National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8240

Target Organs and Levels of Evidence for TR-080

Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,4-Dioxane
123-91-1
03/07/1978Industrial and lab solvent used in lacquers, paints, dyes, resins, oils and waxes. In biological and chemical laboratories, dioxane is employed as a solvent for tissue processing, liquid scintillation counting, and photochemical reactions.Dosed-Water
0,0.5,1.0 %/70R - 100M PER GROUP
IIT Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: (SQUAMOUS CELL CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA)
  • Nasal Cavity: (SQUAMOUS CELL CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.