National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14728

Target Organs and Levels of Evidence for TR-037

Bioassay of Toxaphene for Possible Carcinogenicity (CASRN 8001-35-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Toxaphene
8001-35-2
08/31/1978Insecticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,556,1112 (AVG), FR: 0,540,1080 (AVG), M: 0,99,198 (AVG) PPM/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA, ADENOMA OR CARCINOMA
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.