National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/19260

TDMS Study 96017-05 Pathology Tables

NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04
Route: DOSED WATER                                                                                                Time: 09:19:42

                                                          FINAL#1 RATS




       Facility:  Southern Research Institute

       Chemical CAS #:  631-64-1

       Lock Date:  11/15/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11            6            6            4                                     
    Moribund Sacrifice                                 4            5            9           14                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                35           38           34           32                                     
    Moribund Sacrifice                                              1                                                               
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (50)         (50)         (48)                                   
      Polyp Adenomatous                                                                       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                   1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           2 (4%)                                 1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Serosa, Osteosarcoma, Metastatic, Bone                                                  1 (2%)                                
   Mesentery                                          (12)         (15)         (15)         (8)                                    
      Osteosarcoma, Metastatic, Bone                                                          1 (13%)                               
   Oral Mucosa                                                     (1)          (1)          (1)                                    
      Pharyngeal, Squamous Cell Papilloma                           1 (100%)                  1 (100%)                              
   Pancreas                                           (47)         (50)         (49)         (48)                                   
      Acinus, Adenoma                                                                         1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Mammary Gland                                       1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
   Tongue                                                                                    (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (50)         (50)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
   Parathyroid Gland                                  (50)         (48)         (49)         (47)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Pars Distalis, Adenoma                          25 (50%)     27 (54%)     27 (54%)     22 (45%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Carcinoma                                      1 (2%)                    1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)       1 (2%)                                                          
      C-Cell, Adenoma                                  5 (10%)     10 (20%)      5 (10%)      5 (10%)                               
      C-Cell, Carcinoma                                             1 (2%)                                                          
      Follicular Cell, Adenoma                                                                2 (4%)                                
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (48)         (49)                                   
      Adenoma                                          7 (14%)     10 (20%)      5 (10%)      3 (6%)                                
      Carcinoma                                        1 (2%)       6 (12%)      1 (2%)       5 (10%)                               
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (50)         (50)         (50)         (50)                                   
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Deciduoma NOS                                                 1 (2%)                    1 (2%)                                
      Polyp Stromal                                    3 (6%)      10 (20%)      7 (14%)      4 (8%)                                
      Bilateral, Polyp Stromal                                                                1 (2%)                                
      Cervix, Polyp Stromal                            1 (2%)                                                                       
      Cervix, Sarcoma Stromal                                                    1 (2%)                                             
   Vagina                                             (1)          (4)          (6)          (20)                                   
      Polyp Adenomatous                                                          1 (17%)                                            
      Sarcoma Stromal                                                            1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Lymph Node                                         (13)         (13)         (9)          (21)                                   
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                     1 (8%)                                                          
      Mediastinal, Osteosarcoma, Metastatic, Bone                                             1 (5%)                                
      Pancreatic, Histiocytic Sarcoma                                                         1 (5%)                                
   Lymph Node, Mandibular                             (2)                       (1)          (3)                                    
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (48)                                   
   Spleen                                             (47)         (49)         (50)         (48)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Capsule, Osteosarcoma, Metastatic, Bone                                                 1 (2%)                                
   Thymus                                             (49)         (49)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Multiple                              1 (2%)                    1 (2%)                                             
      Fibroadenoma                                    22 (44%)     18 (36%)     11 (22%)     13 (26%)                               
      Fibroadenoma, Multiple                          10 (20%)     15 (30%)     28 (56%)     23 (46%)                               
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                    1 (2%)                                
      Squamous Cell Papilloma, Multiple                                          1 (2%)                                             
      Trichoepithelioma                                                                       1 (2%)                                
      Pinna, Neural Crest Tumor                                                               1 (2%)                                
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteoma                                                                    1 (2%)                                             
      Osteosarcoma                                                                            1 (2%)                                
      Cranium, Meningioma Malignant, Metastatic,                                                                                    
           Brain                                       1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                       (1)                                    
      Osteosarcoma, Metastatic, Bone                                                          1 (100%)                              
      Rhabdomyosarcoma                                              1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                                   1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                                                          
      Glioma Malignant, Mixed Cell                                               1 (2%)                                             
      Meningioma Malignant                             1 (2%)                                                                       
   Spinal Cord                                        (2)          (4)          (1)          (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)       1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
   Pleura                                                          (1)                                                              
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (50)         (50)                                   
   Zymbal's Gland                                     (1)                                    (2)                                    
      Carcinoma                                        1 (100%)                               2 (100%)                              
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                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Renal Tubule, Adenoma                                         1 (2%)                                                          
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            11 (22%)     13 (26%)     16 (32%)     22 (44%)                               
      Mesothelioma Malignant                                                     1 (2%)                                             
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          49          48          49                                       
     Total Primary Neoplasms                          103         129         118         126                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          47          43          43                                       
     Total Benign Neoplasms                            85         102          91          87                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          24          20          32                                       
     Total Malignant Neoplasms                         18          26          27          37                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           1           2                                       
     Total Metastatic Neoplasm                          1           5           1           7                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                       2                                       
     Total Uncertain Neoplasms                                      1                       2                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4           15           12           12                                     
    Natural Death                                     12           11            8            9                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           24           27           28                                     
    Moribund Sacrifice                                                           1                                                  
    Natural Death                                                                2                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (50)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Cecum                             (45)         (47)         (46)         (47)                                   
   Intestine Small, Duodenum                          (45)         (48)         (47)         (48)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma                                                   1 (2%)                                             
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Mesentery                                          (10)         (14)         (11)         (17)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (9%)                                             
      Histiocytic Sarcoma                              1 (10%)                                                                      
      Rhabdomyosarcoma                                 1 (10%)                                                                      
   Oral Mucosa                                                                  (1)                                                 
      Pharyngeal, Squamous Cell Carcinoma                                        1 (100%)                                           
   Pancreas                                           (48)         (50)         (48)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Acinus, Adenoma                                               2 (4%)       2 (4%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (49)         (50)                                   
   Stomach, Forestomach                               (50)         (49)         (49)         (50)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (48)         (48)         (50)                                   
   Tooth                                                                        (1)                                                 
      Odontoma                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Lung                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (49)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (49)         (50)         (49)         (50)                                   
      Pheochromocytoma Malignant                                    2 (4%)                    1 (2%)                                
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          7 (14%)      5 (10%)      7 (14%)      5 (10%)                               
      Bilateral, Pheochromocytoma Benign                            1 (2%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (48)         (50)         (48)         (50)                                   
      Adenoma                                          5 (10%)      3 (6%)       4 (8%)       1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Parathyroid Gland                                  (50)         (50)         (48)         (47)                                   
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (49)         (50)                                   
      Pars Distalis, Adenoma                          23 (46%)     21 (43%)     17 (35%)      8 (16%)                               
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (49)         (50)                                   
      C-Cell, Adenoma                                  6 (12%)      5 (10%)      5 (10%)      7 (14%)                               
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)                       (4)                                    
      Schwannoma Malignant, Metastatic, Peripheral                                                                                  
          Nerve                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (49)                                   
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       5 (10%)      8 (16%)      4 (8%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (49)         (50)                                   
   Testes                                             (50)         (50)         (49)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     42 (84%)     34 (69%)     39 (78%)                               
      Interstitial Cell, Adenoma                       7 (14%)      4 (8%)       7 (14%)      7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (50)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Lung                                     1 (2%)                                             
   Lymph Node                                         (22)         (26)         (25)         (25)                                   
      Bronchial, Thymoma Malignant, Metastatic,                                                                                     
           Thymus                                                                1 (4%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (4%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Lung                                     1 (2%)                                             
   Thymus                                             (49)         (48)         (48)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
      Thymoma Benign                                   1 (2%)                                                                       
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                                                                 1 (2%)                                
      Carcinoma                                        1 (2%)                    1 (2%)       1 (2%)                                
      Fibroadenoma                                     4 (8%)       5 (10%)      3 (6%)       5 (10%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Keratoacanthoma                                  3 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Trichoepithelioma                                1 (2%)       1 (2%)                                                          
      Sebaceous Gland, Adenoma, Multiple                                                      1 (2%)                                
      Subcutaneous Tissue, Fibroma                     5 (10%)      4 (8%)       3 (6%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                             3 (6%)       3 (6%)       2 (4%)                                
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Neural Crest Tumor          1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Vertebra, Chordoma                                            1 (2%)                                                          
   Skeletal Muscle                                    (2)          (1)          (1)          (3)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (100%)                                                        
      Hemangioma                                       1 (50%)                                                                      
      Histiocytic Sarcoma                                                        1 (100%)                                           
      Sarcoma                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Glioma Malignant, Mixed Cell                                               1 (2%)                                             
      Pineal Gland, Glioma Malignant                   1 (2%)                                                                       
   Peripheral Nerve                                   (2)          (1)          (2)          (2)                                    
      Schwannoma Malignant                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    4 (8%)       2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
      Schwannoma Malignant, Metastatic, Eye                         1 (2%)                                                          
      Schwannoma Malignant, Metastatic, Heart                                    1 (2%)                                             
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Mediastinum, Sarcoma                             1 (2%)                                                                       
      Serosa, Thymoma Malignant, Metastatic, Thymus                              1 (2%)                                             
   Pleura                                             (1)                       (1)                                                 
      Histiocytic Sarcoma                              1 (100%)                                                                     
      Thymoma Malignant, Metastatic, Thymus                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Schwannoma Malignant                                          1 (2%)                                                          
   Harderian Gland                                    (50)         (50)         (49)         (50)                                   
   Zymbal's Gland                                     (2)                                    (2)                                    
      Adenoma                                          1 (50%)                                1 (50%)                               
      Carcinoma                                                                               1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (49)         (50)                                   
      Lipoma                                                                                  1 (2%)                                
      Renal Tubule, Adenoma                            1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Papilloma                                                     1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              2 (4%)                    1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            17 (34%)     31 (62%)     24 (48%)     13 (26%)                               
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Mesothelioma Malignant                           3 (6%)       1 (2%)                   10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 04/14/04  
Route: DOSED WATER                                                                                                Time: 09:19:42  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          49          50                                       
     Total Primary Neoplasms                          145         146         147         127                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          48          45          48                                       
     Total Benign Neoplasms                           111         103         108          94                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          38          35          26                                       
     Total Malignant Neoplasms                         33          43          39          33                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          4           3                                                   
     Total Metastatic Neoplasm                                      7           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.