National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7120

Target Organs and Levels of Evidence for TR-143

Bioassay of 1,5-Naphthalenediamine for Possible Carcinogenicity (CASRN 2243-62-1)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,5-Naphthalenediamine
2243-62-1
06/29/1978Dye and drug intermediateDosed-Feed
R: 0,.05,1.0, M: 0,.1,.2 %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Clitoral Gland: (ADENOMA OR CARCINOMA)
  • Uterus/Cervix: (POLYP)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland C-Cell: ADENOMA OR CARCINOMA, ADENOMA
  • Liver: (ADENOMA, CARCINOMA)
  • Lung: (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)


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