)                                   
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       6 (12%)      5 (10%)                                            
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)                    3 (6%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                           23 (46%)     25 (50%)     29 (58%)     29 (58%)                               
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
      Inflammation                                                               1 (2%)                                             
   Testes                                             (50)         (50)         (49)         (50)                                   
      Germinal Epithelium, Atrophy                    11 (22%)     24 (48%)     13 (27%)     10 (20%)                               
      Interstitial Cell, Hyperplasia                   1 (2%)       5 (10%)      4 (8%)       4 (8%)                                
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Depletion Cellular                                                                      1 (2%)                                
      Hyperplasia                                      2 (4%)       4 (8%)       2 (4%)       5 (10%)                               
      Myelofibrosis                                                              3 (6%)                                             
   Lymph Node                                         (22)         (26)         (25)         (25)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Hyperplasia, Lymphoid                          1 (4%)                                                          
      Mediastinal, Congestion                          1 (5%)                    1 (4%)       2 (8%)                                
      Mediastinal, Hyperplasia, Lymphoid               8 (36%)      8 (31%)     13 (52%)     14 (56%)                               
      Pancreatic, Congestion                           1 (5%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                2 (9%)       2 (8%)       2 (8%)       2 (8%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Congestion                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         5 (10%)      2 (4%)       2 (4%)                                
   Spleen                                             (50)         (50)         (49)         (49)                                   
      Fibrosis                                         2 (4%)       2 (4%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       4 (8%)       7 (14%)      5 (10%)                               
      Hemorrhage                                                                              1 (2%)                                
      Necrosis                                                      2 (4%)       2 (4%)       2 (4%)                                
      Pigmentation                                     4 (8%)       1 (2%)       4 (8%)                                             
      Lymphoid Follicle, Hyperplasia                   1 (2%)                                                                       
   Thymus                                             (49)         (48)         (48)         (50)                                   
      Cyst                                                                                    2 (4%)                                
      Hemorrhage                                       1 (2%)       2 (4%)       3 (6%)       2 (4%)                                
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 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Cyst                                            15 (30%)     17 (34%)     17 (34%)      8 (16%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        4 (8%)       2 (4%)       4 (8%)       1 (2%)                                
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      2 (4%)       1 (2%)                                
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 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hypertrophy                                                   1 (2%)                                                          
      Cranium, Osteopetrosis                                                                  1 (2%)                                
   Skeletal Muscle                                    (2)          (1)          (1)          (3)                                    
      Hemorrhage                                                                              1 (33%)                               
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96017-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04    
Route: DOSED WATER                                                                                                Time: 08:50:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Compression                                      7 (14%)      5 (10%)      7 (14%)      2 (4%)                                
      Hemorrhage                                       1 (2%)       3 (6%)       3 (6%)       3 (6%)                                
      Necrosis                                                      1 (2%)                                                          
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       6 (12%)      2 (4%)       6 (12%)      2 (4%)                                
      Hemorrhage                                       3 (6%)       2 (4%)       3 (6%)       1 (2%)                                
      Infiltration Cellular, Histiocyte               31 (62%)     27 (54%)     26 (52%)     28 (56%)                               
      Inflammation, Chronic                           29 (58%)     28 (56%)     27 (54%)     35 (70%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 6 (12%)      5 (10%)     10 (20%)     11 (22%)                               
   Nose                                               (49)         (50)         (49)         (50)                                   
      Foreign Body                                    10 (20%)      8 (16%)     10 (20%)      8 (16%)                               
      Inflammation, Chronic                           14 (29%)     13 (26%)     14 (29%)     14 (28%)                               
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Cataract                                         3 (6%)                                                                       
      Inflammation, Chronic                            2 (4%)                                 1 (2%)                                
   Harderian Gland                                    (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
   Lacrimal Gland                                                                            (1)                                    
      Inflammation, Suppurative                                                               1 (100%)                              
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (50)                                   
      Cyst                                             2 (4%)                                 1 (2%)                                
      Hydronephrosis                                   1 (2%)                    1 (2%)                                             
      Infarct                                          1 (2%)       1 (2%)                    1 (2%)                                
      Nephropathy                                     43 (88%)     48 (96%)     46 (94%)     47 (94%)                               
      Capsule, Hemorrhage                                                        1 (2%)                                             
      Transitional Epithelium, Hyperplasia             3 (6%)       9 (18%)      8 (16%)      3 (6%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                    2 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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