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TDMS Study 96017-06 Pathology Tables

NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04
Route: DOSED WATER                                                                                                Time: 09:19:23

                                                          FINAL#1 MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  631-64-1

       Lock Date:  11/15/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10           13           13           11                                     
    Moribund Sacrifice                                 2            2            5            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           35           31           32                                     
    Natural Death                                                                1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (46)         (49)         (46)                                   
   Intestine Small, Duodenum                          (46)         (48)         (48)         (45)                                   
      Polyp Adenomatous                                             2 (4%)                                                          
   Intestine Small, Jejunum                           (46)         (47)         (49)         (43)                                   
      Carcinoma                                                                               1 (2%)                                
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Intestine Small, Ileum                             (45)         (47)         (47)         (46)                                   
      Fibrosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
   Liver                                              (49)         (50)         (50)         (49)                                   
      Hemangioma                                       1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)                                             
      Hepatoblastoma                                   1 (2%)                    1 (2%)                                             
      Hepatoblastoma, Multiple                                                                1 (2%)                                
      Hepatocellular Carcinoma                         2 (4%)       2 (4%)       7 (14%)      5 (10%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       1 (2%)       5 (10%)      3 (6%)                                
      Hepatocellular Adenoma                           8 (16%)     12 (24%)      9 (18%)      9 (18%)                               
      Hepatocellular Adenoma, Multiple                11 (22%)     14 (28%)     23 (46%)     26 (53%)                               
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Ito Cell Tumor Malignant                                                                1 (2%)                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                                     1 (2%)                                                          
   Mesentery                                          (28)         (20)         (16)         (19)                                   
      Hemangioma                                       1 (4%)                                                                       
      Hemangiosarcoma                                                            1 (6%)       1 (5%)                                
      Leiomyosarcoma                                                             1 (6%)                                             
      Sarcoma                                          1 (4%)                                                                       
      Sarcoma, Metastatic, Pancreas                                              1 (6%)                                             
      Sarcoma, Metastatic, Skin                                     1 (5%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Schwannoma Malignant, Metastatic, Skin                        1 (5%)                                                          
   Oral Mucosa                                                     (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Pancreas                                           (49)         (49)         (49)         (47)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
      Acinus, Carcinoma                                                                       1 (2%)                                
      Acinus, Sarcoma                                                            1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                                    1 (2%)       1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       2 (4%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)         (49)                                   
      Carcinoma                                        1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Skin                        1 (2%)                                                          
      Serosa, Sarcoma, Metastatic, Skin                             1 (2%)                                                          
   Tongue                                             (2)                                                                           
      Squamous Cell Carcinoma                          1 (50%)                                                                      
      Squamous Cell Papilloma                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (49)                                   
      Leiomyosarcoma, Metastatic, Mesentery                                      1 (2%)                                             
      Sarcoma, Metastatic, Pancreas                                              1 (2%)                                             
      Capsule, Adenoma                                                           1 (2%)                                             
      Extra Adrenal Tissue, Sarcoma                    1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (49)         (49)         (49)         (46)                                   
      Adenoma                                          1 (2%)                    2 (4%)       2 (4%)                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (47)         (49)         (49)         (49)                                   
      Pars Distalis, Adenoma                           2 (4%)       4 (8%)                    1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)                    2 (4%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                         3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (2)                                    
      Fibrosarcoma                                                                            1 (50%)                               
      Schwannoma Malignant                                                                    1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (47)         (47)         (49)                                   
      Cystadenoma                                                   2 (4%)       1 (2%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leiomyoma                                                                               1 (2%)                                
      Polyp Stromal                                    1 (2%)       1 (2%)                                                          
      Sarcoma Stromal                                                                         1 (2%)                                
      Cervix, Carcinoma                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (12)         (13)         (11)         (8)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (8%)                                                          
      Iliac, Osteosarcoma, Metastatic, Bone                                                   1 (13%)                               
      Iliac, Sarcoma, Metastatic, Skin                 1 (8%)       1 (8%)                                                          
      Inguinal, Fibrosarcoma, Metastatic, Skin                      1 (8%)                                                          
      Mediastinal, Neurofibrosarcoma, Metastatic,                                                                                   
           Skin                                                     1 (8%)                                                          
      Mediastinal, Sarcoma, Metastatic, Skin                                                  1 (13%)                               
      Pancreatic, Carcinoma, Metastatic, Pancreas                                             1 (13%)                               
      Pancreatic, Leiomyosarcoma, Metastatic,                                                                                       
          Mesentery                                                              1 (9%)                                             
      Renal, Leiomyosarcoma, Metastatic, Mesentery                               1 (9%)                                             
   Lymph Node, Mandibular                             (48)         (49)         (47)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (49)         (48)         (45)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (48)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
   Thymus                                             (44)         (47)         (47)         (48)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Carcinoma                                                     1 (2%)       1 (2%)                                             
      Fibroadenoma                                                  1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma        3 (6%)                                                                       
      Subcutaneous Tissue, Hemangioma                               1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Hemangiopericytoma                       1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Neurofibroma                                                       1 (2%)                                
      Subcutaneous Tissue, Neurofibrosarcoma                        1 (2%)                                                          
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                                                    1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)       1 (2%)       4 (8%)                                
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Tissue NOS                                  1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (3)          (4)          (2)          (5)                                    
      Carcinoma, Metastatic, Harderian Gland                        1 (25%)                                                         
      Fibrosarcoma, Metastatic, Skin                                             1 (50%)                                            
      Hemangiosarcoma                                                                         1 (20%)                               
      Hepatocellular Carcinoma, Metastatic, Liver      1 (33%)                                                                      
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Rhabdomyosarcoma                                                                        1 (20%)                               
      Sarcoma                                          1 (33%)      1 (25%)                   2 (40%)                               
      Sarcoma, Metastatic, Pancreas                                              1 (50%)                                            
      Sarcoma, Metastatic, Skin                        1 (33%)                                                                      
      Schwannoma Malignant, Metastatic, Skin                        1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       3 (6%)       3 (6%)       6 (12%)                               
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Carcinoma, Metastatic, Uterus                                              1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (6%)       1 (2%)       3 (6%)       4 (8%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Neurofibrosarcoma                                             1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)       1 (2%)                    1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
   Harderian Gland                                    (49)         (50)         (50)         (50)                                   
      Adenoma                                          9 (18%)      4 (8%)       6 (12%)      8 (16%)                               
      Adenoma, Multiple                                                          2 (4%)                                             
      Carcinoma                                        1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (49)                                   
   Urinary Bladder                                    (50)         (49)         (50)         (49)                                   
      Fibrosarcoma, Metastatic, Tissue NOS                                                    1 (2%)                                
      Leiomyosarcoma, Metastatic, Mesentery                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       1 (2%)                                
      Lymphoma Malignant                              27 (54%)     24 (48%)     17 (34%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42          43          46          48                                       
     Total Primary Neoplasms                           88          93         102         104                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          33          41          38                                       
     Total Benign Neoplasms                            43          46          54          56                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          37          34          31                                       
     Total Malignant Neoplasms                         45          47          48          48                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           7           7          10                                       
     Total Metastatic Neoplasm                         12          20          13          13                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            6            3            6                                     
    Natural Death                                     14            6           13           13                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           38           34           31                                     
  Other                                                1                                                                            
                                                                                                                                    
  Animals Examined Microscopically                    49           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
   Intestine Large, Colon                             (48)         (50)         (49)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
      Hemangioma                                                    1 (2%)                                                          
   Intestine Small, Duodenum                          (42)         (50)         (46)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
      Polyp Adenomatous                                             1 (2%)       2 (4%)       1 (2%)                                
   Intestine Small, Jejunum                           (44)         (49)         (46)         (45)                                   
      Carcinoma                                                     2 (4%)                    3 (7%)                                
      Polyp Adenomatous                                1 (2%)       1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (49)         (47)         (48)                                   
      Polyp Adenomatous                                             1 (2%)                                                          
   Liver                                              (49)         (50)         (50)         (50)                                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       2 (4%)                    2 (4%)                                
      Hepatoblastoma                                                4 (8%)       3 (6%)      16 (32%)                               
      Hepatoblastoma, Multiple                                                   3 (6%)       2 (4%)                                
      Hepatocellular Carcinoma                        11 (22%)      7 (14%)     14 (28%)     11 (22%)                               
      Hepatocellular Carcinoma, Multiple               3 (6%)       2 (4%)       5 (10%)     15 (30%)                               
      Hepatocellular Adenoma                          12 (24%)     20 (40%)     13 (26%)     15 (30%)                               
      Hepatocellular Adenoma, Multiple                 6 (12%)     17 (34%)     24 (48%)     27 (54%)                               
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Mesentery                                          (7)          (7)          (10)         (7)                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hepatoblastoma, Metastatic, Liver                                          1 (10%)      1 (14%)                               
      Osteosarcoma, Metastatic, Bone                                             1 (10%)                                            
      Sarcoma                                                       1 (14%)                                                         
   Pancreas                                           (46)         (50)         (50)         (49)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                    1 (2%)                                
      Acinus, Carcinoma                                             1 (2%)                                                          
      Acinus, Sarcoma                                               1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (47)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)         (50)                                   
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                             2 (4%)                                
      Capsule, Adenoma                                 3 (6%)       3 (6%)       2 (4%)                                             
      Capsule, Carcinoma                                            1 (2%)                                                          
   Adrenal Medulla                                    (49)         (50)         (50)         (50)                                   
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (46)         (50)         (50)         (49)                                   
      Adenoma                                                       2 (4%)       4 (8%)       3 (6%)                                
      Adenoma, Multiple                                             1 (2%)                                                          
   Thyroid Gland                                      (48)         (50)         (50)         (50)                                   
      Follicular Cell, Adenoma                                                   1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)          (1)                                                 
      Hemangioma                                                                 1 (100%)                                           
   Prostate                                           (48)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
   Testes                                             (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Interstitial Cell, Adenoma                                    2 (4%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (47)         (50)         (50)         (50)                                   
   Lymph Node                                         (1)          (2)          (5)          (1)                                    
      Iliac, Carcinoma, Metastatic, Pancreas                        1 (50%)                                                         
      Renal, Carcinoma, Metastatic, Pancreas                        1 (50%)                                                         
   Lymph Node, Mandibular                             (48)         (50)         (48)         (48)                                   
   Lymph Node, Mesenteric                             (46)         (49)         (49)         (47)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Spleen                                             (47)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       3 (6%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (42)         (45)         (46)         (47)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)         (50)         (50)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                       (1)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                               1 (100%)                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     7 (14%)      4 (8%)      15 (30%)      8 (16%)                               
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)       2 (4%)       4 (8%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       7 (14%)      6 (12%)      4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         2 (4%)       1 (2%)       2 (4%)       3 (6%)                                
      Carcinoma, Metastatic, Pancreas                               1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                             1 (2%)       2 (4%)       6 (12%)                               
      Hepatocellular Carcinoma, Metastatic, Liver      8 (16%)      5 (10%)      7 (14%)     13 (26%)                               
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Bronchus, Adenoma                                1 (2%)                    1 (2%)                                             
      Mediastinum, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (49)         (50)         (50)         (50)                                   
      Adenoma                                          3 (6%)       4 (8%)       5 (10%)      6 (12%)                               
      Adenoma, Multiple                                             1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(49)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Lymphoma Malignant                                            5 (10%)      3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96017-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                         WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)                    Date: 05/19/04  
Route: DOSED WATER                                                                                                Time: 09:19:23  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       50 MG/L      500 MG/L     1000                                      
                                                                                          MG/L                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          44          49          50                                       
     Total Primary Neoplasms                           61         103         110         130                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          38          42          46                                       
     Total Benign Neoplasms                            35          61          71          68                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          28          32          43                                       
     Total Malignant Neoplasms                         26          42          39          62                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              9           7          10          21                                       
     Total Metastatic Neoplasm                         10          13          13          28                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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