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Target Organs and Levels of Evidence for TR-162

Bioassay of 2,4-Diaminotoluene for Possible Carcinogenicity (CASRN 95-80-7)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4-Diaminotoluene (2,4-toluene diamine)
95-80-7
12/13/1978Intermediate for polyurethanes and dyes; in hair dyes (formerly)Dosed-Feed
MR: 0,79,176 (AVG), FR: 0,79,171 (AVG), M: 0,100,200 PPM/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: (ADENOMA, CARCINOMA)
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
May Have Been Related
  • Hematopoietic System: (LYMPHOMA)