National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20435

TDMS Study 97013-05 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                   WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                            DATE: 05/18/05  
EXPERIMENT: 97013 TEST: 05                                                                                        TIME: 09:03:54    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED WATER                                            NTP:  C97013E     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)             DATE: 05/18/05    
EXPERIMENT: 97013 TEST: 05                                                                                        TIME:  9:10:45    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED WATER                                            NTP:  97013E      
CONT: NO1-ES-65406                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                       SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1     7.7    23.1       2.1     22.6    0.27       16      1.4     22.6    0.18       21      1.1     22.7    0.14       34       
  2     4.6    24.6       2.7     24.1    0.59       20      2.6     23.2    0.57       39      1.7     20.8    0.37       57       
  3     5.9    26.1       3.1     25.7    0.53       21      2.8     25.0    0.47       40      2.1     23.9    0.36       61       
  4     4.4    26.8       3.1     26.7    0.70       20      2.9     25.8    0.66       39      2.4     25.9    0.55       65       
  5     4.8    27.8       3.2     27.7    0.67       20      2.8     27.3    0.58       36      2.4     26.5    0.50       63       
  6     5.3    29.4       3.2     28.9    0.60       19      2.8     28.1    0.53       35      2.4     27.3    0.45       61       
  7     4.8    30.0       3.6     29.4    0.75       22      3.0     28.6    0.63       36      2.9     27.4    0.60       74       
  8     5.0    30.2       3.8     29.9    0.76       22      3.4     28.9    0.68       41      2.6     28.1    0.52       65       
  9     4.7    31.0       4.0     30.5    0.85       23      3.4     29.5    0.72       40      2.7     28.7    0.57       65       
 10     4.9    32.0       3.7     31.1    0.76       21      3.0     30.1    0.61       35      2.7     29.3    0.55       65       
 11     5.2    32.8       3.8     31.4    0.73       21      3.2     30.0    0.62       37      2.6     30.2    0.50       61       
 12     6.0    32.6       4.3     32.2    0.72       23      3.2     30.6    0.53       36      2.6     30.7    0.43       60       
 13     4.7    34.2       4.2     33.1    0.89       22      3.3     31.4    0.70       37      2.7     31.8    0.57       60       
 14     5.3    34.9       4.0     33.5    0.75       21      3.1     31.6    0.58       34      2.7     32.1    0.51       59       
 15     5.2    35.2       4.1     33.6    0.79       21      3.6     31.3    0.69       41      2.8     32.1    0.54       62       
 16     4.6    35.7       3.7     34.5    0.80       19      3.1     31.9    0.67       34      2.8     33.1    0.61       59       
 17     4.6    35.8       4.1     34.7    0.89       21      3.5     32.0    0.76       39      3.1     32.8    0.67       66       
 18     5.3    35.9       4.3     35.0    0.81       22      3.6     32.1    0.68       39      3.2     33.1    0.60       68       
 19     5.0    35.6       4.0     34.6    0.80       20      3.6     32.7    0.72       38      2.8     32.9    0.56       60       
 20     5.0    36.9       3.9     35.4    0.78       19      3.4     33.5    0.68       35      3.1     32.7    0.62       65       
 21     5.3    37.6       4.1     36.4    0.77       20      3.7     34.7    0.70       38      3.1     32.6    0.58       66       
 22     4.9    38.4       3.9     37.9    0.80       18      3.4     34.9    0.69       34      3.0     33.2    0.61       64       
 23     4.3    39.2       3.8     38.7    0.88       17      3.5     35.6    0.81       34      2.9     34.9    0.67       59       
 24     4.6    39.6       4.1     39.9    0.89       18      3.6     35.9    0.78       35      2.9     36.2    0.63       55       
 25     4.8    40.2       3.9     40.2    0.81       17      3.6     37.3    0.75       34      2.9     35.9    0.60       56       
 26     4.1    41.0       3.7     40.4    0.90       16      3.6     38.3    0.88       33      2.9     36.5    0.71       55       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.2    29.3       3.4     28.7    0.68       21      2.9     27.8    0.58       36      2.4     27.2    0.47       61       
SD(D)   0.9               0.6             0.16        2      0.5             0.14        5      0.5             0.13        9       
CV(E)  17.1              18.1            23.3       8.8     18.1            24.1      13.5     20.8            26.6      14.8       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.8    37.4       4.0     36.5    0.82       19      3.5     34.0    0.72       36      2.9     33.7    0.61       61       
SD(D)   0.4               0.2             0.05        2      0.2             0.07        3      0.1             0.06        4       
CV(E)   8.0               4.8             6.2       9.9      5.4            10.2       7.0      4.9             9.1       7.1       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                  
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                           
==========================================                                                                                          
                      TPA                                                                                                           
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       WATER/   WEIGHT  WATER (B)  DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1                                                                                                                                 
  2     6.9     22.6     1.50     382                                                                                               
  3     7.2     24.2     1.22     371                                                                                               
  4     5.6     25.2     1.27     277                                                                                               
  5     5.8     26.3     1.21     273                                                                                               
  6     6.1     26.8     1.15     286                                                                                               
  7     5.6     27.2     1.17     258                                                                                               
  8                                                                                                                                 
  9     6.5     28.4     1.38     288                                                                                               
 10     5.6     29.2     1.14     239                                                                                               
 11     7.7     29.1     1.48     329                                                                                               
 12                                                                                                                                 
 13     5.6     30.0     1.19     233                                                                                               
 14     7.8     30.3     1.47     322                                                                                               
 15                                                                                                                                 
 16                                                                                                                                 
 17                                                                                                                                 
 18                                                                                                                                 
 19                                                                                                                                 
 20                                                                                                                                 
 21                                                                                                                                 
 22                                                                                                                                 
 23                                                                                                                                 
 24                                                                                                                                 
 25                                                                                                                                 
 26                                                                                                                                 
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    6.3     26.9     1.27     293                                                                                               
SD(D)   0.8              0.13      51                                                                                               
CV(E)  12.2             10.6     17.5                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    7.8     30.3     1.47     322                                                                                               
SD(D)                                                                                                                               
CV(E)                                                                                                                               
==========================================                                                                                          
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                       SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    
==================================================================================================================================  
           0 MG/L                     175 MG/L                           350 MG/L                           700 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  1                       2.7     19.1               24      1.5     19.0               28      1.5     18.9               55       
  2     6.0    20.0       3.4     20.3     0.57      29      3.1     20.2     0.52      54      3.6     20.2     0.60     126       
  3     6.6    21.2       4.1     21.4     0.62      33      4.3     21.3     0.65      70      5.0     21.4     0.76     163       
  4     6.0    22.3       4.0     22.3     0.67      32      4.6     22.3     0.77      72      4.3     22.3     0.72     135       
  5     4.9    23.2       4.2     23.1     0.86      32      4.1     22.7     0.84      64      4.1     22.7     0.84     128       
  6     6.6    24.2       4.3     24.1     0.65      31      4.6     23.6     0.70      68      4.8     23.8     0.73     140       
  7     6.6    24.6       4.6     24.3     0.70      33      4.8     23.9     0.73      71      4.6     23.8     0.70     135       
  8                       4.8     24.7               34      5.0     24.4               71      4.9     24.0              142       
  9     5.8    24.8       5.1     25.8     0.88      35      4.9     24.8     0.84      70      4.8     25.0     0.83     136       
 10     5.8    25.4       5.3     25.6     0.91      36      5.0     25.1     0.86      69      5.2     25.3     0.90     145       
 11     5.1    24.5       4.9     27.1     0.96      32      4.8     25.5     0.94      65      5.3     25.8     1.04     144       
 12     6.3    25.3       4.9     27.2     0.78      32      4.9     26.2     0.78      65      5.4     26.2     0.86     145       
 13     4.8    26.3       5.1     28.2     1.06      32      4.7     26.7     0.98      62      5.3     26.8     1.10     138       
 14     6.4    26.4       5.2     28.5     0.81      32      4.8     26.9     0.75      62      5.0     26.8     0.78     131       
 15     5.6    26.6       5.5     29.0     0.98      33      4.9     27.8     0.88      61      5.4     27.9     0.96     136       
 16     4.9    27.6       5.9     29.5     1.20      35      4.9     28.0     1.00      61      5.8     28.1     1.18     144       
 17     5.3    27.0       5.6     29.1     1.06      34      4.8     27.8     0.91      61      5.4     28.2     1.02     135       
 18     6.2    27.5       6.0     30.4     0.97      34      4.7     27.8     0.76      60      5.5     28.4     0.89     137       
 19     5.5    27.9       5.5     30.5     1.00      32      4.9     29.0     0.89      59      5.5     28.6     1.00     135       
 20     5.3    29.3       5.0     31.0     0.94      28      4.7     29.8     0.89      55      5.1     29.5     0.96     120       
 21     5.7    29.2       4.8     31.6     0.84      26      5.1     29.9     0.89      60      5.3     30.1     0.93     124       
 22     4.8    29.5       5.0     31.9     1.04      27      4.8     30.7     1.00      54      5.0     30.7     1.04     115       
 23     4.8    29.9       5.1     33.1     1.06      27      4.4     31.8     0.92      49      5.4     31.2     1.13     120       
 24     4.8    30.2       5.3     33.9     1.10      28      5.1     32.1     1.06      55      5.2     32.5     1.08     112       
 25     5.0    28.5       5.0     34.6     1.00      25      4.9     33.5     0.98      51      5.3     32.9     1.06     113       
 26     4.9    29.9       5.2     34.9     1.06      26      5.0     33.9     1.02      52      5.2     33.2     1.06     109       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.9    23.8       4.4     24.1     0.79      32      4.3     23.5     0.78      64      4.5     23.6     0.82     133       
SD(D)   0.7               0.8              0.16       3      1.0              0.13      12      1.0              0.15      25       
CV(E)  11.2              17.2             20.2      8.8     22.7             16.9     18.5     23.1             18.1     18.8       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.3    28.4       5.3     31.4     1.01      30      4.8     29.9     0.92      57      5.3     29.8     1.01     126       
SD(D)   0.5               0.4              0.10       4      0.2              0.09       4      0.2              0.11      11       
CV(E)  10.0               7.0             10.3     11.9      3.7             10.3      7.8      4.1             10.5      9.0       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                
SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                                           
==========================================                                                                                          
                      TPA                                                                                                           
       ---------------------------------                                                                                            
                         DOSE/                                                                                                      
       GRAMS    BODY    CONTROL                                                                                                     
       WATER/   WEIGHT  WATER (B)  DOSE/                                                                                            
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                                                            
==========================================                                                                                          
  1                                                                                                                                 
  2     4.7     19.3     0.78     307                                                                                               
  3     8.1     20.2     1.23     500                                                                                               
  4     5.9     21.8     0.98     337                                                                                               
  5     5.7     22.9     1.16     309                                                                                               
  6     6.9     23.1     1.05     371                                                                                               
  7     6.0     23.5     0.91     322                                                                                               
  8     6.0     23.8              316                                                                                               
  9     5.6     24.0     0.97     293                                                                                               
 10     5.6     24.5     0.97     286                                                                                               
 11     6.1     24.4     1.20     313                                                                                               
 12     5.7     24.6     0.90     288                                                                                               
 13     6.6     25.4     1.38     326                                                                                               
 14     6.7     25.4     1.05     331                                                                                               
 15     7.1     25.2     1.27     350                                                                                               
 16     7.7     25.4     1.57     379                                                                                               
 17                                                                                                                                 
 18                                                                                                                                 
 19     7.4     26.7     1.35     347                                                                                               
 20     6.8     26.8     1.28     319                                                                                               
 21                                                                                                                                 
 22                                                                                                                                 
 23                                                                                                                                 
 24                                                                                                                                 
 25                                                                                                                                 
 26                                                                                                                                 
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    6.1     23.1     1.05     331                                                                                               
SD(D)   0.8              0.17      58                                                                                               
CV(E)  13.6             16.6     17.6                                                                                               
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    7.2     25.9     1.30     345                                                                                               
SD(D)   0.4              0.19      23                                                                                               
CV(E)   5.6             14.4      6.6                                                                                               
==========================================                                                                                          
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                            
                      SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                     
==================================================================================================================================  
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                   TPA                 
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM     
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS    
=================================================================================================================================== 
  B               23.1  15                 22.6  15                 22.6  15                 22.7  15                 21.4  15      
  1   7.7   357   23.1  15     2.1  1035   22.6  15     1.4  1035   22.6  15     1.1  1031   22.7  15     4.8   213   21.4  15      
  2   4.6  1013   24.6  15     2.7  2520   24.1  15     2.6  2416   23.2  15     1.7  2475   20.8  15     6.9   299   22.6  15      
  3   5.9  1364   26.1  15     3.1  2485   25.7  15     2.8  2487   25.0  15     2.1  2500   23.9  15     7.2  1231   24.2  15      
  4   4.4  1466   26.8  15     3.1  2570   26.7  15     2.9  2575   25.8  15     2.4  2565   25.9  15     5.6   474   25.2  15      
  5   4.8  1160   27.8  15     3.2  2413   27.7  15     2.8  2390   27.3  15     2.4  1937   26.5  15     5.8   684   26.3  15      
  6   5.3   527   29.4  15     3.2  2460   28.9  15     2.8  2512   28.1  15     2.4  1918   27.3  15     6.1   276   26.8  15      
  7   4.8   448   30.0  15     3.6  2580   29.4  15     3.0  2509   28.6  15     2.9  2406   27.4  15     5.6   396   27.2  15      
  8   5.0   418   30.2  15     3.8  2296   29.9  15     3.4  2294   28.9  15     2.6  2366   28.1  15     6.4    94   27.5  15      
  9   4.7   452   31.0  15     4.0  2366   30.5  15     3.4  2536   29.5  15     2.7  2310   28.7  15     6.5   300   28.4  15      
 10   4.9   374   32.0  15     3.7  2283   31.1  15     3.0  2535   30.1  15     2.7  2490   29.3  15     5.6   187   29.2  14      
 11   5.2   513   32.8  15     3.8  2206   31.4  15     3.2  2545   30.0  15     2.6  2550   30.2  15     7.7   198   29.1  12      
 12   6.0   562   32.6  15     4.3  2145   32.2  14     3.2  2381   30.6  15     2.6  2475   30.7  15     6.5    27   28.2   7      
 13   4.7   759   34.2  15     4.2  2347   33.1  14     3.3  2418   31.4  15     2.7  2513   31.8  15     5.6    71   30.0   5      
 14   5.3   530   34.9  15     4.0  2128   33.5  14     3.1  2176   31.6  15     2.7  2545   32.1  15     7.8    96   30.3   3      
 15   5.2   487   35.2  15     4.1  2227   33.6  14     3.6  2260   31.3  15     2.8  2500   32.1  15                               
 16   4.6  1529   35.7  15     3.7  2000   34.5  13     3.1  2289   31.9  15     2.8  2532   33.1  15                               
 17   4.6  1543   35.8  15     4.1  2086   34.7  13     3.5  2253   32.0  15     3.1  2465   32.8  15                               
 18   5.3   852   35.9  15     4.3  2087   35.0  13     3.6  2016   32.1  15     3.2  2440   33.1  15                               
 19   5.0   844   35.6  15     4.0  2216   34.6  13     3.6  2565   32.7  15     2.8  2461   32.9  15                               
 20   5.0   906   36.9  14     3.9  1850   35.4  13     3.4  2275   33.5  15     3.1  2200   32.7  15                               
 21   5.3   913   37.6  14     4.1  2028   36.4  12     3.7  2270   34.7  14     3.1  2511   32.6  15                               
 22   4.9  1364   38.4  14     3.9  2004   37.9  12     3.4  2243   34.9  14     3.0  2410   33.2  15                               
 23   4.3  1303   39.2  14     3.8  2040   38.7  12     3.5  2380   35.6  14     2.9  2370   34.9  14                               
 24   4.6   768   39.6  13     4.1  1992   39.9  12     3.6  2085   35.9  14     2.9  2259   36.2  14                               
 25   4.8  1181   40.2  13     3.9  1978   40.2  12     3.6  1883   37.3  12     2.9  2310   35.9  14                               
 26   4.1  1769   41.0  13     3.7  2023   40.4  12     3.6  2028   38.3  12     2.9  2308   36.5  14                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           29.3                     28.7                     27.8                     27.2                     26.6          
14 TO 52          37.4                     36.5                     34.0                     33.7                     30.3          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                          
                      SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                     
==================================================================================================================================  
           0 MG/L                  175 MG/L                 350 MG/L                 700 MG/L                   TPA                 
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM     
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS    
=================================================================================================================================== 
  B               19.2  15                 19.1  15                 19.0  15                 18.9  15                 18.4  15      
  1   6.6   178   19.2  15     2.7  1030   19.1  15     1.5  1040   19.0  15     1.5   973   18.9  15     6.3    96   18.4  15      
  2   6.0   775   20.0  15     3.4  2118   20.3  15     3.1  2391   20.2  15     3.6  2330   20.2  15     4.7   360   19.3  15      
  3   6.6  1081   21.2  15     4.1  2257   21.4  15     4.3  2500   21.3  15     5.0  2228   21.4  15     8.1  1275   20.2  15      
  4   6.0  1026   22.3  15     4.0  2175   22.3  15     4.6  2490   22.3  15     4.3  2396   22.3  15     5.9   788   21.8  15      
  5   4.9   819   23.2  15     4.2  1983   23.1  15     4.1  2182   22.7  15     4.1  2051   22.7  15     5.7   633   22.9  15      
  6   6.6   265   24.2  15     4.3  2014   24.1  15     4.6  2004   23.6  14     4.8  1986   23.8  15     6.9   310   23.1  15      
  7   6.6   219   24.6  15     4.6  1823   24.3  15     4.8  1894   23.9  14     4.6  1825   23.8  15     6.0   245   23.5  15      
  8   4.4   163   24.5  15     4.8  1332   24.7  15     5.0  1569   24.4  14     4.9  1448   24.0  15     6.0   251   23.8  15      
  9   5.8   211   24.8  14     5.1  1625   25.8  15     4.9  1943   24.8  14     4.8  1771   25.0  15     5.6   470   24.0  15      
 10   5.8   167   25.4  13     5.3  1960   25.6  15     5.0  1924   25.1  14     5.2  1625   25.3  15     5.6   404   24.5  15      
 11   5.1   296   24.5  13     4.9  1851   27.1  15     4.8  1673   25.5  14     5.3  2089   25.8  15     6.1   489   24.4  13      
 12   6.3   293   25.3  13     4.9  1251   27.2  13     4.9  1554   26.2  14     5.4  1437   26.2  15     5.7   190   24.6  10      
 13   4.8   240   26.3  13     5.1  1770   28.2  13     4.7  1529   26.7  14     5.3  1646   26.8  15     6.6   263   25.4   5      
 14   6.4   554   26.4  13     5.2  1523   28.5  13     4.8  2010   26.9  14     5.0  2172   26.8  15     6.7   361   25.4   5      
 15   5.6   426   26.6  13     5.5  1596   29.0  13     4.9  2005   27.8  14     5.4  2194   27.9  15     7.1   286   25.2   3      
 16   4.9   960   27.6  13     5.9  1256   29.5  13     4.9  2043   28.0  14     5.8  1977   28.1  15     7.7    97   25.4   3      
 17   5.3   794   27.0  11     5.6  1313   29.1  13     4.8  1652   27.8  14     5.4  1864   28.2  15                 25.2   2      
 18   6.2   548   27.5  11     6.0  1247   30.4  13     4.7  1820   27.8  14     5.5  1512   28.4  15                 27.5   2      
 19   5.5   588   27.9  11     5.5  1648   30.5  13     4.9  1943   29.0  13     5.5  2287   28.6  15     7.4   270   26.7   2      
 20   5.3   941   29.3  11     5.0  1694   31.0  13     4.7  2032   29.8  13     5.1  2250   29.5  15     6.8   336   26.8   2      
 21   5.7   653   29.2  11     4.8  1545   31.6  13     5.1  1954   29.9  13     5.3  2268   30.1  15                               
 22   4.8   961   29.5  10     5.0  1742   31.9  13     4.8  1768   30.7  13     5.0  1933   30.7  15                               
 23   4.8   759   29.9  10     5.1  1794   33.1  13     4.4  1790   31.8  13     5.4  2016   31.2  15                               
 24   4.8   748   30.2  10     5.3  1641   33.9  13     5.1  1752   32.1  13     5.2  1657   32.5  14                               
 25   5.0   706   28.5  10     5.0  1553   34.6  13     4.9  1390   33.5  11     5.3  1746   32.9  13                               
 26   4.9   967   29.9  10     5.2  1769   34.9  13     5.0  1509   33.9  11     5.2  1696   33.2  13                               
 27   4.0   713                5.4  1170                4.9   878                4.7   977                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.5                     24.1                     23.5                     23.6                     22.8          
14 TO 52          28.4                     31.4                     29.9                     29.8                     26.0          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.