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https://ntp.niehs.nih.gov/go/14762

Target Organs and Levels of Evidence for TR-055

Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dichloroethane
107-06-2
03/06/1978Production of vinyl chloride and other chlorinated chemicals; lead scavenger; fumigant; solvent for pharmaceutical products, upholstery and carpet cleaner, rubber goods (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,47,95 (AVG), MM: 0,97,195 (AVG), FM: 0,149,299 (AVG) MG/KG/50 PER GROUP
Hazleton, Vienna

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: (SQUAMOUS CELL CARCINOMA)
  • Vascular System (Unspecified): (HEMANGIOSARCOMA)
  • Subcutaneous Tissue: (FIBROMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: (ADENOCARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA)
  • Mammary Gland: (ADENOCARCINOMA)
  • Uterus/Cervix: (POLYP, SARCOMA)