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TDMS Study 96017-06 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst            WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                           DATE: 05/19/04  
EXPERIMENT: 96017 TEST: 06                                                                                        TIME: 09:02:07    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96017      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)          DATE: 05/19/04    
EXPERIMENT: 96017 TEST: 06                                                                                        TIME:  9:45:39    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96017      
CONT: N01-ES-85420                                                                                                CAS: 631-64-1     
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.8    21.9       4.1     22.1    1.08      9.4      4.1     22.4    1.08     92.4      4.0     22.5    1.05    176.9       
  2     4.0    24.2       4.1     24.4    1.03      8.4      4.0     24.9    1.00     79.8      4.0     24.7    1.00    161.7       
  3     4.2    25.7       4.2     25.9    1.00      8.1      3.9     26.3    0.93     73.8      3.9     26.2    0.93    149.4       
  4     4.3    27.1       4.3     27.4    1.00      7.8      4.0     27.8    0.93     72.6      3.9     27.5    0.91    143.4       
  5     4.2    28.9       4.4     29.2    1.05      7.5      3.9     29.3    0.93     65.8      3.8     29.1    0.90    129.5       
  6     4.0    30.2       4.2     30.6    1.05      6.9      3.7     30.6    0.93     61.1      3.7     30.1    0.93    122.3       
  7     4.0    31.9       4.0     32.4    1.00      6.2      3.5     32.2    0.88     54.8      3.7     31.9    0.93    115.5       
  8     4.0    33.4       4.0     33.8    1.00      5.9      3.4     33.4    0.85     51.5      3.3     33.1    0.83    101.0       
  9     4.0    34.8       4.1     35.1    1.03      5.9      3.6     34.4    0.90     51.8      3.7     33.9    0.93    109.4       
 10     3.8    35.9       3.9     36.3    1.03      5.4      3.8     35.6    1.00     53.8      3.7     35.2    0.97    105.9       
 11     3.7    37.4       3.7     37.9    1.00      4.8      3.5     36.9    0.95     47.6      3.3     36.6    0.89     91.2       
 12     3.7    38.3       3.8     39.1    1.03      4.8      3.5     38.3    0.95     45.1      3.6     37.8    0.97     94.3       
 13     3.8    39.7       3.8     40.2    1.00      4.7      3.4     39.3    0.89     43.7      3.2     38.9    0.84     83.0       
 17     3.4    43.7       3.4     44.8    1.00      3.8      3.0     43.0    0.88     35.4      3.1     42.7    0.91     73.7       
 21     3.8    47.0       3.7     47.8    0.97      3.8      3.5     46.8    0.92     37.5      3.4     46.5    0.89     72.2       
 25     3.8    49.4       3.8     49.6    1.00      3.8      3.5     48.9    0.92     36.3      3.2     49.3    0.84     64.8       
 29     4.0    50.0       4.2     50.5    1.05      4.2      3.8     49.8    0.95     38.2      3.8     50.0    0.95     75.7       
 33     3.6    50.9       3.9     51.3    1.08      3.8      3.5     50.5    0.97     34.7      3.4     50.8    0.94     66.9       
 37     3.9    52.2       4.5     52.6    1.15      4.3      3.8     51.7    0.97     36.6      3.5     51.8    0.90     67.5       
 41     3.8    52.1       4.1     52.9    1.08      3.8      3.8     52.2    1.00     36.3      3.5     52.2    0.92     66.4       
 45     4.0    52.2       4.5     52.5    1.13      4.3      4.0     52.3    1.00     38.0      3.9     52.3    0.98     74.9       
 49     4.3    52.1       4.8     53.0    1.12      4.5      4.4     52.4    1.02     42.4      4.0     52.8    0.93     75.4       
 53     4.4    52.2       4.8     53.3    1.09      4.5      4.2     52.6    0.95     40.1      3.9     53.1    0.89     72.9       
 57     4.5    51.1       4.6     52.7    1.02      4.4      4.4     52.6    0.98     41.7      4.1     52.8    0.91     77.8       
 61     5.1    52.0       5.4     53.3    1.06      5.0      5.2     53.1    1.02     48.7      5.1     53.1    1.00     95.4       
 65     4.6    52.5       4.9     54.0    1.07      4.5      4.6     53.4    1.00     43.2      4.3     53.8    0.93     79.8       
 69     4.3    51.7       4.5     54.0    1.05      4.1      4.5     53.3    1.05     41.8      4.0     52.6    0.93     76.5       
 73     4.3    52.1       4.6     54.1    1.07      4.3      4.4     53.0    1.02     41.4      4.3     52.6    1.00     81.4       
 77     4.6    51.6       4.6     53.8    1.00      4.3      4.6     52.9    1.00     43.9      4.5     52.0    0.98     86.3       
 81     4.7    51.8       4.8     53.8    1.02      4.5      4.7     52.1    1.00     45.0      4.6     52.0    0.98     89.0       
 85     4.8    50.7       4.9     52.8    1.02      4.6      5.0     51.9    1.04     48.5      4.8     50.5    1.00     95.1       
 89     4.6    48.7       4.5     51.7    0.98      4.3      5.0     51.5    1.09     48.3      4.9     50.3    1.07     97.1       
 93     4.2    48.1       4.5     51.0    1.07      4.4      5.0     51.6    1.19     48.4      5.0     49.3    1.19    100.8       
 97     4.1    47.3       4.2     49.9    1.02      4.2      4.9     50.5    1.20     48.9      4.7     48.3    1.15     98.0       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101     4.4    46.7       4.7     50.0     1.07     4.8      5.6     51.1     1.27    54.4      5.3     46.6     1.20   113.6       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.0    31.5       4.0     31.9     1.02     6.6      3.7     31.7     0.94    61.1      3.7     31.3     0.93   121.8       
SD(D)   0.2               0.2              0.03     1.5      0.2              0.06    14.9      0.3              0.06    28.9       
CV(E)   4.6               5.3              2.5     23.2      6.6              6.4     24.4      6.9              6.6     23.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.9    49.9       4.1     50.6     1.06     4.0      3.7     49.8     0.96    37.3      3.5     49.8     0.92    70.8       
SD(D)   0.3               0.4              0.06     0.3      0.4              0.05     2.2      0.3              0.04     4.4       
CV(E)   6.7              11.0              5.9      6.8     10.3              4.8      6.0      8.5              4.2      6.2       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.5    50.5       4.7     52.6     1.04     4.5      4.8     52.3     1.06    45.7      4.6     51.3     1.02    89.5       
SD(D)   0.3               0.3              0.03     0.2      0.4              0.10     4.2      0.4              0.10    11.7       
CV(E)   6.2               5.9              3.2      5.4      7.9              9.2      9.1      9.5             10.3     13.1       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     3.1    18.4       3.3     18.6     1.06     8.8      3.2     18.8     1.03    84.8      3.0     18.5     0.97   164.4       
  2     3.4    19.4       4.1     19.3     1.21    10.5      3.3     19.7     0.97    83.8      3.2     19.7     0.94   162.8       
  3     3.7    20.5       4.2     20.4     1.14    10.3      3.9     20.8     1.05    93.1      3.5     20.7     0.95   168.9       
  4     3.5    21.2       3.8     21.1     1.09     9.0      3.9     21.5     1.11    90.4      3.4     21.3     0.97   160.9       
  5     4.0    22.2       4.0     22.2     1.00     9.1      3.6     22.7     0.90    79.6      3.2     22.5     0.80   141.2       
  6     3.9    23.4       4.3     23.3     1.10     9.1      3.5     23.9     0.90    72.3      3.4     23.5     0.87   143.9       
  7     3.7    24.3       3.4     24.2     0.92     7.1      3.5     24.7     0.95    71.5      3.3     24.4     0.89   136.9       
  8     3.6    24.6       3.6     24.9     1.00     7.1      3.4     25.4     0.94    67.5      3.2     24.9     0.89   130.6       
  9     3.6    25.7       3.6     25.7     1.00     6.9      3.7     26.3     1.03    71.3      3.6     25.8     1.00   138.1       
 10     3.9    26.7       4.0     26.1     1.03     7.6      3.3     27.4     0.85    60.5      3.3     26.7     0.85   125.4       
 11     3.5    28.0       3.5     27.8     1.00     6.3      3.3     28.3     0.94    58.8      3.1     27.8     0.89   112.3       
 12     3.8    28.4       4.1     28.3     1.08     7.3      3.3     29.4     0.87    56.1      3.3     27.9     0.87   117.2       
 13     4.0    29.8       4.0     29.0     1.00     6.9      3.5     30.0     0.88    59.0      2.8     29.2     0.70    95.7       
 17     3.2    34.8       3.2     34.0     1.00     4.8      3.0     34.7     0.94    43.6      2.9     33.0     0.91    86.5       
 21     4.6    38.9       3.5     38.2     0.76     4.6      3.3     38.4     0.72    43.3      3.0     36.3     0.65    81.4       
 25     3.9    44.0       3.2     44.0     0.82     3.6      3.3     43.5     0.85    37.7      2.7     42.1     0.69    63.5       
 29     3.5    47.6       3.0     47.9     0.86     3.1      2.7     46.7     0.77    29.4      2.6     45.0     0.74    58.0       
 33     3.0    49.7       2.4     50.4     0.80     2.4      3.4     49.2     1.13    34.6      3.1     47.1     1.03    65.6       
 37     2.5    53.5       2.6     54.6     1.04     2.4      2.7     52.4     1.08    25.9      2.6     50.4     1.04    50.7       
 41     2.6    56.2       2.8     56.2     1.08     2.5      2.8     54.3     1.08    25.5      2.6     52.4     1.00    49.4       
 45     2.9    57.0       2.8     57.9     0.97     2.4      2.7     55.5     0.93    24.6      3.0     53.9     1.03    55.7       
 49     3.4    58.0       2.7     59.1     0.79     2.3      2.8     57.3     0.82    24.5      2.7     55.6     0.79    48.3       
 53     2.8    60.1       3.2     60.4     1.14     2.6      2.7     59.2     0.96    22.6      2.6     57.3     0.93    44.7       
 57     2.6    60.9       2.8     60.6     1.08     2.3      2.9     59.8     1.12    24.3      2.8     58.2     1.08    47.5       
 61     3.3    63.4       3.5     62.1     1.06     2.8      3.5     61.2     1.06    28.7      3.3     60.0     1.00    54.6       
 65     3.1    63.5       2.8     62.3     0.90     2.3      2.7     62.0     0.87    21.7      2.5     61.0     0.81    41.1       
 69     2.5    64.1       2.7     62.7     1.08     2.2      2.7     62.5     1.08    21.4      2.4     61.2     0.96    39.3       
 73     2.6    63.8       3.0     63.1     1.15     2.4      2.9     62.9     1.12    23.0      2.7     61.1     1.04    43.6       
 77     2.7    64.3       2.9     63.6     1.07     2.3      3.1     63.3     1.15    24.2      2.6     62.0     0.96    41.4       
 81     2.9    63.2       3.2     63.1     1.10     2.5      3.3     61.3     1.14    26.7      2.7     60.7     0.93    44.3       
 85     3.0    63.1       3.0     61.8     1.00     2.5      3.1     61.8     1.03    25.4      2.9     59.2     0.97    48.5       
 89     3.2    63.2       3.2     62.5     1.00     2.5      3.4     61.4     1.06    27.4      2.8     60.4     0.88    46.4       
 93     3.2    63.6       3.2     63.9     1.00     2.5      3.9     61.9     1.22    31.9      3.3     60.9     1.03    54.2       
 97     3.1    60.8       3.0     62.1     0.97     2.4      3.8     59.2     1.23    32.3      3.3     58.3     1.06    56.7       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                            CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                         
==================================================================================================================================  
           0 MG/L                     50 MG/L                            500 MG/L                         1000    MG/L              
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
101     4.0    59.0       3.3     59.5     0.83     2.8      4.0     57.9     1.00    34.7      3.8     56.6     0.95    66.6       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.7    24.0       3.8     23.9     1.05     8.2      3.5     24.5     0.96    73.0      3.3     24.1     0.89   138.3       
SD(D)   0.3               0.3              0.07     1.4      0.2              0.08    12.5      0.2              0.08    22.2       
CV(E)   6.9               8.5              7.1     16.9      6.4              8.5     17.2      6.3              9.0     16.1       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.3    48.9       2.9     49.1     0.90     3.1      3.0     48.0     0.92    32.1      2.8     46.2     0.88    62.1       
SD(D)   0.7               0.3              0.12     1.0      0.3              0.15     7.9      0.2              0.16    13.8       
CV(E)  20.2              11.7             13.2     31.6      9.6             16.0     24.6      7.2             18.1     22.2       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    3.0    62.5       3.1     62.1     1.03     2.5      3.2     61.1     1.08    26.5      2.9     59.8     0.97    48.4       
SD(D)   0.4               0.2              0.09     0.2      0.5              0.10     4.3      0.4              0.08     7.7       
CV(E)  13.5               7.1              9.1      7.8     14.8              9.2     16.3     14.1              7.8     15.9       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               DIAGNOSTIC TRAILER REPORT                                                                                            
               WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                   
               CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                      
=========================================================================================================                           
           0 MG/L                  50 MG/L                  500 MG/L               1000    MG/L                                     
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               21.9  50                 22.1  50                 22.4  50                 22.5  50                               
  1   3.8  7022   21.9  50     4.1  6899   22.1  50     4.1  6965   22.4  50     4.0  7045   22.5  50                               
  2   4.0  8421   24.2  50     4.1  8219   24.4  50     4.0  8426   24.9  50     4.0  8345   24.7  50                               
  3   4.2  8255   25.7  50     4.2  8254   25.9  50     3.9  8267   26.3  50     3.9  8351   26.2  50                               
  4   4.3  8207   27.1  50     4.3  7968   27.4  50     4.0  8162   27.8  50     3.9  8191   27.5  50                               
  5   4.2  8308   28.9  50     4.4  8258   29.2  50     3.9  8266   29.3  50     3.8  8293   29.1  50                               
  6   4.0  8216   30.2  50     4.2  8170   30.6  50     3.7  8263   30.6  50     3.7  8274   30.1  50                               
  7   4.0  8349   31.9  50     4.0  8216   32.4  50     3.5  8381   32.2  50     3.7  8218   31.9  50                               
  8   4.0  8176   33.4  50     4.0  8083   33.8  50     3.4  8221   33.4  50     3.3  8233   33.1  50                               
  9   4.0  8272   34.8  50     4.1  8286   35.1  50     3.6  8337   34.4  50     3.7  8379   33.9  50                               
 10   3.8  8255   35.9  50     3.9  8084   36.3  50     3.8  8152   35.6  50     3.7  7975   35.2  50                               
 11   3.7  8361   37.4  50     3.7  8346   37.9  50     3.5  8462   36.9  50     3.3  8429   36.6  50                               
 12   3.7  8216   38.3  50     3.8  8253   39.1  50     3.5  8254   38.3  50     3.6  8037   37.8  50                               
 13   3.8  8076   39.7  45     3.8  7927   40.2  50     3.4  8025   39.3  50     3.2  7805   38.9  50                               
 17   3.4  8141   43.7  50     3.4  8329   44.8  50     3.0  8030   43.0  50     3.1  8138   42.7  50                               
 21   3.8  8262   47.0  50     3.7  8088   47.8  50     3.5  8287   46.8  50     3.4  7865   46.5  50                               
 25   3.8  8057   49.4  50     3.8  8183   49.6  50     3.5  7961   48.9  50     3.2  7939   49.3  50                               
 29   4.0  7843   50.0  50     4.2  7965   50.5  50     3.8  7839   49.8  50     3.8  7709   50.0  50                               
 33   3.6  4569   50.9  49     3.9  8005   51.3  50     3.5  8043   50.5  50     3.4  7801   50.8  50                               
 37   3.9  7976   52.2  49     4.5  8195   52.6  50     3.8  7976   51.7  50     3.5  8097   51.8  50                               
 41   3.8  8039   52.1  49     4.1  8165   52.9  50     3.8  8128   52.2  50     3.5  8342   52.2  50                               
 45   4.0  7885   52.2  49     4.5  7734   52.5  49     4.0  8162   52.3  50     3.9  8216   52.3  50                               
 49   4.3  7741   52.1  49     4.8  7732   53.0  49     4.4  7962   52.4  50     4.0  7596   52.8  50                               
 53   4.4  7853   52.2  49     4.8  7923   53.3  49     4.2  8036   52.6  50     3.9  8177   53.1  50                               
 57   4.5  7611   51.1  49     4.6  7861   52.7  49     4.4  7697   52.6  49     4.1  8092   52.8  50                               
 61   5.1  7492   52.0  49     5.4  7961   53.3  49     5.2  7982   53.1  49     5.1  8028   53.1  50                               
 65   4.6  7444   52.5  48     4.9  8001   54.0  49     4.6  7565   53.4  48     4.3  8200   53.8  50                               
 69   4.3  7444   51.7  46     4.5  7603   54.0  49     4.5  7404   53.3  48     4.0  7419   52.6  48                               
 73   4.3  6993   52.1  45     4.6  7874   54.1  49     4.4  7734   53.0  48     4.3  7277   52.6  47                               
 77   4.6  6950   51.6  44     4.6  7692   53.8  49     4.6  7319   52.9  47     4.5  7333   52.0  47                               
 81   4.7  6525   51.8  44     4.8  7272   53.8  48     4.7  7519   52.1  47     4.6  6812   52.0  46                               
 85   4.8  6270   50.7  44     4.9  7176   52.8  46     5.0  7031   51.9  45     4.8  7102   50.5  45                               
 89   4.6  5843   48.7  42     4.5  6673   51.7  45     5.0  6793   51.5  43     4.9  6946   50.3  44                               
 93   4.2  5332   48.1  39     4.5  7132   51.0  45     5.0  6608   51.6  40     5.0  6015   49.3  41                               
 97   4.1  5370   47.3  36     4.2  6912   49.9  43     4.9  6070   50.5  38     4.7  5924   48.3  38                               
101   4.4  4303   46.7  36     4.7  6411   50.0  40     5.6  5259   51.1  36     5.3  4727   46.6  34                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           31.5                     31.9                     31.7                     31.3                                   
14 TO 52          49.9                     50.6                     49.8                     49.8                                   
 > 52             50.5                     52.6                     52.3                     51.3                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
               DIAGNOSTIC TRAILER REPORT                                                                                            
               WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                 
               CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                                      
=========================================================================================================                           
           0 MG/L                  50 MG/L                  500 MG/L               1000    MG/L                                     
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.4  50                 18.6  50                 18.8  50                 18.5  50                               
  1   3.1  7040   18.4  50     3.3  6502   18.6  50     3.2  7040   18.8  50     3.0  7012   18.5  50                               
  2   3.4  8407   19.4  50     4.1  7922   19.3  50     3.3  8375   19.7  50     3.2  8515   19.7  50                               
  3   3.7  7184   20.5  50     4.2  7169   20.4  50     3.9  8016   20.8  50     3.5  8402   20.7  50                               
  4   3.5  7688   21.2  50     3.8  6544   21.1  50     3.9  8029   21.5  50     3.4  8410   21.3  50                               
  5   4.0  7937   22.2  50     4.0  8176   22.2  50     3.6  8318   22.7  50     3.2  7885   22.5  50                               
  6   3.9  8269   23.4  50     4.3  8271   23.3  50     3.5  8380   23.9  50     3.4  7906   23.5  50                               
  7   3.7  7887   24.3  50     3.4  8520   24.2  50     3.5  8445   24.7  50     3.3  8445   24.4  50                               
  8   3.6  8209   24.6  50     3.6  8287   24.9  50     3.4  8254   25.4  50     3.2  8410   24.9  50                               
  9   3.6  8109   25.7  50     3.6  8435   25.7  50     3.7  8432   26.3  50     3.6  7942   25.8  50                               
 10   3.9  8303   26.7  50     4.0  8243   26.1  50     3.3  8027   27.4  50     3.3  8375   26.7  50                               
 11   3.5  8510   28.0  50     3.5  8103   27.8  50     3.3  7959   28.3  50     3.1  8464   27.8  50                               
 12   3.8  7853   28.4  50     4.1  7815   28.3  50     3.3  7791   29.4  50     3.3  6693   27.9  50                               
 13   4.0  8220   29.8  50     4.0  8115   29.0  50     3.5  7556   30.0  50     2.8  8045   29.2  50                               
 17   3.2  7945   34.8  50     3.2  7910   34.0  50     3.0  7876   34.7  50     2.9  8175   33.0  50                               
 21   4.6  8288   38.9  50     3.5  6659   38.2  50     3.3  8289   38.4  50     3.0  8253   36.3  50                               
 25   3.9  8212   44.0  50     3.2  7420   44.0  50     3.3  8091   43.5  50     2.7  7537   42.1  50                               
 29   3.5  7430   47.6  50     3.0  7361   47.9  50     2.7  7115   46.7  50     2.6  8315   45.0  50                               
 33   3.0  4262   49.7  50     2.4  7850   50.4  50     3.4  7765   49.2  50     3.1  7759   47.1  50                               
 37   2.5  7912   53.5  50     2.6  7700   54.6  50     2.7  6665   52.4  50     2.6  7580   50.4  50                               
 41   2.6  7891   56.2  50     2.8  8117   56.2  50     2.8  7042   54.3  50     2.6  7341   52.4  49                               
 45   2.9  7697   57.0  50     2.8  7678   57.9  50     2.7  7873   55.5  50     3.0  7858   53.9  49                               
 49   3.4  7802   58.0  50     2.7  7779   59.1  50     2.8  7418   57.3  50     2.7  7166   55.6  49                               
 53   2.8  8099   60.1  50     3.2  7852   60.4  50     2.7  8184   59.2  50     2.6  7787   57.3  49                               
 57   2.6  8116   60.9  50     2.8  6621   60.6  49     2.9  6456   59.8  50     2.8  7097   58.2  49                               
 61   3.3  7177   63.4  50     3.5  6829   62.1  49     3.5  7852   61.2  50     3.3  7094   60.0  49                               
 65   3.1  8244   63.5  50     2.8  7943   62.3  49     2.7  7450   62.0  50     2.5  7897   61.0  48                               
 69   2.5  8135   64.1  49     2.7  7724   62.7  49     2.7  7001   62.5  50     2.4  7578   61.2  48                               
 73   2.6  7169   63.8  49     3.0  7566   63.1  47     2.9  6857   62.9  49     2.7  6728   61.1  48                               
 77   2.7  7919   64.3  48     2.9  7779   63.6  47     3.1  6755   63.3  48     2.6  7269   62.0  48                               
 81   2.9  6850   63.2  47     3.2  6202   63.1  47     3.3  6659   61.3  47     2.7  7057   60.7  48                               
 85   3.0  7097   63.1  46     3.0  7067   61.8  46     3.1  7457   61.8  46     2.9  7030   59.2  48                               
 89   3.2  7349   63.2  45     3.2  6766   62.5  44     3.4  7213   61.4  45     2.8  6877   60.4  46                               
 93   3.2  6675   63.6  44     3.2  7346   63.9  44     3.9  6317   61.9  40     3.3  7160   60.9  44                               
 97   3.1  5470   60.8  42     3.0  6710   62.1  43     3.8  5894   59.2  38     3.3  6279   58.3  42                               
101   4.0  5320   59.0  42     3.3  6146   59.5  40     4.0  5464   57.9  35     3.8  5485   56.6  38                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.0                     23.9                     24.5                     24.1                                   
14 TO 52          48.9                     49.1                     48.0                     46.2                                   
 > 52             62.5                     62.1                     61.1                     59.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.