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Target Organs and Levels of Evidence for TR-013

Bioassay of Tetrachloroethylene for Possible Carcinogenicity (CASRN 127-18-4)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetrachloroethylene
127-18-4
09/26/1977Dry-cleaning solvent, metal degreaser, intermediate, textile processing, antihelmintic (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,600,1200 (AVG), MM: 0,500,1000 (AVG), FM: 0,350,700 (AVG) MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Inadequate Study
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)