National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14746

Target Organs and Levels of Evidence for TR-047

Bioassay of 4,4'-Thiodianiline for Possible Carcinogenicity (CASRN 139-65-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4,4'-Thiodianiline
139-65-1
01/18/1978Dye intermediateDosed-Feed
R: 0,1500,3000, M: 0,2500,5000 PPM/35 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Intestines: ADENOCARCINOMA
  • Thyroid Gland Follicular Cell: CARCINOMA
  • Zymbal Gland: SQUAMOUS CELL PAPILLOMA OR CARCINOMA
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: CARCINOMA
  • Zymbal Gland: SQUAMOUS CELL PAPILLOMA OR CARCINOMA
  • Uterus/Cervix: ADENOCARCINOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Thyroid Gland Follicular Cell: CARCINOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA
  • Thyroid Gland Follicular Cell: ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA


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