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Target Organs and Levels of Evidence for TR-198

Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CASRN 57653-85-7, CASRN 19408-74-3)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin
57653-85-7
02/15/1980Not used commercially in the U.S. contaminant of herbicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&MM: 0,1.25,2.5,5.0, FM: 0,2.5,5.0,10.0 UG/KG/50 PER GROUP
IIT Research Institute

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE OR CARCINOMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (NEOPLASTIC NODULE, CARCINOMA)
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA, CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA, CARCINOMA)