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TDMS Study 88004-05 Pathology Tables

                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 07/14/05       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 13:30:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
Rats(F 344)                                                                                                                         
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Kidney                                                                             
                                                 Kidney, Renal Tubule (Step Section)                                                
                                                 Kidney, Renal Tubule (Step and Original Sections)                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                      DIVINYLBENZENE                                    DATE: 07/14/05       
EXPERIMENT: 88004 TEST: 05                                                                                     TIME: 13:30:09       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 88004B       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 1321-74-0       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                     DIVINYLBENZENE                                                                               
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney, Renal Tubule (Step Section)    Hyperplasia                                                                                  
                                       Hyperplasia and Adenoma                                                                      
                                       Hyperplasia, Carcinoma or Adenoma                                                            
Kidney, Renal Tubule (Step and Original Sections)                                                                                   
                                       Carcinoma                                                                                    
                                       Carcinoma and Adenoma                                                                        
                                       Hyperplasia                                                                                  
                                       Hyperplasia and Adenoma                                                                      
                                       Hyperplasia, Carcinoma or Adenoma                                                            
Kidney: Renal Tubule                   Carcinoma                                                                                    
===============================================================                                                                     
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 1       
                     Statistical Analysis of Primary Tumors in Rats(F 344)        -                      DIVINYLBENZENE             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step Section)                                                                                              | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      2/44.46      1/44.04     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          619          708         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      (e)          P=0.249      P=0.517     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.249      (e)          P=0.244      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247      (e)          P=0.240      P=0.501     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.248      (e)          P=0.249      P=0.507     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.238      P=0.503     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      (e)          P=0.247      P=0.495     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step Section)                                                                                              | 
|     Carcinoma and Adenoma                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      2/44.46      1/44.04     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          619          708         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      (e)          P=0.249      P=0.517     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.249      (e)          P=0.244      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247      (e)          P=0.240      P=0.501     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.248      (e)          P=0.249      P=0.507     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.238      P=0.503     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      (e)          P=0.247      P=0.495     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 2       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step Section)                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    5/50 (10%)   14/49 (29%) |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.15      3/45.37      5/45.22      14/44.97    |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         6.6%         11.1%        31.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    3/35 (9%)    2/32 (6%)    10/32 (31%) |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.556      P=0.237      P=0.002 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.523      P=0.235      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.509      P=0.225      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.540      P=0.250      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.556      P=0.217      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.490      P=0.218      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step Section)                                                                                              | 
|     Hyperplasia and Adenoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    7/50 (14%)   14/49 (29%) |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.15      3/45.37      7/45.61      14/44.97    |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         6.6%         15.4%        31.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    3/35 (9%)    3/32 (9%)    10/32 (31%) |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.556      P=0.097      P=0.002 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.523      P=0.092      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.509      P=0.085      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.540      P=0.103      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.556      P=0.081      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.490      P=0.080      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 3       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step Section)                                                                                              | 
|     Hyperplasia, Carcinoma or Adenoma                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/49 (6%)    7/50 (14%)   14/49 (29%) |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.15      3/45.37      7/45.61      14/44.97    |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     4.6%         6.6%         15.4%        31.1%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/31 (7%)    3/35 (9%)    3/32 (9%)    10/32 (31%) |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.556      P=0.097      P=0.002 **  |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P<0.001 **   P=0.523      P=0.092      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P<0.001 **   P=0.509      P=0.085      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P<0.001 **   P=0.540      P=0.103      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.556      P=0.081      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.490      P=0.080      P<0.001 **  |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    1/49 (2%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      2/44.46      1/44.04     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    0/32 (0%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          619          708         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.250      (e)          P=0.249      P=0.517     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.249      (e)          P=0.244      P=0.504     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247      (e)          P=0.240      P=0.501     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.248      (e)          P=0.249      P=0.507     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.240      (e)          P=0.238      P=0.503     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.242      (e)          P=0.247      P=0.495     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 4       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      2/44.14     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          682         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.252     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.246     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.046 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Carcinoma and Adenoma                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    2/50 (4%)    3/49 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      2/44.46      3/44.22     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.5%         6.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    1/32 (3%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          619          682         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    (e)          P=0.249      P=0.136     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.027 *    (e)          P=0.244      P=0.123     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.027 *    (e)          P=0.240      P=0.120     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.027 *    (e)          P=0.249      P=0.126     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.027 *    (e)          P=0.238      P=0.122     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.027 *    (e)          P=0.247      P=0.117     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.038 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 5       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   5/50 (10%)   15/49 (31%) |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.15      5/45.37      5/45.22      15/45.18    |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     7.0%         11.0%        11.1%        33.2%       |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   5/35 (14%)   2/32 (6%)    10/32 (31%) |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.423      P=0.379      P=0.004 **  |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P<0.001 **   P=0.384      P=0.382      P=0.002 **  |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P<0.001 **   P=0.368      P=0.368      P<0.001 **  |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P<0.001 **   P=0.406      P=0.402      P=0.002 **  |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.423      P=0.356      P=0.002 **  |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.346      P=0.357      P<0.001 **  |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Hyperplasia and Adenoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   7/50 (14%)   15/49 (31%) |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.15      5/45.37      7/45.61      15/45.18    |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     7.0%         11.0%        15.4%        33.2%       |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   5/35 (14%)   3/32 (9%)    10/32 (31%) |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.423      P=0.181      P=0.004 **  |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P<0.001 **   P=0.384      P=0.180      P=0.002 **  |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P<0.001 **   P=0.368      P=0.168      P<0.001 **  |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P<0.001 **   P=0.406      P=0.198      P=0.002 **  |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.423      P=0.159      P=0.002 **  |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.346      P=0.159      P<0.001 **  |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 6       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney, Renal Tubule (Step and Original Sections)                                                                                | 
|     Hyperplasia, Carcinoma or Adenoma                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    5/49 (10%)   7/50 (14%)   17/49 (35%) |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.15      5/45.37      7/45.61      17/45.36    |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     7.0%         11.0%        15.4%        37.5%       |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/31 (10%)   5/35 (14%)   3/32 (9%)    11/32 (34%) |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      578          569         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.423      P=0.181      P<0.001 **  |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P<0.001 **   P=0.384      P=0.180      P<0.001 **  |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P<0.001 **   P=0.368      P=0.168      P<0.001 **  |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P<0.001 **   P=0.406      P=0.198      P<0.001 **  |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.423      P=0.159      P<0.001 **  |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.346      P=0.159      P<0.001 **  |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.15      0/45.37      0/44.07      2/44.14     |0/42.30      0/43.50      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/35 (0%)    0/32 (0%)    1/32 (3%)   |0/33 (0%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          682         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.252     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.246     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.046 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 7       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.37      0/44.07      2/44.25     |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         4.5%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    0/32 (0%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          674         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.543      P=0.494N     P=0.528     |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P=0.476      P=0.518      P=0.496N     P=0.509     |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P=0.472      P=0.507      P=0.499N     P=0.503     |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P=0.480      P=0.531      P=0.492N     P=0.515     |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.470      P=0.543      (e)          P=0.503     |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.465      P=0.492      P=0.500N     P=0.492     |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.418      (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia and Adenoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    2/49 (4%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.37      0/44.07      2/44.25     |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         4.5%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    0/32 (0%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          674         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.476      P=0.543      P=0.494N     P=0.528     |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P=0.476      P=0.518      P=0.496N     P=0.509     |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P=0.472      P=0.507      P=0.499N     P=0.503     |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P=0.480      P=0.531      P=0.492N     P=0.515     |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.470      P=0.543      (e)          P=0.503     |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.465      P=0.492      P=0.500N     P=0.492     |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.418      (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  07/14/05                           EXPERIMENT: 88004 TEST: 05                                            Page 8       
                     Statistical Analysis of Primary Tumors in Rats(F 344)       -                      DIVINYLBENZENE              
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      100 PPM      200 PPM      400 PPM     |CONTROL      100 PPM      200 PPM      400 PPM      | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia, Carcinoma or Adenoma                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    4/49 (8%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.15      2/45.37      0/44.07      4/44.43     |1/42.30      1/43.64      0/43.33      0/37.73      | 
|POLY-3 PERCENT (g) |     2.3%         4.4%         0.0%         9.0%        |2.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/31 (3%)    2/35 (6%)    0/32 (0%)    1/32 (3%)   |1/33 (3%)    0/30 (0%)    0/33 (0%)    0/22 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          674         |731 (T)      696          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.112      P=0.543      P=0.494N     P=0.207     |P=0.283N     P=0.750      P=0.500N     P=0.581N     | 
|POLY 3             |     P=0.108      P=0.518      P=0.496N     P=0.187     |P=0.237N     P=0.754N     P=0.495N     P=0.523N     | 
|POLY 1.5           |     P=0.107      P=0.507      P=0.499N     P=0.182     |P=0.238N     P=0.756N     P=0.498N     P=0.512N     | 
|POLY 6             |     P=0.110      P=0.531      P=0.492N     P=0.194     |P=0.234N     P=0.755N     P=0.493N     P=0.542N     | 
|LOGISTIC REGRESSION|     P=0.107      P=0.543      (e)          P=0.182     |P=0.256N     P=0.758N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.105      P=0.492      P=0.500N     P=0.175     |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.079      (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).