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TDMS Study 93020-08 Pathology Tables

NTP  EXP/TEST: 93020-08                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 1
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 07/19/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:02:50

                                                         EIS REPORT 03


       FACILITY:  Southern Research Institute

       NTP C#:  93020D

       CONTRACT NUMBER:  N01-ES-05451

       CAS NUMBER:  693-13-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 93020-08                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 2
TEST TYPE: CHRONIC                              INITIAL AND CURRENT BODY WEIGHT                                   DATE: 07/19/04
ROUTE: SKIN APPLICATION                                     EISRPT03                                              TIME: 09:02:50
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 SPECIES-STRAIN: B6C3F1-MICE                SEX: FEMALE      WEEK ON DOSE: 106    FIRST DOSE: 05/08/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     18.6    1.0        33     60.6    9.8                     33     42.0   10.1

 10 MG/KG           50     18.6    1.0        32     62.7    6.5       103.4         32     44.2    6.1

 20 MG/KG           50     18.5    1.0        38     58.7   11.8        96.8         38     40.1   11.8

 40 MG/KG           50     18.7    0.8        40     59.1    8.7        97.5         40     40.6    8.7




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 SPECIES-STRAIN: B6C3F1-MICE                SEX: MALE        WEEK ON DOSE: 106    FIRST DOSE: 05/08/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            50     22.4    1.3        38     51.1    9.0                     38     28.9    9.0

 10 MG/KG           50     22.4    1.2        40     50.8    8.2        99.4         40     28.4    7.8

 20 MG/KG           50     22.4    1.1        38     52.3    5.4       102.3         38     30.0    5.0

 40 MG/KG           50     22.4    1.3        36     51.9    6.1       101.5         36     29.5    5.6

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