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TDMS Study 97013-98 Pathology Tables

NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03
Route: GAVAGE                                                                                                     Time: 12:08:05

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1


NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |          2     2           2                                             |      3  2.0|
      Inflammation                         | 1  1        1     1  1  1                                                |      6  1.0|
      Hepatocyte, Fatty Change             |       1        1        2                                                |      3  1.3|
      Hepatocyte, Vacuolization Cytoplasmic| 1  2  2  3  1  1  2  2  2                                                |      9  1.8|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       |                            +                                             |   1        |
      Cyst                                 |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                         2                                                |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +                    +                                                   |   2        |
      Infiltration Cellular, Lymphocyte    | 2                    2                                                   |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |             1           1                                                |      2  1.0|
      Endometrium, Hyperplasia, Cystic     | 2  1  1  2  2  2  1  2  2                                                |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +                                             |   9        |
      Atrophy                              |                            4                                             |      1  4.0|
      Cyst                                 | 1  1  1  1        1     1                                                |      6  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Casts Protein                        | 1           1  1  1  1  1  1                                             |      7  1.0|
      Mineralization                       |                            1                                             |      1  1.0|
      Nephropathy                          |       1  1                                                               |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 7| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 1                       1                                                |      2  1.0|
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
      Necrosis                             |                      1     1                                             |      2  1.0|
      Hepatocyte, Fatty Change             |       1  1  2                                                            |      3  1.3|
      Hepatocyte, Vacuolization Cytoplasmic| 2  1  1  2  2  1  1  1  3  2                                             |     10  1.6|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1     1  1                                             |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 7| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |          1     1                                                         |      2  1.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  2  2  1  2     1     1                                             |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                   1                                                      |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                      3  2                                                |      2  2.5|
      Cyst                                 | 1  1     1  2  1  1     2  1                                             |      8  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |             +        +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 7| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 5| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |             1     1                                                      |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Casts Protein                        |    1  1  1           1                                                   |      4  1.0|
      Nephropathy                          | 1              1        1                                                |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 5| 8| 8| 1|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 2| 9| 9| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               |                            +                                             |   1        |
      Perforation                          |                            X                                             |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 1  1     2                                                               |      3  1.3|
      Inflammation                         | 1  1  1  1  1        1  1                                                |      7  1.0|
      Necrosis                             |                   3                                                      |      1  3.0|
      Hepatocyte, Fatty Change             | 2  2     1  1        1  1                                                |      6  1.3|
      Hepatocyte, Vacuolization Cytoplasmic| 2  3  2  2  2  1  1  3  3                                                |      9  2.1|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperkeratosis                       |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 5| 8| 8| 1|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 2| 9| 9| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  1  1                                                |      9  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |          1                                                               |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |    1  1     2                                                            |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |   1        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 1                                                                        |      1  1.0|
      Endometrium, Hyperplasia, Cystic     | 3  2  2  1  2  2     1  2                                                |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                   3                                                      |      1  3.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 5| 8| 8| 1|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 2| 9| 9| 0|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                   4     2                                                |      2  3.0|
      Cyst                                 | 1  1  1  1  1     1  1  1                                                |      8  1.0|
      Necrosis                             |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accumulation, Hyaline Droplet        |                   3                                                      |      1  3.0|
      Casts Protein                        | 1  1           1  1     1  1                                             |      6  1.0|
      Nephropathy                          |             1                                                            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 6| 8| 8| 8| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         | 1  1  1  1  1  1  1     1                                                |      8  1.0|
      Hepatocyte, Fatty Change             | 3  2  1  2     4  2  3  1  3                                             |      9  2.3|
      Hepatocyte, Vacuolization Cytoplasmic| 3  3  2  1  2  3  2  3  2  3                                             |     10  2.4|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Subcapsular, Hyperplasia             | 1  1  1  1  1  1  1  1  1  1                                             |     10  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 6| 8| 8| 8| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |          1                                                               |      1  1.0|
      Endometrium, Hyperplasia, Cystic     | 2  1  2  2  1  1  2  2  2  2                                             |     10  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |             3                                                            |      1  3.0|
      Cyst                                 |    1  1  1  1  1  1     1  2                                             |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 6| 8| 8| 8| 8| 8|                                            |            |
                                           | 9| 9| 9| 9| 0| 9| 9| 9| 9| 9|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) FEMALE                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Casts Protein                        | 1  1        1  1     1     1                                             |      6  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                1     2                                                   |      2  1.5|
      Inflammation                         |       1  1  1  1  1  1  1                                                |      7  1.0|
      Hepatocyte, Fatty Change             | 1  2  1              1  2  1                                             |      6  1.3|
      Hepatocyte, Vacuolization Cytoplasmic| 3  2  3  1  3  4  4  3  4  4                                             |     10  3.1|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 1     1     1                                                            |      3  1.0|
      Subcapsular, Hyperplasia             |             1  1                                                         |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                                                               |   1        |
      Cyst                                 |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 1        1        1        1                                             |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Germinal Epithelium, Degeneration    |             1              1                                             |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +                                             |   9        |
      Cyst                                 | 1     1  1     1  1     2                                                |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Casts Protein                        | 1                                                                        |      1  1.0|
      Cyst                                 |       1                                                                  |      1  1.0|
      Nephropathy                          |       1  1     1  1                                                      |      4  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      | 1  1     2  1  1  1  1  1                                                |      8  1.1|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          1                                                               |      1  1.0|
      Infiltration Cellular, Lymphocyte    | 1              1  1                                                      |      3  1.0|
      Inflammation                         | 1  1  1     1  1  2  1  1  1                                             |      9  1.1|
      Hepatocyte, Fatty Change             |    1        1  1     1  1  1                                             |      6  1.0|
      Hepatocyte, Vacuolization Cytoplasmic| 2  3  2     3  4  3  2  4  3                                             |      9  2.9|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |                1        1                                                |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |          1  1                                                            |      2  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                            2                                             |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                      1     1                                             |      2  1.0|
      Germinal Epithelium, Degeneration    |    1              1  2  1  2                                             |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 1  1     1  1  1  1     1                                                |      7  1.0|
      Epithelial Cell, Hyperplasia         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 7| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    25 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Casts Protein                        |       1     1                                                            |      2  1.0|
      Nephropathy                          | 1  1                       1                                             |      3  1.0|
      Renal Tubule, Degeneration           |    3                                                                     |      1  3.0|
      Renal Tubule, Dilatation             |             1                                                            |      1  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |             1  1  1  1  1                                                |      5  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                2                                                         |      1  2.0|
      Inflammation                         | 1  1     1  1  1  1  1  1  1                                             |      9  1.0|
      Hepatocyte, Fatty Change             |       2     2     2  2     1                                             |      5  1.8|
      Hepatocyte, Vacuolization Cytoplasmic| 3  1  3  3  3  2  2  4  2  4                                             |     10  2.7|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 1                 1                                                      |      2  1.0|
      Subcapsular, Hyperplasia             |                            1                                             |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 1                    1     1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation                         |                2                                                         |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                1                                                         |      1  1.0|
      Germinal Epithelium, Degeneration    |             1  2                                                         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +     +  +  +  +  +  +                                             |   9        |
      Cyst                                 |    1           1  1  2  2  1                                             |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |    1        1     1        1                                             |      4  1.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                      1                                                   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                2        1  1                                             |      3  1.3|
      Inflammation                         | 1     1  1  1  1  1  1  1  1                                             |      9  1.0|
      Necrosis                             |             1                                                            |      1  1.0|
      Hepatocyte, Fatty Change             | 3  3  3  3  2  3  3  3  4  3                                             |     10  3.0|
      Hepatocyte, Vacuolization Cytoplasmic| 3  3  4  3  2  2  4  2  4  3                                             |     10  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |    1                                                                     |      1  1.0|
      Subcapsular, Hyperplasia             | 1     1                                                                  |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       1                                                                  |      1  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Germinal Epithelium, Degeneration    |                   1     1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |    1                                                                     |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +                                             |   9        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       1  1     1     1                                                   |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-98                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                      WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                      Date: 11/04/03    
Route: GAVAGE                                                                                                     Time: 12:08:05    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   P53+/-(C57BL/6) MALE                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    100                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |    2                                                                     |      1  2.0|
      Nephropathy                          | 1  1  1  1  1  1  1     1  1                                             |      9  1.0|
      Renal Tubule, Degeneration           | 3  4  3  2  3  2  2  1  2  3                                             |     10  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------