National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17651

TDMS Study 88004-05 Pathology Tables

NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00

                                                         FINAL #1 RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  1321-74-0

       Lock Date:  04/16/02

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                            2  1        2                 3               |             
      Hepatodiaphragmatic Nodule           |                               4  4                                       |             
      Vacuolization Cytoplasmic            | 2     3                                                        2         |             
      Periportal, Inflammation, Chronic    |    2                                                                     |             
      Portal, Bile Stasis                  |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +           +           +  +     +        +  +|             
      Necrosis                             |                            3           3           3  3     3        3  3|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Pharyngeal, Ulcer                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                     3                          1         |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            | 1              4                       2  4           1        1        2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 2           4            |             
      Pars Distalis, Angiectasis           |                   3                                                      |             
      Pars Distalis, Hyperplasia           |                   3                             3                        |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Cyst                                 |             4                                                            |             
      Hyperplasia                          |                                     3                                    |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    4              4                                                      |             
      Bilateral, Cyst                      |                                                                         3|             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia             |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +           +  +         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  M  M  M  +  M  M  M  M  M  M  M  +  M  M  +  M  M  M  M  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  M  M  +  +  M  +  +  M  M  M  M  +  +  +  M  +  +  +  M  +  M|             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                        X     X                           |             
      Fibrosis                             |    3                       3           3                                 |             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +  +            |             
      Necrosis                             |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3           4                             2                       4      |             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                             +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          4               |             
      Hemorrhage                           |                                                       2                  |             
      Infiltration Cellular, Histiocyte    |                                                          4               |             
      Inflammation, Chronic, Diffuse       |                                                          3               |             
      Inflammation, Chronic, Focal         |    1        1  1     1     1  1  1  1     1                       1     1|             
      Alveolar Epithelium, Hyperplasia     |          2                                         1                     |             
      Alveolar Epithelium, Hypertrophy     |                                                 1                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               | 1           1                                         1              1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Mediastinum, Necrosis, Fatty         |                                                          4               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                          3               |             
      Inflammation, Suppurative            |                      3                                   2     1         |             
      Ulcer                                |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      3   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3              1  2                    1           1  2  1               |             
      Olfactory Epithelium, Regeneration,  |                                                                          |             
           Focal                           |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 3                                                              1         |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Cornea, Inflammation                 |                                                                      2   |             
      Lens, Cataract                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      4   |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1     3  1              2                          1  2  1     1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 6| 5| 5| 7|             
                             DAY ON TEST   | 1| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| 8| 4| 1| 3|             
                                           | 6| 3| 7| 3| 3| 2| 2| 2| 5| 2| 2| 3| 2| 2| 2| 3| 3| 2| 7| 2| 2| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Cortex, Renal Tubule, Hyperplasia    |          3                                                               |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                2         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Mineralization                  |                                                                2         |             
      Renal Tubule, Dilatation             |          4                                                               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                            2                                             |      5  2.0|
      Hepatodiaphragmatic Nodule           |                            4              4        4                     |      5  4.0|
      Vacuolization Cytoplasmic            |                                                                         1|      4  2.0|
      Periportal, Inflammation, Chronic    |    2                             3                                       |      3  2.3|
      Portal, Bile Stasis                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +        +     +        +           +  +              +           +   |  15        |
      Necrosis                             |    3        3              3           3  3              3           3   |     14  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                         +                                                |   1        |
      Pharyngeal, Ulcer                    |                         4                                                |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             1                                                            |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Hyperplasia              |                                                       2                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
      Epithelium, Hyperplasia              |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |       2     1              2        1                 4           1     1|     14  1.9|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    4                             4  4                          3         |      6  3.5|
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                    3                    3|      4  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                        2                                 |      1  2.0|
      C-Cell, Hyperplasia                  |                3                             3              2        4   |      5  2.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     3              4                     |      3  3.7|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                     3              4                     |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    4              2                                                     4|      5  3.6|
      Bilateral, Cyst                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia             |                            3                                             |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                      +                 +               |   6        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M|   8        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |             2                                                            |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  +  +  M  M|  32        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |                         3                                                |      2  3.0|
      Inflammation, Suppurative            |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      2     |
      Fibrosis                             |                                                                          |      3  3.0|
      Hemorrhage                           | 4                                                        3               |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                   3        3                          4           2  3   |      9  3.1|
      Hemorrhage                           |                   1                    1                                 |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epiglottis, Metaplasia, Squamous     |                                                                         2|      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         | 1  1  2  2  1  2        1     1     2     1  1  1  2  2        1     2   |     27  1.3|
      Alveolar Epithelium, Hyperplasia     |                                                 4           2            |      4  2.3|
      Alveolar Epithelium, Hypertrophy     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |          2                                1  1                    1      |      8  1.1|
      Mediastinum, Necrosis, Fatty         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                         4                                            2   |      5  2.4|
      Ulcer                                |                         4                                                |      1  4.0|
      Goblet Cell, Hyperplasia             |                                        2                                 |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    1                                                     2               |      3  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                   1        2                 1                           |     10  1.5|
      Olfactory Epithelium, Regeneration,  |                                                                          |            |
           Focal                           |                                              1                           |      1  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          1                                      2                 2      |      5  1.8|
      Respiratory Epithelium, Hyperplasia  |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 4| 6| 7| 4| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 0| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 1| 2| 2| 2| 1| 1| 2| 7| 5| 2| 6| 1| 1| 2| 1| 1| 3| 4| 2| 1| 2| 3| 3| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Cornea, Inflammation                 |                                                                          |      1  2.0|
      Lens, Cataract                       |                               4                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |          2  1     1                          1  3     1           2     1|     19  1.4|
      Cortex, Renal Tubule, Hyperplasia    |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Mineralization                  |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia |                                                             4            |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Epithelium, Metaplasia, Focal,       |                                                                          |             
          Squamous                         |                                           3                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                X                    3                    X        3      |             
      Hepatodiaphragmatic Nodule           |    4                                         4              4     4     4|             
      Vacuolization Cytoplasmic            |                                                                          |             
      Hepatocyte, Regeneration             |                4                                                         |             
      Periportal, Inflammation, Chronic    |                2                                                         |             
      Portal, Bile Stasis                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +     +        +  +              +        +        +  +        +     +|             
      Necrosis                             |    3     3        3  3              3        3        3  3        3     3|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Acinus, Atrophy                      |                         1                                                |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Ulcer                                |                                                             3            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2                                                                        |             
      Necrosis                             |                                                             4            |             
      Vacuolization Cytoplasmic            |                      2                 2     1                           |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               3                                3     1   |             
      Pars Distalis, Hyperplasia           |                                        3                    2  4        3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   2     1                             3        1         |             
      Follicular Cell, Hyperplasia         |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 4                        |             
      Inflammation, Chronic                |                                                                2         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                4  2                          4  3                        |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Endometrium, Hyperplasia             |          2                                                               |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
      Inflammation, Suppurative            |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +     +        +        +     +                                 |             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |          3                             3                                 |             
      Pancreatic, Pigmentation             |                4                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  +  M  M  M  +  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M|             
      Infiltration Cellular, Histiocyte    |                                              3                           |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                             X            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hemorrhage                           |                               4                                          |             
      Hyperplasia, Focal, Lymphoid         |                3                                                         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                           2                              |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            4                                             |             
      Hyperkeratosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Fracture                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                              3     2  2           3      |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                      4                             4                     |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +                                                         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                +                          I                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       1                                                                  |             
      Inflammation, Chronic, Focal         |    1                    2  1     2     2     2     1  1     2  3  2     1|             
      Alveolar Epithelium, Hyperplasia     |                         1                    2                           |             
      Alveolar Epithelium, Hypertrophy     | 1                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |                1                             2              1            |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             1     2                    3                                2|             
      Inflammation, Suppurative            |    1        2  2                 2     2              3     2        1   |             
      Glands, Dilatation                   |          2  1        2     1                             1     2  2  1  1|             
      Goblet Cell, Hyperplasia             |             2                    2                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1        1  1                 1                 1  1               |             
      Olfactory Epithelium, Degeneration   | 2  1  1  2  2  1  2  1  2  1  1  2  2  1  1  2  2  2  2  1  2  2  2  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 1        1  1        1     1  1     1     1  1  1           1  1  2  1   |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                               2                                         2|             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                   +                                                      |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Ciliary Body, Inflammation           |                                                                          |             
      Lens, Cataract                       |                                                 3              4        1|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 4| 9| 3| 4| 3| 3| 1| 8| 3| 3| 7| 3| 1| 8| 3| 3| 3| 3|             
                                           | 3| 2| 2| 2| 1| 2| 3| 2| 6| 3| 2| 1| 2| 5| 7| 3| 2| 0| 2| 7| 8| 2| 3| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |       1  1     2                             2     1  1           1  1   |             
      Cortex, Renal Tubule, Hyperplasia    |                         1                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Metaplasia, Focal,       |                                                                          |            |
          Squamous                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                              2              2  2         |      7  2.4|
      Hepatodiaphragmatic Nodule           |    4                                                  4                  |      7  4.0|
      Vacuolization Cytoplasmic            |                   3                                               2  4   |      3  3.0|
      Hepatocyte, Regeneration             |                                                                          |      1  4.0|
      Periportal, Inflammation, Chronic    |                      4                                                   |      2  3.0|
      Portal, Bile Stasis                  |                      4        3                             4            |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +           +  +        +     +              +  +     +           +     +|  20        |
      Necrosis                             | 3           3  3        3     3              3  3     3           3     3|     20  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |       1                                   1  1              2            |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Squamous         |                                                                      4   |      1  4.0|
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                                        1        3                        |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         2        4                          4            |      6  2.8|
      Pars Distalis, Hyperplasia           |             3              3                 3                          2|      8  2.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      C-Cell, Hyperplasia                  |    2           4     1     2                                             |      8  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        4                                4|      3  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    2        1                                                            |      6  2.7|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             | 4                                                                        |      1  4.0|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                            +                                             |   2        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +              +     +     +        +                              |  10        |
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Histiocyte                      |                      4                                                   |      3  3.3|
      Pancreatic, Pigmentation             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  +  M  +  M  M  M  M  +  M|   9        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                               3                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  37        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                                          |      1     |
      Fibrosis                             |                               4                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                           4                              |      1  4.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Focal, Lymphoid         |                               4                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  M  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Galactocele                          |                                                                   2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                             4            |      2  4.0|
      Hyperkeratosis                       |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Joint, Fracture                      |                                                          4               |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                          +                        |   3        |
      Inflammation, Chronic                |                      4                                                   |      1  4.0|
      Necrosis                             |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       4           3  3                                3           4  4   |     10  3.1|
      Congestion                           |                   1                                                      |      1  1.0|
      Hemorrhage                           |                                                                          |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                 +                        |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                   4      |      1  4.0|
      Inflammation, Suppurative            |                                                                   2      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |    1     1        1                 1  1     1     1  1           1  1   |     22  1.4|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Alveolar Epithelium, Hypertrophy     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                        2                                 |      5  2.0|
      Inflammation, Suppurative            |          1           1                 2                       1         |     12  1.7|
      Glands, Dilatation                   |             1                          1     1     2        1     1  1  1|     17  1.3|
      Goblet Cell, Hyperplasia             |                                           1                              |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                           3                              |      1  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          1        2  1     1        1              1        1  1         |     14  1.1|
      Olfactory Epithelium, Degeneration   | 1  1  1  2  2  1  1  2  1  2  2  1  2  2  1  2  1  1  2  1  1  1  2  1  2|     50  1.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 6| 7| 7| 5| 7| 7| 6| 7| 7| 3| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 6| 6| 0| 0| 4| 3| 3| 7| 3| 3| 7| 3| 3| 2| 3| 0| 3| 3| 1| 0| 3|            |
                                           | 3| 3| 1| 2| 1| 6| 3| 3| 3| 2| 2| 0| 2| 3| 4| 2| 8| 9| 3| 6| 3| 3| 1| 8| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      |    1  1  1              1     1  1  1     1  1     1              1      |     25  1.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                                   2      |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ciliary Body, Inflammation           |                                           2                              |      1  2.0|
      Lens, Cataract                       |                                                                          |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |    1  1        1  2     1     1     1  1     1        2     2     1  2   |     21  1.3|
      Cortex, Renal Tubule, Hyperplasia    |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                4                 2                                   4   |             
      Hepatodiaphragmatic Nodule           |    4                          4                                          |             
      Necrosis                             |                                                          3               |             
      Bile Duct, Hyperplasia               |                                                             4            |             
      Hepatocyte, Regeneration             |                                                                          |             
      Periportal, Inflammation, Chronic    |                2                                                         |             
      Portal, Bile Stasis                  |                4                                                         |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +  +              +  +     +     +                          +     +      |             
      Necrosis                             | 4  3              3  3     3     3                                3      |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Erosion                              |                                                          2               |             
      Ulcer                                |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
      Epithelium, Hyperplasia              |                                                          3               |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                       +                  |             
      Peridontal Tissue, Inflammation      |                                                       4                  |             
      Pulp, Inflammation, Suppurative      |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 4                                                                        |             
      Vacuolization Cytoplasmic            |    1  1  1                                                               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                             4  2        2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                             1            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            4                                             |             
      Hyperplasia                          |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1     2              4              4        3      |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                          4               |             
      Endometrium, Hyperplasia             |                                                                          |             
      Myometrium, Hyperplasia              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                                                          3               |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                     +        +           +           +   |             
      Pancreatic, Pigmentation             |                                                          4               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  +  M  +  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                    3           4         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                          3               |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                     3                                    |             
      Hemorrhage                           |                                                                4         |             
      Inflammation, Chronic Active         |                                                          3               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tibia, Fracture                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                +                                   +        +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             3              2           4  3                          3   |             
      Hemorrhage                           |             4                       3  4     1                           |             
      Infarct                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                +                                   +        +            |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                +                                   +        +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |    4                       4                       4                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Inflammation, Suppurative            |                            2                                             |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Foreign Body                         |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |    2  1  1        2  1           2  4  1  1  1  1  1  1                  |             
      Inflammation, Chronic                |                         2                                                |             
      Alveolar Epithelium, Hyperplasia     |    1                                                              3      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |    2           1        1                                               1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |          1  2                                      2                 1   |             
      Glands, Dilatation                   | 2  1  1  2     1     1        1     2  2  1  1  1  2     1     1  1  1  1|             
      Goblet Cell, Hyperplasia             |                                                    1                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       3                 3|             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                3         |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2     1                             1                                    |             
      Olfactory Epithelium, Degeneration   | 2  1  2  2  2  2  1  2  1  1  2  1  2  2  2  2  2  2  1  2  2  1  2  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  1     1     1  1  1  1  1  1     2  2  2  2  1  1  1  2        1  1  1|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |             1        2                                                   |             
      Respiratory Epithelium, Hyperplasia  |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                +           +                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 8| 1| 3| 3| 2| 5| 3| 0| 3| 3| 7| 2| 1| 6| 3| 3| 3|             
                                           | 2| 1| 3| 2| 2| 3| 2| 1| 1| 5| 3| 3| 6| 4| 3| 0| 3| 3| 4| 2| 1| 6| 2| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lens, Cataract                       | 4                    3                                                   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 |          1     3              1                    1  1     3     2  1  1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                           X        X     1               |      6  2.8|
      Hepatodiaphragmatic Nodule           |                   4  4  1                             4                  |      6  3.5|
      Necrosis                             |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  4.0|
      Hepatocyte, Regeneration             |                               4                                          |      1  4.0|
      Periportal, Inflammation, Chronic    |                                                                          |      1  2.0|
      Portal, Bile Stasis                  |                                           3                              |      2  3.5|
      Serosa, Fibrosis                     |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +     +     +           +  +                 +  +     +     +         |  17        |
      Necrosis                             |    3     3     3           3  4                 3  3     3     3         |     16  3.1|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                    1           1         |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Focal, Squamous         |                                                                3         |      1  3.0|
      Ulcer                                |                                                             4            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +                                                                 +      |   3        |
      Epithelium, Hyperplasia              | 3                                                                 2      |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation      |                                                                          |      1  4.0|
      Pulp, Inflammation, Suppurative      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                  4                                       |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            | 2                          2        3  1                                 |      7  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            3                                             |      5  2.6|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                   4      |      1  4.0|
      Pars Distalis, Hyperplasia           |                                           3              2              4|      4  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 3              1     2                                      2     2      |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                                           3                              |      2  2.5|
      Inflammation, Chronic                |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       2           4                       4                    4  3     4|     11  3.2|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                               3                                          |      1  3.0|
      Myometrium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                  +                    +     +  +     +   |   9        |
      Pancreatic, Pigmentation             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +|   5        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  44        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                   X                                                      |      1     |
      Fibrosis                             |                               3  4                                       |      3  3.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                3                                                         |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tibia, Fracture                      |                   4                                                      |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Skeletal Muscle                         |                +  +        +                          +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       3  2     4  3           2                                   3      |     11  2.9|
      Hemorrhage                           |                            4                                1            |      6  2.8|
      Infarct                              |                                                                      2   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                +  +                                   +                  |   6        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                +  +                                   +                  |   6        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      3  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                  4                                       |      1  4.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Inflammation, Chronic, Focal         | 1     1           1  1     1  1           2     1  1  1  2     1  1      |     26  1.3|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          1                                                               |      3  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                2                       1                                 |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                  3                                       |      1  3.0|
      Inflammation, Suppurative            |                1        1     1  1                                       |      8  1.3|
      Glands, Dilatation                   | 1  2  2        1  2     1     1  1  1     1  1  1  1  1  2  2  2  2  2  1|     38  1.3|
      Goblet Cell, Hyperplasia             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                             1            |      3  2.3|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                1     2        1  1  1     1  1     1     1  1        1  1|     15  1.1|
      Olfactory Epithelium, Degeneration   | 2  2  3  2     2  2  2  2  2  2  2  2  1  1  2  2  2  1  2  2  2  2  2  2|     49  1.8|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 1     1  1     1  1  1  1     2  1  1  1  1  1  2  2  1  2  1  1  1  1  2|     42  1.3|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                                                 1                 1      |      4  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Degeneration, Cystic         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                           4                              |      1  4.0|
      Anterior Chamber, Hemorrhage         |                         4                                                |      1  4.0|
      Lens, Cataract                       |                         4                                               4|      4  3.8|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                   4      |      1  4.0|
      Nephropathy, Chronic                 | 1     2        2        4     3        1           2  1        1  1      |     19  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 9| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 0| 3| 3| 9| 1|            |
                                           | 2| 7| 1| 2| 6| 1| 2| 2| 2| 2| 3| 1| 2| 3| 2| 2| 2| 3| 3| 2| 4| 2| 2| 3| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatodiaphragmatic Nodule           |             4        4        4  4           4                    4     4|             
      Vacuolization Cytoplasmic            | 2                                      3        1                        |             
      Periportal, Inflammation, Chronic    |                                                                          |             
      Portal, Bile Stasis                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |             +           +                                                |             
      Necrosis                             |             3           3                                                |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       3        3                                   3                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                4                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                   +                                               +      |             
      Epithelium, Hyperplasia              |                                                                   4      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                 1                        |             
      Pericardium, Infiltration Cellular,  |                                                                          |             
           Lymphoid                        |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Vacuolization Cytoplasmic            |          2        2  2                 2  1                             1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             4                 2                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2              4                                    |             
      Pars Distalis, Hematocyst            |                                                                          |             
      Pars Distalis, Hyperplasia           |          3           3                                   1     3  2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                                                                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         4|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          3     4         |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia             |                                                                1         |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +                                         +  +            |             
      Muscularis, Hypertrophy              |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                               +     +                 +                 +|             
      Deep Cervical, Infiltration Cellular,|                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  M  M  +  +  +  M  +  M  M  M  M  +  M  +  M  M  M  M  M  M|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation                         |                4                                                         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  M  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                         2|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3                                            4                          3|             
      Hemorrhage                           |                                                       4                  |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Chronic, Diffuse       |                                                             2            |             
      Inflammation, Chronic, Focal         |       1  1  2  1  1     2  1  1     1  2     2  1  1     1     1        1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Hypertrophy     |                                  2                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          2                                                              1|             
      Interstitium, Fibrosis               | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                   1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Glands, Dilatation                   | 2  1  2  1  2  1  1  2  1  2  2  2  2  2  2  2  1  1  2  1     2  2  2  2|             
      Goblet Cell, Hyperplasia             |                   1                                   1                 2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     2                                    |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                     1                    1               |             
      Olfactory Epithelium, Degeneration   | 2  2  1  2  2  1  3  2  2  1  2  2  2  2  2  2  2  3  3  1     3  2  3  3|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  2  2  2  2  2  2  2  1  2  1  2  2  2  2  2  2  2  2  2     2  2  2  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphoid      |                                                             4            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Cataract                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |             +                                                            |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |                                        2                                4|             
      Bilateral, Cortex, Renal Tubule,     |                                                                          |             
           Degeneration                    |                                                                          |             
      Cortex, Infarct                      |                                                                          |             
      Cortex, Renal Tubule, Accumulation,  |                                                                          |             
           Hyaline Droplet                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 5| 7| 7| 5| 7| 6| 6| 7| 6| 5| 6| 7| 7| 6| 5| 7| 6| 6| 1| 7| 5| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 5| 3| 2| 1| 3| 5| 2| 2| 1| 3| 0| 8| 3| 5| 8| 5| 3| 6| 3| 0|             
                                           | 9| 6| 5| 1| 2| 1| 3| 6| 3| 2| 3| 3| 6| 2| 3| 0| 9| 2| 3| 4| 1| 3| 3| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Medulla, Renal Tubule, Degeneration  |                3                                                         |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                         2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +|  48        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatodiaphragmatic Nodule           |                                     4              4                     |      9  4.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  2.0|
      Periportal, Inflammation, Chronic    |             2              1                                             |      2  1.5|
      Portal, Bile Stasis                  |             3                                                            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                          +              +           +               |   6        |
      Necrosis                             |    3                          3              3           3               |      6  3.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                          2               |      4  2.8|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
      Erosion                              |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                        +                                 |   3        |
      Epithelium, Hyperplasia              |                                        4                                 |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                         3     1                                          |      3  1.7|
      Pericardium, Infiltration Cellular,  |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |    1                    1     1  2                             1  2      |     12  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        2                          4  2   |      5  2.8|
      Pars Distalis, Hematocyst            |                                                                   4      |      1  4.0|
      Pars Distalis, Hyperplasia           |          2                             2                                 |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 4                        |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                            2                                            2|      4  2.8|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia             |          2                                                               |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Muscularis, Hypertrophy              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                +                       +                 +  +            |   8        |
      Deep Cervical, Infiltration Cellular,|                                                                          |            |
           Histiocyte                      |                                                          2               |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  +  +  M  M  +  +  M  M  +  M  M  M  M  M  M  M  M  +  M  M  +  M|  14        |
      Infiltration Cellular, Histiocyte    |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M|   3        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pigmentation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M|  34        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                   4                                         4            |      2  4.0|
      Necrosis                             |                                                                      4   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|  39        |
      Cyst                                 |                                  4                                       |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                    4                     |      1  4.0|
      Inflammation, Granulomatous          |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                    +                    +     +                  |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | 3                    3        3              3                           |      7  3.1|
      Hemorrhage                           |                                                             3        4   |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                    +                    +     +                  |   5        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |       +                    +                    +     +                  |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         | 1  1  1  1  1        1     1  1     1  2  2        1  1  2     1  1     1|     33  1.2|
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |      1  3.0|
      Alveolar Epithelium, Hypertrophy     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |    1           1                             1                           |      5  1.2|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Inflammation, Suppurative            |       2     2              1     2                                       |      7  1.6|
      Glands, Dilatation                   | 2  1  2  1  1  2        1  2  1  3        2  2  1  2  2  1  1  2  2     2|     44  1.7|
      Goblet Cell, Hyperplasia             |       2                                                                  |      4  1.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                             1           1|      4  1.0|
      Olfactory Epithelium, Degeneration   | 2  2  3  2  1  2  1  1  2  3  2  2  2  2  2  2  2  3  2  2  1  2  2     3|     48  2.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 1  2  2  1  1  2  1        2  1  2     1  2  1  2  2  2  2  1  2  2     2|     45  1.8|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |
      Infiltration Cellular, Lymphoid      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Degeneration, Cystic         |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 6| 5| 7|            |
                             DAY ON TEST   | 8| 3| 3| 1| 0| 0| 1| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3|            |
                                           | 6| 2| 1| 7| 0| 8| 6| 6| 2| 2| 2| 1| 2| 6| 1| 5| 1| 2| 2| 3| 5| 3| 1| 0| 2|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
      Lens, Cataract                       |                                  4                                       |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                         +                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |          2           2     3  1     1        2     4                    1|     10  2.2|
      Bilateral, Cortex, Renal Tubule,     |                                                                          |            |
           Degeneration                    |                         4                                                |      1  4.0|
      Cortex, Infarct                      |                   1              3                                       |      2  2.0|
      Cortex, Renal Tubule, Accumulation,  |                                                                          |            |
           Hyaline Droplet                 |                         4                                                |      1  4.0|
      Medulla, Renal Tubule, Degeneration  |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                      X                 1                                 |             
      Hemorrhage                           |                      3                                                   |             
      Hepatodiaphragmatic Nodule           |                                        4                                 |             
      Necrosis                             |                                                       4                  |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +        +     +           +                    +  +               |             
      Necrosis                             |       4        1     3                                3  3               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
      Gingival, Hyperplasia, Squamous      |          1                                                               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1              2  3           2        1              1      |             
      Duct, Cyst                           |                            1                                             |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                | 4                                                                        |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1  1  2     2        1  2                                         2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
      Vacuolization Cytoplasmic            |          2     2     2              2                          3     2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     4  4                 4        1           2                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |          2                          4     1                              |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +        +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            2                                   1  1      |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 3     4     4  4                       4              3  4               |             
      Interstitial Cell, Hyperplasia       |    2        2                             4        3                    3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                +        +                 +  +        +                  |             
      Deep Cervical, Angiectasis           |                                                                          |             
      Deep Cervical, Hyperplasia, Lymphoid |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  +  +  M  M  +  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  M  M  M  M  +  +  +  M  M  +  M  M  +  M  +  M  M  M  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Necrosis                             |                                                                          |             
      Lymphocyte, Hyperplasia, Diffuse     |                                                                2         |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  M  M  +  M  M  +  M  +  +  +  +  +  +  +  +|             
      Galactocele                          |                4                                                     3   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                4                                                         |             
      Hyperkeratosis                       |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cartilage, Femur, Hyperplasia        |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2  4                             3                    2           3      |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |          +                                                               |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          4                                                               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Inflammation, Chronic, Focal         | 1                                               1                        |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     3                                    |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          2  2                                               2        2   |             
      Interstitium, Fibrosis               |                                     2                                    |             
      Mediastinum, Abscess                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                3                                   2                     |             
      Inflammation, Suppurative            |                3                                   2                 1   |             
      Glands, Dilatation                   |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |          2                                                               |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Cataract                       |       3                                                           1      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 5| 6| 5| 5| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 8| 0| 3| 3| 3| 0| 3| 2| 5| 2| 2| 2| 2| 2| 8| 7| 3| 4| 2| 2| 2| 2| 2| 2| 2|             
                                           | 9| 6| 0| 0| 1| 4| 1| 9| 5| 9| 9| 9| 9| 9| 9| 0| 6| 3| 2| 9| 9| 9| 3| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  1  2  1  1  1     1     1  2     2           1  1  1  4  2  1  1  2  2|             
      Cortex, Infarct                      |                                                                          |             
      Cortex, Renal Tubule, Hyperplasia    |       2                                                                  |             
      Cortex, Renal Tubule, Hypertrophy    |                      1                                                   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                             4            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      | 2                                                                        |             
      Hemorrhage                           |                                                 4                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      2  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                4         |      2  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +                    +                 +        +        +            |  12        |
      Necrosis                             | 3                                         3                              |      7  2.9|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |          2        3  1     4  1  2        2     1                    1   |     15  1.8|
      Duct, Cyst                           |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Squamous                |                                                    2                     |      1  2.0|
      Ulcer                                |       3                 4                          1                     |      4  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |                                        4                                 |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                                          |      7  1.6|
      Atrium, Thrombosis                   |       3                                      4                           |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                               2                          2               |      8  2.1|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 4     4                 4  3  4                                      3   |     12  3.2|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        1                                 |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |             3                                                            |      1  3.0|
      Pars Distalis, Hyperplasia           |       3                                               1                  |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                4         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +     +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 | 3                                                                        |      1  3.0|
      Hyperplasia                          |                                                 4                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 3                       3                                                |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         |       4           4  4  4     4  4              4        4              4|     16  3.9|
      Interstitial Cell, Hyperplasia       |                                     4                    3               |      7  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                      +  +  +  +                       +     +            |  11        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Deep Cervical, Angiectasis           |                      4                                                   |      1  4.0|
      Deep Cervical, Hyperplasia, Lymphoid |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  +  M  M  M  M  M  M  M  M  M|   7        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       4                                                                  |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                                          1               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  +  M  +  M  +  M  +  M  M  +  M  M  +  M  +  +  M  +  M|  19        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          4              3                                                |      2  3.5|
      Necrosis                             |       4                 4              4                                 |      3  4.0|
      Lymphocyte, Hyperplasia, Diffuse     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  M  M  +  M  M  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M|  35        |
      Galactocele                          |                                                                      4   |      3  3.7|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |    4        4                                            4               |      4  4.0|
      Hyperkeratosis                       |       3                                                                  |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cartilage, Femur, Hyperplasia        | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
   Skeletal Muscle                         |                                                             +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                4     3  2                                3              3|     10  2.9|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                            4                                             |      2  3.0|
      Inflammation, Chronic, Focal         |                                                                1  1      |      4  1.0|
      Inflammation, Suppurative            |                                                    1                     |      1  1.0|
      Necrosis                             |       2                                                                  |      1  2.0|
      Thrombosis                           |                            4                                             |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |       2        1                                            4            |      4  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                    1     1  2  1  1      |      9  1.6|
      Interstitium, Fibrosis               |                                                                          |      1  2.0|
      Mediastinum, Abscess                 |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                  1                       2  2            |      5  2.0|
      Inflammation, Suppurative            |                                  3                          3            |      5  2.4|
      Glands, Dilatation                   |                                                          1     2     2   |      3  1.7|
      Goblet Cell, Hyperplasia             |                                  2                                       |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 7| 2| 2| 3| 3| 3| 2| 8| 1| 3| 3| 2| 6| 3| 6| 3| 2| 1| 3| 2| 3| 2| 3| 0|            |
                                           | 9| 5| 5| 9| 1| 8| 1| 9| 2| 2| 1| 0| 9| 6| 0| 1| 1| 9| 2| 0| 9| 0| 9| 1| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
           Suppurative                     | 1                    1                                                   |      2  1.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |             1              1                                            1|      4  1.3|
      Respiratory Epithelium, Hyperplasia  |                                                             3            |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Degeneration, Cystic         |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lens, Cataract                       |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3        4  2  2  1  3  4     3  1  1     2     1  2     4  1     1  1  1|     37  1.8|
      Cortex, Infarct                      |       4                                                                  |      1  4.0|
      Cortex, Renal Tubule, Hyperplasia    |                                                                          |      1  2.0|
      Cortex, Renal Tubule, Hypertrophy    |                                                                          |      1  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |             2                                         2  2               |      4  2.0|
      Hemorrhage                           |                                                                2         |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                          2        2  3   |             
      Hepatodiaphragmatic Nodule           |                               4                                          |             
      Inflammation, Granulomatous          |                                                                   3      |             
      Necrosis                             |             2                                                            |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +  +                             +                       +     +   |             
      Necrosis                             |       3  3                             3                       3     3   |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2     1  1              1           2     2  1  2  1     4  1        2   |             
      Acinus, Inflammation                 |                         2                                                |             
      Duct, Cyst                           |                                                       3              2   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Suppurative            |             1                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Ulcer                                |                                              4                           |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |             2                                                            |             
      Ulcer                                |                                                             4            |             
                                           |__________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Epithelium, Hyperplasia              |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               2  2     3                          2      |             
      Atrium, Thrombosis                   |                                                             4            |             
      Pericardium, Epicardium,             |                                                                          |             
          Infiltration Cellular, Histiocyte|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                1        2                 1  3                    2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4  2  2  2  2                          4                           |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          4               |             
      Pars Distalis, Hematocyst            |                                              4                           |             
      Pars Distalis, Hyperplasia           |       2              3              3              2  1           1  3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                4         |             
      Follicular Cell, Hyperplasia         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |          4              2  3           3                                 |             
      Interstitial Cell, Hyperplasia       |                         2  3                             3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +           +              +                 +                           |             
      Deep Cervical, Cyst                  | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mandibular                  | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  M  +  M  +  M  M  +  M  M  +  M  +  +  M  M  M  M  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |             X                                                            |             
      Fibrosis                             |                   3        4              3                       3      |             
      Hemorrhage                           |                                              4                    4      |             
      Hyperplasia, Focal, Lymphoid         |                                                                   3      |             
      Necrosis                             |             4                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Galactocele                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                         4                                                |             
      Hyperkeratosis                       |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fracture                      |                                     4                                    |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                           3                              |             
      Hemorrhage                           |                                                          4               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
   Peripheral Nerve                        |                                     +                                    |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       4                                                                  |             
      Inflammation, Suppurative            |                2                                                         |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
      Inflammation, Chronic, Focal         |                         2                                   2            |             
      Alveolar Epithelium, Hyperplasia     | 1        1        3  2  1                                   2            |             
      Alveolar Epithelium, Hypertrophy     |                                                                1         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          2        3           1        1                                 |             
      Interstitium, Fibrosis               |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         | 3                                                                        |             
      Inflammation, Suppurative            | 3              1        1        1              1  2                     |             
      Glands, Dilatation                   | 1     1  2  1  1     1  1  1     2  2  1  1  1           1  1  1  2  2  2|             
      Goblet Cell, Hyperplasia             | 2              2                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       1              2                             2        2            |             
      Olfactory Epithelium, Degeneration   | 2     1  1  1  1  1  1  2  1  2  2  2  1  2  2  2  2  1  2  2  2  1  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 1        1     1  1  1  1        1  2     1  1  1  1     1     1         |             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
      Turbinate, Cyst                      |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 2| 3| 6| 2| 2| 2| 3| 0| 3| 3| 3| 3| 8| 0| 2| 3| 3| 5| 2| 3| 2| 2| 3|             
                                           | 1| 2| 9| 0| 9| 9| 2| 9| 1| 5| 1| 0| 1| 0| 2| 8| 9| 0| 1| 4| 8| 0| 9| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Cataract                       |                                                                      4   |             
      Retina, Atrophy                      |                4                                                         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 1     1  1  1  1  2  2  1  1  2  2  2  1  1  1  2  1     1        1  1  1|             
      Cortex, Infarct                      |             2                                                            |             
      Cortex, Renal Tubule, Hyperplasia    |                                                                          |             
      Medulla, Infarct                     |                                                                          |             
      Medulla, Infiltration Cellular,      |                                                                          |             
          Lipocyte                         |                                                                         3|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |    4                                                                     |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Necrosis                             |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
      Dilatation                           |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Clear Cell Focus                     |       3                             X                                    |      5  2.5|
      Hepatodiaphragmatic Nodule           |                                              4                           |      2  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                        2                 2               |      2  2.0|
      Serosa, Fibrosis                     |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |          +  +  +        +     +  +  +  +                                 |  13        |
      Necrosis                             |          3  3  3        3     3  3  2  3                                 |     13  2.9|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |    1        2     1           3              1  4                        |     18  1.8|
      Acinus, Inflammation                 |                                                                          |      1  2.0|
      Duct, Cyst                           |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Diverticulum                         |                                                    3                     |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Erosion                              |                   3                                                      |      2  2.5|
      Ulcer                                |                      4                                                   |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                          2               |      5  2.2|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
      Pericardium, Epicardium,             |                                                                          |            |
          Infiltration Cellular, Histiocyte|                                                       4                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                      3  2                                                |      2  2.5|
      Vacuolization Cytoplasmic            |          1                                                     2  2      |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    3     2     3  3  3        2              3                           |     13  2.7|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Pars Distalis, Hematocyst            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                   3                                                      |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |       4           2        2                                             |      4  3.0|
      Follicular Cell, Hyperplasia         |                                                             2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       4                  |      1  4.0|
      Hyperplasia                          |                4                                   4     4        3      |      4  3.8|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                        3                                 |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Germinal Epithelium, Atrophy         | 3  3           3              4           3              3     3  3      |     12  3.1|
      Interstitial Cell, Hyperplasia       |                                  3  3                             3      |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                  +                                       |   5        |
      Deep Cervical, Cyst                  |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  +  M  M|   6        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M|   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Ectasia                              |                                              4                           |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  M  +  +  +  M  M  M  M  M  M  M  +  +  +  A  +  M  M  +  +  M|  23        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Accessory Spleen                     |                            X     X                                       |      3     |
      Fibrosis                             |                   3           3                                          |      6  3.2|
      Hemorrhage                           |                                                                          |      2  4.0|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  43        |
      Galactocele                          |    1                                                              2      |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fracture                      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +     +        +  +                 +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | 2     2        3                                                        2|      5  2.4|
      Hemorrhage                           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                     +                                    |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                    +               |   3        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                4         |      2  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                 1           1            |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                            2                             2               |      8  1.8|
      Alveolar Epithelium, Hypertrophy     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               | 1        1  2                                      1  3  2     1        1|     12  1.6|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Foreign Body                         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    1                                                     2  1            |      9  1.4|
      Glands, Dilatation                   |    1        1     1  1     1     1  1                    1  2  1  1      |     30  1.2|
      Goblet Cell, Hyperplasia             |                                           1                              |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                2        1                                                |      6  1.7|
      Olfactory Epithelium, Degeneration   | 1  2  2  2  1  1  2  1  1  2  2  1  2  1  2  2  2  1     1  2  2  1     1|     47  1.6|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      |    1                                1  1  1                 1  1  1      |     21  1.0|
      Olfactory Epithelium, Metaplasia     |                                                          1               |      1  1.0|
      Turbinate, Cyst                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  48        |
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Cyst                                 |          4                                                               |      1  4.0|
      Nephropathy, Chronic                 | 4  1  1  3     3     1     1  1  2  1  1  2  2  2  1     3     3  2  1  1|     41  1.5|
      Cortex, Infarct                      |                                                                          |      1  2.0|
      Cortex, Renal Tubule, Hyperplasia    |                                                 1                 1      |      2  1.0|
      Medulla, Infarct                     |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 0| 1| 9| 2| 2| 2| 3| 5| 2| 3| 3| 3| 0| 3| 3| 2| 2| 3| 5|            |
                                           | 0| 0| 0| 1| 0| 7| 4| 0| 3| 9| 9| 9| 0| 9| 9| 0| 1| 0| 6| 1| 1| 9| 9| 1| 4|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    100 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Medulla, Infiltration Cellular,      |                                                                          |            |
          Lipocyte                         |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |                3                                               2         |      2  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                4         |             
      Hepatodiaphragmatic Nodule           |                         4                                   4            |             
      Necrosis                             |                                                             4           2|             
      Vacuolization Cytoplasmic            |             3                                                            |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Hepatocyte, Regeneration             |                                                                         4|             
      Periportal, Inflammation, Chronic    |                                                                2         |             
                                           |__________________________________________________________________________|             
   Mesentery                               |    +        +     +        +  +                 +                        |             
      Necrosis                             |    3        3     3        2  2                 3                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                         4|             
      Acinus, Atrophy                      | 1        1  1  2        2  4  1  3     1        1  1        2  1  3  2  1|             
      Acinus, Hyperplasia                  |                      3                                                   |             
      Duct, Cyst                           |                                              3                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         2|             
      Ulcer                                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Atrium, Thrombosis                   |                         4                                                |             
      Pericardium, Inflammation            |                                                          3               |             
      Pericardium, Pigmentation            |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |          3  2  2           1                                             |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                                  3                 3|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  4                                       |             
      Pars Distalis, Hyperplasia           | 2  3                                      2                 1     3      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     2     4              1              3        3        4        2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Penis                                   |                            +                                            +|             
      Inflammation                         |                                                                         4|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          4               |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                   2                                                     4|             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Germinal Epithelium, Atrophy         |                      3     4           2        3     4        3         |             
      Interstitial Cell, Hyperplasia       |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +           +                          +         |             
      Deep Cervical, Hemorrhage            |                                                                3         |             
      Pancreatic, Ectasia                  |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      4                                                   |             
      Infiltration Cellular, Histiocyte    |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  M  M  M  +  +  M  +  +  +  +  M  +  +  M  M  +  M  M|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    4                                            3                        |             
      Hemorrhage                           |                         4                                                |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                            4  4                                      4   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |    4                                                                     |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                        4                       4         |             
      Ulcer                                |             4                                                  3         |             
      Subcutaneous Tissue, Thrombosis      |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    3           3     3   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  4              4                        |             
      Inflammation, Suppurative            |                                     4                                    |             
      Epiglottis, Metaplasia, Squamous     |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                       2                    2        1               |             
      Inflammation, Chronic, Diffuse       |                                                          2               |             
      Inflammation, Chronic, Focal         |                                                                1         |             
      Inflammation, Chronic                |                                                                         3|             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2           1           3                    1              2         |             
      Alveolar Epithelium, Hypertrophy     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |    2     2     2           1  1                 2     1  1               |             
      Interstitium, Fibrosis               |    1                                                                     |             
      Mediastinum, Inflammation, Chronic   |                                                          2               |             
      Mediastinum, Pigmentation            |                                                          4               |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              1                    1      |             
      Inflammation, Suppurative            | 1           1        1     2  1     3  1  2  2  2              2     2  2|             
      Glands, Dilatation                   | 1  1  1  1  2  2  2  1  2  1  2  2  1  1  2  1  2  2  1     1  2  2     2|             
      Goblet Cell, Hyperplasia             |          1                 2        3     1  2                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                  2                                       |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                           1                              |             
      Olfactory Epithelium, Degeneration   | 2  2  1  2  2  2  2  1  2  2  2  2  3  2  2  2  2  1  2     2  2  2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| 1| 4| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 6| 2| 8| 9| 6| 2| 2| 3| 3| 5| 2| 3| 9| 1| 3| 1| 6| 2| 2| 8| 2|             
                                           | 0| 1| 1| 0| 1| 9| 7| 4| 8| 9| 9| 1| 1| 3| 9| 1| 4| 7| 0| 4| 0| 9| 9| 6| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    200 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  2  2  1  2  2  2  2  2  1  2  1  1  2  1     2  1  1     2  2  2     1|             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Hyperplasia             |                                                          2               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lens, Cataract                       |                                              3                           |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                 +                        |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1        2  4  1  3  2     2  1  1  2     1  1     1  3        3  2  2  2|             
                                           |__________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |    2                                                                    4|             
      Hemorrhage                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  45        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    4                     |      1  4.0|
      Clear Cell Focus                     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                  4        4                              |      4  4.0|
      Necrosis                             |                1                                                         |      3  2.3|
      Vacuolization Cytoplasmic            |    3                    2                                                |      3  2.7|
      Bile Duct, Hyperplasia               |          2        2              2                                       |      3  2.0|
      Hepatocyte, Regeneration             |                                                                          |      1  4.0|
      Periportal, Inflammation, Chronic    |          2                                                               |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +  +        +           +  +  +  +        +        +        +  +  +|  18        |
      Necrosis                             |       3  3        3           3  3  3  3        3        3        3  3  3|     18  2.9|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thrombosis                           |                                                                          |      1  4.0|
      Acinus, Atrophy                      |    1  1  2  3  1                 3     1     3  2  1        1            |     27  1.7|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Duct, Cyst                           |                3                 3                                       |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ulcer                                |    4                                                                     |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                          3               |      2  2.5|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                            2                                             |      1  2.0|
      Atrium, Thrombosis                   |                   4                                                      |      2  4.0|
      Pericardium, Inflammation            |                                                                          |      1  3.0|
      Pericardium, Pigmentation            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |    2                    1                 1                              |      7  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                        1           3              2  1  3|      8  2.4|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            3                                      1      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 4                    3              1     4                              |      9  2.6|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          2                                                               |      9  2.6|
      Follicular Cell, Hyperplasia         |                      1                    4                              |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     4                                    |      2  4.0|
      Hyperplasia                          |                                     4                                    |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                       1                  |      1  1.0|
      Inflammation, Suppurative            |                                     4                    4               |      4  3.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic Active |       3                 3                                                |      2  3.0|
      Germinal Epithelium, Atrophy         |             2              4     3  4                    4               |     11  3.3|
      Interstitial Cell, Hyperplasia       |             3                                                            |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +     +           +  +        +                       +        +  +   |  11        |
      Deep Cervical, Hemorrhage            |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |                      3                                                   |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                  3                                       |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  +  M  M|  12        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +  +  +  M  M|   4        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  +  +  +  +  +  +  +  M|  25        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          4              2                                                |      4  3.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                   4      |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  46        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Galactocele                          |    4                       4                                4            |      6  4.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                      4              4                                    |      3  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Hyperkeratosis                       |                               4                                   3      |      2  3.5|
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Ulcer                                |                                                                          |      2  3.5|
      Subcutaneous Tissue, Thrombosis      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperostosis                         |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    2        3           3              3        3                        |      8  2.9|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                             4            |      3  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Epiglottis, Metaplasia, Squamous     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      4  1.8|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                              1     1           1  4      |      5  1.6|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |      6  1.7|
      Alveolar Epithelium, Hypertrophy     |             1                                                            |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                                                    1  2     1            |     11  1.5|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  2.0|
      Mediastinum, Pigmentation            |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    3                                                                     |      3  1.7|
      Inflammation, Suppurative            |    2        2        1                                      2            |     17  1.7|
      Glands, Dilatation                   | 1  1  2  2  1  1  2  1  1  2  2  2  1  2  1  1  1  1  2  1  2  2  2  1  1|     48  1.5|
      Goblet Cell, Hyperplasia             |       1                                               2                  |      7  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                                                                        |      1  1.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                        1                                 |      2  1.0|
      Olfactory Epithelium, Degeneration   | 1  2  2  2  1  1  2  1  1  1  1  2  1  1  1  2  1  2  2  1  2  2  1  1  2|     49  1.7|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 1  1  2  1  1  1  1  1     1  1  2  1  1  1  1     1  2  1  2  2  1     1|     44  1.4|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelium, Hyperplasia             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Anterior Chamber, Hemorrhage         |                            4                                             |      1  4.0|
      Lens, Cataract                       |                                                    3                 3   |      3  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 1| 3| 2| 2| 3| 3| 2| 7| 3| 2| 2| 7| 1| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 3|            |
                                           | 0| 7| 0| 9| 2| 0| 0| 9| 6| 1| 9| 9| 8| 9| 0| 0| 9| 9| 9| 3| 1| 0| 1| 4| 1|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    200 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                           4                              |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                            +                 +                           |   3        |
      Inflammation, Suppurative            |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  4  2  2  1  2  2  4  1  1  2  1  1  2     3  3  2     4  2  2  3  3|     41  2.1|
                                           |__________________________________________________________________________|____________|
   Urethra                                 |                                     +                                    |   1        |
      Transitional Epithelium, Hyperplasia |                                     3                                    |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                     4                       X            |      4  3.3|
      Hemorrhage                           |                                                          3               |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                                                                   4      |             
      Hepatodiaphragmatic Nodule           |             4                                4                    4      |             
      Necrosis                             |                         3                                                |             
      Vacuolization Cytoplasmic            |                                  2                                       |             
      Serosa, Fibrosis                     |                                                                          |             
      Serosa, Hemorrhage                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +                                +                              |             
      Necrosis                             | 3        3                                3                              |             
      Fat, Hemorrhage                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                     |             
      Gingival, Cyst                       |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  3  3  2        1     1  3  2  2           2  4  2        3        1|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 3           2            |             
      Epithelium, Hyperplasia              |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Atrium, Thrombosis                   |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                                   |             
      Vacuolization Cytoplasmic            |                                                 2  2              1      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3           2     3              1        3     2  2              3      |             
      Bilateral, Hyperplasia               |                                                             4            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                3         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       3                                                                  |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia           |             3  3     3                 2  3        3                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3                 2        3                                         2   |             
      Follicular Cell, Hyperplasia         |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |__________________________________________________________________________|             
   Peritoneum                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         | 4        3        4     3                                                |             
      Interstitial Cell, Hyperplasia       | 2                       3                          3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +     +           +      |             
      Deep Cervical, Angiectasis           |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M|             
      Hemorrhage                           |                                                                   3      |             
      Infiltration Cellular                |                         3                                                |             
      Pigmentation                         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Infiltration Cellular, Histiocyte    |                                              4     3           3         |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                            4                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Spleen                     |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                         4                                                |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                   4                             4                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     3           3              3         |             
      Gliosis                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +         |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             3                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Epiglottis, Metaplasia, Squamous     |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                         1     1                                          |             
      Inflammation, Chronic, Focal         | 1           1     1  1              2        1                    1      |             
      Alveolar Epithelium, Hyperplasia     |                         4              2              3                  |             
      Alveolar Epithelium, Hypertrophy     |                                                                   1      |             
      Alveolus, Hypertrophy                |                                                                   1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Focal, Histiocyte               |          2                    2        1                                 |             
      Interstitium, Fibrosis               |                                        1                                 |             
      Perivascular, Edema                  |                                        1                                 |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Eosinophil                      |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                1                       3                 1        1      |             
      Glands, Dilatation                   | 1  1  2  1  1  2  1  1  2  1  1  1     1  2  2  1  2  2  1  1  2  2  2  1|             
      Goblet Cell, Hyperplasia             |       1  1  3        1        1              3        2  2        2  1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1                                                            |             
      Nasopharyngeal Duct, Cyst            |    4                                                                     |             
      Nasopharyngeal Duct, Foreign Body    |                                                                   1      |             
      Nasopharyngeal Duct, Respiratory     |                                                                          |             
          Epithelium, Hyperplasia          | 4                                                                        |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 2| 3| 2| 2| 3| 2| 6| 3| 3| 3| 8| 1| 3| 2| 2| 2| 3| 2| 0| 3| 3| 3| 2|             
                                           | 0| 7| 9| 1| 9| 9| 0| 9| 2| 1| 1| 8| 7| 3| 1| 9| 4| 9| 0| 9| 8| 1| 1| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    400 PPM                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
      Olfactory Epithelium, Degeneration   | 2  2  3  2  2  2  2  2  2  3  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Basal Cell                      | 2  2  3  1  2  2  1  1  2  2  2  1     2  2  2  2  1  2  2  2  2  1  2  2|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
                                           |__________________________________________________________________________|             
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Degeneration, Cystic         |                   1  2        2                                1         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Mineralization               |                                                                   1      |             
      Lens, Cataract                       |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy, Chronic                 | 1  1  2  2  1  2  2  1  1  2  1  1  2  1     2  2  2  3  1  4  2  4  1  1|             
      Cortex, Renal Tubule, Degeneration   |                                     2                                    |             
      Cortex, Renal Tubule, Hyperplasia    |                                                             4            |             
      Papilla, Renal Tubule, Dilatation    |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Mineralization                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       3                       2  1                                       |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                X                                                         |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                3         |      1  3.0|
      Clear Cell Focus                     |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                   4           4              4  4        4               |      8  4.0|
      Necrosis                             |                                           4                              |      2  3.5|
      Vacuolization Cytoplasmic            |       3                                                              2   |      3  2.3|
      Serosa, Fibrosis                     |                      4                                                   |      1  4.0|
      Serosa, Hemorrhage                   |                      4                                                   |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +  +        +  +  +  +                                   +  +      |  11        |
      Necrosis                             |                   3  4  3  2                                   3  3      |      9  3.0|
      Fat, Hemorrhage                      |          4                                                               |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             | +                    +        +                                          |   4        |
      Gingival, Cyst                       |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |          1  1     2     1                    1           2              2|     21  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                          |      2  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |                                                       2                  |      1  2.0|
      Atrium, Thrombosis                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      2                                                   |      2  1.5|
      Vacuolization Cytoplasmic            |                2     2                                      2            |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |          2  2  2                             2  2     3                  |     14  2.3|
      Bilateral, Hyperplasia               |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             3            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +|  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hemorrhage                           |                               3                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                  2                    3                  |      8  2.8|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                              3  2        2               |      7  2.4|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Peritoneum                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                +         |   1        |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                 4                        |      1  4.0|
      Hyperplasia                          |                                                 4                        |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                         2|      2  1.5|
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                4                                                         |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Germinal Epithelium, Atrophy         | 4              3  4           3                             3            |      9  3.4|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                               +     +               |   6        |
      Deep Cervical, Angiectasis           |    2                                                                     |      1  2.0|
      Pancreatic, Hemorrhage               |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  M  +  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   5        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular                |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  +  +  +  +  M  M  +  M  M  M  +  +  +  M  +  M  M  +|  38        |
      Angiectasis                          |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Spleen                     |                                                    X                     |      1     |
      Fibrosis                             |                                                    4                     |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |                                                          4               |      1  4.0|
      Necrosis                             |                                  4                                       |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  M  +  +  +  M  +  M  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          |                                                                4         |      3  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                  X           4                           |      2  4.0|
      Inflammation, Granulomatous          |                                                                4         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                       +     +                                    |   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |             4     4                                                     4|      6  3.5|
      Gliosis                              |                         3                                                |      1  3.0|
      Hemorrhage                           |                                                                         3|      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                               +                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                               +                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                2                                                         |      2  2.5|
      Inflammation, Suppurative            |                1                                                         |      1  1.0|
      Epiglottis, Metaplasia, Squamous     |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                      2   |      1  2.0|
      Hemorrhage                           |                                           3  1                           |      4  1.5|
      Inflammation, Chronic, Focal         |                1           1        1  1        1                 1  2   |     14  1.1|
      Alveolar Epithelium, Hyperplasia     |                      3     4  3                                          |      6  3.2|
      Alveolar Epithelium, Hypertrophy     |                                              1                           |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolus, Hypertrophy                |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Focal, Histiocyte               |                   1                                                      |      4  1.5|
      Interstitium, Fibrosis               |                                                                          |      1  1.0|
      Perivascular, Edema                  |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Eosinophil                      |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            | 2     2        1  2                    2     1                           |     10  1.6|
      Glands, Dilatation                   | 1  2  2  2  1  1  1     1  2  2  2  2  2     1  2     2  1  2  1  1  2  2|     46  1.5|
      Goblet Cell, Hyperplasia             | 1                       1  1  2        2                          1      |     16  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |    3                                                     2              3|      4  2.3|
      Nasopharyngeal Duct, Cyst            |                                                                          |      1  4.0|
      Nasopharyngeal Duct, Foreign Body    |                                                                          |      1  1.0|
      Nasopharyngeal Duct, Respiratory     |                                                                          |            |
          Epithelium, Hyperplasia          |                                                                          |      1  4.0|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          2                                                               |      1  2.0|
      Olfactory Epithelium, Degeneration   | 2  2  2  2  1  2  2  1  2  2  2  2  2  2     2  2  2  2  1  2  2  2  2  2|     49  2.0|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Basal Cell                      | 2  2  2  1  1  2  1  1  2  2  2  2  2  2     2  2  1  2  1  1  1  2  2  2|     48  1.7|
      Olfactory Epithelium, Metaplasia     |       1     2                                                            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Pleura                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Degeneration, Cystic         |             2                                                            |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Cornea, Mineralization               |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 88004-05                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                                           DIVINYLBENZENE                                      Date: 12/17/03    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:44:00    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 2| 8| 7| 1| 3| 2| 8| 3| 3| 2| 9| 3| 2| 2| 2| 3| 8| 2| 6| 2| 8| 2| 2| 1|            |
                                           | 9| 9| 2| 4| 4| 0| 9| 0| 3| 0| 9| 4| 1| 9| 3| 9| 0| 9| 9| 9| 9| 0| 9| 9| 0|            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    400 PPM                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                             4            |      1  4.0|
      Nephropathy, Chronic                 | 2  1     4  3  4  1  1     1  1  1  2  2     2  1     2  1  2  3  1  3  3|     45  1.8|
      Cortex, Renal Tubule, Degeneration   |                                                                          |      1  2.0|
      Cortex, Renal Tubule, Hyperplasia    |          4                                                               |      2  4.0|
      Papilla, Renal Tubule, Dilatation    |                                        4                                 |      1  4.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Mineralization                  |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      | 2                                                                        |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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