National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14581

Target Organs and Levels of Evidence for TR-000

Report on Carcinogenesis Bioassay of Technical Grade Chlordecone (Kepone) (CASRN 143-50-0) and Chloroform (CASRN 67-66-3)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Chlordecone (kepone)
143-50-0
NA Insecticide for fruit trees; as a fungicide; base material for the manufacture of kelevan. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Dosed-Feed
FR: 0,18,26 (AVG), MR: 0,8,24 (AVG), FM: 0,20,40 (AVG), MM: 0,20,23 (AVG) PPM
Gulf South Research Institute

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA; HYPERPLASIA
Female Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA; HYPERPLASIA
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA; HYPERPLASIA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA; HYPERPLASIA





Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Chloroform
67-66-3
09/00/1976 Chemical intermediate for fluorocarbon 22, mildewcide for tobacco seedlings, soil fumigant & insecticide, dry cleaning agent, chemical intermediate for dyes (HSDB 1990) Gavage
MR:0,90,180 FR:0,125,250 (WK 1-22) 0,90,180 (WK23-SAC) FM:0,7,14 MM:0,4,8 MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA OR ADENOCARCINOMA COMBINED
Female Rats: Negative
Male Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
Female Mice: Positive
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA


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