National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10513

Target Organs and Levels of Evidence for TR-063

Bioassay of 4-Chloro-o-phenylenediamine for Possible Carcinogenicity (CASRN 95-83-0)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4-Chloro-o-phenylenediamine
95-83-0
03/06/1978Oxidation base; chemical intermediate for dyes; (formerly) ingredient in hair dyes; curing agent in epoxy resins (HSDB)Dosed-Feed
R: 0,.5,1.0 (AVG), M: 0,.7,1.4 (AVG) %DIET/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA)
  • Forestomach: (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


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