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TDMS Study 97013-96 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                            DATE: 10/08/03  
EXPERIMENT: 97013 TEST: 96                                                                                        TIME: 15:23:31    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED WATER                                            NTP:  C97013J     
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                                                             FINAL/MICE                                                             
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)             DATE: 10/08/03    
EXPERIMENT: 97013 TEST: 96                                                                                        TIME: 15:27:34    
SPECIES: MICE, P53+/-(C57BL/6)                                                                                                      
TEST TYPE: 26                                       ROUTE: DOSED WATER                                            NTP:  97013J      
CONT: NO1-ES-65406                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE                                                     
                  26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                           
==========================================================================================================                          
WEEK     0 MG/L                 175 MG/L                 350 MG/L                 700 MG/L                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        23.0       10        22.5     97.8    10      23.0    100.0    10      22.8     99.1    10                               
  1        23.0       10        22.5     97.8    10      23.0    100.0    10      22.8     99.1    10                               
  2        23.8       10        23.3     97.9    10      23.0     96.6    10      20.3     85.3    10                               
  3        24.8       10        24.2     97.6    10      24.1     97.2    10      22.8     91.9    10                               
  4        25.5       10        25.4     99.6    10      25.5    100.0    10      24.3     95.3    10                               
  5        26.3       10        26.5    100.8    10      26.0     98.9    10      24.6     93.5    10                               
  6        27.2       10        27.5    101.1    10      26.4     97.1    10      25.0     91.9    10                               
  7        29.1       10        28.9     99.3    10      27.4     94.2    10      25.7     88.3    10                               
  8        29.4       10        29.8    101.4    10      28.2     95.9    10      27.1     92.2    10                               
  9        31.7       10        31.0     97.8    10      28.9     91.2    10      28.2     89.0    10                               
 10        33.5       10        32.3     96.4    10      30.8     91.9    10      29.5     88.1    10                               
 11        34.6       10        32.7     94.5    10      30.9     89.3    10      30.3     87.6    10                               
 12        35.7       10        34.8     97.5    10      32.4     90.8    10      31.7     88.8    10                               
 13        36.8       10        35.1     95.4    10      33.5     91.0    10      31.3     85.1    10                               
 14        37.4       10        36.2     96.8    10      33.9     90.6    10      31.8     85.0    10                               
 15        38.2       10        37.0     96.9    10      34.8     91.1    10      32.9     86.1     9                               
 16        39.3       10        38.0     96.7    10      35.6     90.6    10      33.5     85.2     9                               
 17        40.5       10        39.8     98.3    10      37.0     91.4    10      34.4     84.9     9                               
 18        41.5       10        40.2     96.9    10      38.0     91.6    10      34.5     83.1     9                               
 19        41.3       10        41.3    100.0    10      38.3     92.7    10      35.7     86.4     9                               
 20        41.5       10        41.8    100.7    10      38.9     93.7    10      36.6     88.2     9                               
 21        43.0       10        42.3     98.4    10      39.1     90.9    10      37.2     86.5     9                               
 22        43.7       10        43.5     99.5    10      40.2     92.0    10      36.6     83.8     9                               
 23        44.9       10        43.9     97.8    10      41.5     92.4    10      37.1     82.6     9                               
 24        45.8       10        44.5     97.2    10      41.6     90.8    10      37.6     82.1     9                               
 25        46.0       10        44.6     97.0    10      40.7     88.5    10      36.4     79.1     9                               
 26        46.8       10        44.3     94.7    10      41.1     87.8    10      39.7     84.8     8                               
 27        47.4       10        45.4     95.8    10      41.5     87.6    10      40.4     85.2     8                               
 28        47.9       10        45.8     95.6    10      42.5     88.7    10      39.6     82.7     8                               
 29        48.2       10        46.3     96.1    10      42.9     89.0    10      41.0     85.1     8                               
 30        48.3       10        46.4     96.1    10      41.6     86.1    10      41.4     85.7     8                               
 31        47.2       10        46.2     97.9    10      42.6     90.3    10      40.9     86.7     8                               
 32        47.0       10        46.7     99.4    10      44.3     94.3    10      42.4     90.2     8                               
 33        49.1        9        47.5     96.7    10      44.1     89.8    10      43.0     87.6     8                               
 34        49.8        9        47.7     95.8    10      44.9     90.2    10      44.1     88.6     8                               
 35        50.1        9        47.7     95.2    10      45.3     90.4    10      43.4     86.6     8                               
 36        49.9        9        48.3     96.8    10      45.4     91.0    10      43.0     86.2     8                               
 37        49.7        9        47.2     95.0    10      45.5     91.5    10      44.5     89.5     7                               
 38        50.3        9        48.7     96.8    10      46.5     92.4    10      45.0     89.5     7                               
 39        50.9        9        48.2     94.7    10      46.7     91.7    10      44.5     87.4     7                               
 40        51.0        9        48.5     95.1    10      45.8     89.8    10      44.3     86.9     7                               
 41        51.3        9        48.8     95.1    10      46.1     89.9     9      44.3     86.4     7                               
 42        51.6        9        49.1     95.2    10      45.6     88.4     9      43.7     84.7     7                               
TERM. SAC.             9                         10                        9                        7                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                   
                  26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                           
==========================================================================================================                          
WEEK     0 MG/L                 175 MG/L                 350 MG/L                 700 MG/L                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        18.8       10        18.7     99.5    10      18.4     97.9    10      19.1    101.6    10                               
  1        18.8       10        18.7     99.5    10      18.4     97.9    10      19.1    101.6    10                               
  2        19.5       10        19.6    100.5    10      18.7     95.9    10      19.4     99.5    10                               
  3        20.0       10        20.5    102.5    10      19.5     97.5    10      19.6     98.0    10                               
  4        21.0       10        21.4    101.9    10      20.7     98.6    10      21.5    102.4    10                               
  5        21.3       10        21.5    100.9    10      21.0     98.6    10      21.7    101.9    10                               
  6        22.2       10        22.4    100.9    10      22.0     99.1    10      22.7    102.3    10                               
  7        22.5       10        22.8    101.3    10      21.8     96.9    10      23.1    102.7    10                               
  8        23.0       10        23.5    102.2    10      22.8     99.1    10      23.5    102.2    10                               
  9        23.7       10        23.6     99.6    10      23.3     98.3    10      23.9    100.8     9                               
 10        24.2       10        24.4    100.8    10      23.9     98.8    10      24.9    102.9     9                               
 11        24.0       10        25.1    104.6    10      24.0    100.0    10      24.6    102.5     9                               
 12        23.9       10        25.9    108.4    10      24.3    101.7    10      24.8    103.8     9                               
 13        24.9       10        26.5    106.4    10      25.3    101.6    10      25.3    101.6     9                               
 14        25.6       10        26.9    105.1    10      25.6    100.0    10      26.1    102.0     9                               
 15        25.6       10        27.1    105.9    10      25.6    100.0    10      26.1    102.0     9                               
 16        25.8       10        27.2    105.4    10      26.5    102.7    10      26.4    102.3     9                               
 17        27.0       10        28.4    105.2    10      27.4    101.5    10      27.3    101.1     9                               
 18        27.6       10        29.0    105.1    10      27.8    100.7    10      28.3    102.5     9                               
 19        27.9       10        29.4    105.4    10      28.0    100.4    10      28.9    103.6     9                               
 20        28.7       10        30.6    106.6    10      28.7    100.0    10      28.7    100.0     9                               
 21        28.7       10        30.0    104.5    10      28.4     99.0    10      28.3     98.6     9                               
 22        29.5       10        31.0    105.1    10      29.6    100.3    10      30.0    101.7     9                               
 23        30.4       10        32.1    105.6    10      30.8    101.3    10      31.0    102.0     9                               
 24        30.8       10        32.5    105.5    10      31.2    101.3    10      32.1    104.2     9                               
 25        31.5       10        32.0    101.6    10      30.9     98.1    10      32.0    101.6     9                               
 26        32.1       10        31.9     99.4    10      32.3    100.6    10      32.3    100.6     9                               
 27        32.9       10        31.6     96.0    10      32.8     99.7    10      33.6    102.1     9                               
 28        34.0       10        34.3    100.9     9      33.8     99.4    10      35.3    103.8     9                               
 29        35.3       10        35.3    100.0     9      35.3    100.0    10      35.2     99.7     9                               
 30        36.3       10        36.3    100.0     9      36.5    100.6    10      36.9    101.7     9                               
 31        35.4       10        36.1    102.0     9      36.4    102.8    10      34.5     97.5     9                               
 32        37.0       10        37.3    100.8     9      36.6     98.9    10      34.4     93.0     9                               
 33        37.8       10        37.8    100.0     9      37.4     98.9    10      36.0     95.2     9                               
 34        38.3       10        39.3    102.6     9      39.1    102.1    10      38.6    100.8     8                               
 35        39.0       10        39.7    101.8     9      38.9     99.7    10      39.3    100.8     8                               
 36        39.7       10        40.4    101.8     9      38.9     98.0    10      39.9    100.5     8                               
 37        39.4       10        40.8    103.6     9      38.9     98.7    10      39.5    100.3     8                               
 38        40.8       10        41.4    101.5     9      40.2     98.5    10      39.4     96.6     8                               
 39        41.5       10        42.3    101.9     9      41.2     99.3    10      40.0     96.4     8                               
 40        42.4       10        43.5    102.6     9      41.2     97.2    10      39.7     93.6     8                               
 41        43.6       10        44.2    101.4     9      42.5     97.5    10      39.9     91.5     8                               
 42        44.5        9        43.6     98.0     9      43.9     98.7    10      40.4     90.8     8                               
TERM. SAC.             9                          9                       10                        8                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.