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TDMS Study 97013-99 Pathology Tables

NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  75-27-4

       Lock Date:  07/19/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 4            4            3            4                                     
    Natural Death                                      1            2                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 5            4            7            5                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 4 [1.0]      2 [1.0]      1 [1.0]      4 [1.3]                               
      Inflammation                                     7 [1.1]      6 [1.0]      9 [1.1]      5 [1.0]                               
      Necrosis                                                      1 [1.0]      1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic            4 [1.3]      4 [1.3]      7 [1.6]      6 [1.2]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperplasia                          1 [1.0]                                1 [1.0]                               
   Tooth                                              (4)          (4)          (4)          (3)                                    
      Peridontal Tissue, Hyperplasia                                1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                                           1 [1.0]      1 [1.0]                               
      Subcapsular, Hyperplasia                         7 [1.0]      5 [1.0]      5 [1.0]      7 [1.0]                               
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 [1.0]                                                                      
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 [1.0]      1 [1.0]      1 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [1.0]      3 [1.0]      1 [1.0]      1 [1.0]                               
      Inflammation                                                                            1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 [2.0]                   3 [1.3]      1 [2.0]                               
      Cyst                                             1 [2.0]      1 [1.0]      2 [1.5]      1 [1.0]                               
      Inflammation                                                  1 [3.0]                                                         
      Inflammation, Suppurative                        1 [2.0]                                                                      
   Oviduct                                                                      (1)                                                 
      Inflammation                                                               1 [3.0]                                            
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Hydrometra                                                                 1 [2.0]                                            
      Inflammation                                                  1 [2.0]                                                         
      Endometrium, Hyperplasia, Cystic                 5 [1.8]      4 [1.5]      5 [1.2]      7 [1.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (9)                                    
      Hyperplasia                                      3 [2.0]                   1 [1.0]      1 [2.0]                               
      Infiltration Cellular, Plasma Cell                            1 [1.0]                                                         
   Lymph Node, Mesenteric                             (9)          (9)          (10)         (10)                                   
      Hyperplasia                                      1 [2.0]                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 3 [1.0]      2 [1.0]      1 [1.0]      2 [1.0]                               
      Lymphoid Follicle, Atrophy                                    1 [2.0]                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          2 [1.5]      6 [2.2]      2 [2.0]      2 [2.0]                               
      Cyst                                             3 [1.0]      2 [1.0]      2 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                                2 [2.0]      1 [1.0]                               
      Inflammation, Focal                              2 [1.5]      1 [1.0]                   1 [1.0]                               
      Control Epidermis, Hyperplasia                   2 [2.0]                                1 [2.0]                               
      Epidermis, Hyperplasia, Focal                    1 [3.0]      1 [2.0]      1 [3.0]      1 [2.0]                               
      Site of Application - Epidermis, Hyperplasia                  1 [1.0]                   1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Site of Application - Epidermis, Inflammation                 1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 [1.0]                                                                      
      Alveolar Epithelium, Hyperplasia                                           2 [1.5]                                            
      Perivascular, Infiltration Cellular,                                                                                          
        Mononuclear Cell                               1 [2.0]                                                                      
      Perivascular, Inflammation                                                              1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (1)                                    
      Retina, Degeneration                                                                    1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Accumulation, Hyaline Droplet                    1 [3.0]      1 [1.0]                                                         
      Casts Protein                                    2 [1.0]      1 [1.0]      1 [1.0]      1 [2.0]                               
      Cyst                                             1 [1.0]                                2 [1.0]                               
      Hydronephrosis                                   1 [1.0]      1 [1.0]                                                         
      Inflammation                                                  1 [1.0]                                                         
      Mineralization                                                             1 [1.0]                                            
      Nephropathy                                      2 [1.5]      1 [2.0]      4 [1.0]      1 [1.0]                               
      Artery, Inflammation                             1 [1.0]                                                                      
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 [1.0]      3 [2.0]                   2 [2.5]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 3                         1            1                                     
    Natural Death                                      1            2                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            8            9            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 3 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
      Inflammation                                     6 [1.0]      3 [1.0]      6 [1.0]      3 [1.0]                               
      Necrosis                                         1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
      Hepatocyte, Fatty Change                                      1 [1.0]                                                         
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.3]      7 [1.3]      8 [1.1]      7 [1.3]                               
   Mesentery                                                                    (1)                                                 
      Fat, Necrosis                                                              1 [3.0]                                            
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Hyperkeratosis                                                                          1 [1.0]                               
      Epithelium, Hyperplasia                          2 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      5 [1.0]      3 [1.7]      4 [1.8]      4 [1.0]                               
      Subcapsular, Hyperplasia                                                   1 [1.0]      1 [1.0]                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Cyst                                             1 [1.0]      2 [1.0]      1 [1.0]      2 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Cyst                                                                                    3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Inflammation                                                               1 [1.0]                                            
   Testes                                             (10)         (10)         (10)         (10)                                   
      Germinal Epithelium, Degeneration                1 [1.0]      2 [2.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 [2.0]      1 [2.0]                                            
      Infiltration Cellular, Plasma Cell               2 [1.0]                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 4 [1.3]      2 [1.0]      3 [1.0]      1 [1.0]                               
      Pigmentation                                                                            1 [1.0]                               
      Lymphoid Follicle, Atrophy                                                              1 [2.0]                               
   Thymus                                             (9)          (10)         (9)          (9)                                    
      Atrophy                                          1 [3.0]                   2 [2.0]      1 [3.0]                               
      Cyst                                             4 [1.0]      2 [1.0]      1 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Hyperplasia                                                   1 [2.0]                   1 [1.0]                               
      Inflammation                                                                            1 [1.0]                               
      Inflammation, Focal                              1 [1.0]      2 [2.0]      1 [1.0]                                            
      Ulcer                                                                                   1 [2.0]                               
      Control Epidermis, Hyperplasia                                                          1 [2.0]                               
      Epidermis, Hyperplasia, Focal                    1 [1.0]      1 [2.0]                                                         
      Site of Application - Dermis, Inflammation                                              1 [1.0]                               
      Site of Application - Epidermis, Hyperplasia                               1 [2.0]      1 [2.0]                               
      Site of Application - Epidermis, Hyperplasia,                                                                                 
         Focal                                         1 [3.0]                                                                      
      Site of Application - Epidermis,                                                                                              
        Inflammation, Focal                            1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/05/03    
Route: SKIN APPLICATION                        WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                    Time: 10:10:29    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      64 MG/KG     128          256                                    
                                                                                MG/KG        MG/KG                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation                                     1 [1.0]                   1 [1.0]                                            
      Alveolar Epithelium, Hyperplasia                                           1 [1.0]                                            
      Perivascular, Inflammation                       1 [2.0]                   1 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Casts Protein                                    1 [1.0]      2 [1.0]      4 [1.0]      2 [1.0]                               
      Cyst                                             1 [1.0]      1 [1.0]      2 [1.0]      2 [1.0]                               
      Hydronephrosis                                                2 [1.5]                                                         
      Nephropathy                                      6 [1.0]      5 [1.0]      3 [1.0]      6 [1.0]                               
      Artery, Inflammation                                                       1 [2.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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