National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/20663

TDMS Study 97013-06 Pathology Tables

NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 002    0 MG/KG
                               Include 004    64 MG/KG
                               Include 006    128     MG/KG
                               Include 008    256     MG/KG
                               Include 001    0 MG/KG
                               Include 003    64 MG/KG
                               Include 005    128     MG/KG
                               Include 007    256     MG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            1            4                                     
    Natural Death                                      2            2            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           10           12           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]      1 [1.0]      1 [1.0]      3 [1.0]                               
      Inflammation                                    14 [1.1]     11 [1.0]     14 [1.1]     11 [1.1]                               
      Necrosis                                         3 [1.0]      2 [1.0]      4 [1.0]      2 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            3 [1.0]      7 [1.0]      5 [1.0]      5 [1.0]                               
   Mesentery                                          (1)                                                                           
      Necrosis                                         1 [3.0]                                                                      
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation                                                               1 [1.0]                                            
      Epithelium, Hyperkeratosis                       1 [2.0]                                                                      
      Epithelium, Hyperplasia                          1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Subcapsular, Hyperplasia                         8 [1.0]      8 [1.0]     11 [1.0]      5 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Cyst                                             4 [1.0]      1 [1.0]      1 [1.0]      2 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Cyst                                             2 [1.5]      1 [2.0]      1 [2.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (14)         (15)         (15)                                   
      Cyst                                             1 [1.0]                                2 [1.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Suppurative                        2 [1.0]                   1 [1.0]                                            
      Endometrium, Hyperplasia, Cystic                 7 [1.3]      6 [1.2]     10 [1.3]      6 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (1)                                                                           
      Mediastinal, Hyperplasia                         1 [1.0]                                                                      
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                                        1 [2.0]                               
      Infiltration Cellular, Plasma Cell                            1 [2.0]      1 [1.0]      1 [2.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]      1 [1.0]      1 [1.0]      4 [1.3]                               
   Thymus                                             (15)         (15)         (15)         (14)                                   
      Atrophy                                                       3 [2.7]      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Epidermis, Hyperplasia, Focal                                              1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation                                     1 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia                 1 [4.0]                                                                      
      Artery, Inflammation                                          1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (1)                                    
      Retina, Degeneration                                          1 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    6 [1.0]      5 [1.0]      5 [1.0]      4 [1.0]                               
      Cyst                                             2 [1.0]      2 [1.0]                   1 [1.0]                               
      Hydronephrosis                                                             1 [1.0]                                            
      Mineralization                                                1 [1.0]                                                         
      Nephropathy                                                                2 [1.0]      3 [1.0]                               
      Artery, Inflammation                                          1 [2.0]                   1 [1.0]                               
      Renal Tubule, Hypertrophy                                     1 [1.0]      1 [1.0]      4 [1.0]                               
      Renal Tubule, Necrosis                           1 [1.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            1                                                               
    Natural Death                                                                             2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           15           13                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]      1 [1.0]                   1 [1.0]                               
      Inflammation                                     8 [1.1]      8 [1.0]      5 [1.0]      6 [1.0]                               
      Necrosis                                         1 [1.0]      1 [1.0]      1 [1.0]      2 [1.5]                               
      Hepatocyte, Fatty Change                         1 [1.0]                                                                      
      Hepatocyte, Vacuolization Cytoplasmic            4 [1.0]      2 [1.0]      5 [1.0]      4 [1.0]                               
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 [2.0]                                            
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                                                          1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hyperplasia                                      1 [1.0]                                                                      
      Hypertrophy                                      9 [1.1]      9 [1.1]      6 [1.5]      8 [1.1]                               
      Vacuolization Cytoplasmic                                                               1 [1.0]                               
      Subcapsular, Hyperplasia                         1 [1.0]      1 [1.0]                   2 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]                   2 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (15)         (15)         (15)         (15)                                   
      Germinal Epithelium, Degeneration                3 [1.7]      1 [2.0]      2 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (14)         (14)                                   
      Atrophy                                                                                 1 [2.0]                               
      Infiltration Cellular, Plasma Cell               1 [2.0]                                                                      
   Lymph Node, Mesenteric                             (14)         (15)         (15)         (15)                                   
      Atrophy                                                       1 [2.0]                                                         
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]      2 [1.0]      1 [1.0]      1 [1.0]                               
      Lymphoid Follicle, Atrophy                                                              1 [2.0]                               
      Lymphoid Follicle, Hyperplasia                                                          1 [2.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [3.0]      1 [1.0]                   2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Epidermis, Hyperplasia, Focal                    1 [1.0]                                                                      
      Subcutaneous Tissue, Inflammation                             1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 06/11/04    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 08:41:45    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation                                                  1 [1.0]      1 [1.0]                                            
      Thrombosis                                                                 1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Casts Protein                                    3 [1.0]      1 [1.0]                   2 [1.0]                               
      Cyst                                             1 [1.0]                                1 [1.0]                               
      Hydronephrosis                                   1 [1.0]                                1 [1.0]                               
      Inflammation                                                                            1 [2.0]                               
      Nephropathy                                      7 [1.0]      6 [1.0]      7 [1.0]      6 [1.0]                               
      Artery, Inflammation                             1 [1.0]                   1 [1.0]                                            
      Renal Tubule, Dilatation                         1 [1.0]                                1 [1.0]                               
      Renal Tubule, Hypertrophy                                                               1 [1.0]                               
      Renal Tubule, Necrosis                                                                  1 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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