National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6199

Target Organs and Levels of Evidence for TR-153

Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
o-Toluidine hydrochloride
636-21-5
10/25/1978Dye intermediate; photographic dye; lab reagent; rubber manufacture. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,3000,6000, M: 0,1000,3000 PPM/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (SARCOMA)
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA
  • Subcutaneous Tissue: (FIBROMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: (SARCOMA)
  • Urinary Bladder: (TRANSITIONAL CELL CARCINOMA)
  • Mammary Gland: (ADENOMA OR FIBROADENOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA OR CARCINOMA)


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