National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8407

Target Organs and Levels of Evidence for TR-181

Bioassay of Michler's Ketone for Possible Carcinogenicity (CASRN 90-94-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Michler's ketone
90-94-8
10/25/1978Dye intermediateDosed-Feed
MR: 0,250,500, FR: 0,500,1000, M: 0,1250,2500 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


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