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Target Organs and Levels of Evidence for TR-193

Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Reserpine
50-55-5
05/01/1979Antihypertensive drugDosed-Feed
0,5,10 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Seminal Vesicle: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: (FIBROADENOMA, ADENOCARCINOMA, ADENOSQUAMOUS CARCINOMA)